Sertraline


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24194395
GO:0006749 Glutathione metabolic process Affects phenotype PMID:25656284
GO:0006914 Autophagy Increases phenotype PMID:33124469
GO:0006915 Apoptotic process Increases phenotype PMID:24194395; PMID:24194395; PMID:24865413
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:24194395
GO:0007254 Jnk cascade Increases phenotype PMID:24194395
GO:0008217 Regulation of blood pressure Increases phenotype PMID:3045113
GO:0008283 Cell population proliferation Decreases phenotype PMID:33124469
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:28844482
GO:0010894 Negative regulation of steroid biosynthetic process Increases phenotype PMID:29850907
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25656284; PMID:26162595
GO:0032277 Negative regulation of gonadotropin secretion Increases phenotype PMID:29679653
GO:0032278 Positive regulation of gonadotropin secretion Increases phenotype PMID:29679653
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:29850907
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:24865413
GO:0038066 P38mapk cascade Increases phenotype PMID:24194395
GO:0042310 Vasoconstriction Increases phenotype PMID:15770431
GO:0042311 Vasodilation Increases phenotype PMID:15770431
GO:0044754 Autolysosome Increases phenotype PMID:33124469
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:25656284
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:29679653
GO:0046034 Atp metabolic process Affects phenotype PMID:33124469
GO:0046460 Neutral lipid biosynthetic process Increases phenotype PMID:38643950
GO:0046718 Viral entry into host cell Decreases phenotype PMID:29033372
GO:0060143 Positive regulation of syncytium formation by plasma membrane fusion Increases phenotype PMID:29679653
GO:0070371 Erk1 and erk2 cascade Increases phenotype PMID:24194395
GO:0097191 Extrinsic apoptotic signaling pathway Increases phenotype PMID:24194395
GO:0097193 Intrinsic apoptotic signaling pathway Increases phenotype PMID:24194395
GO:1901216 Positive regulation of neuron death Increases phenotype PMID:25656284
GO:1905673 Positive regulation of lysosome organization Increases phenotype PMID:38643950
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:26162595
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:26162595
GO:2000872 Positive regulation of progesterone secretion Decreases phenotype PMID:26162595
GO:2000986 Negative regulation of behavioral fear response Increases phenotype PMID:34262461
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.