DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Aflatoxin B1

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000084	Mitotic s phase	Increases phenotype	PMID:32607778
GO:0000086	G2/m transition of mitotic cell cycle	Increases phenotype	PMID:32106047; PMID:34396909
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:38382706
GO:0001676	Long-chain fatty acid metabolic process	Decreases phenotype	PMID:29897551
GO:0002377	Immunoglobulin production	Affects phenotype	PMID:38763499
GO:0002638	Negative regulation of immunoglobulin production	Increases phenotype	PMID:20737424
GO:0003810	Protein-glutamine gamma-glutamyltransferase activity	Increases phenotype	PMID:34506763
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:34506763; PMID:35608386
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:34015426
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:18636399; PMID:25450479; PMID:32894639; PMID:34506763; PMID:35063475
GO:0004457	Lactate dehydrogenase activity	Increases phenotype	PMID:35608386
GO:0004602	Glutathione peroxidase activity	Affects phenotype	PMID:28442411; PMID:32894639; PMID:35063475; PMID:35304092
GO:0004784	Superoxide dismutase activity	Decreases phenotype	PMID:25154877; PMID:25154877; PMID:28442411; PMID:35063475; PMID:35304092
GO:0006006	Glucose metabolic process	Affects phenotype	PMID:35608386
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:35608386
GO:0006284	Base-excision repair	Increases phenotype	PMID:24675474; PMID:33595290
GO:0006304	Dna modification	Increases phenotype	PMID:30714215; PMID:32106047; PMID:33595290; PMID:35063475
GO:0006309	Apoptotic dna fragmentation	Increases phenotype	PMID:26084420
GO:0006497	Protein lipidation	Increases phenotype	PMID:34396909
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:32418920
GO:0006695	Cholesterol biosynthetic process	Increases phenotype	PMID:28442411
GO:0006702	Androgen biosynthetic process	Affects phenotype	PMID:24373827
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:20737424; PMID:20737424; PMID:35063475; PMID:32894639; PMID:33421461; PMID:34089297; PMID:35063475
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:18636399; PMID:25154877
GO:0006754	Atp biosynthetic process	Decreases phenotype	PMID:35435491; PMID:35810998
GO:0006790	Sulfur compound metabolic process	Increases phenotype	PMID:30126036
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:28442411
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:34748853
GO:0006915	Apoptotic process	Affects phenotype	PMID:24211421; PMID:24211421; PMID:27017951; PMID:27017951; PMID:28181396; PMID:28442411; PMID:32607778; PMID:33421461; PMID:34089297; PMID:35304092; PMID:36941454; PMID:38763499
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:25154877; PMID:25154877; PMID:27288928; PMID:28442411; PMID:32418920; PMID:26739636; PMID:27017951; PMID:28882572; PMID:29218508; PMID:29549414; PMID:31542801; PMID:27017951; PMID:27288928; PMID:27288928; PMID:32418920; PMID:28181396; PMID:28882572; PMID:29218508; PMID:29549414; PMID:31542801; PMID:34089297; PMID:34762139
GO:0006997	Nucleus organization	Decreases phenotype	PMID:35063475
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:34116104; PMID:35304092
GO:0007059	Chromosome segregation	Increases phenotype	PMID:27913846
GO:0007204	Positive regulation of cytosolic calcium ion concentration	Increases phenotype	PMID:26026912
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:29274131
GO:0007286	Spermatid development	Decreases phenotype	PMID:30126036
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:32418920
GO:0008219	Cell death	Increases phenotype	PMID:18636399; PMID:25660481; PMID:27153755; PMID:30714215
GO:0008234	Cysteine-type peptidase activity	Increases phenotype	PMID:36941454
GO:0008283	Cell population proliferation	Affects phenotype	PMID:21361338; PMID:23423819; PMID:23850736; PMID:24211421; PMID:24211421; PMID:28943387; PMID:28943387; PMID:32106047
GO:0008284	Positive regulation of cell population proliferation	Affects phenotype	PMID:28789997; PMID:28965971
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:29555536; PMID:33164849; PMID:33811995; PMID:33811995
GO:0010424	Dna methylation on cytosine within a cg sequence	Decreases phenotype	PMID:27017951
GO:0010669	Epithelial structure maintenance	Decreases phenotype	PMID:29274131
GO:0010823	Negative regulation of mitochondrion organization	Increases phenotype	PMID:30126036
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:35810998
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:18347083; PMID:20233841; PMID:22447115; PMID:20233841; PMID:20737424; PMID:22524704; PMID:23397584
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:28181396; PMID:28442411; PMID:32418920; PMID:32894639; PMID:34089297
GO:0016049	Cell growth	Decreases phenotype	PMID:18636399; PMID:30668976
GO:0018158	Protein oxidation	Increases phenotype	PMID:28181396
GO:0018216	Peptidyl-arginine methylation	Increases phenotype	PMID:27242039
GO:0019216	Regulation of lipid metabolic process	Increases phenotype	PMID:23385219; PMID:34358323
GO:0019432	Triglyceride biosynthetic process	Increases phenotype	PMID:28442411
GO:0019627	Urea metabolic process	Affects phenotype	PMID:32418920; PMID:35608386
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:34506763
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:35063475; PMID:38763499
GO:0031324	Negative regulation of cellular metabolic process	Increases phenotype	PMID:29445054
GO:0032125	Micronucleus organization	Increases phenotype	PMID:31733235; PMID:34762139; PMID:36442682; PMID:38382706
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:28789997
GO:0034418	Urate biosynthetic process	Increases phenotype	PMID:27288928; PMID:32418920
GO:0034440	Lipid oxidation	Increases phenotype	PMID:20737424; PMID:30126036
GO:0036146	Cellular response to mycotoxin	Increases phenotype	PMID:23385219
GO:0036164	Cell-abiotic substrate adhesion	Decreases phenotype	PMID:28458013
GO:0040015	Negative regulation of multicellular organism growth	Increases phenotype	PMID:30126036
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:28181396; PMID:32106047
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:30126036
GO:0044237	Cellular metabolic process	Decreases phenotype	PMID:31733235; PMID:32607778; PMID:33984424; PMID:34089297; PMID:34116104; PMID:34396909; PMID:34748853; PMID:38382706
GO:0044255	Cellular lipid metabolic process	Increases phenotype	PMID:25154877
GO:0044319	Wound healing, spreading of cells	Decreases phenotype	PMID:34396909
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:34396909
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:30126036
GO:0045722	Positive regulation of gluconeogenesis	Affects phenotype	PMID:23385219
GO:0045930	Negative regulation of mitotic cell cycle	Affects phenotype	PMID:27017951; PMID:28181396; PMID:32106047; PMID:32607778
GO:0046034	Atp metabolic process	Increases phenotype	PMID:33164849; PMID:34089297; PMID:35304092
GO:0046222	Aflatoxin metabolic process	Affects phenotype	PMID:34015426
GO:0046223	Aflatoxin catabolic process	Decreases phenotype	PMID:27071940
GO:0046329	Negative regulation of jnk cascade	Affects phenotype	PMID:24373827
GO:0046415	Urate metabolic process	Affects phenotype	PMID:27288928
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:27288928; PMID:32418920
GO:0046459	Short-chain fatty acid metabolic process	Decreases phenotype	PMID:29897551; PMID:34358323
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:35810998
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:30126036
GO:0048874	Host-mediated regulation of intestinal microbiota composition	Affects phenotype	PMID:34358323
GO:0050729	Positive regulation of inflammatory response	Affects phenotype	PMID:23385219
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:27017951; PMID:28181396; PMID:32607778; PMID:35304092
GO:0051899	Membrane depolarization	Increases phenotype	PMID:36941454
GO:0060429	Epithelium development	Decreases phenotype	PMID:30126036
GO:0070265	Necrotic cell death	Increases phenotype	PMID:38763499
GO:0070374	Positive regulation of erk1 and erk2 cascade	Affects phenotype	PMID:24373827
GO:0070509	Calcium ion import	Affects phenotype	PMID:27818125
GO:0070858	Negative regulation of bile acid biosynthetic process	Increases phenotype	PMID:34358323
GO:0070859	Positive regulation of bile acid biosynthetic process	Increases phenotype	PMID:37030333
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:33421461; PMID:35063475; PMID:35304092; PMID:36941454
GO:0071736	Igg immunoglobulin complex, circulating	Affects phenotype	PMID:38763499
GO:0071746	Iga immunoglobulin complex, circulating	Affects phenotype	PMID:38763499
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:24211421; PMID:32106047; PMID:32607778; PMID:34396909; PMID:34748853; PMID:35304092
GO:0090037	Positive regulation of protein kinase c signaling	Increases phenotype	PMID:26026912
GO:0090592	Dna synthesis involved in dna replication	Decreases phenotype	PMID:33164849
GO:0097189	Apoptotic body	Increases phenotype	PMID:32607778
GO:0097368	Establishment of sertoli cell barrier	Decreases phenotype	PMID:33421461
GO:0097707	Ferroptosis	Affects phenotype	PMID:34116104
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:35063475
GO:0140454	Protein aggregate center assembly	Increases phenotype	PMID:36941454
GO:1900409	Positive regulation of cellular response to oxidative stress	Affects phenotype	PMID:23385219
GO:1900744	Regulation of p38mapk cascade	Affects phenotype	PMID:24373827
GO:1901526	Positive regulation of mitophagy	Increases phenotype	PMID:35810998
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:20737424
GO:1901798	Positive regulation of signal transduction by p53 class mediator	Affects phenotype	PMID:23385219
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:29274131
GO:1902969	Mitotic dna replication	Decreases phenotype	PMID:32106047
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:34396909
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:18636399; PMID:18636399; PMID:27017951; PMID:27017951; PMID:28181396; PMID:35810998
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:20737424; PMID:28943387
GO:1904251	Regulation of bile acid metabolic process	Affects phenotype	PMID:29897551; PMID:37030333
GO:1905071	Tight junction disassembly	Increases phenotype	PMID:36100150
GO:1905464	Positive regulation of dna duplex unwinding	Increases phenotype	PMID:33164849
GO:1990051	Activation of protein kinase c activity	Increases phenotype	PMID:26968497
GO:2000573	Positive regulation of dna biosynthetic process	Increases phenotype	PMID:28965971
GO:2000819	Regulation of nucleotide-excision repair	Increases phenotype	PMID:24380836
GO:2000844	Negative regulation of testosterone secretion	Affects phenotype	PMID:24373827
GO:2000866	Positive regulation of estradiol secretion	Increases phenotype	PMID:26968497
GO:2000872	Positive regulation of progesterone secretion	Increases phenotype	PMID:26968497
GO:2001022	Positive regulation of response to dna damage stimulus	Increases phenotype	PMID:33164849
GO:2001057	Reactive nitrogen species metabolic process	Increases phenotype	PMID:28181396; PMID:34089297
GO:2001272	Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	Increases phenotype	PMID:28943387

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.