DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Bis(2-ethylhexyl) phthalate

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000003	Reproduction	Decreases phenotype	PMID:26545148
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:29606031; PMID:30320191; PMID:36394428
GO:0000084	Mitotic s phase	Decreases phenotype	PMID:31163220
GO:0000104	Succinate dehydrogenase activity	Decreases phenotype	PMID:35510228
GO:0000105	Histidine biosynthetic process	Decreases phenotype	PMID:30284816
GO:0000212	Meiotic spindle organization	Affects phenotype	PMID:34492810
GO:0000239	Pachytene	Increases phenotype	PMID:28771232
GO:0000240	Diplotene	Decreases phenotype	PMID:28771232
GO:0000266	Mitochondrial fission	Increases phenotype	PMID:31408635
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:36608567
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:26845775; PMID:28771232; PMID:35521929; PMID:36356568; PMID:36394428
GO:0001503	Ossification	Affects phenotype	PMID:28921615
GO:0001510	Rna methylation	Increases phenotype	PMID:31923814; PMID:34120004
GO:0001541	Ovarian follicle development	Decreases phenotype	PMID:24458533; PMID:26678702; PMID:29969652; PMID:30939196; PMID:32209209; PMID:34597818; PMID:35762964
GO:0001543	Ovarian follicle rupture	Decreases phenotype	PMID:25888850
GO:0001544	Initiation of primordial ovarian follicle growth	Affects phenotype	PMID:28286118; PMID:34051340; PMID:34492810; PMID:39265699
GO:0001546	Preantral ovarian follicle growth	Increases phenotype	PMID:28286118; PMID:30939196
GO:0001547	Antral ovarian follicle growth	Decreases phenotype	PMID:26845775; PMID:28013214
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:27495896; PMID:28286118; PMID:36774801
GO:0001553	Luteinization	Affects phenotype	PMID:26161573
GO:0001556	Oocyte maturation	Decreases phenotype	PMID:26545148
GO:0001568	Blood vessel development	Increases phenotype	PMID:37021957
GO:0001649	Osteoblast differentiation	Increases phenotype	PMID:28921615
GO:0001675	Acrosome assembly	Affects phenotype	PMID:32619501; PMID:36087924
GO:0001824	Blastocyst development	Decreases phenotype	PMID:40279284
GO:0001825	Blastocyst formation	Decreases phenotype	PMID:22147016; PMID:27417426; PMID:28042535; PMID:28286118
GO:0001843	Neural tube closure	Decreases phenotype	PMID:28123099
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:25799571; PMID:28842438
GO:0002209	Behavioral defense response	Affects phenotype	PMID:38152552
GO:0002381	Immunoglobulin production involved in immunoglobulin-mediated immune response	Increases phenotype	PMID:25093321
GO:0002437	Inflammatory response to antigenic stimulus	Increases phenotype	PMID:25093321
GO:0002438	Acute inflammatory response to antigenic stimulus	Increases phenotype	PMID:23148021
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:30691201
GO:0002636	Positive regulation of germinal center formation	Increases phenotype	PMID:25093321
GO:0002830	Positive regulation of type 2 immune response	Increases phenotype	PMID:36209858; PMID:36508822
GO:0003006	Developmental process involved in reproduction	Increases phenotype	PMID:29471507; PMID:37788136
GO:0003016	Respiratory system process	Decreases phenotype	PMID:30737192
GO:0003093	Regulation of glomerular filtration	Affects phenotype	PMID:32645486
GO:0003229	Ventricular cardiac muscle tissue development	Decreases phenotype	PMID:31086358
GO:0003279	Cardiac septum development	Decreases phenotype	PMID:31086358
GO:0003993	Acid phosphatase activity	Affects phenotype	PMID:25882133; PMID:26361869
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:30691201
GO:0004022	Alcohol dehydrogenase (nad+) activity	Decreases phenotype	PMID:34534558
GO:0004035	Alkaline phosphatase activity	Increases phenotype	PMID:26361869; PMID:28025108; PMID:28921615; PMID:31979393
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Affects phenotype	PMID:28025108; PMID:30691201; PMID:31979393
GO:0004095	Carnitine o-palmitoyltransferase activity	Decreases phenotype	PMID:30284816
GO:0004345	Glucose-6-phosphate dehydrogenase activity	Decreases phenotype	PMID:31606821
GO:0004357	Glutamate-cysteine ligase activity	Increases phenotype	PMID:30523571
GO:0004457	Lactate dehydrogenase activity	Decreases phenotype	PMID:26361869; PMID:30284816
GO:0004565	Beta-galactosidase activity	Increases phenotype	PMID:31160972
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:27084994; PMID:28065941; PMID:29328408; PMID:32303808; PMID:32884073; PMID:33484791; PMID:35196152; PMID:35196152; PMID:39360521; PMID:35659966; PMID:39360521
GO:0004691	Camp-dependent protein kinase activity	Increases phenotype	PMID:33711355
GO:0004738	Pyruvate dehydrogenase activity	Increases phenotype	PMID:30284816
GO:0004784	Superoxide dismutase activity	Affects phenotype	PMID:25882133; PMID:25882133; PMID:26854921; PMID:29328408; PMID:26854921; PMID:27084994; PMID:28025108; PMID:28065941; PMID:28115068; PMID:29328408; PMID:30691201; PMID:33484791; PMID:31112013; PMID:35521929; PMID:31486570; PMID:32303808; PMID:33484791; PMID:34097988; PMID:34793900; PMID:35196152; PMID:35196152; PMID:39360521; PMID:35521929; PMID:35659966; PMID:39360521
GO:0005739	Mitochondrion	Increases phenotype	PMID:35659966
GO:0005776	Autophagosome	Affects phenotype	PMID:36394428
GO:0005977	Glycogen metabolic process	Increases phenotype	PMID:30565266; PMID:33484791
GO:0006006	Glucose metabolic process	Decreases phenotype	PMID:23277027; PMID:34303773; PMID:34600010
GO:0006007	Glucose catabolic process	Decreases phenotype	PMID:30597186
GO:0006045	N-acetylglucosamine biosynthetic process	Decreases phenotype	PMID:30284816
GO:0006085	Acetyl-coa biosynthetic process	Affects phenotype	PMID:33391822
GO:0006094	Gluconeogenesis	Decreases phenotype	PMID:30284816
GO:0006096	Glycolytic process	Increases phenotype	PMID:30284816
GO:0006099	Tricarboxylic acid cycle	Decreases phenotype	PMID:30284816
GO:0006109	Regulation of carbohydrate metabolic process	Affects phenotype	PMID:35550907
GO:0006140	Regulation of nucleotide metabolic process	Affects phenotype	PMID:35550907; PMID:37458746
GO:0006171	Camp biosynthetic process	Affects phenotype	PMID:32126385; PMID:33234378; PMID:37552060
GO:0006172	Adp biosynthetic process	Decreases phenotype	PMID:30550969
GO:0006260	Dna replication	Increases phenotype	PMID:32435917
GO:0006306	Dna methylation	Affects phenotype	PMID:38833407
GO:0006325	Chromatin organization	Affects phenotype	PMID:37302538
GO:0006355	Regulation of dna-templated transcription	Affects phenotype	PMID:25853433
GO:0006520	Amino acid metabolic process	Affects phenotype	PMID:26630026; PMID:35550907
GO:0006537	Glutamate biosynthetic process	Affects phenotype	PMID:30284816
GO:0006542	Glutamine biosynthetic process	Affects phenotype	PMID:30284816
GO:0006571	Tyrosine biosynthetic process	Affects phenotype	PMID:31706747
GO:0006590	Thyroid hormone generation	Increases phenotype	PMID:31979393
GO:0006601	Creatine biosynthetic process	Increases phenotype	PMID:30284816
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:35818422
GO:0006626	Protein targeting to mitochondrion	Affects phenotype	PMID:31408635
GO:0006629	Lipid metabolic process	Affects phenotype	PMID:28105114
GO:0006633	Fatty acid biosynthetic process	Decreases phenotype	PMID:30284816
GO:0006635	Fatty acid beta-oxidation	Decreases phenotype	PMID:30284816
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:22792086; PMID:23277027; PMID:28105114; PMID:32325186; PMID:33484791; PMID:23277027; PMID:28105114; PMID:33484791; PMID:26630026; PMID:30145988; PMID:32325186; PMID:33166671; PMID:33484791; PMID:33832334; PMID:36988346
GO:0006693	Prostaglandin metabolic process	Affects phenotype	PMID:25888850
GO:0006694	Steroid biosynthetic process	Decreases phenotype	PMID:35762964
GO:0006695	Cholesterol biosynthetic process	Decreases phenotype	PMID:30284816; PMID:31979393
GO:0006749	Glutathione metabolic process	Increases phenotype	PMID:25882133; PMID:32500380; PMID:35196152; PMID:35196152; PMID:39360521; PMID:35460826; PMID:35500696; PMID:35521929; PMID:39360521
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:26361869; PMID:26361869; PMID:26854921; PMID:26854921; PMID:28115068
GO:0006874	Cellular calcium ion homeostasis	Affects phenotype	PMID:25418486
GO:0006900	Vesicle budding from membrane	Increases phenotype	PMID:33229049
GO:0006909	Phagocytosis	Decreases phenotype	PMID:26133781
GO:0006915	Apoptotic process	Affects phenotype	PMID:24393508; PMID:25068794; PMID:25418486; PMID:25975992; PMID:26845775; PMID:27084994; PMID:28042535; PMID:28532275; PMID:28532275; PMID:29606031; PMID:31163220; PMID:35659966; PMID:36394428; PMID:37302538; PMID:37406783; PMID:39515621
GO:0006950	Response to stress	Affects phenotype	PMID:28842438
GO:0006954	Inflammatory response	Increases phenotype	PMID:35510228
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:24084170; PMID:26854921; PMID:28115068; PMID:29777724; PMID:29777724; PMID:31486570; PMID:30543897; PMID:34822940
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:21673306; PMID:30320191; PMID:34822940; PMID:35917956; PMID:36087924; PMID:36174316; PMID:39360521
GO:0007009	Plasma membrane organization	Decreases phenotype	PMID:35659966
GO:0007033	Vacuole organization	Affects phenotype	PMID:30320191; PMID:36087924
GO:0007132	Meiotic metaphase i	Affects phenotype	PMID:22147016
GO:0007137	Meiotic metaphase ii	Affects phenotype	PMID:28042535
GO:0007144	Female meiosis i	Affects phenotype	PMID:28771232
GO:0007179	Transforming growth factor beta receptor signaling pathway	Affects phenotype	PMID:37059381
GO:0007281	Germ cell development	Decreases phenotype	PMID:28123099; PMID:30802670; PMID:37059381; PMID:37788136
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:18570050; PMID:22147016; PMID:23892333; PMID:25882133; PMID:25882133; PMID:29663635; PMID:29940330; PMID:27060630; PMID:27417426; PMID:29029336; PMID:31175881; PMID:32235866; PMID:35196152; PMID:36087924; PMID:36423848; PMID:29029336; PMID:29328408; PMID:29328408; PMID:30320191; PMID:34015638; PMID:29663635; PMID:29940330; PMID:30802670; PMID:31175881; PMID:32050098; PMID:32619501; PMID:33923623; PMID:37692514; PMID:35196152; PMID:36174316; PMID:36174712; PMID:37364641; PMID:38730545; PMID:39360521
GO:0007286	Spermatid development	Decreases phenotype	PMID:30802670
GO:0007507	Heart development	Decreases phenotype	PMID:29377175; PMID:31086358
GO:0007566	Embryo implantation	Decreases phenotype	PMID:40279284
GO:0007568	Aging	Increases phenotype	PMID:36174712
GO:0007611	Learning or memory	Decreases phenotype	PMID:30523571; PMID:35354077; PMID:37858774
GO:0007612	Learning	Affects phenotype	PMID:37302538
GO:0007613	Memory	Decreases phenotype	PMID:37061009; PMID:37302538
GO:0007614	Short-term memory	Decreases phenotype	PMID:29688563
GO:0007617	Mating behavior	Decreases phenotype	PMID:36435455
GO:0007625	Grooming behavior	Decreases phenotype	PMID:26168342; PMID:35254616
GO:0007626	Locomotory behavior	Decreases phenotype	PMID:32303808
GO:0007631	Feeding behavior	Affects phenotype	PMID:30078309; PMID:31979393; PMID:31979393; PMID:36087924
GO:0008049	Male courtship behavior	Affects phenotype	PMID:28934723
GO:0008203	Cholesterol metabolic process	Affects phenotype	PMID:23277027; PMID:28105114; PMID:32325186; PMID:33484791; PMID:23756648; PMID:27827939; PMID:33166671; PMID:33484791; PMID:36988346
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:26630026; PMID:28611354; PMID:33309551; PMID:34597818
GO:0008217	Regulation of blood pressure	Affects phenotype	PMID:28842438
GO:0008219	Cell death	Increases phenotype	PMID:33711355; PMID:39360521
GO:0008283	Cell population proliferation	Increases phenotype	PMID:24213142; PMID:24213142; PMID:36328110; PMID:25068794; PMID:25418486; PMID:25995009; PMID:26630026; PMID:27853917; PMID:28054989; PMID:28115068; PMID:29663635; PMID:30078309; PMID:30543897; PMID:31175881; PMID:34186418; PMID:34428494; PMID:34728246; PMID:34801851; PMID:36328110; PMID:36608567; PMID:37302538; PMID:39109301
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:17929048; PMID:23793038; PMID:24496636; PMID:26519955; PMID:25369342; PMID:28412506; PMID:30090590; PMID:32681327; PMID:35263089; PMID:35810816; PMID:37734194
GO:0008285	Negative regulation of cell population proliferation	Increases phenotype	PMID:30720231; PMID:31228551; PMID:31771930; PMID:32353385; PMID:32949729; PMID:33091774; PMID:34492810; PMID:35500696; PMID:35716406; PMID:35739755; PMID:35841924; PMID:36209858; PMID:36774801
GO:0008344	Adult locomotory behavior	Affects phenotype	PMID:29982774
GO:0008361	Regulation of cell size	Affects phenotype	PMID:36198370
GO:0008542	Visual learning	Decreases phenotype	PMID:29688563
GO:0008584	Male gonad development	Affects phenotype	PMID:23959011; PMID:28611354; PMID:29328408; PMID:30802670; PMID:39307383
GO:0008585	Female gonad development	Affects phenotype	PMID:26845775
GO:0009094	L-phenylalanine biosynthetic process	Affects phenotype	PMID:31706747
GO:0009098	Leucine biosynthetic process	Affects phenotype	PMID:30284816
GO:0009099	Valine biosynthetic process	Affects phenotype	PMID:30284816
GO:0009100	Glycoprotein metabolic process	Affects phenotype	PMID:33309551
GO:0009117	Nucleotide metabolic process	Affects phenotype	PMID:37458746
GO:0009312	Oligosaccharide biosynthetic process	Decreases phenotype	PMID:34600010
GO:0009435	Nad biosynthetic process	Decreases phenotype	PMID:36781136
GO:0009448	Gamma-aminobutyric acid metabolic process	Affects phenotype	PMID:29774754; PMID:32303808
GO:0009566	Fertilization	Decreases phenotype	PMID:33711355
GO:0009749	Response to glucose	Decreases phenotype	PMID:29175711
GO:0009790	Embryo development	Decreases phenotype	PMID:33711355
GO:0010424	Dna methylation on cytosine within a cg sequence	Affects phenotype	PMID:33872906; PMID:37120575
GO:0010468	Regulation of gene expression	Affects phenotype	PMID:38995844
GO:0010507	Negative regulation of autophagy	Increases phenotype	PMID:38488668
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:31262386; PMID:32710958; PMID:36583613
GO:0010511	Regulation of phosphatidylinositol biosynthetic process	Affects phenotype	PMID:31577137
GO:0010718	Positive regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:29669060; PMID:33229049
GO:0010719	Negative regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:31726466
GO:0010729	Positive regulation of hydrogen peroxide biosynthetic process	Increases phenotype	PMID:36610486
GO:0010867	Positive regulation of triglyceride biosynthetic process	Increases phenotype	PMID:31606821; PMID:31706747; PMID:34303773; PMID:34600010; PMID:35019730; PMID:37753369; PMID:37753369; PMID:38050670
GO:0010868	Negative regulation of triglyceride biosynthetic process	Increases phenotype	PMID:38050670
GO:0010884	Positive regulation of lipid storage	Increases phenotype	PMID:32353385
GO:0010893	Positive regulation of steroid biosynthetic process	Decreases phenotype	PMID:27405655
GO:0010894	Negative regulation of steroid biosynthetic process	Increases phenotype	PMID:34492810
GO:0010906	Regulation of glucose metabolic process	Affects phenotype	PMID:35739755; PMID:37364641
GO:0010917	Negative regulation of mitochondrial membrane potential	Increases phenotype	PMID:36583613
GO:0010918	Positive regulation of mitochondrial membrane potential	Affects phenotype	PMID:23793038
GO:0010940	Positive regulation of necrotic cell death	Increases phenotype	PMID:37734194
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:27417426; PMID:30090590; PMID:35716406
GO:0010983	Positive regulation of high-density lipoprotein particle clearance	Increases phenotype	PMID:31606821
GO:0010987	Negative regulation of high-density lipoprotein particle clearance	Increases phenotype	PMID:30550969; PMID:35970509; PMID:31262386; PMID:31706747; PMID:31732953
GO:0010989	Negative regulation of low-density lipoprotein particle clearance	Increases phenotype	PMID:30550969; PMID:31262386; PMID:31606821; PMID:31706747; PMID:31732953; PMID:34303773; PMID:37753369
GO:0014067	Negative regulation of phosphatidylinositol 3-kinase signaling	Increases phenotype	PMID:32710958
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	Affects phenotype	PMID:23793038
GO:0015908	Fatty acid transport	Decreases phenotype	PMID:30284816
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:26854921; PMID:28025108; PMID:28115068; PMID:31112013; PMID:31486570; PMID:33484791; PMID:34097988; PMID:35521929
GO:0016049	Cell growth	Increases phenotype	PMID:30543897; PMID:33526986
GO:0016209	Antioxidant activity	Decreases phenotype	PMID:31923814; PMID:33649816
GO:0016342	Catenin complex	Decreases phenotype	PMID:36087924
GO:0016477	Cell migration	Increases phenotype	PMID:36328110
GO:0016788	Hydrolase activity, acting on ester bonds	Increases phenotype	PMID:37406783
GO:0016887	Atp hydrolysis activity	Affects phenotype	PMID:30284816
GO:0018108	Peptidyl-tyrosine phosphorylation	Increases phenotype	PMID:33711355
GO:0018158	Protein oxidation	Affects phenotype	PMID:32500380; PMID:34793900; PMID:35196152
GO:0018963	Phthalate metabolic process	Increases phenotype	PMID:30078309; PMID:35354077; PMID:36933457
GO:0019216	Regulation of lipid metabolic process	Affects phenotype	PMID:35550907; PMID:37806616; PMID:38199361
GO:0019218	Regulation of steroid metabolic process	Affects phenotype	PMID:28115639
GO:0019369	Arachidonic acid metabolic process	Affects phenotype	PMID:30284816
GO:0019432	Triglyceride biosynthetic process	Affects phenotype	PMID:23756648; PMID:28433925; PMID:30284816; PMID:30722647
GO:0019577	Aldaric acid metabolic process	Affects phenotype	PMID:31706747
GO:0019627	Urea metabolic process	Affects phenotype	PMID:32500380
GO:0019695	Choline metabolic process	Decreases phenotype	PMID:32949613; PMID:34600010
GO:0019752	Carboxylic acid metabolic process	Affects phenotype	PMID:39842396
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:31706747
GO:0021983	Pituitary gland development	Affects phenotype	PMID:34728246
GO:0022602	Ovulation cycle process	Decreases phenotype	PMID:29471507; PMID:29969652
GO:0030010	Establishment of cell polarity	Decreases phenotype	PMID:36608567
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:25882133; PMID:28611354; PMID:29029336
GO:0030308	Negative regulation of cell growth	Increases phenotype	PMID:27996362
GO:0030324	Lung development	Decreases phenotype	PMID:28576411
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:33229049; PMID:36232341; PMID:37734194
GO:0030534	Adult behavior	Decreases phenotype	PMID:35354077
GO:0030728	Ovulation	Increases phenotype	PMID:25888850; PMID:33316053
GO:0030850	Prostate gland development	Decreases phenotype	PMID:30802670
GO:0031016	Pancreas development	Affects phenotype	PMID:21673306
GO:0031394	Positive regulation of prostaglandin biosynthetic process	Increases phenotype	PMID:35810816
GO:0031987	Locomotion involved in locomotory behavior	Increases phenotype	PMID:35818324; PMID:38152552
GO:0032008	Positive regulation of tor signaling	Affects phenotype	PMID:23793038
GO:0032024	Positive regulation of insulin secretion	Increases phenotype	PMID:34600010; PMID:39265699
GO:0032205	Negative regulation of telomere maintenance	Increases phenotype	PMID:36174712
GO:0032308	Positive regulation of prostaglandin secretion	Increases phenotype	PMID:33316053
GO:0032338	Regulation of inhibin secretion	Affects phenotype	PMID:25296284
GO:0032341	Aldosterone metabolic process	Affects phenotype	PMID:21389346
GO:0032469	Endoplasmic reticulum calcium ion homeostasis	Affects phenotype	PMID:25418486
GO:0032776	Dna methylation on cytosine	Increases phenotype	PMID:25280772
GO:0032790	Ribosome disassembly	Increases phenotype	PMID:37858774
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:33348264
GO:0033037	Polysaccharide localization	Increases phenotype	PMID:37753369
GO:0033132	Negative regulation of glucokinase activity	Increases phenotype	PMID:31606821
GO:0033212	Iron import into cell	Increases phenotype	PMID:36438553; PMID:36696656; PMID:38050670
GO:0033327	Leydig cell differentiation	Decreases phenotype	PMID:27417426; PMID:29325824
GO:0033684	Regulation of luteinizing hormone secretion	Affects phenotype	PMID:32209209
GO:0033685	Negative regulation of luteinizing hormone secretion	Increases phenotype	PMID:34015638; PMID:37812459; PMID:37975621
GO:0033686	Positive regulation of luteinizing hormone secretion	Increases phenotype	PMID:34049116
GO:0034113	Heterotypic cell-cell adhesion	Decreases phenotype	PMID:38730545
GO:0034199	Activation of protein kinase a activity	Increases phenotype	PMID:37552060
GO:0034255	Regulation of urea metabolic process	Affects phenotype	PMID:32949613
GO:0034440	Lipid oxidation	Increases phenotype	PMID:25882133; PMID:25882133; PMID:29328408; PMID:32050098; PMID:29328408; PMID:30691201; PMID:32050098; PMID:32500380; PMID:35460826; PMID:35500696; PMID:35818324; PMID:36198370; PMID:36328110; PMID:39360521
GO:0034599	Cellular response to oxidative stress	Increases phenotype	PMID:38503103
GO:0034729	Histone h3-k79 methylation	Increases phenotype	PMID:37545493
GO:0035116	Embryonic hindlimb morphogenesis	Decreases phenotype	PMID:24503621
GO:0035176	Social behavior	Decreases phenotype	PMID:26168342; PMID:34781058; PMID:35254616
GO:0035265	Organ growth	Affects phenotype	PMID:30078309
GO:0035360	Positive regulation of peroxisome proliferator activated receptor signaling pathway	Increases phenotype	PMID:26519955
GO:0035640	Exploration behavior	Decreases phenotype	PMID:32303808; PMID:38152552
GO:0035847	Uterine epithelium development	Affects phenotype	PMID:36435455
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:38152552
GO:0035936	Testosterone secretion	Decreases phenotype	PMID:24393508; PMID:28013214; PMID:29688563; PMID:30802670; PMID:31175881; PMID:31199487; PMID:35259346; PMID:38730545
GO:0035938	Estradiol secretion	Affects phenotype	PMID:28013214; PMID:28637469
GO:0035941	Androstenedione secretion	Decreases phenotype	PMID:28013214
GO:0035943	Estrone secretion	Decreases phenotype	PMID:28013214
GO:0036123	Histone h3-k9 dimethylation	Decreases phenotype	PMID:25975992
GO:0036126	Sperm flagellum	Affects phenotype	PMID:36174316; PMID:39360521
GO:0036145	Dendritic cell homeostasis	Affects phenotype	PMID:33424850
GO:0036162	Oxytocin production	Decreases phenotype	PMID:34576011
GO:0036211	Protein modification process	Affects phenotype	PMID:39360521
GO:0036269	Swimming behavior	Decreases phenotype	PMID:32303808
GO:0038028	Insulin receptor signaling pathway via phosphatidylinositol 3-kinase	Decreases phenotype	PMID:35460826
GO:0040015	Negative regulation of multicellular organism growth	Increases phenotype	PMID:32619501
GO:0040016	Embryonic cleavage	Decreases phenotype	PMID:22147016; PMID:28042535; PMID:28286118
GO:0040029	Epigenetic regulation of gene expression	Affects phenotype	PMID:33497755; PMID:33872906
GO:0042221	Response to chemical	Increases phenotype	PMID:34428494
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:28054989; PMID:28054989; PMID:28065941; PMID:28065941
GO:0042412	Taurine biosynthetic process	Affects phenotype	PMID:30284816
GO:0042427	Serotonin biosynthetic process	Affects phenotype	PMID:32303808
GO:0042448	Progesterone metabolic process	Affects phenotype	PMID:30186573; PMID:34597818
GO:0042554	Superoxide anion generation	Affects phenotype	PMID:34793900
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:30565266; PMID:30660623; PMID:31228551
GO:0042632	Cholesterol homeostasis	Decreases phenotype	PMID:35739755; PMID:35970509
GO:0042692	Muscle cell differentiation	Affects phenotype	PMID:24067726
GO:0042701	Progesterone secretion	Affects phenotype	PMID:25888850; PMID:33316053
GO:0042711	Maternal behavior	Decreases phenotype	PMID:34576011
GO:0042756	Drinking behavior	Affects phenotype	PMID:31979393
GO:0042759	Long-chain fatty acid biosynthetic process	Increases phenotype	PMID:30284816
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:24646702; PMID:28082598; PMID:30755103; PMID:31160972; PMID:31228551; PMID:31920986; PMID:31923814; PMID:32710958; PMID:32619501; PMID:33091774; PMID:33162236; PMID:33511402; PMID:33754040; PMID:38008054; PMID:34492810; PMID:35716406; PMID:35739755; PMID:36583613; PMID:37059381; PMID:37364641; PMID:37734194; PMID:37979351; PMID:38008054; PMID:38488668; PMID:38522500
GO:0043467	Regulation of generation of precursor metabolites and energy	Affects phenotype	PMID:36516674
GO:0043966	Histone h3 acetylation	Increases phenotype	PMID:37545493
GO:0043967	Histone h4 acetylation	Increases phenotype	PMID:37545493
GO:0044029	Hypomethylation of cpg island	Increases phenotype	PMID:30691201
GO:0044030	Regulation of dna methylation	Affects phenotype	PMID:25853433; PMID:32864567
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:25418486; PMID:26445464; PMID:27084994; PMID:27853917; PMID:28065941; PMID:28367427; PMID:30120713; PMID:31112013; PMID:35521929; PMID:31163220; PMID:31408635; PMID:34822940; PMID:35457000; PMID:35521929; PMID:35659966; PMID:35887207; PMID:36328110; PMID:36394428; PMID:36674557; PMID:37302538; PMID:39515621
GO:0044524	Protein sulfhydration	Decreases phenotype	PMID:31486570
GO:0044849	Estrous cycle	Decreases phenotype	PMID:29471507; PMID:30186573; PMID:32209209; PMID:37560165; PMID:36435455; PMID:36929940
GO:0045017	Glycerolipid biosynthetic process	Decreases phenotype	PMID:38050670
GO:0045023	G0 to g1 transition	Increases phenotype	PMID:31163220
GO:0045329	Carnitine biosynthetic process	Affects phenotype	PMID:30284816
GO:0045444	Fat cell differentiation	Increases phenotype	PMID:21673306; PMID:23277027; PMID:24503497; PMID:26188368; PMID:29991372
GO:0045454	Cell redox homeostasis	Decreases phenotype	PMID:30523571; PMID:36438553; PMID:36610486; PMID:36610486; PMID:36696656
GO:0045540	Regulation of cholesterol biosynthetic process	Affects phenotype	PMID:33649816
GO:0045541	Negative regulation of cholesterol biosynthetic process	Increases phenotype	PMID:31262386; PMID:31732953; PMID:38050670
GO:0045542	Positive regulation of cholesterol biosynthetic process	Increases phenotype	PMID:30550969; PMID:31262386; PMID:31606821; PMID:31706747; PMID:31732953; PMID:34303773; PMID:38050670
GO:0045740	Positive regulation of dna replication	Affects phenotype	PMID:23793038
GO:0045764	Positive regulation of amino acid metabolic process	Increases phenotype	PMID:37806616
GO:0045777	Positive regulation of blood pressure	Increases phenotype	PMID:37734331
GO:0045792	Negative regulation of cell size	Increases phenotype	PMID:29325824
GO:0045795	Positive regulation of cell volume	Increases phenotype	PMID:28065941
GO:0045821	Positive regulation of glycolytic process	Increases phenotype	PMID:37458746
GO:0045833	Negative regulation of lipid metabolic process	Affects phenotype	PMID:30550969; PMID:34600010
GO:0045930	Negative regulation of mitotic cell cycle	Affects phenotype	PMID:31163220
GO:0046034	Atp metabolic process	Affects phenotype	PMID:27853917; PMID:30284816; PMID:32949729; PMID:33711355; PMID:34822940
GO:0046058	Camp metabolic process	Affects phenotype	PMID:32303808
GO:0046086	Adenosine biosynthetic process	Affects phenotype	PMID:30284816
GO:0046101	Hypoxanthine biosynthetic process	Affects phenotype	PMID:30284816
GO:0046320	Regulation of fatty acid oxidation	Affects phenotype	PMID:37806616
GO:0046322	Negative regulation of fatty acid oxidation	Increases phenotype	PMID:33391822
GO:0046323	Glucose import	Affects phenotype	PMID:26630026; PMID:28025108
GO:0046325	Negative regulation of glucose import	Increases phenotype	PMID:30597186
GO:0046449	Creatinine metabolic process	Affects phenotype	PMID:32500380; PMID:35510228
GO:0046511	Sphinganine biosynthetic process	Affects phenotype	PMID:30284816
GO:0046621	Negative regulation of organ growth	Increases phenotype	PMID:29325824; PMID:30090590; PMID:32050098; PMID:32050098; PMID:32619501
GO:0046651	Lymphocyte proliferation	Increases phenotype	PMID:23892333
GO:0046676	Negative regulation of insulin secretion	Increases phenotype	PMID:35550907
GO:0046880	Regulation of follicle-stimulating hormone secretion	Affects phenotype	PMID:37812459
GO:0046881	Positive regulation of follicle-stimulating hormone secretion	Increases phenotype	PMID:34015638; PMID:37364641
GO:0046889	Positive regulation of lipid biosynthetic process	Increases phenotype	PMID:34303773; PMID:34600010; PMID:38199361
GO:0048240	Sperm capacitation	Increases phenotype	PMID:33711355
GO:0048246	Macrophage chemotaxis	Increases phenotype	PMID:40323316
GO:0048311	Mitochondrion distribution	Decreases phenotype	PMID:37858774
GO:0048599	Oocyte development	Decreases phenotype	PMID:28013214
GO:0048666	Neuron development	Decreases phenotype	PMID:35254616
GO:0050679	Positive regulation of epithelial cell proliferation	Increases phenotype	PMID:40323316
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:31199487; PMID:33497755; PMID:33846374; PMID:33908429; PMID:36438553; PMID:37734331
GO:0050804	Modulation of chemical synaptic transmission	Affects phenotype	PMID:37458746
GO:0050810	Regulation of steroid biosynthetic process	Affects phenotype	PMID:38730545
GO:0050890	Cognition	Decreases phenotype	PMID:35354077
GO:0050996	Positive regulation of lipid catabolic process	Increases phenotype	PMID:30523571; PMID:30755103; PMID:31606821; PMID:32884073; PMID:33649816; PMID:35970509; PMID:36438553; PMID:36696656; PMID:37979351; PMID:38050670
GO:0051092	Positive regulation of nf-kappab transcription factor activity	Increases phenotype	PMID:29669060
GO:0051321	Meiotic cell cycle	Affects phenotype	PMID:30939196
GO:0051567	Histone h3-k9 methylation	Decreases phenotype	PMID:25975992
GO:0051598	Meiotic recombination checkpoint signaling	Increases phenotype	PMID:28771232
GO:0051790	Short-chain fatty acid biosynthetic process	Increases phenotype	PMID:34600010
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:28115068; PMID:31112013; PMID:31175881; PMID:35510228
GO:0051897	Positive regulation of protein kinase b signaling	Affects phenotype	PMID:23793038
GO:0051898	Negative regulation of protein kinase b signaling	Increases phenotype	PMID:32710958; PMID:35460826
GO:0051901	Positive regulation of mitochondrial depolarization	Increases phenotype	PMID:31160972
GO:0055008	Cardiac muscle tissue morphogenesis	Affects phenotype	PMID:35716406
GO:0055069	Zinc ion homeostasis	Decreases phenotype	PMID:30755103; PMID:35841924
GO:0055072	Iron ion homeostasis	Decreases phenotype	PMID:35500696; PMID:39360521
GO:0055074	Calcium ion homeostasis	Affects phenotype	PMID:30056177; PMID:32303808
GO:0055088	Lipid homeostasis	Decreases phenotype	PMID:32353385
GO:0060008	Sertoli cell differentiation	Decreases phenotype	PMID:27060630
GO:0060009	Sertoli cell development	Decreases phenotype	PMID:37059381; PMID:38730545
GO:0060047	Heart contraction	Increases phenotype	PMID:25351189; PMID:25799571
GO:0060125	Negative regulation of growth hormone secretion	Increases phenotype	PMID:35550907
GO:0060132	Prolactin secreting cell development	Affects phenotype	PMID:34728246
GO:0060133	Somatotropin secreting cell development	Affects phenotype	PMID:34728246
GO:0060135	Maternal process involved in female pregnancy	Decreases phenotype	PMID:30649530
GO:0060173	Limb development	Affects phenotype	PMID:28123099
GO:0060206	Estrous cycle phase	Affects phenotype	PMID:26678702
GO:0060271	Cilium assembly	Increases phenotype	PMID:33526986
GO:0060283	Negative regulation of oocyte development	Increases phenotype	PMID:38008054
GO:0060299	Negative regulation of sarcomere organization	Increases phenotype	PMID:35716406
GO:0060305	Regulation of cell diameter	Affects phenotype	PMID:37021957
GO:0060376	Positive regulation of mast cell differentiation	Increases phenotype	PMID:37021957
GO:0060467	Negative regulation of fertilization	Increases phenotype	PMID:30649530
GO:0060512	Prostate gland morphogenesis	Decreases phenotype	PMID:31199487
GO:0060618	Nipple development	Affects phenotype	PMID:37788136
GO:0060713	Labyrinthine layer morphogenesis	Decreases phenotype	PMID:29753845
GO:0060716	Labyrinthine layer blood vessel development	Decreases phenotype	PMID:29753845
GO:0060754	Positive regulation of mast cell chemotaxis	Increases phenotype	PMID:25031359
GO:0060964	Regulation of mirna-mediated gene silencing	Affects phenotype	PMID:28085963
GO:0060996	Dendritic spine development	Affects phenotype	PMID:25295592
GO:0061002	Negative regulation of dendritic spine morphogenesis	Increases phenotype	PMID:34781058
GO:0061107	Seminal vesicle development	Decreases phenotype	PMID:26168342; PMID:30802670
GO:0061179	Negative regulation of insulin secretion involved in cellular response to glucose stimulus	Increases phenotype	PMID:33091774
GO:0061370	Testosterone biosynthetic process	Decreases phenotype	PMID:23959011; PMID:25882133; PMID:25882133; PMID:30186573; PMID:34197824; PMID:36198370; PMID:26361869; PMID:26361869; PMID:29663635; PMID:27417426; PMID:29663635; PMID:29774754; PMID:31979393; PMID:33983380; PMID:34197824; PMID:34597818; PMID:35196152; PMID:35196152; PMID:39307383; PMID:36198370
GO:0061458	Reproductive system development	Decreases phenotype	PMID:37788136
GO:0061470	T follicular helper cell differentiation	Increases phenotype	PMID:25093321
GO:0061517	Macrophage proliferation	Increases phenotype	PMID:23892333
GO:0061827	Sperm head	Affects phenotype	PMID:36174316; PMID:39360521
GO:0061956	Penetration of cumulus oophorus	Decreases phenotype	PMID:36087924
GO:0070091	Glucagon secretion	Decreases phenotype	PMID:36674557
GO:0070265	Necrotic cell death	Increases phenotype	PMID:25882133; PMID:28054989
GO:0070266	Necroptotic process	Increases phenotype	PMID:35659966
GO:0070276	Halogen metabolic process	Affects phenotype	PMID:28054989
GO:0070327	Thyroid hormone transport	Affects phenotype	PMID:33309551
GO:0070328	Triglyceride homeostasis	Decreases phenotype	PMID:16038268; PMID:35739755
GO:0070341	Fat cell proliferation	Increases phenotype	PMID:25909471; PMID:28105114
GO:0070342	Brown fat cell proliferation	Increases phenotype	PMID:32522588
GO:0070346	Positive regulation of fat cell proliferation	Increases phenotype	PMID:30550969; PMID:31262386
GO:0070483	Detection of hypoxia	Decreases phenotype	PMID:31160972
GO:0070623	Regulation of thiamine biosynthetic process	Affects phenotype	PMID:31706747
GO:0070730	Camp transport	Affects phenotype	PMID:26985823
GO:0070859	Positive regulation of bile acid biosynthetic process	Increases phenotype	PMID:16038268
GO:0070874	Negative regulation of glycogen metabolic process	Increases phenotype	PMID:34600010
GO:0070994	Detection of oxidative stress	Increases phenotype	PMID:21976414; PMID:26845775; PMID:27352406; PMID:28065941; PMID:31160972; PMID:34793900; PMID:34822940; PMID:35196152; PMID:35510228; PMID:35659966; PMID:35818324; PMID:35917956; PMID:39515621
GO:0070997	Neuron death	Increases phenotype	PMID:35818324
GO:0071493	Cellular response to uv-b	Affects phenotype	PMID:35887207
GO:0071625	Vocalization behavior	Affects phenotype	PMID:28934723
GO:0071763	Nuclear membrane organization	Decreases phenotype	PMID:36087924
GO:0072520	Seminiferous tubule development	Decreases phenotype	PMID:29029336; PMID:29029336; PMID:34863575; PMID:30755103; PMID:30802670; PMID:31175881; PMID:34015638; PMID:37364641; PMID:39307383
GO:0072574	Hepatocyte proliferation	Affects phenotype	PMID:25683344; PMID:28065941
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:25418486; PMID:30120713; PMID:30691201; PMID:33526986; PMID:34822940; PMID:35521929; PMID:35659966; PMID:36328110
GO:0072676	Lymphocyte migration	Increases phenotype	PMID:35917956
GO:0072757	Cellular response to camptothecin	Decreases phenotype	PMID:30720231
GO:0080009	Mrna methylation	Increases phenotype	PMID:36423848
GO:0080182	Histone h3-k4 trimethylation	Increases phenotype	PMID:37545493
GO:0086064	Cell communication by electrical coupling involved in cardiac conduction	Affects phenotype	PMID:37812252
GO:0090030	Regulation of steroid hormone biosynthetic process	Affects phenotype	PMID:31709857
GO:0090116	C-5 methylation of cytosine	Increases phenotype	PMID:19912166; PMID:31211961; PMID:32628958
GO:0090181	Regulation of cholesterol metabolic process	Affects phenotype	PMID:34438493; PMID:35970509; PMID:37093692; PMID:38199361
GO:0090207	Regulation of triglyceride metabolic process	Affects phenotype	PMID:31577137
GO:0090357	Regulation of tryptophan metabolic process	Affects phenotype	PMID:37458746
GO:0097189	Apoptotic body	Increases phenotype	PMID:37406783
GO:0097198	Histone h3-k36 trimethylation	Increases phenotype	PMID:37545493
GO:0097202	Activation of cysteine-type endopeptidase activity	Increases phenotype	PMID:29029336
GO:0097237	Cellular response to toxic substance	Increases phenotype	PMID:29502735
GO:0097368	Establishment of sertoli cell barrier	Decreases phenotype	PMID:23892333; PMID:30320191; PMID:36087924; PMID:36174316
GO:0097432	Hippocampal pyramidal neuron differentiation	Decreases phenotype	PMID:29688563
GO:0097722	Sperm motility	Decreases phenotype	PMID:25882133; PMID:30802670; PMID:33711355; PMID:35196152; PMID:35196152; PMID:36174316; PMID:36174316; PMID:39360521
GO:0098743	Cell aggregation	Affects phenotype	PMID:36198370
GO:0098907	Regulation of sa node cell action potential	Affects phenotype	PMID:37812252
GO:0110122	Myotube cell migration	Affects phenotype	PMID:24067726
GO:0140042	Lipid droplet formation	Increases phenotype	PMID:26630026; PMID:30284816; PMID:32325186; PMID:32353385; PMID:34864131; PMID:38092172; PMID:39778647
GO:0140354	Lipid import into cell	Increases phenotype	PMID:35739755; PMID:37753369
GO:0140639	Positive regulation of pyroptosis	Increases phenotype	PMID:36610486; PMID:36774801; PMID:37692514
GO:0140747	Regulation of ncrna transcription	Affects phenotype	PMID:37003585
GO:0150078	Positive regulation of neuroinflammatory response	Increases phenotype	PMID:23148021
GO:0150129	Positive regulation of interleukin-33 production	Increases phenotype	PMID:37545493
GO:0150172	Regulation of phosphatidylcholine metabolic process	Affects phenotype	PMID:31577137
GO:0150175	Regulation of phosphatidylethanolamine metabolic process	Affects phenotype	PMID:31577137
GO:0160020	Positive regulation of ferroptosis	Increases phenotype	PMID:34863575; PMID:35500696; PMID:36438553; PMID:36696656; PMID:38050670
GO:0160024	Leydig cell proliferation	Affects phenotype	PMID:28611354
GO:1900015	Regulation of cytokine production involved in inflammatory response	Affects phenotype	PMID:38954831
GO:1900017	Positive regulation of cytokine production involved in inflammatory response	Increases phenotype	PMID:33424850; PMID:35460826; PMID:37545493; PMID:40323316
GO:1900100	Positive regulation of plasma cell differentiation	Increases phenotype	PMID:25093321
GO:1900409	Positive regulation of cellular response to oxidative stress	Affects phenotype	PMID:23793038
GO:1900535	Palmitic acid biosynthetic process	Decreases phenotype	PMID:37734194
GO:1901033	Positive regulation of response to reactive oxygen species	Affects phenotype	PMID:23793038
GO:1901142	Insulin metabolic process	Decreases phenotype	PMID:31606821
GO:1901318	Negative regulation of flagellated sperm motility	Increases phenotype	PMID:24140385; PMID:32619501
GO:1901526	Positive regulation of mitophagy	Increases phenotype	PMID:36583613
GO:1901570	Fatty acid derivative biosynthetic process	Decreases phenotype	PMID:38050670
GO:1901670	Negative regulation of superoxide dismutase activity	Increases phenotype	PMID:30755103; PMID:32050098; PMID:32710958; PMID:33348264; PMID:32050098; PMID:32884073; PMID:33120273; PMID:33348264; PMID:33649816; PMID:35460826; PMID:35500696
GO:1901750	Leukotriene d4 biosynthetic process	Increases phenotype	PMID:35810816
GO:1901992	Positive regulation of mitotic cell cycle phase transition	Affects phenotype	PMID:23793038
GO:1901994	Negative regulation of meiotic cell cycle phase transition	Increases phenotype	PMID:35842051
GO:1902552	Negative regulation of catalase activity	Increases phenotype	PMID:33649816
GO:1902721	Negative regulation of prolactin secretion	Increases phenotype	PMID:25296284; PMID:35550907
GO:1902807	Negative regulation of cell cycle g1/s phase transition	Increases phenotype	PMID:36423848; PMID:37059381
GO:1902884	Positive regulation of response to oxidative stress	Increases phenotype	PMID:33120273; PMID:33348264; PMID:35739755; PMID:37806616
GO:1902894	Negative regulation of mirna transcription	Increases phenotype	PMID:37003585
GO:1902902	Negative regulation of autophagosome assembly	Increases phenotype	PMID:35254616
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:30755103; PMID:32050098; PMID:32710958; PMID:32050098; PMID:35460826
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:19382104; PMID:26361869; PMID:28115068; PMID:31112013; PMID:31175881; PMID:31408635
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:30720231; PMID:31160972; PMID:32884073; PMID:33091774; PMID:33120273; PMID:35500696; PMID:36423848; PMID:36610486; PMID:36610486; PMID:36696656; PMID:39265699
GO:1903537	Meiotic cell cycle process involved in oocyte maturation	Affects phenotype	PMID:22147016; PMID:28042535
GO:1903726	Negative regulation of phospholipid metabolic process	Increases phenotype	PMID:34600010
GO:1903786	Regulation of glutathione biosynthetic process	Affects phenotype	PMID:32949613
GO:1903787	Negative regulation of glutathione biosynthetic process	Increases phenotype	PMID:30523571; PMID:36438553; PMID:36696656; PMID:37979351
GO:1903788	Positive regulation of glutathione biosynthetic process	Increases phenotype	PMID:33649816
GO:1903863	P granule assembly	Decreases phenotype	PMID:33754040
GO:1903998	Regulation of eating behavior	Affects phenotype	PMID:29982774
GO:1904000	Positive regulation of eating behavior	Increases phenotype	PMID:30660623
GO:1904177	Regulation of adipose tissue development	Affects phenotype	PMID:37021957
GO:1904445	Negative regulation of establishment of sertoli cell barrier	Affects phenotype	PMID:29940330
GO:1904598	Positive regulation of connective tissue replacement involved in inflammatory response wound healing	Increases phenotype	PMID:35739755; PMID:37734331
GO:1905053	Positive regulation of base-excision repair	Increases phenotype	PMID:33120273
GO:1905075	Positive regulation of tight junction disassembly	Increases phenotype	PMID:36781136
GO:1905166	Negative regulation of lysosomal protein catabolic process	Increases phenotype	PMID:38488668
GO:1905605	Positive regulation of blood-brain barrier permeability	Increases phenotype	PMID:37858774
GO:1905642	Negative regulation of dna methylation	Increases phenotype	PMID:33497755
GO:1905867	Epididymis development	Affects phenotype	PMID:30802670
GO:1905937	Negative regulation of germ cell proliferation	Increases phenotype	PMID:33754040
GO:1990034	Calcium ion export across plasma membrane	Increases phenotype	PMID:25799571
GO:1990403	Embryonic brain development	Decreases phenotype	PMID:25068794
GO:1990428	Mirna transport	Affects phenotype	PMID:30481674
GO:1990636	Reproductive senescence	Affects phenotype	PMID:26678702
GO:1990789	Thyroid gland epithelial cell proliferation	Increases phenotype	PMID:28065941
GO:2000019	Negative regulation of male gonad development	Increases phenotype	PMID:37979351
GO:2000020	Positive regulation of male gonad development	Decreases phenotype	PMID:27417426
GO:2000066	Positive regulation of cortisol biosynthetic process	Increases phenotype	PMID:35550907
GO:2000134	Negative regulation of g1/s transition of mitotic cell cycle	Increases phenotype	PMID:25369342; PMID:31709857
GO:2000182	Regulation of progesterone biosynthetic process	Affects phenotype	PMID:25296284
GO:2000183	Negative regulation of progesterone biosynthetic process	Increases phenotype	PMID:36435455
GO:2000184	Positive regulation of progesterone biosynthetic process	Increases phenotype	PMID:37552060
GO:2000224	Regulation of testosterone biosynthetic process	Affects phenotype	PMID:31709857; PMID:37059381
GO:2000225	Negative regulation of testosterone biosynthetic process	Increases phenotype	PMID:24140385; PMID:29325824; PMID:31923814; PMID:35739735; PMID:37788136
GO:2000253	Positive regulation of feeding behavior	Increases phenotype	PMID:32784060
GO:2000354	Regulation of ovarian follicle development	Affects phenotype	PMID:37812459
GO:2000355	Negative regulation of ovarian follicle development	Increases phenotype	PMID:29385306; PMID:31920986; PMID:33234378; PMID:38008054
GO:2000387	Regulation of antral ovarian follicle growth	Decreases phenotype	PMID:34492810
GO:2000388	Positive regulation of antral ovarian follicle growth	Decreases phenotype	PMID:28286118
GO:2000391	Positive regulation of neutrophil extravasation	Increases phenotype	PMID:36610486
GO:2000408	Negative regulation of t cell extravasation	Increases phenotype	PMID:36209858
GO:2000409	Positive regulation of t cell extravasation	Increases phenotype	PMID:36209858
GO:2000421	Positive regulation of eosinophil extravasation	Increases phenotype	PMID:32884073
GO:2000439	Positive regulation of monocyte extravasation	Increases phenotype	PMID:30550969; PMID:34303773
GO:2000466	Negative regulation of glycogen (starch) synthase activity	Increases phenotype	PMID:30565266
GO:2000609	Regulation of thyroid hormone generation	Affects phenotype	PMID:33649816; PMID:38522500
GO:2000610	Negative regulation of thyroid hormone generation	Increases phenotype	PMID:25596636; PMID:29734584; PMID:32681327; PMID:33789034; PMID:34708313; PMID:35354077; PMID:36005737; PMID:38042133
GO:2000611	Positive regulation of thyroid hormone generation	Increases phenotype	PMID:34708313; PMID:35228410
GO:2000613	Negative regulation of thyroid-stimulating hormone secretion	Increases phenotype	PMID:29734584; PMID:33649816; PMID:36714560
GO:2000614	Positive regulation of thyroid-stimulating hormone secretion	Increases phenotype	PMID:30716676
GO:2000670	Positive regulation of dendritic cell apoptotic process	Increases phenotype	PMID:33424850
GO:2000786	Positive regulation of autophagosome assembly	Increases phenotype	PMID:33908429; PMID:38522500
GO:2000833	Positive regulation of steroid hormone secretion	Affects phenotype	PMID:31709857
GO:2000839	Positive regulation of androstenedione secretion	Decreases phenotype	PMID:27405655
GO:2000841	Negative regulation of dehydroepiandrosterone secretion	Increases phenotype	PMID:30523571
GO:2000844	Negative regulation of testosterone secretion	Increases phenotype	PMID:29777495; PMID:29777495; PMID:32050098; PMID:30523571; PMID:32533902; PMID:32710958; PMID:34015638; PMID:32050098; PMID:32235866; PMID:37975621; PMID:37839492; PMID:38050670; PMID:39947446
GO:2000845	Positive regulation of testosterone secretion	Increases phenotype	PMID:30769184; PMID:31709857; PMID:34595713; PMID:37364641
GO:2000848	Positive regulation of corticosteroid hormone secretion	Increases phenotype	PMID:34051340
GO:2000853	Negative regulation of corticosterone secretion	Increases phenotype	PMID:34864161
GO:2000863	Positive regulation of estrogen secretion	Increases phenotype	PMID:34051340
GO:2000864	Regulation of estradiol secretion	Affects phenotype	PMID:32209209
GO:2000865	Negative regulation of estradiol secretion	Increases phenotype	PMID:29029336; PMID:31160972; PMID:32533902; PMID:34015638; PMID:34492810; PMID:36435455; PMID:37839492
GO:2000866	Positive regulation of estradiol secretion	Affects phenotype	PMID:27405655; PMID:30769184; PMID:31771930; PMID:34049116; PMID:37364641
GO:2000870	Regulation of progesterone secretion	Affects phenotype	PMID:32209209
GO:2000871	Negative regulation of progesterone secretion	Increases phenotype	PMID:29777495; PMID:31160972
GO:2000872	Positive regulation of progesterone secretion	Affects phenotype	PMID:27405655; PMID:31771930; PMID:34051340
GO:2001022	Positive regulation of response to dna damage stimulus	Increases phenotype	PMID:35842051; PMID:36423848
GO:2001038	Regulation of cellular response to drug	Affects phenotype	PMID:34801851
GO:2001200	Positive regulation of dendritic cell differentiation	Increases phenotype	PMID:21538406

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.