Hexachlorobenzene


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000278 Mitotic cell cycle Affects phenotype PMID:28215542
GO:0002377 Immunoglobulin production Affects phenotype PMID:15831097
GO:0002449 Lymphocyte mediated immunity Affects phenotype PMID:15831097
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:28634113
GO:0004784 Superoxide dismutase activity Increases phenotype PMID:34374107
GO:0006119 Oxidative phosphorylation Increases phenotype PMID:34311058
GO:0006306 Dna methylation Decreases phenotype PMID:20064773
GO:0006590 Thyroid hormone generation Decreases phenotype PMID:27219111
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:28634113
GO:0006783 Heme biosynthetic process Affects phenotype PMID:18941586
GO:0006915 Apoptotic process Decreases phenotype PMID:28634113
GO:0006959 Humoral immune response Affects phenotype PMID:15831097
GO:0007005 Mitochondrion organization Increases phenotype PMID:34311058
GO:0007283 Spermatogenesis Decreases phenotype PMID:34374107
GO:0007566 Embryo implantation Decreases phenotype PMID:22204795
GO:0008217 Regulation of blood pressure Affects phenotype PMID:29277037
GO:0008219 Cell death Increases phenotype PMID:28923513; PMID:30075218
GO:0008283 Cell population proliferation Increases phenotype PMID:28215542; PMID:28634113; PMID:28923513; PMID:29277037; PMID:37169060
GO:0010595 Positive regulation of endothelial cell migration Increases phenotype PMID:26358519
GO:0010918 Positive regulation of mitochondrial membrane potential Increases phenotype PMID:34311058
GO:0014829 Vascular associated smooth muscle contraction Increases phenotype PMID:29277037
GO:0016042 Lipid catabolic process Decreases phenotype PMID:28634113
GO:0016209 Antioxidant activity Increases phenotype PMID:26365763
GO:0016477 Cell migration Increases phenotype PMID:28923513; PMID:33571556
GO:0030182 Neuron differentiation Affects phenotype PMID:24157519
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:26365763
GO:0031175 Neuron projection development Decreases phenotype PMID:24157519
GO:0032609 Type ii interferon production Decreases phenotype PMID:11266329
GO:0035744 T-helper 1 cell cytokine production Decreases phenotype PMID:11266329
GO:0040007 Growth Increases phenotype PMID:23963708
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:19750101
GO:0042554 Superoxide anion generation Affects phenotype PMID:31923579
GO:0042701 Progesterone secretion Affects phenotype PMID:34311058
GO:0044065 Regulation of respiratory system process Decreases phenotype PMID:31362153
GO:0044237 Cellular metabolic process Increases phenotype PMID:34311058; PMID:37169060
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:27519288; PMID:35181438; PMID:37169060
GO:0045428 Regulation of nitric oxide biosynthetic process Affects phenotype PMID:32526215
GO:0045454 Cell redox homeostasis Affects phenotype PMID:30064338
GO:0045766 Positive regulation of angiogenesis Increases phenotype PMID:32526215
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:25093615; PMID:26219504; PMID:28923513
GO:0046034 Atp metabolic process Affects phenotype PMID:34311058
GO:0046323 Glucose import Decreases phenotype PMID:31923579; PMID:34311058
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:30064338
GO:0060322 Head development Increases phenotype PMID:25095280
GO:0060326 Cell chemotaxis Increases phenotype PMID:33571556; PMID:35181438
GO:0061028 Establishment of endothelial barrier Decreases phenotype PMID:33571556
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:26358519
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34374107
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24157519; PMID:31923579
GO:0097498 Endothelial tube lumen extension Increases phenotype PMID:26358519
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:26358519
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:26365763
GO:1905555 Positive regulation of blood vessel branching Increases phenotype PMID:32526215
GO:1905956 Positive regulation of endothelial tube morphogenesis Increases phenotype PMID:32526215
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:33945905
GO:2000612 Regulation of thyroid-stimulating hormone secretion Affects phenotype PMID:19750101
GO:2001057 Reactive nitrogen species metabolic process Affects phenotype PMID:31923579
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.