Monobutyl phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0003093 Regulation of glomerular filtration Affects phenotype PMID:32645486
GO:0006006 Glucose metabolic process Affects phenotype PMID:36736749
GO:0006096 Glycolytic process Increases phenotype PMID:36736749
GO:0006304 Dna modification Decreases phenotype PMID:30965081
GO:0006590 Thyroid hormone generation Increases phenotype PMID:31093596
GO:0006606 Protein import into nucleus Affects phenotype PMID:34273429; PMID:36736749
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:36736749
GO:0006672 Ceramide metabolic process Affects phenotype PMID:35075242
GO:0006701 Progesterone biosynthetic process Increases phenotype PMID:28735033
GO:0006749 Glutathione metabolic process Affects phenotype PMID:38048874
GO:0006879 Cellular iron ion homeostasis Affects phenotype PMID:37121744
GO:0006909 Phagocytosis Decreases phenotype PMID:30398665
GO:0006936 Muscle contraction Decreases phenotype PMID:27581612
GO:0007254 Jnk cascade Increases phenotype PMID:32738922
GO:0007283 Spermatogenesis Decreases phenotype PMID:17003688; PMID:28496037
GO:0007611 Learning or memory Decreases phenotype PMID:25493564
GO:0007612 Learning Affects phenotype PMID:24978879
GO:0007628 Adult walking behavior Affects phenotype PMID:37018009
GO:0008209 Androgen metabolic process Affects phenotype PMID:27148549
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:29162477
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:37120575
GO:0010866 Regulation of triglyceride biosynthetic process Affects phenotype PMID:37741207
GO:0016209 Antioxidant activity Decreases phenotype PMID:34141174
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:35861251
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35861251
GO:0033327 Leydig cell differentiation Increases phenotype PMID:34280466
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:31015488
GO:0034440 Lipid oxidation Increases phenotype PMID:28496037; PMID:37121744
GO:0035176 Social behavior Affects phenotype PMID:32073305
GO:0035936 Testosterone secretion Increases phenotype PMID:34280466
GO:0035942 Dehydroepiandrosterone secretion Decreases phenotype PMID:24945889
GO:0036343 Psychomotor behavior Decreases phenotype PMID:31351385
GO:0042632 Cholesterol homeostasis Affects phenotype PMID:34425642
GO:0042701 Progesterone secretion Increases phenotype PMID:23889939
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:29162477
GO:0044237 Cellular metabolic process Affects phenotype PMID:34273429; PMID:37121744
GO:0045333 Cellular respiration Increases phenotype PMID:36736749
GO:0046034 Atp metabolic process Affects phenotype PMID:36736749
GO:0046339 Diacylglycerol metabolic process Affects phenotype PMID:35075242
GO:0046722 Lactic acid secretion Affects phenotype PMID:36736749
GO:0050810 Regulation of steroid biosynthetic process Affects phenotype PMID:31015488
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:38048874
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:32151056
GO:0051965 Positive regulation of synapse assembly Increases phenotype PMID:35278568
GO:0060011 Sertoli cell proliferation Increases phenotype PMID:32738922
GO:0060014 Granulosa cell differentiation Affects phenotype PMID:39752319
GO:0060443 Mammary gland morphogenesis Affects phenotype PMID:26903627
GO:0060612 Adipose tissue development Affects phenotype PMID:31275917
GO:0061179 Negative regulation of insulin secretion involved in cellular response to glucose stimulus Increases phenotype PMID:34141174; PMID:38048874
GO:0061890 Positive regulation of astrocyte activation Increases phenotype PMID:35278568
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:29162477
GO:0070994 Detection of oxidative stress Increases phenotype PMID:27352406
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:31015488
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:35487445
GO:0140042 Lipid droplet formation Increases phenotype PMID:36736749
GO:0140354 Lipid import into cell Increases phenotype PMID:36736749
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:30398665
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:17003688
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30965081
GO:1902808 Positive regulation of cell cycle g1/s phase transition Increases phenotype PMID:35278568
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:30965081
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28496037
GO:1904446 Positive regulation of establishment of sertoli cell barrier Decreases phenotype PMID:26922907
GO:1990428 Mirna transport Affects phenotype PMID:30481674
GO:1990636 Reproductive senescence Increases phenotype PMID:31015488
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:31015488
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:32464474
GO:2000736 Regulation of stem cell differentiation Affects phenotype PMID:25247782
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:31015488
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:31015488
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:26745512
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.