4,4'-Bisphenol F


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:31601247
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:31601247
GO:0000212 Meiotic spindle organization Decreases phenotype PMID:29102535
GO:0000266 Mitochondrial fission Increases phenotype PMID:34023961
GO:0000423 Mitophagy Increases phenotype PMID:39929295
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:37601897
GO:0001541 Ovarian follicle development Decreases phenotype PMID:31424294
GO:0001547 Antral ovarian follicle growth Increases phenotype PMID:31424294
GO:0001556 Oocyte maturation Decreases phenotype PMID:29102535
GO:0001774 Microglial cell activation Increases phenotype PMID:38266696
GO:0002157 Positive regulation of thyroid hormone mediated signaling pathway Increases phenotype PMID:29146198
GO:0002281 Macrophage activation involved in immune response Increases phenotype PMID:32044397
GO:0003093 Regulation of glomerular filtration Increases phenotype PMID:33755180
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:37611474
GO:0004000 Adenosine deaminase activity Increases phenotype PMID:39577800
GO:0004112 Cyclic-nucleotide phosphodiesterase activity Increases phenotype PMID:39577800
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:37601897
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:37601897
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:31453682; PMID:37601897
GO:0004722 Protein serine/threonine phosphatase activity Increases phenotype PMID:34023961
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:31424294; PMID:31453682; PMID:37601897; PMID:39059691
GO:0005739 Mitochondrion Increases phenotype PMID:34023961
GO:0005757 Mitochondrial permeability transition pore complex Decreases phenotype PMID:34474090
GO:0005911 Cell-cell junction Decreases phenotype PMID:28808208
GO:0006089 Lactate metabolic process Affects phenotype PMID:34147605
GO:0006094 Gluconeogenesis Affects phenotype PMID:31121516
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:39929295
GO:0006163 Purine nucleotide metabolic process Affects phenotype PMID:38685157
GO:0006306 Dna methylation Affects phenotype PMID:36473650
GO:0006338 Chromatin remodeling Increases phenotype PMID:33916708; PMID:38685157
GO:0006518 Peptide metabolic process Affects phenotype PMID:38685157
GO:0006520 Amino acid metabolic process Affects phenotype PMID:38685157
GO:0006523 Alanine biosynthetic process Affects phenotype PMID:31121516
GO:0006537 Glutamate biosynthetic process Affects phenotype PMID:31121516
GO:0006542 Glutamine biosynthetic process Affects phenotype PMID:31121516
GO:0006545 Glycine biosynthetic process Affects phenotype PMID:31121516
GO:0006568 Tryptophan metabolic process Affects phenotype PMID:38266696
GO:0006571 Tyrosine biosynthetic process Affects phenotype PMID:31121516
GO:0006626 Protein targeting to mitochondrion Affects phenotype PMID:34023961
GO:0006629 Lipid metabolic process Affects phenotype PMID:31820560; PMID:36632902
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:36632902; PMID:38685157
GO:0006633 Fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:36632902
GO:0006646 Phosphatidylethanolamine biosynthetic process Affects phenotype PMID:31453682
GO:0006653 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process Affects phenotype PMID:38685157
GO:0006659 Phosphatidylserine biosynthetic process Decreases phenotype PMID:31453682
GO:0006670 Sphingosine metabolic process Affects phenotype PMID:38685157
GO:0006686 Sphingomyelin biosynthetic process Decreases phenotype PMID:31453682
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:38685157
GO:0006701 Progesterone biosynthetic process Decreases phenotype PMID:31424294
GO:0006749 Glutathione metabolic process Increases phenotype PMID:28259788; PMID:31875995; PMID:39736419
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:31453682
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:29079494
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34023961
GO:0006915 Apoptotic process Increases phenotype PMID:31453682; PMID:35387338; PMID:37601897; PMID:39577800
GO:0006954 Inflammatory response Increases phenotype PMID:37601897
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:26916392; PMID:29102535; PMID:31207516; PMID:32244372
GO:0006979 Response to oxidative stress Affects phenotype PMID:34619205
GO:0007056 Spindle assembly involved in female meiosis Decreases phenotype PMID:33476676
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:30195206
GO:0007283 Spermatogenesis Decreases phenotype PMID:29940534; PMID:35803362; PMID:37601897
GO:0008152 Metabolic process Affects phenotype PMID:34774955
GO:0008202 Steroid metabolic process Affects phenotype PMID:24563381; PMID:38685157
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:36632902; PMID:37601897; PMID:38685157
GO:0008206 Bile acid metabolic process Affects phenotype PMID:36632902
GO:0008210 Estrogen metabolic process Increases phenotype PMID:24563381; PMID:33753083
GO:0008219 Cell death Increases phenotype PMID:35387338
GO:0008234 Cysteine-type peptidase activity Increases phenotype PMID:33312107; PMID:33916708
GO:0008283 Cell population proliferation Increases phenotype PMID:26916392; PMID:28616630; PMID:28808208; PMID:28808208; PMID:39577800
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28591870; PMID:29146198; PMID:30099086; PMID:30195206; PMID:30196065; PMID:32023790
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30196065; PMID:32023790; PMID:32044397; PMID:32763284; PMID:34831106; PMID:36534918
GO:0008584 Male gonad development Affects phenotype PMID:37164221
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:31121516
GO:0009070 Serine family amino acid biosynthetic process Affects phenotype PMID:31121516
GO:0009085 Lysine biosynthetic process Affects phenotype PMID:31121516
GO:0009088 Threonine biosynthetic process Affects phenotype PMID:31121516
GO:0009094 L-phenylalanine biosynthetic process Affects phenotype PMID:31121516
GO:0009097 Isoleucine biosynthetic process Affects phenotype PMID:31121516
GO:0009098 Leucine biosynthetic process Affects phenotype PMID:31121516
GO:0009099 Valine biosynthetic process Affects phenotype PMID:31121516
GO:0009308 Amine metabolic process Affects phenotype PMID:38685157
GO:0009437 Carnitine metabolic process Affects phenotype PMID:38685157
GO:0009696 Salicylic acid metabolic process Affects phenotype PMID:38685157
GO:0009820 Alkaloid metabolic process Affects phenotype PMID:38685157
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:31601247; PMID:38898774
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:27998958
GO:0010942 Positive regulation of cell death Increases phenotype PMID:30196065; PMID:32023790; PMID:34831106
GO:0015936 Coenzyme a metabolic process Affects phenotype PMID:38685157
GO:0015943 Formate biosynthetic process Affects phenotype PMID:31121516
GO:0016042 Lipid catabolic process Increases phenotype PMID:31424294; PMID:31453682
GO:0016344 Meiotic chromosome movement towards spindle pole Decreases phenotype PMID:29102535
GO:0016477 Cell migration Increases phenotype PMID:28808208
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:29079494
GO:0018158 Protein oxidation Increases phenotype PMID:29079494
GO:0019413 Acetate biosynthetic process Affects phenotype PMID:31121516
GO:0019530 Taurine metabolic process Affects phenotype PMID:38685157
GO:0019674 Nad metabolic process Affects phenotype PMID:38266696
GO:0019695 Choline metabolic process Affects phenotype PMID:38685157
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:38685157
GO:0019858 Cytosine metabolic process Affects phenotype PMID:38685157
GO:0030182 Neuron differentiation Decreases phenotype PMID:39577800
GO:0030861 Negative regulation of polarized epithelial cell differentiation Increases phenotype PMID:35278557
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:30195206
GO:0032776 Dna methylation on cytosine Increases phenotype PMID:30196065
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:31388671; PMID:34831106
GO:0033566 Gamma-tubulin complex localization Affects phenotype PMID:29102535
GO:0034063 Stress granule assembly Increases phenotype PMID:33431410
GO:0034440 Lipid oxidation Increases phenotype PMID:28259788; PMID:29940534; PMID:36632902; PMID:39577800
GO:0035264 Multicellular organism growth Increases phenotype PMID:33755180
GO:0035640 Exploration behavior Decreases phenotype PMID:38266696
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:30196065
GO:0036124 Histone h3-k9 trimethylation Decreases phenotype PMID:29102535
GO:0036151 Phosphatidylcholine acyl-chain remodeling Affects phenotype PMID:31453682
GO:0036152 Phosphatidylethanolamine acyl-chain remodeling Affects phenotype PMID:31453682
GO:0036343 Psychomotor behavior Affects phenotype PMID:39577800
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:38338858
GO:0040038 Polar body extrusion after meiotic divisions Decreases phenotype PMID:29102535
GO:0042048 Olfactory behavior Affects phenotype PMID:36706583
GO:0042116 Macrophage activation Increases phenotype PMID:34147605
GO:0042127 Regulation of cell population proliferation Affects phenotype PMID:30196065
GO:0042158 Lipoprotein biosynthetic process Increases phenotype PMID:37837293
GO:0042278 Purine nucleoside metabolic process Affects phenotype PMID:38685157
GO:0042428 Serotonin metabolic process Affects phenotype PMID:38266696
GO:0042431 Indole metabolic process Affects phenotype PMID:38685157
GO:0042701 Progesterone secretion Affects phenotype PMID:37182577
GO:0042733 Embryonic digit morphogenesis Affects phenotype PMID:38898774
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:35940389; PMID:38134982
GO:0043974 Histone h3-k27 acetylation Affects phenotype PMID:29102535; PMID:38685157
GO:0044030 Regulation of dna methylation Affects phenotype PMID:38338858
GO:0044237 Cellular metabolic process Increases phenotype PMID:31601247; PMID:31812737; PMID:32244372; PMID:32976987; PMID:33916708; PMID:34023961; PMID:34474090; PMID:35457000; PMID:36674557; PMID:39736419
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:31601247
GO:0045333 Cellular respiration Decreases phenotype PMID:39929295
GO:0045444 Fat cell differentiation Affects phenotype PMID:34186270
GO:0045792 Negative regulation of cell size Increases phenotype PMID:35803362
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:32023790
GO:0046034 Atp metabolic process Affects phenotype PMID:33312107; PMID:34023961; PMID:39929295
GO:0046083 Adenine metabolic process Affects phenotype PMID:38685157
GO:0046085 Adenosine metabolic process Affects phenotype PMID:38685157
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:39577800
GO:0046323 Glucose import Increases phenotype PMID:34147605
GO:0046449 Creatinine metabolic process Affects phenotype PMID:38685157
GO:0046474 Glycerophospholipid biosynthetic process Increases phenotype PMID:31453682
GO:0046483 Heterocycle metabolic process Affects phenotype PMID:38685157
GO:0046512 Sphingosine biosynthetic process Increases phenotype PMID:31453682
GO:0046513 Ceramide biosynthetic process Increases phenotype PMID:31453682
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:35278557
GO:0048143 Astrocyte activation Increases phenotype PMID:39577800
GO:0050765 Negative regulation of phagocytosis Increases phenotype PMID:32044397
GO:0050768 Negative regulation of neurogenesis Increases phenotype PMID:36706583
GO:0050898 Nitrile metabolic process Affects phenotype PMID:38685157
GO:0051310 Metaphase plate congression Decreases phenotype PMID:33476676
GO:0051646 Mitochondrion localization Affects phenotype PMID:39929295
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:39929295
GO:0051899 Membrane depolarization Affects phenotype PMID:39929295
GO:0052838 Thiazole metabolic process Affects phenotype PMID:38685157
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:26916392; PMID:28858478
GO:0060011 Sertoli cell proliferation Affects phenotype PMID:37601897
GO:0060073 Micturition Increases phenotype PMID:33755180
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28482050; PMID:31424294; PMID:33753083; PMID:37601897
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:35940389
GO:0070091 Glucagon secretion Decreases phenotype PMID:36674557
GO:0070189 Kynurenine metabolic process Affects phenotype PMID:38266696
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:30195206
GO:0070994 Detection of oxidative stress Increases phenotype PMID:35940389; PMID:37601897
GO:0071557 Histone h3-k27 demethylation Affects phenotype PMID:33476676
GO:0072539 T-helper 17 cell differentiation Decreases phenotype PMID:32911021
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:32023790; PMID:34474090; PMID:39736419
GO:0097621 Monoamine oxidase activity Increases phenotype PMID:39577800
GO:0140042 Lipid droplet formation Increases phenotype PMID:32220626; PMID:32763284; PMID:33865937; PMID:35736896; PMID:38685157; PMID:39778647
GO:0140354 Lipid import into cell Increases phenotype PMID:38388800
GO:0160024 Leydig cell proliferation Affects phenotype PMID:37601897
GO:1900194 Negative regulation of oocyte maturation Increases phenotype PMID:33476676
GO:1900825 Regulation of membrane depolarization during cardiac muscle cell action potential Affects phenotype PMID:38310357
GO:1901275 Tartrate metabolic process Affects phenotype PMID:38685157
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:31875995
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:28259788
GO:1901726 Negative regulation of histone deacetylase activity Increases phenotype PMID:36534918
GO:1901741 Positive regulation of myoblast fusion Increases phenotype PMID:32750123
GO:1901988 Negative regulation of cell cycle phase transition Increases phenotype PMID:37717640
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:31601247
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:31875995
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:28259788
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26916392; PMID:29102535; PMID:31453682
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28259788; PMID:29940534; PMID:30195206; PMID:32023790; PMID:39059691
GO:1903430 Negative regulation of cell maturation Increases phenotype PMID:35803362
GO:1903966 Monounsaturated fatty acid biosynthetic process Decreases phenotype PMID:30145421; PMID:31453682
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:33755180
GO:1990138 Neuron projection extension Decreases phenotype PMID:31812737
GO:1990375 Baculum development Affects phenotype PMID:37164221
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:25576683
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:29940534; PMID:35803362
GO:2000288 Positive regulation of myoblast proliferation Increases phenotype PMID:32750123
GO:2000469 Negative regulation of peroxidase activity Increases phenotype PMID:29940534
GO:2000611 Positive regulation of thyroid hormone generation Increases phenotype PMID:30940137
GO:2000833 Positive regulation of steroid hormone secretion Increases phenotype PMID:37717640; PMID:38966215
GO:2000835 Negative regulation of androgen secretion Increases phenotype PMID:38966215
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29940534; PMID:35803362
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:25576683; PMID:37837293
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:37837293
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:37717640
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:37717640
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.