Decabromobiphenyl ether


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000239 Pachytene Affects phenotype PMID:34936917
GO:0001503 Ossification Decreases phenotype PMID:27286044
GO:0001541 Ovarian follicle development Decreases phenotype PMID:32207525
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:27181932
GO:0002253 Activation of immune response Increases phenotype PMID:33571618
GO:0002260 Lymphocyte homeostasis Decreases phenotype PMID:33571618; PMID:38097007
GO:0002377 Immunoglobulin production Affects phenotype PMID:33571618; PMID:38808594
GO:0003006 Developmental process involved in reproduction Affects phenotype PMID:32207525; PMID:33252648
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:27286044
GO:0004303 Estradiol 17-beta-dehydrogenase activity Decreases phenotype PMID:29578053; PMID:30300726
GO:0004457 Lactate dehydrogenase activity Decreases phenotype PMID:28572024; PMID:31039416
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:34936917; PMID:35266255
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:28572024; PMID:31039416; PMID:31039416; PMID:33571618; PMID:33675858; PMID:34571075
GO:0006094 Gluconeogenesis Decreases phenotype PMID:28572024
GO:0006182 Cgmp biosynthetic process Increases phenotype PMID:29151189
GO:0006306 Dna methylation Decreases phenotype PMID:28597690
GO:0006590 Thyroid hormone generation Decreases phenotype PMID:26602377; PMID:31161897
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34757160
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:30468867
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:28572024
GO:0006749 Glutathione metabolic process Increases phenotype PMID:23640034; PMID:30844666; PMID:34571075
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25462306
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:34571075
GO:0006909 Phagocytosis Affects phenotype PMID:38808594
GO:0006915 Apoptotic process Increases phenotype PMID:25462306; PMID:26206603; PMID:28572024; PMID:31039416; PMID:34571075; PMID:34632857
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:34571075
GO:0006979 Response to oxidative stress Affects phenotype PMID:23640034
GO:0006997 Nucleus organization Affects phenotype PMID:34571075
GO:0007005 Mitochondrion organization Decreases phenotype PMID:34757160
GO:0007129 Homologous chromosome pairing at meiosis Affects phenotype PMID:34936917
GO:0007283 Spermatogenesis Decreases phenotype PMID:25479311; PMID:31039416; PMID:34936917
GO:0007286 Spermatid development Decreases phenotype PMID:34936917
GO:0007611 Learning or memory Decreases phenotype PMID:31161897
GO:0007612 Learning Affects phenotype PMID:34632857
GO:0007613 Memory Decreases phenotype PMID:34632857; PMID:39788477
GO:0008283 Cell population proliferation Decreases phenotype PMID:26206603; PMID:29578053
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:38641160
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:34166751
GO:0008291 Acetylcholine metabolic process Affects phenotype PMID:38808594
GO:0008542 Visual learning Decreases phenotype PMID:39788477
GO:0008584 Male gonad development Decreases phenotype PMID:25479311; PMID:29578053; PMID:30300726
GO:0009636 Response to toxic substance Affects phenotype PMID:23640034
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:37330034
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:30743236
GO:0016042 Lipid catabolic process Increases phenotype PMID:26206603; PMID:28572024; PMID:31039416; PMID:31039416; PMID:33571618; PMID:34757160; PMID:34936917
GO:0016049 Cell growth Decreases phenotype PMID:30232031
GO:0019249 Lactate biosynthetic process Decreases phenotype PMID:28572024; PMID:31039416
GO:0019953 Sexual reproduction Decreases phenotype PMID:31039416
GO:0022008 Neurogenesis Decreases phenotype PMID:34632857
GO:0030154 Cell differentiation Decreases phenotype PMID:34632857
GO:0030182 Neuron differentiation Decreases phenotype PMID:28597690
GO:0032024 Positive regulation of insulin secretion Increases phenotype PMID:30743236
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:30743236
GO:0034101 Erythrocyte homeostasis Affects phenotype PMID:27181932; PMID:38808594
GO:0034418 Urate biosynthetic process Decreases phenotype PMID:27286044
GO:0034440 Lipid oxidation Increases phenotype PMID:30844666
GO:0034728 Nucleosome organization Affects phenotype PMID:24834073
GO:0035176 Social behavior Decreases phenotype PMID:30836164
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:39788477
GO:0035825 Homologous recombination Decreases phenotype PMID:34936917
GO:0035936 Testosterone secretion Decreases phenotype PMID:25479311; PMID:29578053
GO:0036093 Germ cell proliferation Decreases phenotype PMID:29578053
GO:0042065 Glial cell growth Affects phenotype PMID:23914054
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:34166751; PMID:37330034
GO:0042415 Norepinephrine metabolic process Affects phenotype PMID:38808594
GO:0042445 Hormone metabolic process Affects phenotype PMID:23333513
GO:0042593 Glucose homeostasis Decreases phenotype PMID:23640034; PMID:30743236
GO:0042701 Progesterone secretion Increases phenotype PMID:31132478
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:38641160
GO:0043197 Dendritic spine Decreases phenotype PMID:39788477
GO:0044237 Cellular metabolic process Decreases phenotype PMID:34571075; PMID:34632857; PMID:35266255
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:29151189
GO:0045444 Fat cell differentiation Increases phenotype PMID:34757160
GO:0045795 Positive regulation of cell volume Increases phenotype PMID:30743236
GO:0045851 Ph reduction Increases phenotype PMID:31622892
GO:0046058 Camp metabolic process Affects phenotype PMID:38808594
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:29699156
GO:0046651 Lymphocyte proliferation Increases phenotype PMID:33571618; PMID:38808594
GO:0046959 Habituation Decreases phenotype PMID:25194327
GO:0048520 Positive regulation of behavior Increases phenotype PMID:25194327
GO:0050890 Cognition Decreases phenotype PMID:36566971
GO:0050995 Negative regulation of lipid catabolic process Increases phenotype PMID:38097007
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:34571075
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:34757160
GO:0060009 Sertoli cell development Decreases phenotype PMID:25479311
GO:0060068 Vagina development Decreases phenotype PMID:32207525
GO:0060209 Estrus Decreases phenotype PMID:32207525
GO:0060750 Epithelial cell proliferation involved in mammary gland duct elongation Increases phenotype PMID:33252648
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:26602377; PMID:30300726; PMID:29578053; PMID:30300726
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:30743236
GO:0070343 White fat cell proliferation Increases phenotype PMID:30468867
GO:0070633 Transepithelial transport Increases phenotype PMID:31622892
GO:0070661 Leukocyte proliferation Decreases phenotype PMID:38808594
GO:0070994 Detection of oxidative stress Increases phenotype PMID:35266255
GO:0071735 Igg immunoglobulin complex Increases phenotype PMID:33571618
GO:0071753 Igm immunoglobulin complex Increases phenotype PMID:33571618
GO:0072520 Seminiferous tubule development Affects phenotype PMID:34936917
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33675858; PMID:33675858; PMID:35266255; PMID:34571075; PMID:34757160; PMID:34936917
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:34936917
GO:0090557 Establishment of endothelial intestinal barrier Decreases phenotype PMID:33675858
GO:0097006 Regulation of plasma lipoprotein particle levels Decreases phenotype PMID:30743236
GO:0097028 Dendritic cell differentiation Increases phenotype PMID:23235302
GO:0097722 Sperm motility Decreases phenotype PMID:31039416
GO:0098727 Maintenance of cell number Affects phenotype PMID:30836164
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:29578053; PMID:30300726
GO:0110090 Positive regulation of hippocampal neuron apoptotic process Increases phenotype PMID:36566971
GO:0140042 Lipid droplet formation Increases phenotype PMID:30743236; PMID:34757160
GO:0140059 Dendrite arborization Increases phenotype PMID:23235302
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:23640034; PMID:30743236; PMID:30844666
GO:1901988 Negative regulation of cell cycle phase transition Increases phenotype PMID:38641160
GO:1903046 Meiotic cell cycle process Affects phenotype PMID:34936917
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24395120; PMID:25462306; PMID:26206603; PMID:31039416
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:35950316
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:36566971
GO:2000609 Regulation of thyroid hormone generation Affects phenotype PMID:39626304
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:30844666; PMID:37330034
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.