Arsenic trioxide


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:31846860; PMID:32112876; PMID:32781346; PMID:33462182; PMID:34062077
GO:0000080 Mitotic g1 phase Affects phenotype PMID:31539632; PMID:32645343
GO:0000084 Mitotic s phase Affects phenotype PMID:32645343; PMID:34025784; PMID:36352148
GO:0000085 Mitotic g2 phase Affects phenotype PMID:31597699
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:31307525; PMID:31734849; PMID:32645343; PMID:34413873; PMID:36352148; PMID:36442592
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:32781346
GO:0000132 Establishment of mitotic spindle orientation Decreases phenotype PMID:22496355
GO:0000278 Mitotic cell cycle Increases phenotype PMID:12181429; PMID:17718811; PMID:31307525; PMID:31539632; PMID:32645343
GO:0000723 Telomere maintenance Affects phenotype PMID:16107885
GO:0001525 Angiogenesis Decreases phenotype PMID:31421153
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:32781346
GO:0001553 Luteinization Affects phenotype PMID:32781346
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:24531206
GO:0001755 Neural crest cell migration Decreases phenotype PMID:26238599
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:30376134
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:30376134; PMID:37166470
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:11304686; PMID:16405743; PMID:18022205; PMID:23082001; PMID:23337567; PMID:24157283; PMID:26772155; PMID:27461142; PMID:30338810; PMID:32305283
GO:0001933 Negative regulation of protein phosphorylation Affects phenotype PMID:32184170
GO:0001934 Positive regulation of protein phosphorylation Increases phenotype PMID:32184170
GO:0002270 Plasmacytoid dendritic cell activation Increases phenotype PMID:32642412
GO:0002295 T-helper cell lineage commitment Affects phenotype PMID:32642412
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:24337744; PMID:28978146; PMID:34333357; PMID:35317438; PMID:36473683; PMID:36791901
GO:0002526 Acute inflammatory response Increases phenotype PMID:22099998
GO:0002675 Positive regulation of acute inflammatory response Increases phenotype PMID:27174766
GO:0002763 Positive regulation of myeloid leukocyte differentiation Increases phenotype PMID:26110921
GO:0002838 Negative regulation of immune response to tumor cell Decreases phenotype PMID:28454374
GO:0003159 Morphogenesis of an endothelium Decreases phenotype PMID:31274337
GO:0003720 Telomerase activity Decreases phenotype PMID:27039805
GO:0003993 Acid phosphatase activity Increases phenotype PMID:17718811
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:17718811; PMID:23283742; PMID:35088608
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:29751151; PMID:29867492; PMID:33846815; PMID:35088608; PMID:32920515; PMID:33846815; PMID:35088608
GO:0004096 Catalase activity Decreases phenotype PMID:37730986
GO:0004111 Creatine kinase activity Increases phenotype PMID:32920515; PMID:32920515; PMID:33173984; PMID:33173984; PMID:33603344; PMID:33603344; PMID:34333357; PMID:34333357
GO:0004197 Cysteine-type endopeptidase activity Increases phenotype PMID:23968587
GO:0004198 Calcium-dependent cysteine-type endopeptidase activity Increases phenotype PMID:37446117
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:23283742; PMID:24948398; PMID:28209094; PMID:28209094; PMID:28494415; PMID:28494415; PMID:32920515
GO:0004396 Hexokinase activity Decreases phenotype PMID:31149761
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:24948398; PMID:29867492; PMID:33603344; PMID:34333357; PMID:32920515; PMID:32920515; PMID:33173984; PMID:33173984; PMID:33603344; PMID:34303041; PMID:34333357
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:23023136; PMID:23283742; PMID:28978146; PMID:38070468; PMID:23283742; PMID:23283742; PMID:37689273; PMID:28209094; PMID:28474970; PMID:28978146; PMID:29751151; PMID:31473893; PMID:32920515; PMID:32920515; PMID:33173984; PMID:33173984; PMID:33603344; PMID:33846815; PMID:34062077; PMID:37689273; PMID:38070468
GO:0004611 Phosphoenolpyruvate carboxykinase activity Increases phenotype PMID:32226249
GO:0004679 Amp-activated protein kinase activity Increases phenotype PMID:32184170
GO:0004725 Protein tyrosine phosphatase activity Decreases phenotype PMID:32337366
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:23023136; PMID:23023136; PMID:23283742; PMID:28978146; PMID:29130132; PMID:38070468; PMID:23283742; PMID:23283742; PMID:29130132; PMID:37689273; PMID:24948398; PMID:25966753; PMID:25966753; PMID:26187899; PMID:26187899; PMID:28209094; PMID:28209094; PMID:29130132; PMID:28978146; PMID:29130132; PMID:29130132; PMID:38741475; PMID:29751151; PMID:30090573; PMID:31473893; PMID:32683294; PMID:32920515; PMID:33173984; PMID:33603344; PMID:33846815; PMID:34333357; PMID:35317438; PMID:33603344; PMID:33846815; PMID:35317438; PMID:33634982; PMID:34062077; PMID:34333357; PMID:35088608; PMID:35317438; PMID:37689273; PMID:37730986; PMID:38070468; PMID:38741475
GO:0005388 P-type calcium transporter activity Decreases phenotype PMID:29751151
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:29751151
GO:0005757 Mitochondrial permeability transition pore complex Affects phenotype PMID:29867492
GO:0005776 Autophagosome Increases phenotype PMID:30237538
GO:0005978 Glycogen biosynthetic process Decreases phenotype PMID:30362509
GO:0006089 Lactate metabolic process Affects phenotype PMID:38160894
GO:0006090 Pyruvate metabolic process Affects phenotype PMID:38160894
GO:0006094 Gluconeogenesis Decreases phenotype PMID:24091382
GO:0006116 Nadh oxidation Decreases phenotype PMID:29095437
GO:0006231 Dtmp biosynthetic process Decreases phenotype PMID:28265077
GO:0006260 Dna replication Affects phenotype PMID:35714947
GO:0006281 Dna repair Decreases phenotype PMID:25092648
GO:0006289 Nucleotide-excision repair Affects phenotype PMID:33562002
GO:0006304 Dna modification Affects phenotype PMID:33562002
GO:0006306 Dna methylation Decreases phenotype PMID:24680928
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:10389765; PMID:10477740; PMID:11304686; PMID:11304686; PMID:12429934; PMID:12063550; PMID:12296996; PMID:14632209; PMID:15493360; PMID:15761769; PMID:9734658; PMID:15774171; PMID:17376498; PMID:18636201; PMID:21061466; PMID:23337567; PMID:25258189; PMID:34303041; PMID:9450572; PMID:9734658
GO:0006338 Chromatin remodeling Affects phenotype PMID:31205918
GO:0006469 Negative regulation of protein kinase activity Increases phenotype PMID:23832679; PMID:23911876
GO:0006497 Protein lipidation Increases phenotype PMID:31846860; PMID:33462182
GO:0006526 Arginine biosynthetic process Decreases phenotype PMID:24091382
GO:0006537 Glutamate biosynthetic process Increases phenotype PMID:24091382
GO:0006553 Lysine metabolic process Affects phenotype PMID:31846860
GO:0006570 Tyrosine metabolic process Affects phenotype PMID:31846860
GO:0006585 Dopamine biosynthetic process from tyrosine Decreases phenotype PMID:23392890
GO:0006587 Serotonin biosynthetic process from tryptophan Decreases phenotype PMID:23392890
GO:0006592 Ornithine biosynthetic process Decreases phenotype PMID:30090573
GO:0006596 Polyamine biosynthetic process Affects phenotype PMID:27044562
GO:0006606 Protein import into nucleus Increases phenotype PMID:22496356; PMID:31421153; PMID:33462182; PMID:34037972; PMID:34303041
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:31846860; PMID:34047416; PMID:38237221
GO:0006651 Diacylglycerol biosynthetic process Increases phenotype PMID:29986281
GO:0006656 Phosphatidylcholine biosynthetic process Decreases phenotype PMID:24091382
GO:0006658 Phosphatidylserine metabolic process Affects phenotype PMID:31846860
GO:0006684 Sphingomyelin metabolic process Affects phenotype PMID:31846860
GO:0006730 One-carbon metabolic process Affects phenotype PMID:27044562
GO:0006735 Nadh regeneration Decreases phenotype PMID:24126434
GO:0006749 Glutathione metabolic process Increases phenotype PMID:22753750; PMID:22922937; PMID:24004876; PMID:24126434; PMID:24276018; PMID:24327821; PMID:24327821; PMID:28494415; PMID:24634002; PMID:25003661; PMID:25003661; PMID:25144547; PMID:25144547; PMID:25246272; PMID:25341331; PMID:25542264; PMID:25542264; PMID:25815309; PMID:25728215; PMID:25815309; PMID:26184899; PMID:27592447; PMID:28494415; PMID:31355259; PMID:31846860; PMID:32683294; PMID:32781346; PMID:32919218; PMID:32920515; PMID:33634982; PMID:34037972; PMID:34333357; PMID:36791901; PMID:37689273; PMID:37730986
GO:0006750 Glutathione biosynthetic process Increases phenotype PMID:23283742; PMID:23283742; PMID:29130132; PMID:24091382; PMID:24948398; PMID:25410152; PMID:25966753; PMID:27044562; PMID:28115242; PMID:28209094; PMID:28209094; PMID:29130132; PMID:28458011; PMID:28803342; PMID:29130132; PMID:29751151; PMID:30012499; PMID:30090573; PMID:30385301; PMID:31332900
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:27461142; PMID:29867492
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:30090573
GO:0006810 Transport Affects phenotype PMID:36473683
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:17376498; PMID:31054354; PMID:34037972
GO:0006883 Cellular sodium ion homeostasis Affects phenotype PMID:31054354
GO:0006909 Phagocytosis Decreases phenotype PMID:27461142; PMID:27461142; PMID:38237221
GO:0006914 Autophagy Increases phenotype PMID:15592527; PMID:16882451; PMID:20574048; PMID:21971985; PMID:21971985; PMID:29743969; PMID:25449439; PMID:29111283; PMID:29743969; PMID:30338810; PMID:31846860; PMID:32112876; PMID:32781346; PMID:33462182
GO:0006915 Apoptotic process Increases phenotype PMID:10070961; PMID:10190895; PMID:15534931; PMID:10340400; PMID:10340400; PMID:10373566; PMID:10721769; PMID:12239215; PMID:12513784; PMID:12750708; PMID:19457607; PMID:19763917; PMID:9716575; PMID:10373566; PMID:10373634; PMID:10382944; PMID:10477740; PMID:12684647; PMID:12931215; PMID:16818652; PMID:29163777; PMID:30316766; PMID:10382944; PMID:11775865; PMID:11776809; PMID:12429934; PMID:12684647; PMID:14610070; PMID:14619570; PMID:17666343; PMID:20471514; PMID:24273890; PMID:25953102; PMID:28961318; PMID:35590355; PMID:9716575; PMID:10389765; PMID:10428472; PMID:10721769; PMID:21969006; PMID:23387208; PMID:10477740; PMID:10721769; PMID:10841286; PMID:17203211; PMID:18718063; PMID:23082001; PMID:28901456; PMID:29159499; PMID:30145367; PMID:30333888; PMID:30338810; PMID:34675983; PMID:9716575; PMID:9734658; PMID:10850458; PMID:10942401; PMID:11135700; PMID:21418039; PMID:24884809; PMID:11146441; PMID:11146441; PMID:15904916; PMID:19457607; PMID:20403207; PMID:26598702; PMID:11279639; PMID:11488934; PMID:11299786; PMID:11304686; PMID:11304686; PMID:11721366; PMID:12296996; PMID:12297426; PMID:15031205; PMID:15476326; PMID:15979894; PMID:16360329; PMID:20148895; PMID:25953102; PMID:29944906; PMID:30472098; PMID:32305283; PMID:34025784; PMID:11304686; PMID:11776809; PMID:14610070; PMID:15581621; PMID:16174796; PMID:25758096; PMID:29699374; PMID:30012499; PMID:9716575; PMID:11304686; PMID:14610070; PMID:11480559; PMID:11739184; PMID:11739184; PMID:9864171; PMID:11775865; PMID:11776809; PMID:12962562; PMID:17487402; PMID:30333888; PMID:11779429; PMID:11779429; PMID:12851490; PMID:12962562; PMID:14619570; PMID:14701702; PMID:15228664; PMID:15735709; PMID:17487402; PMID:17956674; PMID:24377552; PMID:24944602; PMID:25110043; PMID:25130820; PMID:25953102; PMID:28961318; PMID:29266867; PMID:29574283; PMID:29944906; PMID:32305283; PMID:39152142; PMID:11783079; PMID:11783079; PMID:17237268; PMID:20039766; PMID:8704214; PMID:12063550; PMID:12063550; PMID:12181429; PMID:12903512; PMID:14729614; PMID:18726487; PMID:22496355; PMID:22496356; PMID:29059232; PMID:12083632; PMID:12181429; PMID:15493360; PMID:24392034; PMID:32645343; PMID:12083632; PMID:30127993; PMID:31539632; PMID:32645343; PMID:36442592; PMID:12181429; PMID:12181429; PMID:15844663; PMID:16237756; PMID:18281123; PMID:18636201; PMID:24312908; PMID:25174355; PMID:26772155; PMID:12239215; PMID:12296996; PMID:12296996; PMID:12702573; PMID:16467208; PMID:12513784; PMID:12513834; PMID:12647012; PMID:12750841; PMID:14632209; PMID:16882451; PMID:12725324; PMID:12750708; PMID:12750841; PMID:12883267; PMID:15493360; PMID:12903512; PMID:14610070; PMID:14632209; PMID:14701702; PMID:14729614; PMID:15031205; PMID:15031205; PMID:18354491; PMID:15093545; PMID:15142122; PMID:15231573; PMID:17145888; PMID:20408844; PMID:15382040; PMID:15493360; PMID:19771260; PMID:15621810; PMID:15625759; PMID:15705788; PMID:15735709; PMID:15746941; PMID:15761769; PMID:9734658; PMID:15781666; PMID:15815728; PMID:16166054; PMID:16174796; PMID:16237756; PMID:16237756; PMID:24884809; PMID:25972196; PMID:31205918; PMID:16360329; PMID:16467208; PMID:16569477; PMID:16569477; PMID:34953944; PMID:35467087; PMID:38797699; PMID:16572199; PMID:16572199; PMID:17145888; PMID:16646077; PMID:16818652; PMID:16818652; PMID:9716575; PMID:16882451; PMID:16904648; PMID:17145888; PMID:17203211; PMID:17217047; PMID:17237268; PMID:17495969; PMID:17512576; PMID:17666343; PMID:20471514; PMID:17869043; PMID:17963750; PMID:18172319; PMID:18281123; PMID:18281123; PMID:18636201; PMID:18297255; PMID:18357729; PMID:18482988; PMID:18575716; PMID:18599993; PMID:18636201; PMID:18718063; PMID:18726487; PMID:19208092; PMID:19437134; PMID:19457607; PMID:19468689; PMID:19771260; PMID:19950589; PMID:20039766; PMID:20079407; PMID:20408844; PMID:20799280; PMID:20889596; PMID:21061466; PMID:21118639; PMID:21418039; PMID:21740082; PMID:21969006; PMID:22496355; PMID:22496356; PMID:23082001; PMID:23337567; PMID:23387208; PMID:23926672; PMID:23926672; PMID:26966376; PMID:24157283; PMID:24273890; PMID:24312908; PMID:24377552; PMID:24392034; PMID:24801902; PMID:24884809; PMID:25110043; PMID:25130820; PMID:25256833; PMID:25410152; PMID:25449439; PMID:25449439; PMID:38160894; PMID:25758096; PMID:25953102; PMID:25972196; PMID:25983101; PMID:26118777; PMID:26598702; PMID:26772155; PMID:27039805; PMID:29164574; PMID:29274334; PMID:29486283; PMID:27461142; PMID:29042487; PMID:29059232; PMID:29163777; PMID:29266867; PMID:29274334; PMID:29274627; PMID:29549912; PMID:29549912; PMID:29738779; PMID:29574283; PMID:29610575; PMID:29699374; PMID:29699374; PMID:31307525; PMID:29751151; PMID:29767511; PMID:29774349; PMID:29910624; PMID:29944906; PMID:30012499; PMID:30145367; PMID:30316766; PMID:30338810; PMID:30472098; PMID:30472098; PMID:35590355; PMID:30983542; PMID:31054354; PMID:31079498; PMID:31205918; PMID:31307525; PMID:31539632; PMID:31846860; PMID:32305283; PMID:32321992; PMID:32645343; PMID:32919218; PMID:32920515; PMID:33634982; PMID:33846815; PMID:33846815; PMID:35088608; PMID:34025784; PMID:34037972; PMID:34333357; PMID:34333357; PMID:35676786; PMID:34413873; PMID:36352148; PMID:34675983; PMID:34953944; PMID:35088608; PMID:35195477; PMID:35317438; PMID:35487055; PMID:35590355; PMID:35676786; PMID:36707890; PMID:36352148; PMID:36400307; PMID:36707890; PMID:38160894; PMID:38797699; PMID:39152142; PMID:9716575; PMID:9864171
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:22977528; PMID:22988968; PMID:23440206; PMID:23721794; PMID:23440206; PMID:29944906
GO:0006954 Inflammatory response Increases phenotype PMID:23023136; PMID:27044562; PMID:32683294; PMID:32920515; PMID:33846815; PMID:33846815; PMID:35088608; PMID:35088608; PMID:37166470
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:23337567; PMID:25972196; PMID:29130132; PMID:29277637
GO:0006979 Response to oxidative stress Increases phenotype PMID:12513784; PMID:15904916; PMID:18636201; PMID:20471514; PMID:24327821
GO:0006997 Nucleus organization Decreases phenotype PMID:31307525
GO:0007005 Mitochondrion organization Decreases phenotype PMID:29867492; PMID:31846860; PMID:32781346; PMID:34333357; PMID:35195477
GO:0007009 Plasma membrane organization Decreases phenotype PMID:29751151; PMID:30660605
GO:0007029 Endoplasmic reticulum organization Affects phenotype PMID:29111283
GO:0007033 Vacuole organization Increases phenotype PMID:23023136; PMID:31258454
GO:0007040 Lysosome organization Increases phenotype PMID:30338810; PMID:33462182
GO:0007049 Cell cycle Affects phenotype PMID:10389765; PMID:10477740; PMID:11135700; PMID:12148893; PMID:9864171; PMID:12181429; PMID:12181429; PMID:15493360; PMID:12684647; PMID:12725324; PMID:12851490; PMID:12883267; PMID:12903512; PMID:15493360; PMID:15979894; PMID:20148895; PMID:17617380; PMID:19457607; PMID:21473291; PMID:9864171
GO:0007095 Mitotic g2 dna damage checkpoint signaling Increases phenotype PMID:25499136
GO:0007155 Cell adhesion Increases phenotype PMID:27039805
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:23363563; PMID:27638049; PMID:31274337
GO:0007224 Smoothened signaling pathway Affects phenotype PMID:24859340
GO:0007254 Jnk cascade Affects phenotype PMID:23664956
GO:0007283 Spermatogenesis Decreases phenotype PMID:18630931; PMID:32112876; PMID:28956719; PMID:34062077
GO:0007286 Spermatid development Affects phenotype PMID:32112876
GO:0007613 Memory Decreases phenotype PMID:34050381
GO:0008121 Ubiquinol-cytochrome-c reductase activity Increases phenotype PMID:18022205
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:18022205
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:31332900
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:31846860; PMID:38237221
GO:0008206 Bile acid metabolic process Affects phenotype PMID:31846860
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34050381
GO:0008219 Cell death Increases phenotype PMID:10070961; PMID:11027660; PMID:12883035; PMID:15093545; PMID:15555283; PMID:16007134; PMID:16107885; PMID:16196273; PMID:16283431; PMID:16497877; PMID:16646077; PMID:21138464; PMID:17963750; PMID:18022205; PMID:18022205; PMID:36801614; PMID:18354491; PMID:20810208; PMID:20810208; PMID:26772155; PMID:26884726; PMID:21138464; PMID:23337567; PMID:23337567; PMID:29307831; PMID:24392034; PMID:24392034; PMID:29277637; PMID:25410152; PMID:25410152; PMID:29944906; PMID:30091188; PMID:37446117; PMID:25953102; PMID:26772155; PMID:26884726; PMID:27608960; PMID:27608960; PMID:35195477; PMID:28458011; PMID:29260515; PMID:29307831; PMID:29944906; PMID:29944906; PMID:30091188; PMID:30090573; PMID:32337366; PMID:35195477; PMID:36801614; PMID:37446117
GO:0008283 Cell population proliferation Increases phenotype PMID:10070961; PMID:10340400; PMID:12135670; PMID:10340400; PMID:12239215; PMID:19763917; PMID:9716575; PMID:10626785; PMID:10841286; PMID:18718063; PMID:28978663; PMID:30145367; PMID:9716575; PMID:10850458; PMID:10850458; PMID:12684647; PMID:12931215; PMID:29119387; PMID:30316766; PMID:11135700; PMID:24884809; PMID:11146441; PMID:18161919; PMID:20403207; PMID:29409467; PMID:11299786; PMID:11721366; PMID:11798775; PMID:12135670; PMID:12933582; PMID:16360329; PMID:17997939; PMID:20148895; PMID:25953102; PMID:11776647; PMID:12429934; PMID:12684647; PMID:14619570; PMID:20471514; PMID:24273890; PMID:25758096; PMID:25953102; PMID:28961318; PMID:29805662; PMID:29950208; PMID:9716575; PMID:11779429; PMID:12962562; PMID:14619570; PMID:14701702; PMID:15228664; PMID:16882451; PMID:17697580; PMID:17956674; PMID:19099629; PMID:24377552; PMID:24791595; PMID:24944602; PMID:25110043; PMID:25130820; PMID:25953102; PMID:28961318; PMID:29805662; PMID:12135670; PMID:12239215; PMID:12239215; PMID:15493360; PMID:12239215; PMID:23926672; PMID:35487055; PMID:12429934; PMID:25758096; PMID:29699374; PMID:9716575; PMID:12647012; PMID:16882451; PMID:12883035; PMID:12931215; PMID:12933582; PMID:12962562; PMID:14729614; PMID:14729614; PMID:18726487; PMID:15493360; PMID:25945059; PMID:15493360; PMID:36400307; PMID:15534931; PMID:15621810; PMID:15774171; PMID:15815728; PMID:15844663; PMID:16237756; PMID:24312908; PMID:25174355; PMID:25335113; PMID:26772155; PMID:30237564; PMID:16107885; PMID:16166054; PMID:16237756; PMID:16237756; PMID:24884809; PMID:25972196; PMID:16360329; PMID:16569477; PMID:38797699; PMID:16818652; PMID:16818652; PMID:9716575; PMID:17617380; PMID:17869043; PMID:18599993; PMID:18718063; PMID:19468689; PMID:19950589; PMID:20471514; PMID:21061466; PMID:21118639; PMID:21924320; PMID:21969006; PMID:21969006; PMID:25076250; PMID:24157283; PMID:24273890; PMID:24312908; PMID:24377552; PMID:24392034; PMID:24801890; PMID:24884809; PMID:25076250; PMID:25130820; PMID:25258189; PMID:25449439; PMID:25449439; PMID:38160894; PMID:25758096; PMID:25791921; PMID:25945059; PMID:25945059; PMID:35030298; PMID:25953102; PMID:25972196; PMID:26114099; PMID:26118777; PMID:26772155; PMID:27039805; PMID:29164574; PMID:29274334; PMID:27608960; PMID:28978663; PMID:29119387; PMID:29274334; PMID:29274627; PMID:29396848; PMID:29699374; PMID:29767511; PMID:29805662; PMID:29910624; PMID:30012499; PMID:30145367; PMID:30237564; PMID:30316766; PMID:30748021; PMID:34058077; PMID:35030298; PMID:35487055; PMID:35590355; PMID:35714947; PMID:36400307; PMID:36473683; PMID:37072838; PMID:38160894; PMID:9716575; PMID:9864171
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:22922937; PMID:22922937; PMID:23700110; PMID:23980369; PMID:26160715; PMID:27189198; PMID:27430728; PMID:27807322; PMID:27812249; PMID:23255002; PMID:23255470; PMID:23293885; PMID:23700110; PMID:23980369; PMID:24345465; PMID:24345465; PMID:24691991; PMID:24685274; PMID:25416439; PMID:25416439; PMID:27717846; PMID:25436934; PMID:25555879; PMID:25574600; PMID:25728215; PMID:25815518; PMID:26160715; PMID:26821882; PMID:27318970; PMID:27430728; PMID:27592447; PMID:27717846; PMID:27784375; PMID:27793025; PMID:27794399; PMID:27807322; PMID:27812249; PMID:27840903; PMID:28587418; PMID:38275666
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:21176356; PMID:21687957; PMID:21687957; PMID:22693909; PMID:22753750; PMID:22959511; PMID:23382965; PMID:23440206; PMID:23497375; PMID:23542114; PMID:22753750; PMID:23159075; PMID:30677399; PMID:31274337; PMID:32642412; PMID:33070465; PMID:38266058; PMID:38275666; PMID:39223679
GO:0008542 Visual learning Decreases phenotype PMID:34050381
GO:0009086 Methionine biosynthetic process Increases phenotype PMID:24091382
GO:0009435 Nad biosynthetic process Decreases phenotype PMID:27044562; PMID:28501332
GO:0010459 Negative regulation of heart rate Increases phenotype PMID:28494415
GO:0010466 Negative regulation of peptidase activity Increases phenotype PMID:23253724
GO:0010498 Proteasomal protein catabolic process Increases phenotype PMID:23673342
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:22898604; PMID:25446377; PMID:30677399; PMID:33070465; PMID:36100036
GO:0010629 Negative regulation of gene expression Increases phenotype PMID:22988968
GO:0010666 Positive regulation of cardiac muscle cell apoptotic process Affects phenotype PMID:23664956
GO:0010750 Positive regulation of nitric oxide mediated signal transduction Increases phenotype PMID:23106696
GO:0010763 Positive regulation of fibroblast migration Increases phenotype PMID:35276128
GO:0010822 Positive regulation of mitochondrion organization Decreases phenotype PMID:27638049
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:20723298; PMID:21138464; PMID:21327864; PMID:21138464; PMID:21327864; PMID:22753750; PMID:26628001; PMID:36100036; PMID:37230480; PMID:38275666
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:24126434; PMID:24276018; PMID:24466103; PMID:25144547; PMID:25446377; PMID:25574600; PMID:27638049; PMID:27794399; PMID:28391263
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:23201927; PMID:24126434; PMID:24307199; PMID:37402917
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23967052; PMID:24126434; PMID:24276018; PMID:24738333; PMID:25003661; PMID:25246272; PMID:25317073; PMID:25446377; PMID:26708503; PMID:27015953; PMID:27638049; PMID:27829220; PMID:28458011; PMID:33070465; PMID:36100036; PMID:37301138
GO:0010971 Positive regulation of g2/m transition of mitotic cell cycle Decreases phenotype PMID:24004876; PMID:27840903
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Increases phenotype PMID:21792014; PMID:22730174; PMID:24934751; PMID:27592447
GO:0014067 Negative regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:22391160
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:21649584
GO:0016042 Lipid catabolic process Increases phenotype PMID:23283742; PMID:23283742; PMID:28978146; PMID:29130132; PMID:29986281; PMID:23283742; PMID:29130132; PMID:24948398; PMID:26187899; PMID:28209094; PMID:28209094; PMID:28474970; PMID:29130132; PMID:28474970; PMID:28803342; PMID:28978146; PMID:29130132; PMID:29751151; PMID:29986281; PMID:30090573; PMID:30385301; PMID:31149761; PMID:31149761; PMID:31473893; PMID:31258454; PMID:31332900; PMID:31846860; PMID:32781346; PMID:32919218; PMID:32919218; PMID:33173984; PMID:32920515; PMID:33603344; PMID:35195477
GO:0016049 Cell growth Decreases phenotype PMID:28803342; PMID:28901456; PMID:28978663; PMID:30145367; PMID:30333888; PMID:30338810; PMID:28961318; PMID:29266867; PMID:29574283; PMID:29944906; PMID:28961318; PMID:29867492; PMID:30316766; PMID:28978663; PMID:29039521; PMID:29042487; PMID:29042487; PMID:29274334; PMID:29486283; PMID:29059232; PMID:29260515; PMID:29274627; PMID:30127993; PMID:29266867; PMID:29274334; PMID:29274627; PMID:29277637; PMID:29277637; PMID:30093655; PMID:29467594; PMID:29574283; PMID:29610575; PMID:29662624; PMID:29738779; PMID:29867492; PMID:29751151; PMID:29867492; PMID:29876539; PMID:29944906; PMID:30012499; PMID:30012499; PMID:30316766; PMID:30093655; PMID:30127993; PMID:30145367; PMID:30237538; PMID:30316766; PMID:30333888; PMID:30338810; PMID:30660605
GO:0016174 Nad(p)h oxidase h2o2-forming activity Increases phenotype PMID:27638049; PMID:38070468
GO:0016209 Antioxidant activity Decreases phenotype PMID:29297235
GO:0016477 Cell migration Increases phenotype PMID:25047463; PMID:25791921; PMID:26118777; PMID:29396848; PMID:29805662; PMID:30093655; PMID:31054354; PMID:31054354; PMID:31421153; PMID:31421153; PMID:36400307
GO:0016605 Pml body Increases phenotype PMID:29774349; PMID:32240679
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:29274627
GO:0018126 Protein hydroxylation Increases phenotype PMID:31612257
GO:0018158 Protein oxidation Increases phenotype PMID:26560635; PMID:32781346; PMID:32919218
GO:0018171 Peptidyl-cysteine oxidation Increases phenotype PMID:33462182
GO:0019344 Cysteine biosynthetic process Increases phenotype PMID:24091382
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:38758479
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:24091382; PMID:30237538
GO:0019627 Urea metabolic process Affects phenotype PMID:31612257; PMID:37689273
GO:0019860 Uracil metabolic process Increases phenotype PMID:28265077
GO:0021537 Telencephalon development Increases phenotype PMID:31258454
GO:0021702 Cerebellar purkinje cell differentiation Affects phenotype PMID:30032600
GO:0022008 Neurogenesis Decreases phenotype PMID:30225639
GO:0022602 Ovulation cycle process Affects phenotype PMID:32781346
GO:0022604 Regulation of cell morphogenesis Affects phenotype PMID:25054231
GO:0030154 Cell differentiation Affects phenotype PMID:10070961; PMID:10942401; PMID:12702573; PMID:16818652; PMID:17217047; PMID:18354491; PMID:26892147; PMID:29767511; PMID:29774349
GO:0030163 Protein catabolic process Increases phenotype PMID:21613260; PMID:23430110
GO:0030185 Nitric oxide transport Increases phenotype PMID:29751151
GO:0030218 Erythrocyte differentiation Decreases phenotype PMID:16360329
GO:0030219 Megakaryocyte differentiation Increases phenotype PMID:16360329
GO:0030224 Monocyte differentiation Increases phenotype PMID:15781666
GO:0030263 Apoptotic chromosome condensation Affects phenotype PMID:15142122; PMID:30032600; PMID:30225639; PMID:31205918; PMID:34953944
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:20143188; PMID:20615082; PMID:20698225; PMID:20723298; PMID:22944098; PMID:22949821; PMID:22988968; PMID:22949821
GO:0030335 Positive regulation of cell migration Affects phenotype PMID:24276018; PMID:25728215; PMID:37424815; PMID:38746032; PMID:39223679
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:23232515; PMID:38266058; PMID:39223679
GO:0030502 Negative regulation of bone mineralization Increases phenotype PMID:22465848
GO:0030511 Positive regulation of transforming growth factor beta receptor signaling pathway Decreases phenotype PMID:25196641
GO:0030578 Pml body organization Increases phenotype PMID:20943951; PMID:26060329; PMID:32240679
GO:0030851 Granulocyte differentiation Increases phenotype PMID:11480559; PMID:30076181
GO:0030854 Positive regulation of granulocyte differentiation Increases phenotype PMID:24953245
GO:0030878 Thyroid gland development Affects phenotype PMID:31258454
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:38382534
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:34050381
GO:0032008 Positive regulation of tor signaling Increases phenotype PMID:23469683
GO:0032148 Activation of protein kinase b activity Affects phenotype PMID:23255002; PMID:23700110; PMID:23980369; PMID:25416439; PMID:28454374; PMID:32184170; PMID:35226250
GO:0032206 Positive regulation of telomere maintenance Decreases phenotype PMID:23293885
GO:0032436 Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Increases phenotype PMID:20943951; PMID:23028697
GO:0032528 Microvillus organization Decreases phenotype PMID:29355690
GO:0032727 Positive regulation of interferon-alpha production Increases phenotype PMID:32642412
GO:0032776 Dna methylation on cytosine Decreases phenotype PMID:29223816
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:22753750; PMID:24126434; PMID:24634002; PMID:27638049
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:24762191; PMID:38237221
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:30677399
GO:0033034 Positive regulation of myeloid cell apoptotic process Increases phenotype PMID:28454374
GO:0033212 Iron import into cell Increases phenotype PMID:38266058
GO:0033235 Positive regulation of protein sumoylation Increases phenotype PMID:21613260; PMID:26060329; PMID:28318385
GO:0033292 T-tubule organization Increases phenotype PMID:16711005
GO:0034063 Stress granule assembly Increases phenotype PMID:29486283
GO:0034356 Nad biosynthesis via nicotinamide riboside salvage pathway Decreases phenotype PMID:28501332
GO:0034440 Lipid oxidation Increases phenotype PMID:17718811; PMID:25542264; PMID:25542264; PMID:25815309; PMID:25815309; PMID:26184899; PMID:26184899; PMID:26560635; PMID:28494415; PMID:26184899; PMID:27713174; PMID:38070468; PMID:26184899; PMID:28494415; PMID:26184899; PMID:37689273; PMID:26560635; PMID:27561292; PMID:27713174; PMID:27750169; PMID:28494415; PMID:34333357; PMID:36791901; PMID:37072838; PMID:37689273; PMID:37730986; PMID:38070468
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:32017938
GO:0034614 Cellular response to reactive oxygen species Increases phenotype PMID:32017938
GO:0035148 Tube formation Decreases phenotype PMID:31421153
GO:0035640 Exploration behavior Decreases phenotype PMID:34050381
GO:0035666 Trif-dependent toll-like receptor signaling pathway Increases phenotype PMID:23106696
GO:0035774 Positive regulation of insulin secretion involved in cellular response to glucose stimulus Affects phenotype PMID:25859628
GO:0035825 Homologous recombination Decreases phenotype PMID:37530740
GO:0036446 Myofibroblast differentiation Decreases phenotype PMID:30317545
GO:0038065 Collagen-activated signaling pathway Decreases phenotype PMID:24466103
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:25542264
GO:0042102 Positive regulation of t cell proliferation Increases phenotype PMID:28454374
GO:0042310 Vasoconstriction Increases phenotype PMID:31054354
GO:0042391 Regulation of membrane potential Decreases phenotype PMID:29297235
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:31258454
GO:0042412 Taurine biosynthetic process Increases phenotype PMID:24091382
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:23518225
GO:0042421 Norepinephrine biosynthetic process Decreases phenotype PMID:23392890; PMID:23392890; PMID:23518225
GO:0042425 Choline biosynthetic process Increases phenotype PMID:24091382
GO:0042427 Serotonin biosynthetic process Decreases phenotype PMID:23518225
GO:0042531 Positive regulation of tyrosine phosphorylation of stat protein Increases phenotype PMID:23106696
GO:0042554 Superoxide anion generation Increases phenotype PMID:25410152; PMID:28115242
GO:0042593 Glucose homeostasis Decreases phenotype PMID:25859628; PMID:30368975; PMID:30376134
GO:0042632 Cholesterol homeostasis Affects phenotype PMID:30368975; PMID:32929351
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:31258454
GO:0042866 Pyruvate biosynthetic process Decreases phenotype PMID:24091382
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:20143188; PMID:20723295; PMID:21971985; PMID:22614916; PMID:22664115; PMID:25436934; PMID:27736728; PMID:20143188; PMID:22330069; PMID:24571310; PMID:20615082; PMID:20723298; PMID:21327864; PMID:21649584; PMID:21703238; PMID:21788103; PMID:22391160; PMID:22406621; PMID:22684020; PMID:22693909; PMID:22719067; PMID:22753750; PMID:22944098; PMID:22949821; PMID:22959511; PMID:22988968; PMID:23239002; PMID:23271742; PMID:23373993; PMID:23382965; PMID:23469683; PMID:23497375; PMID:23548265; PMID:23563754; PMID:23688753; PMID:23721794; PMID:23725168; PMID:23851143; PMID:23861973; PMID:23877794; PMID:23883479; PMID:23949314; PMID:20723295; PMID:21327864; PMID:21518486; PMID:21649584; PMID:21703238; PMID:21788103; PMID:21792014; PMID:21867610; PMID:21867610; PMID:23911876; PMID:21971985; PMID:22362285; PMID:22406621; PMID:22614916; PMID:22664115; PMID:22753750; PMID:22801079; PMID:22801079; PMID:23542815; PMID:22922937; PMID:22922937; PMID:23700110; PMID:23980369; PMID:24129092; PMID:24993472; PMID:25144547; PMID:26110921; PMID:26160715; PMID:26592252; PMID:27189198; PMID:27430728; PMID:32587277; PMID:33070465; PMID:22949821; PMID:22977528; PMID:23041229; PMID:23201927; PMID:23293885; PMID:23363563; PMID:23440206; PMID:23469683; PMID:23542815; PMID:23688753; PMID:23700110; PMID:23892647; PMID:23980369; PMID:24004876; PMID:24126434; PMID:24129092; PMID:24307199; PMID:24345465; PMID:24466103; PMID:24571310; PMID:24641850; PMID:24685274; PMID:24738333; PMID:24934751; PMID:24956101; PMID:25144547; PMID:25341331; PMID:25499136; PMID:25416439; PMID:25436934; PMID:25499136; PMID:25574600; PMID:25787108; PMID:25815518; PMID:25913414; PMID:26110921; PMID:26160715; PMID:26592252; PMID:27430728; PMID:27736728; PMID:27794399; PMID:27812249; PMID:27840903; PMID:28391263; PMID:28501332; PMID:28587418; PMID:29095437; PMID:31274337; PMID:32017938; PMID:32587277; PMID:32642412; PMID:32929351; PMID:33120864; PMID:33562002; PMID:36229210; PMID:36509116; PMID:37230480; PMID:38275666; PMID:38382534; PMID:39223679
GO:0043117 Positive regulation of vascular permeability Increases phenotype PMID:31274337
GO:0043161 Proteasome-mediated ubiquitin-dependent protein catabolic process Increases phenotype PMID:24801902
GO:0043267 Negative regulation of potassium ion transport Increases phenotype PMID:21220927; PMID:23474023
GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:23832679
GO:0043406 Positive regulation of map kinase activity Increases phenotype PMID:23363563; PMID:23664956
GO:0043410 Positive regulation of mapk cascade Increases phenotype PMID:23253724; PMID:23363563; PMID:23664956
GO:0043507 Positive regulation of jun kinase activity Increases phenotype PMID:21327864
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:27174766
GO:0043616 Keratinocyte proliferation Increases phenotype PMID:31232011
GO:0043966 Histone h3 acetylation Affects phenotype PMID:25815518; PMID:27189198; PMID:29159556; PMID:30748021
GO:0043967 Histone h4 acetylation Decreases phenotype PMID:29159556
GO:0044029 Hypomethylation of cpg island Increases phenotype PMID:28565807
GO:0044237 Cellular metabolic process Increases phenotype PMID:22496356; PMID:23968587; PMID:29159499; PMID:34675983; PMID:30983542; PMID:30983542; PMID:34037972; PMID:35291620; PMID:36400307; PMID:31054354; PMID:31054354; PMID:31421153; PMID:31079498; PMID:31149761; PMID:31307525; PMID:31421153; PMID:31539632; PMID:31539632; PMID:32645343; PMID:34037972; PMID:36442592; PMID:31539632; PMID:32645343; PMID:35030298; PMID:31846860; PMID:32096187; PMID:32240679; PMID:32305283; PMID:32305283; PMID:34025784; PMID:32305283; PMID:39152142; PMID:32321992; PMID:32645343; PMID:32683294; PMID:32802093; PMID:33634982; PMID:34025784; PMID:34037972; PMID:35030298; PMID:34058077; PMID:34182011; PMID:34303041; PMID:34303041; PMID:34560123; PMID:34413873; PMID:36352148; PMID:34675983; PMID:34953944; PMID:34953944; PMID:35467087; PMID:38797699; PMID:35030298; PMID:35195477; PMID:35291620; PMID:35291620; PMID:38130211; PMID:35714947; PMID:36352148; PMID:36707890; PMID:36801614; PMID:37530740; PMID:37730986; PMID:38160894; PMID:39152142; PMID:39903385
GO:0044242 Cellular lipid catabolic process Affects phenotype PMID:26560635
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:29274334; PMID:29274334; PMID:35291620; PMID:38130211; PMID:29409467; PMID:31003765; PMID:35291620; PMID:36442592; PMID:38160894; PMID:38797699
GO:0044754 Autolysosome Increases phenotype PMID:30237538
GO:0045023 G0 to g1 transition Affects phenotype PMID:31307525; PMID:34025784; PMID:35487055; PMID:36352148
GO:0045329 Carnitine biosynthetic process Decreases phenotype PMID:24091382
GO:0045333 Cellular respiration Decreases phenotype PMID:21473291; PMID:31846860
GO:0045429 Positive regulation of nitric oxide biosynthetic process Affects phenotype PMID:23106696; PMID:27750169
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:25815309; PMID:30368975
GO:0045591 Positive regulation of regulatory t cell differentiation Decreases phenotype PMID:28454374
GO:0045597 Positive regulation of cell differentiation Increases phenotype PMID:20226526; PMID:20226526; PMID:22967415; PMID:23864846; PMID:20615082; PMID:22614916
GO:0045639 Positive regulation of myeloid cell differentiation Increases phenotype PMID:28454374
GO:0045668 Negative regulation of osteoblast differentiation Increases phenotype PMID:22465848
GO:0045669 Positive regulation of osteoblast differentiation Increases phenotype PMID:21257625
GO:0045732 Positive regulation of protein catabolic process Increases phenotype PMID:22406621; PMID:22898604; PMID:23271742; PMID:23949314
GO:0045741 Positive regulation of epidermal growth factor-activated receptor activity Increases phenotype PMID:23548265
GO:0045742 Positive regulation of epidermal growth factor receptor signaling pathway Increases phenotype PMID:21649584
GO:0045746 Negative regulation of notch signaling pathway Increases phenotype PMID:23497375; PMID:23542114; PMID:24685274
GO:0045766 Positive regulation of angiogenesis Decreases phenotype PMID:25196641
GO:0045822 Negative regulation of heart contraction Increases phenotype PMID:39059093
GO:0045860 Positive regulation of protein kinase activity Increases phenotype PMID:23469683
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:10850458; PMID:10850458; PMID:30012499; PMID:30316766; PMID:12429934; PMID:20143188; PMID:20723295; PMID:12429934; PMID:30012499; PMID:12864950; PMID:29159499; PMID:30145367; PMID:12962562; PMID:12962562; PMID:15228664; PMID:17697580; PMID:24377552; PMID:25110043; PMID:25758096; PMID:14703445; PMID:26772155; PMID:15774171; PMID:15904916; PMID:18726487; PMID:22496355; PMID:29059232; PMID:20143188; PMID:22496355; PMID:24392034; PMID:24801890; PMID:25574600; PMID:25758096; PMID:25791921; PMID:26708503; PMID:26772155; PMID:27794399; PMID:29059232; PMID:29274334; PMID:29274334; PMID:29898774; PMID:29574283; PMID:29944906; PMID:30012499; PMID:30145367; PMID:30316766; PMID:31274337; PMID:31734849; PMID:35276128
GO:0045931 Positive regulation of mitotic cell cycle Affects phenotype PMID:24685274; PMID:25728215; PMID:26671917
GO:0045944 Positive regulation of transcription by rna polymerase ii Increases phenotype PMID:23255470; PMID:23271742
GO:0046007 Negative regulation of activated t cell proliferation Increases phenotype PMID:23802174
GO:0046034 Atp metabolic process Affects phenotype PMID:38160894
GO:0046058 Camp metabolic process Affects phenotype PMID:24327821
GO:0046166 Glyceraldehyde-3-phosphate biosynthetic process Decreases phenotype PMID:24091382
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:31258454; PMID:37730986
GO:0046323 Glucose import Decreases phenotype PMID:30362509; PMID:31332900; PMID:35714947
GO:0046326 Positive regulation of glucose import Increases phenotype PMID:35226250
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:23664956; PMID:27829220; PMID:28391263
GO:0046337 Phosphatidylethanolamine metabolic process Affects phenotype PMID:31846860
GO:0046415 Urate metabolic process Decreases phenotype PMID:30368975; PMID:37689273
GO:0046427 Positive regulation of receptor signaling pathway via jak-stat Increases phenotype PMID:27174766
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:30368975; PMID:31612257; PMID:37689273
GO:0046459 Short-chain fatty acid metabolic process Affects phenotype PMID:36791901
GO:0046470 Phosphatidylcholine metabolic process Affects phenotype PMID:31846860
GO:0046474 Glycerophospholipid biosynthetic process Affects phenotype PMID:27044562
GO:0046500 S-adenosylmethionine metabolic process Affects phenotype PMID:31355259
GO:0046620 Regulation of organ growth Decreases phenotype PMID:17512576
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:32929351
GO:0046622 Positive regulation of organ growth Decreases phenotype PMID:25542264
GO:0046628 Positive regulation of insulin receptor signaling pathway Increases phenotype PMID:35226250
GO:0046685 Response to arsenic-containing substance Increases phenotype PMID:24091382; PMID:27561292; PMID:27713174; PMID:27717846; PMID:27736728; PMID:28494415; PMID:36399430
GO:0046827 Positive regulation of protein export from nucleus Increases phenotype PMID:33070465
GO:0046849 Bone remodeling Decreases phenotype PMID:22465848
GO:0046902 Regulation of mitochondrial membrane permeability Affects phenotype PMID:18022205
GO:0046916 Cellular transition metal ion homeostasis Affects phenotype PMID:26560635
GO:0048146 Positive regulation of fibroblast proliferation Increases phenotype PMID:35276128
GO:0048609 Multicellular organismal reproductive process Affects phenotype PMID:32781346
GO:0048874 Host-mediated regulation of intestinal microbiota composition Affects phenotype PMID:36473683
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:18022205; PMID:23082001; PMID:24762191
GO:0050709 Negative regulation of protein secretion Increases phenotype PMID:23253724
GO:0050714 Positive regulation of protein secretion Decreases phenotype PMID:22922937
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:27750169; PMID:29355690
GO:0050868 Negative regulation of t cell activation Decreases phenotype PMID:28454374
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:38266058
GO:0051092 Positive regulation of nf-kappab transcription factor activity Decreases phenotype PMID:25196641
GO:0051281 Positive regulation of release of sequestered calcium ion into cytosol Increases phenotype PMID:22959511
GO:0051452 Intracellular ph reduction Decreases phenotype PMID:11304686
GO:0051480 Regulation of cytosolic calcium ion concentration Affects phenotype PMID:25258189; PMID:26560635
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:17912452
GO:0051726 Regulation of cell cycle Increases phenotype PMID:21176356; PMID:22730174
GO:0051790 Short-chain fatty acid biosynthetic process Affects phenotype PMID:36473683
GO:0051881 Regulation of mitochondrial membrane potential Increases phenotype PMID:10477740; PMID:12931215; PMID:10850458; PMID:11304686; PMID:11739184; PMID:12148893; PMID:11776809; PMID:11779429; PMID:11779429; PMID:12851490; PMID:11783079; PMID:12063550; PMID:12063550; PMID:14729614; PMID:12148893; PMID:12513784; PMID:16818652; PMID:12851490; PMID:14632209; PMID:14729614; PMID:15761769; PMID:16818652; PMID:16864106; PMID:17203211; PMID:21473291; PMID:17237268; PMID:18281123; PMID:19771260; PMID:20408844; PMID:20471514; PMID:21418039; PMID:23082001; PMID:24801902; PMID:25174355; PMID:25335113; PMID:26772155; PMID:25258189; PMID:26772155; PMID:27461142; PMID:29549912; PMID:29751151; PMID:29867492; PMID:29944906; PMID:31205918; PMID:31332900; PMID:32305283; PMID:32781346; PMID:37072838; PMID:38684648
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:18022205; PMID:32112876; PMID:35195477
GO:0051897 Positive regulation of protein kinase b signaling Affects phenotype PMID:23041229; PMID:27189198; PMID:27794399
GO:0051898 Negative regulation of protein kinase b signaling Increases phenotype PMID:22391160; PMID:22730174; PMID:39223679
GO:0051924 Regulation of calcium ion transport Affects phenotype PMID:24327821
GO:0051928 Positive regulation of calcium ion transport Increases phenotype PMID:21220927
GO:0055074 Calcium ion homeostasis Decreases phenotype PMID:28494415; PMID:29751151
GO:0055075 Potassium ion homeostasis Decreases phenotype PMID:28494415
GO:0055078 Sodium ion homeostasis Decreases phenotype PMID:28494415
GO:0055082 Cellular chemical homeostasis Affects phenotype PMID:34675983
GO:0060326 Cell chemotaxis Decreases phenotype PMID:33634982; PMID:36400307; PMID:38160894; PMID:38797699
GO:0060545 Positive regulation of necroptotic process Increases phenotype PMID:36509116; PMID:37230480; PMID:38684648
GO:0060575 Intestinal epithelial cell differentiation Decreases phenotype PMID:29355690
GO:0060729 Intestinal epithelial structure maintenance Decreases phenotype PMID:29355690
GO:0061113 Pancreas morphogenesis Affects phenotype PMID:30660605
GO:0061519 Macrophage homeostasis Affects phenotype PMID:38237221
GO:0061577 Calcium ion transmembrane transport via high voltage-gated calcium channel Increases phenotype PMID:28521025
GO:0061580 Colon epithelial cell migration Decreases phenotype PMID:29355690
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:27318970; PMID:33070465
GO:0061909 Autophagosome-lysosome fusion Increases phenotype PMID:33462182
GO:0062000 Positive regulation of cardiac endothelial to mesenchymal transition Increases phenotype PMID:39059093
GO:0065003 Protein-containing complex assembly Increases phenotype PMID:27638049
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:22959511
GO:0070265 Necrotic cell death Increases phenotype PMID:31421153; PMID:31846860; PMID:32112876; PMID:33462182; PMID:33603344; PMID:35317438; PMID:37166470
GO:0070269 Pyroptosis Increases phenotype PMID:24337744; PMID:30237538; PMID:30660605
GO:0070317 Negative regulation of g0 to g1 transition Increases phenotype PMID:25416439
GO:0070328 Triglyceride homeostasis Affects phenotype PMID:30368975; PMID:32929351
GO:0070345 Negative regulation of fat cell proliferation Increases phenotype PMID:21257625
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:23041229; PMID:23664956; PMID:24934751; PMID:27794399; PMID:28391263
GO:0070496 Positive regulation of thrombin-activated receptor signaling pathway Decreases phenotype PMID:24466103
GO:0070534 Protein k63-linked ubiquitination Increases phenotype PMID:24801902
GO:0070633 Transepithelial transport Increases phenotype PMID:29355690; PMID:31274337
GO:0070665 Positive regulation of leukocyte proliferation Decreases phenotype PMID:28454374
GO:0070873 Regulation of glycogen metabolic process Affects phenotype PMID:25859628
GO:0070936 Protein k48-linked ubiquitination Increases phenotype PMID:24801902
GO:0070994 Detection of oxidative stress Affects phenotype PMID:33846815; PMID:35088608; PMID:35317438; PMID:33846815; PMID:35317438; PMID:34062077; PMID:35088608; PMID:35088608; PMID:35317438; PMID:35317438; PMID:36442592; PMID:36791901; PMID:37689273; PMID:38070468; PMID:38741475
GO:0070995 Nadph oxidation Increases phenotype PMID:27750169
GO:0071243 Cellular response to arsenic-containing substance Affects phenotype PMID:31355259
GO:0071268 Homocysteine biosynthetic process Decreases phenotype PMID:24091382
GO:0071481 Cellular response to x-ray Affects phenotype PMID:32321992
GO:0071493 Cellular response to uv-b Affects phenotype PMID:33562002
GO:0071722 Detoxification of arsenic-containing substance Decreases phenotype PMID:33549147
GO:0071897 Dna biosynthetic process Decreases phenotype PMID:31539632
GO:0072520 Seminiferous tubule development Affects phenotype PMID:32112876
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:12750708; PMID:18022205; PMID:24157283; PMID:31205918; PMID:31846860; PMID:32112876; PMID:32305283; PMID:32337366; PMID:32683294; PMID:32781346; PMID:32919218; PMID:32920515; PMID:33173984; PMID:33462182; PMID:33603344; PMID:33634982; PMID:33846815; PMID:34333357; PMID:35088608; PMID:35195477; PMID:35317438; PMID:36400307; PMID:37072838; PMID:37446117; PMID:37730986
GO:0072676 Lymphocyte migration Increases phenotype PMID:36791901
GO:0080009 Mrna methylation Increases phenotype PMID:35226250
GO:0086013 Membrane repolarization during cardiac muscle cell action potential Decreases phenotype PMID:23363563
GO:0090136 Epithelial cell-cell adhesion Decreases phenotype PMID:32683294
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:27638049
GO:0090240 Positive regulation of histone h4 acetylation Increases phenotype PMID:27189198
GO:0090263 Positive regulation of canonical wnt signaling pathway Decreases phenotype PMID:28565807
GO:0090303 Positive regulation of wound healing Increases phenotype PMID:23253724; PMID:38746032
GO:0090305 Nucleic acid phosphodiester bond hydrolysis Increases phenotype PMID:9864171
GO:0090314 Positive regulation of protein targeting to membrane Increases phenotype PMID:27638049
GO:0090324 Negative regulation of oxidative phosphorylation Increases phenotype PMID:29095437
GO:0090363 Regulation of proteasome core complex assembly Increases phenotype PMID:23028697
GO:0090398 Cellular senescence Increases phenotype PMID:31734849; PMID:36801614
GO:0090630 Activation of gtpase activity Increases phenotype PMID:22496355
GO:0097189 Apoptotic body Increases phenotype PMID:34953944
GO:0097212 Lysosomal membrane organization Decreases phenotype PMID:30385301
GO:0097327 Response to antineoplastic agent Increases phenotype PMID:24345465; PMID:27430728; PMID:33070465
GO:0097435 Supramolecular fiber organization Increases phenotype PMID:24762191
GO:0097468 Programmed cell death in response to reactive oxygen species Increases phenotype PMID:21327864
GO:0097479 Synaptic vesicle localization Decreases phenotype PMID:23392890
GO:0097707 Ferroptosis Increases phenotype PMID:35195477
GO:0097722 Sperm motility Decreases phenotype PMID:32112876; PMID:34062077
GO:0098609 Cell-cell adhesion Decreases phenotype PMID:38797699
GO:0098703 Calcium ion import across plasma membrane Decreases phenotype PMID:17963750
GO:0098900 Regulation of action potential Affects phenotype PMID:28768059
GO:0098911 Regulation of ventricular cardiac muscle cell action potential Increases phenotype PMID:28521025
GO:0140042 Lipid droplet formation Increases phenotype PMID:30237538; PMID:30362509; PMID:33462182
GO:0140896 Cgas/sting signaling pathway Increases phenotype PMID:38684648
GO:0150032 Positive regulation of protein localization to lysosome Increases phenotype PMID:32284743
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:36509116; PMID:38266058; PMID:38684648
GO:1900087 Positive regulation of g1/s transition of mitotic cell cycle Affects phenotype PMID:26110921; PMID:29355690
GO:1900103 Positive regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:22922937
GO:1900111 Positive regulation of histone h3-k9 dimethylation Decreases phenotype PMID:25815518
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:22988968; PMID:35226250
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:35226250
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:25003661
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:21327864; PMID:23664956; PMID:27174766; PMID:27829220; PMID:28391263
GO:1901224 Positive regulation of nik/nf-kappab signaling Affects phenotype PMID:27664319
GO:1901388 Regulation of transforming growth factor beta activation Increases phenotype PMID:21649584
GO:1901491 Negative regulation of lymphangiogenesis Increases phenotype PMID:38275666
GO:1901522 Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Increases phenotype PMID:24934751
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:27318970; PMID:38684648
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:24004876; PMID:25144547; PMID:25542264; PMID:26184899; PMID:26560635; PMID:27561292; PMID:27592447; PMID:27713174; PMID:28391263
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:25542264; PMID:28494415
GO:1901731 Positive regulation of platelet aggregation Affects phenotype PMID:24466103
GO:1901800 Positive regulation of proteasomal protein catabolic process Increases phenotype PMID:23208507
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Decreases phenotype PMID:28494415
GO:1901989 Positive regulation of cell cycle phase transition Increases phenotype PMID:38746032
GO:1902107 Positive regulation of leukocyte differentiation Increases phenotype PMID:23208507
GO:1902110 Positive regulation of mitochondrial membrane permeability involved in apoptotic process Increases phenotype PMID:23041229
GO:1902255 Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Increases phenotype PMID:27638049
GO:1902260 Negative regulation of delayed rectifier potassium channel activity Increases phenotype PMID:23103450
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:24634002; PMID:25542264; PMID:27592447
GO:1902531 Regulation of intracellular signal transduction Increases phenotype PMID:23542815; PMID:23911876
GO:1902532 Negative regulation of intracellular signal transduction Increases phenotype PMID:23832679
GO:1902533 Positive regulation of intracellular signal transduction Increases phenotype PMID:23469683; PMID:23542815
GO:1902552 Negative regulation of catalase activity Affects phenotype PMID:24095718
GO:1902618 Cellular response to fluoride Decreases phenotype PMID:27750169
GO:1902957 Negative regulation of mitochondrial electron transport, nadh to ubiquinone Affects phenotype PMID:29095437
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:31597699; PMID:34025784; PMID:34413873; PMID:34413873; PMID:36352148; PMID:35487055; PMID:36352148; PMID:36442592
GO:1903078 Positive regulation of protein localization to plasma membrane Increases phenotype PMID:24956101; PMID:31274337
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:25542264; PMID:26560635; PMID:28494415; PMID:27561292; PMID:27713174; PMID:28391263; PMID:28494415
GO:1903405 Protein localization to nuclear body Increases phenotype PMID:20943951
GO:1903408 Positive regulation of p-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:28494415
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:24273890; PMID:24801890; PMID:25256833; PMID:25972196; PMID:26118777; PMID:27461142; PMID:27608960; PMID:28803342; PMID:28978146; PMID:29274334; PMID:29274627; PMID:29297235; PMID:29307831; PMID:29467594; PMID:29610575; PMID:29662624; PMID:29751151; PMID:29774349; PMID:29867492; PMID:30012499; PMID:30316766; PMID:30317545; PMID:30385301; PMID:30551535; PMID:31054354; PMID:31332900
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:24004876; PMID:25144547; PMID:25144547; PMID:26110921; PMID:25246272; PMID:25341331; PMID:25574600; PMID:25728215; PMID:25815309; PMID:26628001; PMID:27592447; PMID:27638049; PMID:27713174; PMID:27750169; PMID:28391263; PMID:29095437; PMID:31401084; PMID:32642412; PMID:36100036; PMID:37230480; PMID:38266058; PMID:38684648
GO:1903514 Release of sequestered calcium ion into cytosol by endoplasmic reticulum Increases phenotype PMID:27461142
GO:1903578 Regulation of atp metabolic process Increases phenotype PMID:24126434
GO:1903899 Positive regulation of perk-mediated unfolded protein response Increases phenotype PMID:27638049
GO:1903955 Positive regulation of protein targeting to mitochondrion Increases phenotype PMID:27318970; PMID:27638049
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:27174766
GO:1904762 Positive regulation of myofibroblast differentiation Increases phenotype PMID:35276128
GO:1905037 Autophagosome organization Increases phenotype PMID:25110043; PMID:30032600; PMID:30237564
GO:1905102 Positive regulation of apoptosome assembly Increases phenotype PMID:24634002
GO:1905691 Lipid droplet disassembly Increases phenotype PMID:30677399
GO:1990266 Neutrophil migration Increases phenotype PMID:36791901
GO:1990787 Negative regulation of hh target transcription factor activity Increases phenotype PMID:24685274
GO:1990789 Thyroid gland epithelial cell proliferation Affects phenotype PMID:31258454
GO:1990814 Dna/dna annealing activity Decreases phenotype PMID:37530740
GO:2000134 Negative regulation of g1/s transition of mitotic cell cycle Increases phenotype PMID:38275666
GO:2000377 Regulation of reactive oxygen species metabolic process Affects phenotype PMID:24327821
GO:2000480 Negative regulation of camp-dependent protein kinase activity Increases phenotype PMID:23041229
GO:2000481 Positive regulation of camp-dependent protein kinase activity Increases phenotype PMID:23041229
GO:2000491 Positive regulation of hepatic stellate cell activation Increases phenotype PMID:30677399
GO:2000563 Positive regulation of cd4-positive, alpha-beta t cell proliferation Increases phenotype PMID:32642412
GO:2000615 Regulation of histone h3-k9 acetylation Affects phenotype PMID:25574600
GO:2000616 Negative regulation of histone h3-k9 acetylation Increases phenotype PMID:25574600
GO:2000617 Positive regulation of histone h3-k9 acetylation Increases phenotype PMID:25574600
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:21257625
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:25144547; PMID:32284743; PMID:36100036
GO:2001056 Positive regulation of cysteine-type endopeptidase activity Increases phenotype PMID:31274337
GO:2001235 Positive regulation of apoptotic signaling pathway Increases phenotype PMID:21518486; PMID:23737871; PMID:24061648
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.