Tetrachlorodibenzodioxin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000278 Mitotic cell cycle Decreases phenotype PMID:11479202
GO:0000723 Telomere maintenance Affects phenotype PMID:33022284
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:27697457
GO:0001523 Retinoid metabolic process Affects phenotype PMID:33607186
GO:0001541 Ovarian follicle development Affects phenotype PMID:31063829; PMID:32234510
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:36370075
GO:0001825 Blastocyst formation Decreases phenotype PMID:36029422
GO:0001837 Epithelial to mesenchymal transition Affects phenotype PMID:26971374
GO:0001890 Placenta development Decreases phenotype PMID:24475139
GO:0001944 Vasculature development Decreases phenotype PMID:24475139
GO:0002248 Connective tissue replacement involved in inflammatory response wound healing Increases phenotype PMID:27613713
GO:0002250 Adaptive immune response Affects phenotype PMID:24194396
GO:0002283 Neutrophil activation involved in immune response Increases phenotype PMID:24194396
GO:0002286 T cell activation involved in immune response Affects phenotype PMID:24194396; PMID:27783946
GO:0002326 B cell lineage commitment Decreases phenotype PMID:28049042
GO:0002360 T cell lineage commitment Decreases phenotype PMID:27590929
GO:0002377 Immunoglobulin production Decreases phenotype PMID:27473338
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Affects phenotype PMID:24051191; PMID:24713691; PMID:29860352
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:26278112; PMID:26862745; PMID:28302560
GO:0002532 Production of molecular mediator involved in inflammatory response Increases phenotype PMID:24154488
GO:0002534 Cytokine production involved in inflammatory response Increases phenotype PMID:27613713
GO:0002638 Negative regulation of immunoglobulin production Increases phenotype PMID:29462421
GO:0002639 Positive regulation of immunoglobulin production Increases phenotype PMID:22491429; PMID:27535091; PMID:27590929
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:27713108; PMID:28213091
GO:0002763 Positive regulation of myeloid leukocyte differentiation Decreases phenotype PMID:27590929
GO:0002924 Negative regulation of humoral immune response mediated by circulating immunoglobulin Increases phenotype PMID:29462421
GO:0003014 Renal system process Affects phenotype PMID:30790002
GO:0003993 Acid phosphatase activity Increases phenotype PMID:32031418
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:28011154; PMID:30203000; PMID:31887333; PMID:32031418
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:32031418
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:32031418
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:32031418
GO:0006006 Glucose metabolic process Increases phenotype PMID:31520823; PMID:37115651
GO:0006123 Mitochondrial electron transport, cytochrome c to oxygen Decreases phenotype PMID:30165701
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:33677009
GO:0006306 Dna methylation Affects phenotype PMID:21212295; PMID:33449811
GO:0006308 Dna catabolic process Increases phenotype PMID:17669606
GO:0006309 Apoptotic dna fragmentation Affects phenotype PMID:16213648; PMID:19520675; PMID:19520675; PMID:8640813; PMID:21534955; PMID:2543382; PMID:9070360; PMID:9677421
GO:0006349 Regulation of gene expression by genomic imprinting Affects phenotype PMID:26455773
GO:0006355 Regulation of dna-templated transcription Increases phenotype PMID:25975270; PMID:25975270; PMID:29873790; PMID:29873790
GO:0006520 Amino acid metabolic process Affects phenotype PMID:38013089
GO:0006606 Protein import into nucleus Increases phenotype PMID:21652769
GO:0006690 Icosanoid metabolic process Increases phenotype PMID:32387183
GO:0006691 Leukotriene metabolic process Increases phenotype PMID:32387183
GO:0006692 Prostanoid metabolic process Increases phenotype PMID:32387183
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:26278112; PMID:28238261
GO:0006703 Estrogen biosynthetic process Decreases phenotype PMID:30172648
GO:0006725 Cellular aromatic compound metabolic process Increases phenotype PMID:15087167
GO:0006741 Nadp biosynthetic process Increases phenotype PMID:26582802
GO:0006782 Protoporphyrinogen ix biosynthetic process Increases phenotype PMID:28213091
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29162470
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:24469321; PMID:27697457
GO:0006915 Apoptotic process Affects phenotype PMID:10527913; PMID:14718643; PMID:18958664; PMID:20715097; PMID:30499018; PMID:9070360; PMID:10783307; PMID:11309286; PMID:12668121; PMID:16213648; PMID:11309286; PMID:12373453; PMID:18334599; PMID:9772099; PMID:12668121; PMID:12878042; PMID:14728976; PMID:15093247; PMID:19520675; PMID:15664267; PMID:16125745; PMID:16213648; PMID:17823287; PMID:18172213; PMID:18334599; PMID:19167453; PMID:19520675; PMID:20715097; PMID:21534955; PMID:24932542; PMID:24954032; PMID:29885354; PMID:30172648; PMID:31776611; PMID:32234510; PMID:40024514; PMID:8640813; PMID:9677421; PMID:9751521
GO:0006979 Response to oxidative stress Increases phenotype PMID:10771135; PMID:10771135; PMID:11521753; PMID:11979421; PMID:2251677; PMID:10774821; PMID:10774821; PMID:20634294; PMID:11781075; PMID:11836019; PMID:11914781; PMID:12734642; PMID:12355564; PMID:12734642; PMID:15213807; PMID:16226770; PMID:17669606; PMID:18467041; PMID:20634294; PMID:21534955; PMID:8983165; PMID:9538044
GO:0007049 Cell cycle Decreases phenotype PMID:11000096; PMID:15157999; PMID:16636136; PMID:23196670; PMID:9712901
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:28836330
GO:0007281 Germ cell development Decreases phenotype PMID:30172648
GO:0007283 Spermatogenesis Decreases phenotype PMID:12355564; PMID:27713107; PMID:32031418
GO:0007530 Sex determination Affects phenotype PMID:32335222
GO:0007565 Female pregnancy Affects phenotype PMID:37854252
GO:0007566 Embryo implantation Decreases phenotype PMID:32031418
GO:0007612 Learning Affects phenotype PMID:33956508
GO:0007625 Grooming behavior Decreases phenotype PMID:38838945
GO:0008203 Cholesterol metabolic process Increases phenotype PMID:23756648; PMID:28238261
GO:0008206 Bile acid metabolic process Increases phenotype PMID:28487374
GO:0008210 Estrogen metabolic process Affects phenotype PMID:32986415
GO:0008217 Regulation of blood pressure Increases phenotype PMID:18670907; PMID:20634294
GO:0008219 Cell death Affects phenotype PMID:12373453; PMID:16226770; PMID:17669606; PMID:18996433; PMID:26275813; PMID:2734791; PMID:2763295; PMID:8658555
GO:0008283 Cell population proliferation Affects phenotype PMID:10411295; PMID:15157999; PMID:15465647; PMID:2278856; PMID:8384872; PMID:16636136; PMID:17978469; PMID:20623010; PMID:2278856; PMID:24231000; PMID:24932542; PMID:25194622; PMID:26275813; PMID:26860701; PMID:26971374; PMID:27117977; PMID:27312872; PMID:29935225; PMID:7588483; PMID:7826659
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:25843524; PMID:27590929; PMID:31536130
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:24013123; PMID:28836330; PMID:29626627; PMID:39401686
GO:0008360 Regulation of cell shape Decreases phenotype PMID:26454884
GO:0008584 Male gonad development Affects phenotype PMID:32031418
GO:0008585 Female gonad development Affects phenotype PMID:32234510
GO:0008610 Lipid biosynthetic process Decreases phenotype PMID:27544633; PMID:28011154
GO:0009744 Response to sucrose Decreases phenotype PMID:38838945
GO:0009749 Response to glucose Decreases phenotype PMID:29175711
GO:0010468 Regulation of gene expression Affects phenotype PMID:33017471
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:39401686
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:28836330
GO:0010693 Negative regulation of alkaline phosphatase activity Increases phenotype PMID:30203000
GO:0010714 Positive regulation of collagen metabolic process Increases phenotype PMID:29673856
GO:0010759 Positive regulation of macrophage chemotaxis Increases phenotype PMID:28213091
GO:0010877 Lipid transport involved in lipid storage Decreases phenotype PMID:32044341
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:27713108
GO:0010891 Negative regulation of sequestering of triglyceride Increases phenotype PMID:32044341
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28836330
GO:0010942 Positive regulation of cell death Increases phenotype PMID:25686467; PMID:27392949
GO:0016049 Cell growth Decreases phenotype PMID:29140133
GO:0016477 Cell migration Affects phenotype PMID:26275813; PMID:27697457
GO:0019217 Regulation of fatty acid metabolic process Increases phenotype PMID:28487374
GO:0019369 Arachidonic acid metabolic process Increases phenotype PMID:32387183
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:23756648; PMID:26278112; PMID:26862745; PMID:26862745; PMID:28238261; PMID:28433925; PMID:28774668; PMID:30722647
GO:0019722 Calcium-mediated signaling Increases phenotype PMID:18172213; PMID:18996433; PMID:19167453; PMID:7826659
GO:0022604 Regulation of cell morphogenesis Decreases phenotype PMID:26454884
GO:0023019 Signal transduction involved in regulation of gene expression Affects phenotype PMID:23419638
GO:0030041 Actin filament polymerization Increases phenotype PMID:27697457
GO:0030154 Cell differentiation Increases phenotype PMID:12883080; PMID:18483191; PMID:18670907; PMID:19490989; PMID:20715097; PMID:21296099; PMID:2734791; PMID:2763295; PMID:2998748; PMID:7588483
GO:0030183 B cell differentiation Decreases phenotype PMID:24709672
GO:0030217 T cell differentiation Decreases phenotype PMID:24709672; PMID:25051576; PMID:26495820
GO:0030225 Macrophage differentiation Increases phenotype PMID:32796029
GO:0030282 Bone mineralization Decreases phenotype PMID:31887333
GO:0030334 Regulation of cell migration Decreases phenotype PMID:26454884
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:33027880
GO:0030501 Positive regulation of bone mineralization Increases phenotype PMID:29673856
GO:0030595 Leukocyte chemotaxis Increases phenotype PMID:19571490
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:29908305
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:32044341
GO:0031424 Keratinization Increases phenotype PMID:24576722
GO:0032310 Prostaglandin secretion Increases phenotype PMID:30790002
GO:0032733 Positive regulation of interleukin-10 production Affects phenotype PMID:22491429
GO:0032736 Positive regulation of interleukin-13 production Affects phenotype PMID:22491429
GO:0032740 Positive regulation of interleukin-17 production Increases phenotype PMID:22491429; PMID:29040756
GO:0032754 Positive regulation of interleukin-5 production Affects phenotype PMID:22491429
GO:0032782 Bile acid secretion Affects phenotype PMID:29452137
GO:0032829 Regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation Affects phenotype PMID:29040756
GO:0032831 Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation Increases phenotype PMID:24586378
GO:0032966 Negative regulation of collagen biosynthetic process Increases phenotype PMID:28836330
GO:0033077 T cell differentiation in thymus Affects phenotype PMID:16545771; PMID:30499018
GO:0033559 Unsaturated fatty acid metabolic process Increases phenotype PMID:32387183
GO:0034753 Nuclear aryl hydrocarbon receptor complex Increases phenotype PMID:25265996; PMID:31225620
GO:0035264 Multicellular organism growth Decreases phenotype PMID:28487374
GO:0035265 Organ growth Decreases phenotype PMID:25500125
GO:0035332 Positive regulation of hippo signaling Increases phenotype PMID:25843524
GO:0035938 Estradiol secretion Decreases phenotype PMID:31063829
GO:0036037 Cd8-positive, alpha-beta t cell activation Decreases phenotype PMID:36847456
GO:0036145 Dendritic cell homeostasis Affects phenotype PMID:26377647
GO:0036269 Swimming behavior Decreases phenotype PMID:38838945
GO:0036343 Psychomotor behavior Affects phenotype PMID:33956508
GO:0036378 Calcitriol biosynthetic process from calciol Increases phenotype PMID:29673856
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:32387183
GO:0042110 T cell activation Affects phenotype PMID:25051576; PMID:33449811
GO:0042167 Heme catabolic process Increases phenotype PMID:28213091
GO:0042310 Vasoconstriction Increases phenotype PMID:27492226
GO:0042311 Vasodilation Increases phenotype PMID:20634294
GO:0042531 Positive regulation of tyrosine phosphorylation of stat protein Affects phenotype PMID:23639249
GO:0042541 Hemoglobin biosynthetic process Increases phenotype PMID:23369756
GO:0042593 Glucose homeostasis Decreases phenotype PMID:28213091
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25843524; PMID:28213091; PMID:28836330; PMID:31536130; PMID:32283119
GO:0043149 Stress fiber assembly Increases phenotype PMID:27697457
GO:0043456 Regulation of pentose-phosphate shunt Increases phenotype PMID:26582802
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:36782369
GO:0044027 Hypermethylation of cpg island Increases phenotype PMID:24136580; PMID:33849548
GO:0044028 Dna hypomethylation Increases phenotype PMID:28011154
GO:0044029 Hypomethylation of cpg island Increases phenotype PMID:33849548
GO:0044030 Regulation of dna methylation Affects phenotype PMID:29550351; PMID:33017471
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31887333; PMID:32031418; PMID:33387578; PMID:39880321; PMID:40024514
GO:0044849 Estrous cycle Affects phenotype PMID:30172648; PMID:31063829
GO:0045087 Innate immune response Affects phenotype PMID:24194396
GO:0045333 Cellular respiration Decreases phenotype PMID:11781075; PMID:27105554
GO:0045444 Fat cell differentiation Affects phenotype PMID:30203000
GO:0045578 Negative regulation of b cell differentiation Increases phenotype PMID:25543051
GO:0045579 Positive regulation of b cell differentiation Decreases phenotype PMID:28049042
GO:0045597 Positive regulation of cell differentiation Affects phenotype PMID:23639249
GO:0045599 Negative regulation of fat cell differentiation Increases phenotype PMID:29673856
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:32044341
GO:0045668 Negative regulation of osteoblast differentiation Increases phenotype PMID:30203000
GO:0045669 Positive regulation of osteoblast differentiation Affects phenotype PMID:25795401; PMID:29673856
GO:0045793 Positive regulation of cell size Increases phenotype PMID:19969063
GO:0045814 Negative regulation of gene expression, epigenetic Increases phenotype PMID:26455773
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:24013123
GO:0046325 Negative regulation of glucose import Increases phenotype PMID:32044341
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:10771135; PMID:10771135; PMID:3359422; PMID:3378510; PMID:6838590; PMID:10774821; PMID:11836019; PMID:11914781; PMID:12734642; PMID:12355564; PMID:12734642; PMID:15213807; PMID:18996433; PMID:2251677; PMID:2251677; PMID:2362077; PMID:2554534; PMID:2251677; PMID:3114917; PMID:6661579; PMID:2362077; PMID:28836330; PMID:3020934; PMID:3114917; PMID:3378510; PMID:6506766; PMID:6661579; PMID:8296318; PMID:8983165; PMID:9538044
GO:0046513 Ceramide biosynthetic process Increases phenotype PMID:28238261; PMID:34627992
GO:0046620 Regulation of organ growth Affects phenotype PMID:11836019; PMID:12355564; PMID:11836019; PMID:12355564; PMID:1462355; PMID:12355564; PMID:16125745; PMID:6661579
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:32387183
GO:0046622 Positive regulation of organ growth Affects phenotype PMID:28487374; PMID:29452137; PMID:32387183
GO:0046627 Negative regulation of insulin receptor signaling pathway Increases phenotype PMID:32044341
GO:0046649 Lymphocyte activation Increases phenotype PMID:21212295
GO:0046944 Protein carbamoylation Decreases phenotype PMID:38013089
GO:0048023 Positive regulation of melanin biosynthetic process Increases phenotype PMID:28029781
GO:0048302 Regulation of isotype switching to igg isotypes Affects phenotype PMID:38526216
GO:0048539 Bone marrow development Decreases phenotype PMID:29673856
GO:0048666 Neuron development Decreases phenotype PMID:36782369
GO:0048733 Sebaceous gland development Decreases phenotype PMID:28973660; PMID:31225620
GO:0048771 Tissue remodeling Increases phenotype PMID:24576722
GO:0048873 Homeostasis of number of cells within a tissue Affects phenotype PMID:16545771
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:34129049
GO:0050869 Negative regulation of b cell activation Affects phenotype PMID:25543051
GO:0050871 Positive regulation of b cell activation Decreases phenotype PMID:27546522
GO:0051353 Positive regulation of oxidoreductase activity Increases phenotype PMID:33811995
GO:0051607 Defense response to virus Decreases phenotype PMID:36847456
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:18172213; PMID:18334599
GO:0055008 Cardiac muscle tissue morphogenesis Decreases phenotype PMID:26139165
GO:0055072 Iron ion homeostasis Decreases phenotype PMID:28213091
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:26988466
GO:0060021 Roof of mouth development Affects phenotype PMID:32633565; PMID:40024514
GO:0060179 Male mating behavior Affects phenotype PMID:32031418
GO:0060242 Contact inhibition Affects phenotype PMID:23196670
GO:0060244 Negative regulation of cell proliferation involved in contact inhibition Decreases phenotype PMID:25843524
GO:0060261 Positive regulation of transcription initiation by rna polymerase ii Affects phenotype PMID:23419638
GO:0060444 Branching involved in mammary gland duct morphogenesis Increases phenotype PMID:23212921
GO:0060513 Prostatic bud formation Affects phenotype PMID:19805408; PMID:24928892; PMID:29935225
GO:0060613 Fat pad development Affects phenotype PMID:28774668
GO:0060763 Mammary duct terminal end bud growth Affects phenotype PMID:24136580
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:17107848; PMID:32031418
GO:0061450 Trophoblast cell migration Increases phenotype PMID:34747641
GO:0061519 Macrophage homeostasis Affects phenotype PMID:26377647
GO:0062009 Secondary palate development Decreases phenotype PMID:39401686
GO:0065004 Protein-dna complex assembly Increases phenotype PMID:25082669
GO:0070168 Negative regulation of biomineral tissue development Increases phenotype PMID:28836330
GO:0070265 Necrotic cell death Increases phenotype PMID:28302560
GO:0070341 Fat cell proliferation Increases phenotype PMID:25909471
GO:0070455 Positive regulation of heme biosynthetic process Increases phenotype PMID:28213091
GO:0070527 Platelet aggregation Increases phenotype PMID:25797602
GO:0070874 Negative regulation of glycogen metabolic process Increases phenotype PMID:27562557
GO:0070994 Detection of oxidative stress Increases phenotype PMID:32031418
GO:0071736 Igg immunoglobulin complex, circulating Increases phenotype PMID:38526216
GO:0071902 Positive regulation of protein serine/threonine kinase activity Increases phenotype PMID:28070105
GO:0072201 Negative regulation of mesenchymal cell proliferation Increases phenotype PMID:32283119; PMID:33812962
GO:0072582 17-beta-hydroxysteroid dehydrogenase (nadp+) activity Decreases phenotype PMID:32031418
GO:0086004 Regulation of cardiac muscle cell contraction Decreases phenotype PMID:24058054; PMID:26572662
GO:0097237 Cellular response to toxic substance Affects phenotype PMID:24355419
GO:0097251 Leukotriene b4 biosynthetic process Increases phenotype PMID:27697457; PMID:28487374
GO:0097272 Ammonium homeostasis Affects phenotype PMID:38013089
GO:0097722 Sperm motility Decreases phenotype PMID:27713107; PMID:32031418
GO:0098582 Innate vocalization behavior Affects phenotype PMID:29445839
GO:0098586 Cellular response to virus Increases phenotype PMID:33449811
GO:0098801 Regulation of renal system process Affects phenotype PMID:26865671
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:32031418
GO:0120055 Small intestinal transit Decreases phenotype PMID:36782369
GO:0140042 Lipid droplet formation Increases phenotype PMID:36534932
GO:0140059 Dendrite arborization Increases phenotype PMID:33956508
GO:1901522 Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Increases phenotype PMID:26022396
GO:1903012 Positive regulation of bone development Increases phenotype PMID:29673856
GO:1903047 Mitotic cell cycle process Increases phenotype PMID:27312872
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:26495820
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28836330; PMID:36534932
GO:1903488 Negative regulation of lactation Increases phenotype PMID:25265996
GO:1904178 Negative regulation of adipose tissue development Increases phenotype PMID:29673856
GO:1904251 Regulation of bile acid metabolic process Decreases phenotype PMID:29452137
GO:1904613 Cellular response to 2,3,7,8-tetrachlorodibenzodioxine Increases phenotype PMID:25975270
GO:1904674 Positive regulation of somatic stem cell population maintenance Decreases phenotype PMID:28049042
GO:2000077 Negative regulation of type b pancreatic cell development Increases phenotype PMID:37115651
GO:2000082 Regulation of l-ascorbic acid biosynthetic process Increases phenotype PMID:27562557
GO:2000216 Positive regulation of proline metabolic process Increases phenotype PMID:27562557
GO:2000253 Positive regulation of feeding behavior Increases phenotype PMID:32784060
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:28487374
GO:2000491 Positive regulation of hepatic stellate cell activation Increases phenotype PMID:27693115
GO:2000726 Negative regulation of cardiac muscle cell differentiation Increases phenotype PMID:24058054
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:28070105
GO:2001205 Negative regulation of osteoclast development Increases phenotype PMID:29673856
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.