Mono-(2-ethylhexyl)phthalate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Affects phenotype PMID:36087924
GO:0001510 Rna methylation Affects phenotype PMID:31875672
GO:0001545 Primary ovarian follicle growth Increases phenotype PMID:25810477
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:23077170; PMID:31884101
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:38685446
GO:0001556 Oocyte maturation Decreases phenotype PMID:26545148
GO:0001649 Osteoblast differentiation Increases phenotype PMID:28921615
GO:0001678 Cellular glucose homeostasis Decreases phenotype PMID:36438553
GO:0001825 Blastocyst formation Decreases phenotype PMID:28042535; PMID:36535558
GO:0001835 Blastocyst hatching Decreases phenotype PMID:36535558
GO:0001964 Startle response Increases phenotype PMID:37886449
GO:0002191 Cap-dependent translational initiation Affects phenotype PMID:27992464
GO:0003016 Respiratory system process Decreases phenotype PMID:27852937
GO:0004035 Alkaline phosphatase activity Affects phenotype PMID:28921615
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23077170; PMID:24706461
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:24706461; PMID:24836450; PMID:28988496; PMID:29259978
GO:0006006 Glucose metabolic process Affects phenotype PMID:22953781
GO:0006071 Glycerol metabolic process Affects phenotype PMID:32522588
GO:0006089 Lactate metabolic process Affects phenotype PMID:22017230; PMID:32522588
GO:0006096 Glycolytic process Increases phenotype PMID:32522588
GO:0006304 Dna modification Increases phenotype PMID:38563870
GO:0006351 Dna-templated transcription Affects phenotype PMID:22321834
GO:0006520 Amino acid metabolic process Affects phenotype PMID:22017230
GO:0006580 Ethanolamine metabolic process Affects phenotype PMID:22017230
GO:0006600 Creatine metabolic process Affects phenotype PMID:22017230
GO:0006606 Protein import into nucleus Affects phenotype PMID:26751383
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:22017230
GO:0006635 Fatty acid beta-oxidation Affects phenotype PMID:32522588
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:22017230; PMID:22953781; PMID:32916427
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:22017230
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:34942354
GO:0006739 Nadp metabolic process Affects phenotype PMID:22017230
GO:0006749 Glutathione metabolic process Affects phenotype PMID:24836450; PMID:28988496; PMID:29259978; PMID:38048874; PMID:39360521
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:24706461; PMID:25677926
GO:0006882 Cellular zinc ion homeostasis Decreases phenotype PMID:35841924
GO:0006909 Phagocytosis Decreases phenotype PMID:30398665
GO:0006915 Apoptotic process Affects phenotype PMID:12490136; PMID:20453712; PMID:24412242; PMID:24706461; PMID:24836450; PMID:26597031; PMID:28042535; PMID:29259978; PMID:30810372; PMID:36087924; PMID:39307383
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:30476341
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:28988496
GO:0007005 Mitochondrion organization Decreases phenotype PMID:36087924; PMID:39307383
GO:0007010 Cytoskeleton organization Affects phenotype PMID:36087924
GO:0007033 Vacuole organization Affects phenotype PMID:36087924
GO:0007137 Meiotic metaphase ii Affects phenotype PMID:28042535
GO:0007155 Cell adhesion Affects phenotype PMID:22321834
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:36005737
GO:0007568 Aging Increases phenotype PMID:36174712
GO:0007612 Learning Affects phenotype PMID:24978879
GO:0008152 Metabolic process Affects phenotype PMID:38065500
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:22953781
GO:0008217 Regulation of blood pressure Affects phenotype PMID:32916427
GO:0008219 Cell death Increases phenotype PMID:26985823; PMID:34863575
GO:0008283 Cell population proliferation Affects phenotype PMID:22205965; PMID:24412242; PMID:24706461; PMID:26597031; PMID:29259978; PMID:30858031; PMID:38563870
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:31351048; PMID:33159713; PMID:36314267
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:31228551; PMID:31771930; PMID:37364752
GO:0008611 Ether lipid biosynthetic process Affects phenotype PMID:30810372
GO:0009060 Aerobic respiration Increases phenotype PMID:32522588
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:33872906
GO:0010470 Regulation of gastrulation Affects phenotype PMID:28184906
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:38522500
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:34380243
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:31004931; PMID:33091777
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:25777084
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:33029813; PMID:33161305; PMID:36005737
GO:0010918 Positive regulation of mitochondrial membrane potential Increases phenotype PMID:37979351
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26710974; PMID:33161305
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:34380243
GO:0016042 Lipid catabolic process Increases phenotype PMID:25543134; PMID:28988496; PMID:32522588
GO:0016049 Cell growth Decreases phenotype PMID:29663635; PMID:30810372
GO:0016209 Antioxidant activity Decreases phenotype PMID:32566080; PMID:34141174
GO:0016477 Cell migration Increases phenotype PMID:28390675; PMID:33631300; PMID:34910997
GO:0018963 Phthalate metabolic process Increases phenotype PMID:30078309; PMID:35354077
GO:0019216 Regulation of lipid metabolic process Affects phenotype PMID:38050670
GO:0019249 Lactate biosynthetic process Increases phenotype PMID:25543134
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:27384973
GO:0020027 Hemoglobin metabolic process Affects phenotype PMID:32916427
GO:0030154 Cell differentiation Decreases phenotype PMID:30810372
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:22321834; PMID:33027880; PMID:34380243; PMID:35861251
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35861251
GO:0031589 Cell-substrate adhesion Decreases phenotype PMID:38563870
GO:0031941 Filamentous actin Affects phenotype PMID:36087924
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:31228551
GO:0032205 Negative regulation of telomere maintenance Increases phenotype PMID:36174712
GO:0032310 Prostaglandin secretion Affects phenotype PMID:34942354
GO:0032487 Regulation of rap protein signal transduction Increases phenotype PMID:38522500
GO:0032776 Dna methylation on cytosine Decreases phenotype PMID:29081338
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:25677926
GO:0033212 Iron import into cell Increases phenotype PMID:36696656; PMID:38050670
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:31015488
GO:0034440 Lipid oxidation Increases phenotype PMID:24836450; PMID:29259978; PMID:39360521
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:38503103
GO:0034729 Histone h3-k79 methylation Increases phenotype PMID:37545493; PMID:37611859
GO:0035929 Steroid hormone secretion Affects phenotype PMID:31884101
GO:0035936 Testosterone secretion Increases phenotype PMID:24393508; PMID:24945889; PMID:31884101
GO:0035938 Estradiol secretion Increases phenotype PMID:31884101
GO:0035941 Androstenedione secretion Increases phenotype PMID:31884101
GO:0035942 Dehydroepiandrosterone secretion Increases phenotype PMID:31884101
GO:0036211 Protein modification process Affects phenotype PMID:39360521
GO:0040016 Embryonic cleavage Affects phenotype PMID:28042535
GO:0040029 Epigenetic regulation of gene expression Affects phenotype PMID:33872906
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:31351048
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:27152641
GO:0042448 Progesterone metabolic process Affects phenotype PMID:20463053
GO:0042554 Superoxide anion generation Affects phenotype PMID:34627990
GO:0042593 Glucose homeostasis Decreases phenotype PMID:31228551
GO:0042701 Progesterone secretion Increases phenotype PMID:31884101; PMID:34627990
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:20453712
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28238932; PMID:31228551; PMID:31351048; PMID:33029813; PMID:33159713; PMID:33161305; PMID:33162236; PMID:33162236; PMID:37975621; PMID:36889213; PMID:37941498; PMID:37975621; PMID:37979351; PMID:38113427; PMID:38522500
GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:37941498
GO:0043517 Positive regulation of dna damage response, signal transduction by p53 class mediator Increases phenotype PMID:36174712
GO:0043651 Linoleic acid metabolic process Affects phenotype PMID:27384973
GO:0043966 Histone h3 acetylation Increases phenotype PMID:29718165; PMID:37545493
GO:0043967 Histone h4 acetylation Increases phenotype PMID:37545493
GO:0043970 Histone h3-k9 acetylation Increases phenotype PMID:34910997
GO:0043973 Histone h3-k4 acetylation Increases phenotype PMID:37611859
GO:0044237 Cellular metabolic process Increases phenotype PMID:24836450; PMID:33631300; PMID:34910997; PMID:34942354; PMID:35510228; PMID:39307383
GO:0044255 Cellular lipid metabolic process Affects phenotype PMID:34323617
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:36087924
GO:0044381 Glucose import in response to insulin stimulus Decreases phenotype PMID:32255176
GO:0045017 Glycerolipid biosynthetic process Affects phenotype PMID:30810372
GO:0045333 Cellular respiration Decreases phenotype PMID:30648648; PMID:34627990
GO:0045444 Fat cell differentiation Increases phenotype PMID:22953781; PMID:28921615
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:36696656
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:25777084
GO:0045669 Positive regulation of osteoblast differentiation Decreases phenotype PMID:25777084
GO:0045719 Negative regulation of glycogen biosynthetic process Increases phenotype PMID:31228551
GO:0045722 Positive regulation of gluconeogenesis Increases phenotype PMID:31228551
GO:0045778 Positive regulation of ossification Decreases phenotype PMID:25777084
GO:0045880 Positive regulation of smoothened signaling pathway Increases phenotype PMID:26710974
GO:0045992 Negative regulation of embryonic development Increases phenotype PMID:36535558
GO:0046034 Atp metabolic process Affects phenotype PMID:32522588
GO:0046323 Glucose import Increases phenotype PMID:31009676
GO:0046326 Positive regulation of glucose import Increases phenotype PMID:36438553
GO:0046339 Diacylglycerol metabolic process Affects phenotype PMID:35075242
GO:0046474 Glycerophospholipid biosynthetic process Affects phenotype PMID:30810372
GO:0046722 Lactic acid secretion Increases phenotype PMID:31009676
GO:0046879 Hormone secretion Affects phenotype PMID:25810477
GO:0048515 Spermatid differentiation Increases phenotype PMID:34010400
GO:0048599 Oocyte development Decreases phenotype PMID:25810477
GO:0048863 Stem cell differentiation Decreases phenotype PMID:32205227
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31016965; PMID:34010400
GO:0050765 Negative regulation of phagocytosis Increases phenotype PMID:29718165
GO:0050810 Regulation of steroid biosynthetic process Affects phenotype PMID:31015488
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:35143864; PMID:36696656; PMID:38050670
GO:0051560 Mitochondrial calcium ion homeostasis Affects phenotype PMID:39307383
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:24836450; PMID:24836450; PMID:28988496; PMID:28988496; PMID:34627990; PMID:39307383; PMID:39307383
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:24836450
GO:0052697 Xenobiotic glucuronidation Decreases phenotype PMID:27071666
GO:0060014 Granulosa cell differentiation Affects phenotype PMID:39752319
GO:0060326 Cell chemotaxis Increases phenotype PMID:20453712; PMID:33631300
GO:0060706 Cell differentiation involved in embryonic placenta development Affects phenotype PMID:30810372
GO:0061179 Negative regulation of insulin secretion involved in cellular response to glucose stimulus Increases phenotype PMID:34141174; PMID:38048874
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:20463053
GO:0061519 Macrophage homeostasis Affects phenotype PMID:29743262
GO:0070265 Necrotic cell death Increases phenotype PMID:28042535; PMID:29259978
GO:0070341 Fat cell proliferation Increases phenotype PMID:22953781
GO:0070584 Mitochondrion morphogenesis Decreases phenotype PMID:34863575
GO:0070730 Camp transport Affects phenotype PMID:26985823
GO:0070994 Detection of oxidative stress Increases phenotype PMID:35510228; PMID:37286014
GO:0071888 Macrophage apoptotic process Increases phenotype PMID:29743262
GO:0071901 Negative regulation of protein serine/threonine kinase activity Increases phenotype PMID:31351048
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:30476341; PMID:31015488; PMID:33360214; PMID:36189433
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:20463053; PMID:23077170; PMID:24836450; PMID:28988496; PMID:29259978; PMID:34627990; PMID:34627990; PMID:39307383; PMID:36087924; PMID:39307383; PMID:39360521
GO:0080009 Mrna methylation Increases phenotype PMID:36174712; PMID:36314267
GO:0080182 Histone h3-k4 trimethylation Increases phenotype PMID:37545493; PMID:37611859
GO:0090181 Regulation of cholesterol metabolic process Affects phenotype PMID:37093692
GO:0097198 Histone h3-k36 trimethylation Increases phenotype PMID:37545493; PMID:37611859
GO:0097368 Establishment of sertoli cell barrier Decreases phenotype PMID:36087924; PMID:37941498
GO:0097676 Histone h3-k36 dimethylation Decreases phenotype PMID:29718165
GO:0106395 Positive regulation of palmitic acid catabolic process Increases phenotype PMID:32255176
GO:0110017 Cap-independent translational initiation of linear mrna Decreases phenotype PMID:27992464
GO:0140042 Lipid droplet formation Increases phenotype PMID:22953781; PMID:28921615; PMID:30810372; PMID:31004931
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:33159713; PMID:37692514
GO:0140747 Regulation of ncrna transcription Affects phenotype PMID:37003585
GO:0150129 Positive regulation of interleukin-33 production Increases phenotype PMID:37545493
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:34863575; PMID:36696656; PMID:38050670
GO:1900017 Positive regulation of cytokine production involved in inflammatory response Increases phenotype PMID:30398665
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:31016965; PMID:33159713
GO:1900409 Positive regulation of cellular response to oxidative stress Increases phenotype PMID:37692514
GO:1900535 Palmitic acid biosynthetic process Increases phenotype PMID:27384973
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:29940330
GO:1901165 Positive regulation of trophoblast cell migration Decreases phenotype PMID:28416457
GO:1901318 Negative regulation of flagellated sperm motility Increases phenotype PMID:24140385
GO:1901526 Positive regulation of mitophagy Increases phenotype PMID:33161305; PMID:37692514
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:32566080; PMID:33120273
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:32255176
GO:1901740 Negative regulation of myoblast fusion Increases phenotype PMID:32255176
GO:1901858 Regulation of mitochondrial dna metabolic process Affects phenotype PMID:32255176
GO:1902624 Positive regulation of neutrophil migration Increases phenotype PMID:34010400
GO:1902750 Negative regulation of cell cycle g2/m phase transition Increases phenotype PMID:33162236
GO:1902807 Negative regulation of cell cycle g1/s phase transition Increases phenotype PMID:33162236
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:33120273
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26597031; PMID:29663635; PMID:30648648
GO:1903427 Negative regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:31351048
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29940330; PMID:31016965; PMID:32255176; PMID:33029813; PMID:33120273; PMID:33161305; PMID:33360214; PMID:33360214; PMID:37975621; PMID:34863575; PMID:35143864; PMID:36005737; PMID:36438553; PMID:36696656; PMID:37692514; PMID:37975621; PMID:37979351; PMID:38050670
GO:1903537 Meiotic cell cycle process involved in oocyte maturation Affects phenotype PMID:28042535
GO:1903703 Enterocyte differentiation Affects phenotype PMID:38563870
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:32566080; PMID:36696656
GO:1904445 Negative regulation of establishment of sertoli cell barrier Increases phenotype PMID:38565259
GO:1905053 Positive regulation of base-excision repair Increases phenotype PMID:33120273
GO:1905517 Macrophage migration Increases phenotype PMID:29743262
GO:1905523 Positive regulation of macrophage migration Increases phenotype PMID:34010400; PMID:38565259
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:36005737
GO:1990266 Neutrophil migration Increases phenotype PMID:29743262
GO:1990428 Mirna transport Affects phenotype PMID:30481674
GO:1990636 Reproductive senescence Increases phenotype PMID:31015488
GO:2000224 Regulation of testosterone biosynthetic process Increases phenotype PMID:22461451; PMID:25677926
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:24140385
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:31015488; PMID:38685446
GO:2000610 Negative regulation of thyroid hormone generation Increases phenotype PMID:36005737; PMID:38042133
GO:2000611 Positive regulation of thyroid hormone generation Affects phenotype PMID:34708313
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:37692514
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:32566080; PMID:33360214
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:26316063; PMID:31015488; PMID:36189433
GO:2000854 Positive regulation of corticosterone secretion Increases phenotype PMID:37886449
GO:2000866 Positive regulation of estradiol secretion Increases phenotype PMID:31015488; PMID:31771930
GO:2000872 Positive regulation of progesterone secretion Increases phenotype PMID:31771930
GO:2000987 Positive regulation of behavioral fear response Increases phenotype PMID:37886449
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.