Nickel sulfate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001510 Rna methylation Affects phenotype PMID:37061066
GO:0002280 Monocyte activation involved in immune response Increases phenotype PMID:29540657
GO:0002532 Production of molecular mediator involved in inflammatory response Increases phenotype PMID:35499276
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:24112957
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:24112957; PMID:28296042
GO:0006304 Dna modification Increases phenotype PMID:23317420
GO:0006306 Dna methylation Increases phenotype PMID:25957741
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:34612572
GO:0006527 Arginine catabolic process Increases phenotype PMID:23415871
GO:0006749 Glutathione metabolic process Increases phenotype PMID:10484457; PMID:34612572
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:23463385
GO:0006915 Apoptotic process Increases phenotype PMID:28296042; PMID:35499276
GO:0006979 Response to oxidative stress Increases phenotype PMID:35499276
GO:0007033 Vacuole organization Increases phenotype PMID:31734292
GO:0008283 Cell population proliferation Affects phenotype PMID:12781210; PMID:23568779; PMID:24962574; PMID:25290854; PMID:37061066
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:34612572
GO:0010718 Positive regulation of epithelial to mesenchymal transition Increases phenotype PMID:22714537
GO:0010942 Positive regulation of cell death Increases phenotype PMID:29540657
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Decreases phenotype PMID:23317420
GO:0016042 Lipid catabolic process Increases phenotype PMID:26607348
GO:0016477 Cell migration Increases phenotype PMID:21697260; PMID:22683935; PMID:27196738
GO:0030001 Metal ion transport Increases phenotype PMID:34612572
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:34612572
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:35499276
GO:0032631 Interleukin-27 production Increases phenotype PMID:30421605
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:23126276
GO:0034440 Lipid oxidation Increases phenotype PMID:23317420; PMID:34612572
GO:0035936 Testosterone secretion Decreases phenotype PMID:29567110
GO:0036123 Histone h3-k9 dimethylation Increases phenotype PMID:23546878
GO:0042307 Positive regulation of protein import into nucleus Decreases phenotype PMID:25957741
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23317420; PMID:39515573
GO:0043553 Negative regulation of phosphatidylinositol 3-kinase activity Increases phenotype PMID:34612572
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:23415871
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:35499276
GO:0050671 Positive regulation of lymphocyte proliferation Increases phenotype PMID:20677212
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:39515573
GO:0050902 Leukocyte adhesive activation Increases phenotype PMID:23126276
GO:0051897 Positive regulation of protein kinase b signaling Decreases phenotype PMID:23317420
GO:0051898 Negative regulation of protein kinase b signaling Increases phenotype PMID:34612572
GO:0061370 Testosterone biosynthetic process Decreases phenotype PMID:29567110; PMID:31734292
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24412756
GO:0097029 Mature conventional dendritic cell differentiation Increases phenotype PMID:25673294
GO:0140639 Positive regulation of pyroptosis Increases phenotype PMID:39515573
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:23526216; PMID:25957741
GO:1901224 Positive regulation of nik/nf-kappab signaling Increases phenotype PMID:25957741
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:23317420; PMID:34612572
GO:1903238 Positive regulation of leukocyte tethering or rolling Increases phenotype PMID:23126276
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:23317420
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:28296042; PMID:29567110
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23317420; PMID:34612572; PMID:39515573
GO:1905589 Positive regulation of l-arginine import across plasma membrane Affects phenotype PMID:23415871
GO:2000481 Positive regulation of camp-dependent protein kinase activity Increases phenotype PMID:23126276
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.