| GO ID | GO name | Interaction type | Reference |
|---|---|---|---|
| GO:0000045 | Autophagosome assembly | Increases phenotype | PMID:29179951; PMID:31862506; PMID:34952138; PMID:34952138; PMID:35843418 |
| GO:0000050 | Urea cycle | Affects phenotype | PMID:31639282 |
| GO:0000080 | Mitotic g1 phase | Increases phenotype | PMID:31614173 |
| GO:0000084 | Mitotic s phase | Decreases phenotype | PMID:28176351; PMID:31468104; PMID:31614173; PMID:31689473 |
| GO:0000086 | G2/m transition of mitotic cell cycle | Affects phenotype | PMID:28176351; PMID:31468104 |
| GO:0000278 | Mitotic cell cycle | Affects phenotype | PMID:28176351; PMID:31689473 |
| GO:0000422 | Autophagy of mitochondrion | Increases phenotype | PMID:24299490; PMID:25031709 |
| GO:0000423 | Mitophagy | Increases phenotype | PMID:32142837 |
| GO:0000737 | Dna catabolic process, endonucleolytic | Increases phenotype | PMID:26089033; PMID:28464991 |
| GO:0001503 | Ossification | Decreases phenotype | PMID:32522577 |
| GO:0001510 | Rna methylation | Affects phenotype | PMID:33830842 |
| GO:0001555 | Oocyte growth | Decreases phenotype | PMID:28801138 |
| GO:0001649 | Osteoblast differentiation | Decreases phenotype | PMID:36453845 |
| GO:0001662 | Behavioral fear response | Increases phenotype | PMID:27814245 |
| GO:0001755 | Neural crest cell migration | Decreases phenotype | PMID:26238599 |
| GO:0001822 | Kidney development | Increases phenotype | PMID:30629257 |
| GO:0001836 | Release of cytochrome c from mitochondria | Increases phenotype | PMID:23405080; PMID:27389774; PMID:28390674; PMID:30030080; PMID:30973085; PMID:33031904; PMID:36731763 |
| GO:0001837 | Epithelial to mesenchymal transition | Increases phenotype | PMID:28302721 |
| GO:0001889 | Liver development | Affects phenotype | PMID:35770551 |
| GO:0001890 | Placenta development | Decreases phenotype | PMID:27984135 |
| GO:0001892 | Embryonic placenta development | Decreases phenotype | PMID:37941438 |
| GO:0001932 | Regulation of protein phosphorylation | Affects phenotype | PMID:28651161 |
| GO:0001954 | Positive regulation of cell-matrix adhesion | Increases phenotype | PMID:28527916 |
| GO:0002064 | Epithelial cell development | Decreases phenotype | PMID:29214744 |
| GO:0002174 | Mammary stem cell proliferation | Decreases phenotype | PMID:29741670 |
| GO:0002246 | Wound healing involved in inflammatory response | Decreases phenotype | PMID:28666365 |
| GO:0002326 | B cell lineage commitment | Decreases phenotype | PMID:29939372 |
| GO:0002360 | T cell lineage commitment | Decreases phenotype | PMID:29939372 |
| GO:0002432 | Granuloma formation | Increases phenotype | PMID:38712533 |
| GO:0002523 | Leukocyte migration involved in inflammatory response | Increases phenotype | PMID:32392679; PMID:33359024; PMID:36718047; PMID:36718047; PMID:38712533; PMID:38712533; PMID:39396604; PMID:39587603 |
| GO:0003081 | Regulation of systemic arterial blood pressure by renin-angiotensin | Increases phenotype | PMID:32738273 |
| GO:0003351 | Epithelial cilium movement involved in extracellular fluid movement | Decreases phenotype | PMID:30572105 |
| GO:0003677 | Dna binding | Decreases phenotype | PMID:30177602 |
| GO:0003810 | Protein-glutamine gamma-glutamyltransferase activity | Increases phenotype | PMID:36718047 |
| GO:0003876 | Amp deaminase activity | Increases phenotype | PMID:37336463 |
| GO:0003990 | Acetylcholinesterase activity | Decreases phenotype | PMID:27803291 |
| GO:0003993 | Acid phosphatase activity | Affects phenotype | PMID:25022247; PMID:26089033; PMID:37336463 |
| GO:0004035 | Alkaline phosphatase activity | Affects phenotype | PMID:22356231; PMID:22708652; PMID:23961183; PMID:25022247; PMID:26089033; PMID:31639282; PMID:31639282; PMID:36718047; PMID:32522577; PMID:36718047 |
| GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity | Increases phenotype | PMID:17624921; PMID:22356231; PMID:26089033; PMID:29421648; PMID:31390532; PMID:31390532; PMID:36718047; PMID:33359024; PMID:36718047 |
| GO:0004096 | Catalase activity | Decreases phenotype | PMID:32781062; PMID:38284084 |
| GO:0004111 | Creatine kinase activity | Increases phenotype | PMID:38712533 |
| GO:0004129 | Cytochrome-c oxidase activity | Decreases phenotype | PMID:27389774; PMID:33038468 |
| GO:0004197 | Cysteine-type endopeptidase activity | Increases phenotype | PMID:28464991; PMID:33497711 |
| GO:0004252 | Serine-type endopeptidase activity | Decreases phenotype | PMID:27803291 |
| GO:0004303 | Estradiol 17-beta-dehydrogenase activity | Decreases phenotype | PMID:31496657 |
| GO:0004345 | Glucose-6-phosphate dehydrogenase activity | Decreases phenotype | PMID:38284084 |
| GO:0004346 | Glucose-6-phosphatase activity | Increases phenotype | PMID:38284084 |
| GO:0004357 | Glutamate-cysteine ligase activity | Decreases phenotype | PMID:35384154 |
| GO:0004364 | Glutathione transferase activity | Increases phenotype | PMID:18548748; PMID:22101474; PMID:22356231; PMID:23395783; PMID:23961183; PMID:25528414; PMID:26089033; PMID:30359721; PMID:31639282; PMID:37336463; PMID:39701214 |
| GO:0004396 | Hexokinase activity | Increases phenotype | PMID:38284084 |
| GO:0004457 | Lactate dehydrogenase activity | Affects phenotype | PMID:16555952; PMID:18956708; PMID:23961183; PMID:24200859; PMID:25022247; PMID:26089033; PMID:30615929; PMID:31639282; PMID:37336463; PMID:38241915; PMID:39587603 |
| GO:0004602 | Glutathione peroxidase activity | Affects phenotype | PMID:18548748; PMID:18548748; PMID:24299490; PMID:18956708; PMID:21337715; PMID:21337715; PMID:22828241; PMID:22356231; PMID:23961183; PMID:25265456; PMID:23961183; PMID:25265456; PMID:38284084; PMID:24168039; PMID:24184865; PMID:24299490; PMID:24632105; PMID:24632105; PMID:25265456; PMID:24954678; PMID:25265456; PMID:25528414; PMID:26089033; PMID:27647474; PMID:30973085; PMID:31390532; PMID:31639282; PMID:31876186; PMID:32392679; PMID:34767868; PMID:34952138; PMID:35384154; PMID:35489423; PMID:37336463; PMID:38284084 |
| GO:0004743 | Pyruvate kinase activity | Decreases phenotype | PMID:37336463 |
| GO:0004784 | Superoxide dismutase activity | Affects phenotype | PMID:18548748; PMID:18956708; PMID:21337715; PMID:21337715; PMID:22828241; PMID:23395783; PMID:22101474; PMID:22356231; PMID:23395783; PMID:23961183; PMID:23961183; PMID:25265456; PMID:29702088; PMID:38284084; PMID:24168039; PMID:24184865; PMID:24200859; PMID:24200859; PMID:24632105; PMID:25265456; PMID:24632105; PMID:24954678; PMID:26089033; PMID:29548726; PMID:29702088; PMID:30973085; PMID:31639282; PMID:31639282; PMID:36718047; PMID:31876186; PMID:32392679; PMID:32735850; PMID:32781062; PMID:32781062; PMID:36356678; PMID:34510229; PMID:34952138; PMID:35489423; PMID:36356678; PMID:36718047; PMID:37022104; PMID:37336463; PMID:38284084 |
| GO:0004833 | Tryptophan 2,3-dioxygenase activity | Increases phenotype | PMID:35489423 |
| GO:0005245 | Voltage-gated calcium channel activity | Increases phenotype | PMID:35457000 |
| GO:0005388 | P-type calcium transporter activity | Decreases phenotype | PMID:26089033 |
| GO:0005391 | P-type sodium:potassium-exchanging transporter activity | Decreases phenotype | PMID:26089033; PMID:2854566; PMID:37336463 |
| GO:0005506 | Iron ion binding | Decreases phenotype | PMID:32645461 |
| GO:0005776 | Autophagosome | Increases phenotype | PMID:34952138 |
| GO:0005884 | Actin filament | Increases phenotype | PMID:30614199 |
| GO:0006084 | Acetyl-coa metabolic process | Affects phenotype | PMID:26235813 |
| GO:0006089 | Lactate metabolic process | Decreases phenotype | PMID:26235813; PMID:33038468; PMID:34481905 |
| GO:0006094 | Gluconeogenesis | Affects phenotype | PMID:33453195 |
| GO:0006096 | Glycolytic process | Affects phenotype | PMID:34481905 |
| GO:0006099 | Tricarboxylic acid cycle | Decreases phenotype | PMID:26235813 |
| GO:0006119 | Oxidative phosphorylation | Increases phenotype | PMID:34481905 |
| GO:0006140 | Regulation of nucleotide metabolic process | Affects phenotype | PMID:35172228 |
| GO:0006171 | Camp biosynthetic process | Decreases phenotype | PMID:29653258 |
| GO:0006182 | Cgmp biosynthetic process | Increases phenotype | PMID:35122928 |
| GO:0006304 | Dna modification | Increases phenotype | PMID:25111876 |
| GO:0006306 | Dna methylation | Affects phenotype | PMID:39119833 |
| GO:0006308 | Dna catabolic process | Increases phenotype | PMID:35384154 |
| GO:0006309 | Apoptotic dna fragmentation | Increases phenotype | PMID:24111524; PMID:24111524; PMID:28390674; PMID:28390674 |
| GO:0006325 | Chromatin organization | Decreases phenotype | PMID:26562325 |
| GO:0006497 | Protein lipidation | Increases phenotype | PMID:32142837; PMID:33127495; PMID:34481905; PMID:34481905; PMID:36336208; PMID:34695510; PMID:36336208 |
| GO:0006520 | Amino acid metabolic process | Affects phenotype | PMID:35301059 |
| GO:0006521 | Regulation of cellular amino acid metabolic process | Affects phenotype | PMID:27514991 |
| GO:0006522 | Alanine metabolic process | Affects phenotype | PMID:32917723 |
| GO:0006534 | Cysteine metabolic process | Affects phenotype | PMID:32917723 |
| GO:0006544 | Glycine metabolic process | Affects phenotype | PMID:32917723 |
| GO:0006602 | Creatinine catabolic process | Increases phenotype | PMID:27599793 |
| GO:0006629 | Lipid metabolic process | Affects phenotype | PMID:38712533 |
| GO:0006631 | Fatty acid metabolic process | Affects phenotype | PMID:35301059 |
| GO:0006636 | Unsaturated fatty acid biosynthetic process | Affects phenotype | PMID:34405727 |
| GO:0006641 | Triglyceride metabolic process | Increases phenotype | PMID:31152847; PMID:34516972; PMID:35183672; PMID:36718047 |
| GO:0006644 | Phospholipid metabolic process | Affects phenotype | PMID:35301059 |
| GO:0006650 | Glycerophospholipid metabolic process | Affects phenotype | PMID:37451531 |
| GO:0006664 | Glycolipid metabolic process | Affects phenotype | PMID:37482320 |
| GO:0006695 | Cholesterol biosynthetic process | Increases phenotype | PMID:27634282 |
| GO:0006703 | Estrogen biosynthetic process | Affects phenotype | PMID:31793751 |
| GO:0006749 | Glutathione metabolic process | Increases phenotype | PMID:25170436; PMID:26070417; PMID:26089033; PMID:26235813; PMID:29286200; PMID:30399392; PMID:30506660; PMID:30606898; PMID:30804470; PMID:30973085; PMID:31876186; PMID:32392679; PMID:32735850; PMID:33497711; PMID:34405727; PMID:34767868; PMID:35122928; PMID:35384154; PMID:36646412; PMID:36718047; PMID:36731763 |
| GO:0006750 | Glutathione biosynthetic process | Increases phenotype | PMID:18548748; PMID:18548748; PMID:24299490; PMID:21284339; PMID:21284339; PMID:24632105; PMID:25265456; PMID:21337715; PMID:21337715; PMID:7661626; PMID:22101474; PMID:23717155; PMID:25022247; PMID:25265456; PMID:24184865; PMID:24299490; PMID:24632105; PMID:24662163; PMID:24662163; PMID:25502771; PMID:24954678; PMID:25265456; PMID:25446329; PMID:25502771; PMID:25528414; PMID:26260164; PMID:27647474; PMID:28390674; PMID:30359721; PMID:31433112; PMID:31639282; PMID:9152014 |
| GO:0006751 | Glutathione catabolic process | Increases phenotype | PMID:26365678 |
| GO:0006754 | Atp biosynthetic process | Decreases phenotype | PMID:29158198; PMID:29653258 |
| GO:0006778 | Porphyrin-containing compound metabolic process | Affects phenotype | PMID:30529385 |
| GO:0006809 | Nitric oxide biosynthetic process | Increases phenotype | PMID:11031323; PMID:23750309; PMID:23750309; PMID:25265456; PMID:24527689; PMID:25265456; PMID:25446329 |
| GO:0006810 | Transport | Affects phenotype | PMID:23503628 |
| GO:0006813 | Potassium ion transport | Affects phenotype | PMID:33038468 |
| GO:0006826 | Iron ion transport | Increases phenotype | PMID:28802572 |
| GO:0006829 | Zinc ion transport | Increases phenotype | PMID:28802572 |
| GO:0006874 | Cellular calcium ion homeostasis | Affects phenotype | PMID:16555952; PMID:25639782; PMID:26089033; PMID:28176351; PMID:32599263; PMID:33309878; PMID:33617915; PMID:34516972; PMID:36731763; PMID:37300854 |
| GO:0006875 | Cellular metal ion homeostasis | Affects phenotype | PMID:35212737 |
| GO:0006876 | Cellular cadmium ion homeostasis | Increases phenotype | PMID:28464991 |
| GO:0006879 | Cellular iron ion homeostasis | Decreases phenotype | PMID:26089033; PMID:35122928; PMID:37336463 |
| GO:0006882 | Cellular zinc ion homeostasis | Affects phenotype | PMID:37487938 |
| GO:0006914 | Autophagy | Increases phenotype | PMID:25639782; PMID:29218509; PMID:33127495; PMID:36336208 |
| GO:0006915 | Apoptotic process | Increases phenotype | PMID:10506578; PMID:10647914; PMID:10647914; PMID:28457857; PMID:14610070; PMID:14610070; PMID:9344607; PMID:9454737; PMID:15842833; PMID:18271013; PMID:21181359; PMID:21337715; PMID:23405080; PMID:23650964; PMID:23650964; PMID:29421648; PMID:23880315; PMID:23941782; PMID:24299490; PMID:24462979; PMID:24995437; PMID:25031709; PMID:25446329; PMID:25980575; PMID:28163110; PMID:28283887; PMID:28342888; PMID:28949029; PMID:29421648; PMID:30030080; PMID:30796935; PMID:30796935; PMID:32199951; PMID:30804470; PMID:31433112; PMID:31614173; PMID:32599263; PMID:33031904; PMID:33309878; PMID:33359024; PMID:33398418; PMID:33652105; PMID:34558789; PMID:34558789; PMID:34767868; PMID:34743973; PMID:34767868; PMID:34791780; PMID:35384129; PMID:35870590; PMID:36718047; PMID:36718047; PMID:38712533; PMID:36731763; PMID:36731763; PMID:39038763; PMID:37300854; PMID:38001299; PMID:39119833; PMID:9344607; PMID:9344607; PMID:9454737; PMID:9822662 |
| GO:0006950 | Response to stress | Affects phenotype | PMID:8499460 |
| GO:0006954 | Inflammatory response | Increases phenotype | PMID:23503628; PMID:30375035; PMID:35183672; PMID:31390532; PMID:37022104 |
| GO:0006974 | Cellular response to dna damage stimulus | Increases phenotype | PMID:18548748; PMID:23395783; PMID:23405080; PMID:23503628; PMID:24583143; PMID:27647474; PMID:28690196; PMID:33031904; PMID:7871536; PMID:8301701; PMID:9822662 |
| GO:0006979 | Response to oxidative stress | Increases phenotype | PMID:19997867; PMID:21620867; PMID:23503628 |
| GO:0006997 | Nucleus organization | Decreases phenotype | PMID:24291162; PMID:28949029; PMID:34952138 |
| GO:0007005 | Mitochondrion organization | Decreases phenotype | PMID:25159133; PMID:27389774; PMID:29100878; PMID:30614199; PMID:33617915; PMID:34481905; PMID:34952138; PMID:37022104 |
| GO:0007006 | Mitochondrial membrane organization | Affects phenotype | PMID:33038468 |
| GO:0007009 | Plasma membrane organization | Decreases phenotype | PMID:30614199; PMID:30796460 |
| GO:0007033 | Vacuole organization | Increases phenotype | PMID:33652105; PMID:34952138; PMID:35489423; PMID:38712533 |
| GO:0007040 | Lysosome organization | Increases phenotype | PMID:24299490; PMID:25639782 |
| GO:0007042 | Lysosomal lumen acidification | Increases phenotype | PMID:31862506 |
| GO:0007144 | Female meiosis i | Decreases phenotype | PMID:29287790 |
| GO:0007183 | Smad protein complex assembly | Decreases phenotype | PMID:36453845 |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | Increases phenotype | PMID:31348969 |
| GO:0007267 | Cell-cell signaling | Decreases phenotype | PMID:28176351 |
| GO:0007275 | Multicellular organism development | Decreases phenotype | PMID:31053883 |
| GO:0007283 | Spermatogenesis | Decreases phenotype | PMID:27279585; PMID:29527696; PMID:31654709; PMID:32199951; PMID:35870590; PMID:32781062; PMID:34791780; PMID:37972751 |
| GO:0007420 | Brain development | Affects phenotype | PMID:35770551 |
| GO:0007611 | Learning or memory | Decreases phenotype | PMID:29029324; PMID:38579196 |
| GO:0007613 | Memory | Decreases phenotype | PMID:31626305; PMID:34405727; PMID:35489423; PMID:38595292 |
| GO:0007631 | Feeding behavior | Decreases phenotype | PMID:31014900; PMID:31390532 |
| GO:0008121 | Ubiquinol-cytochrome-c reductase activity | Decreases phenotype | PMID:33038468 |
| GO:0008137 | Nadh dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:27389774; PMID:33038468 |
| GO:0008177 | Succinate dehydrogenase (ubiquinone) activity | Decreases phenotype | PMID:33038468 |
| GO:0008203 | Cholesterol metabolic process | Increases phenotype | PMID:30375035; PMID:31152847; PMID:36718047; PMID:37236586 |
| GO:0008210 | Estrogen metabolic process | Affects phenotype | PMID:30478740; PMID:33453195 |
| GO:0008219 | Cell death | Increases phenotype | PMID:21497582; PMID:24518829; PMID:25118938; PMID:25118938; PMID:30796460; PMID:26558471; PMID:26865462; PMID:27647474; PMID:28390674; PMID:28390674; PMID:28747609; PMID:28390674; PMID:28802572; PMID:39933616; PMID:28747609; PMID:29100878; PMID:29218509; PMID:29253600; PMID:29408665; PMID:29502740; PMID:30614199; PMID:31077537; PMID:32735850; PMID:33497711; PMID:35183672; PMID:9545559 |
| GO:0008233 | Peptidase activity | Decreases phenotype | PMID:27803291 |
| GO:0008253 | 5'-nucleotidase activity | Decreases phenotype | PMID:37336463 |
| GO:0008283 | Cell population proliferation | Increases phenotype | PMID:11031323; PMID:16555952; PMID:20219890; PMID:21497582; PMID:21787730; PMID:21796402; PMID:23376331; PMID:23405080; PMID:23499788; PMID:23811327; PMID:23948867; PMID:24111524; PMID:24518829; PMID:24532171; PMID:24962574; PMID:25014244; PMID:25106854; PMID:25118938; PMID:25201352; PMID:26026611; PMID:25446329; PMID:25980575; PMID:26026611; PMID:26138014; PMID:27432484; PMID:27647474; PMID:27888128; PMID:28163110; PMID:28302721; PMID:28302721; PMID:28830677; PMID:28342888; PMID:28830677; PMID:29218509; PMID:30682495; PMID:31614173; PMID:31689473; PMID:32781062; PMID:34952138; PMID:35843418; PMID:36493885; PMID:36602393; PMID:38712533; PMID:9044050; PMID:9152014 |
| GO:0008284 | Positive regulation of cell population proliferation | Increases phenotype | PMID:24291162; PMID:25446860; PMID:25448810; PMID:26385184; PMID:26562325; PMID:27071941; PMID:27510461; PMID:32512071; PMID:34520792 |
| GO:0008285 | Negative regulation of cell population proliferation | Increases phenotype | PMID:28422390; PMID:28651161; PMID:30399392; PMID:31271426; PMID:31348969; PMID:35134237 |
| GO:0008355 | Olfactory learning | Decreases phenotype | PMID:29029324 |
| GO:0008360 | Regulation of cell shape | Affects phenotype | PMID:26138014 |
| GO:0008443 | Phosphofructokinase activity | Decreases phenotype | PMID:38284084 |
| GO:0008584 | Male gonad development | Decreases phenotype | PMID:32199951 |
| GO:0009103 | Lipopolysaccharide biosynthetic process | Increases phenotype | PMID:26352046 |
| GO:0009116 | Nucleoside metabolic process | Affects phenotype | PMID:35301059 |
| GO:0009117 | Nucleotide metabolic process | Affects phenotype | PMID:35301059 |
| GO:0009118 | Regulation of nucleoside metabolic process | Affects phenotype | PMID:35172228 |
| GO:0009649 | Entrainment of circadian clock | Affects phenotype | PMID:23349044 |
| GO:0009749 | Response to glucose | Decreases phenotype | PMID:30629257; PMID:33259630 |
| GO:0009790 | Embryo development | Decreases phenotype | PMID:37941438 |
| GO:0010189 | Vitamin e biosynthetic process | Decreases phenotype | PMID:21284339 |
| GO:0010424 | Dna methylation on cytosine within a cg sequence | Increases phenotype | PMID:34520792 |
| GO:0010718 | Positive regulation of epithelial to mesenchymal transition | Increases phenotype | PMID:27224422 |
| GO:0010729 | Positive regulation of hydrogen peroxide biosynthetic process | Increases phenotype | PMID:37244046 |
| GO:0010825 | Positive regulation of centrosome duplication | Increases phenotype | PMID:38185225 |
| GO:0010886 | Positive regulation of cholesterol storage | Increases phenotype | PMID:29486218 |
| GO:0010890 | Positive regulation of sequestering of triglyceride | Increases phenotype | PMID:29486218 |
| GO:0010893 | Positive regulation of steroid biosynthetic process | Increases phenotype | PMID:32892022 |
| GO:0010894 | Negative regulation of steroid biosynthetic process | Increases phenotype | PMID:31496657 |
| GO:0010917 | Negative regulation of mitochondrial membrane potential | Increases phenotype | PMID:35525383; PMID:39778856 |
| GO:0010918 | Positive regulation of mitochondrial membrane potential | Decreases phenotype | PMID:25981801; PMID:28422390 |
| GO:0010942 | Positive regulation of cell death | Increases phenotype | PMID:23673518; PMID:25159133; PMID:25374377; PMID:25981801; PMID:26259607; PMID:26562325; PMID:26809137; PMID:26827822; PMID:26827822; PMID:29116755; PMID:27377441; PMID:28377212; PMID:29116755; PMID:29486218; PMID:32783891; PMID:38401882 |
| GO:0010983 | Positive regulation of high-density lipoprotein particle clearance | Increases phenotype | PMID:38284084 |
| GO:0010989 | Negative regulation of low-density lipoprotein particle clearance | Increases phenotype | PMID:37482320; PMID:38284084 |
| GO:0014047 | Glutamate secretion | Decreases phenotype | PMID:30614199 |
| GO:0014065 | Phosphatidylinositol 3-kinase signaling | Affects phenotype | PMID:23673518 |
| GO:0015444 | P-type magnesium transporter activity | Decreases phenotype | PMID:26089033 |
| GO:0015727 | Lactate transport | Increases phenotype | PMID:39427783 |
| GO:0015884 | Folic acid transport | Affects phenotype | PMID:27417525 |
| GO:0015936 | Coenzyme a metabolic process | Affects phenotype | PMID:26235813 |
| GO:0016042 | Lipid catabolic process | Increases phenotype | PMID:17624921; PMID:17624921; PMID:21337715; PMID:22828241; PMID:23395783; PMID:18548748; PMID:21284339; PMID:21284339; PMID:24632105; PMID:21337715; PMID:22356231; PMID:23085516; PMID:23395783; PMID:23405080; PMID:23961183; PMID:25022247; PMID:23961183; PMID:25022247; PMID:25993096; PMID:29702088; PMID:24632105; PMID:24662163; PMID:24662163; PMID:25502771; PMID:24954678; PMID:25502771; PMID:27647474; PMID:29253600; PMID:29702088; PMID:31319114; PMID:31390532; PMID:31433112; PMID:31639282; PMID:32735850; PMID:33398418; PMID:34695510; PMID:35384154; PMID:35489423 |
| GO:0016049 | Cell growth | Increases phenotype | PMID:28690196; PMID:29179951; PMID:30213552; PMID:30615929; PMID:30682495 |
| GO:0016160 | Amylase activity | Decreases phenotype | PMID:38712533 |
| GO:0016209 | Antioxidant activity | Increases phenotype | PMID:31496657 |
| GO:0016477 | Cell migration | Increases phenotype | PMID:23811327; PMID:28830677; PMID:28830677; PMID:29179951; PMID:29179951; PMID:34687772 |
| GO:0016525 | Negative regulation of angiogenesis | Increases phenotype | PMID:37487938 |
| GO:0016567 | Protein ubiquitination | Increases phenotype | PMID:10506578 |
| GO:0016656 | Monodehydroascorbate reductase (nadh) activity | Decreases phenotype | PMID:37336463 |
| GO:0016887 | Atp hydrolysis activity | Decreases phenotype | PMID:23961183; PMID:27803291; PMID:34952138 |
| GO:0016925 | Protein sumoylation | Increases phenotype | PMID:28747609 |
| GO:0017015 | Regulation of transforming growth factor beta receptor signaling pathway | Affects phenotype | PMID:29408318 |
| GO:0018158 | Protein oxidation | Increases phenotype | PMID:18548748; PMID:23395783; PMID:24662163; PMID:24662163; PMID:25502771; PMID:25502771; PMID:26089033; PMID:28422390; PMID:29486218; PMID:35384154; PMID:37336463 |
| GO:0018198 | Peptidyl-cysteine modification | Increases phenotype | PMID:26827822 |
| GO:0018335 | Protein succinylation | Decreases phenotype | PMID:29653258 |
| GO:0018345 | Protein palmitoylation | Increases phenotype | PMID:38195004 |
| GO:0019216 | Regulation of lipid metabolic process | Affects phenotype | PMID:27514991; PMID:30529385; PMID:35172228; PMID:38382403; PMID:39418721 |
| GO:0019249 | Lactate biosynthetic process | Increases phenotype | PMID:30615929 |
| GO:0019369 | Arachidonic acid metabolic process | Decreases phenotype | PMID:37482320; PMID:39418721 |
| GO:0019432 | Triglyceride biosynthetic process | Increases phenotype | PMID:26352046; PMID:27634282 |
| GO:0019627 | Urea metabolic process | Affects phenotype | PMID:21284339 |
| GO:0019695 | Choline metabolic process | Affects phenotype | PMID:38241915 |
| GO:0019722 | Calcium-mediated signaling | Affects phenotype | PMID:38579196 |
| GO:0019752 | Carboxylic acid metabolic process | Affects phenotype | PMID:32917723 |
| GO:0019835 | Cytolysis | Increases phenotype | PMID:37336463 |
| GO:0019852 | L-ascorbic acid metabolic process | Affects phenotype | PMID:26089033; PMID:34791780 |
| GO:0019853 | L-ascorbic acid biosynthetic process | Decreases phenotype | PMID:17624921; PMID:21284339 |
| GO:0021953 | Central nervous system neuron differentiation | Decreases phenotype | PMID:31271426 |
| GO:0022008 | Neurogenesis | Decreases phenotype | PMID:31271426; PMID:31626305 |
| GO:0030042 | Actin filament depolymerization | Increases phenotype | PMID:24532171 |
| GO:0030182 | Neuron differentiation | Affects phenotype | PMID:29408665; PMID:31626305; PMID:33387572 |
| GO:0030199 | Collagen fibril organization | Increases phenotype | PMID:37022104; PMID:38712533 |
| GO:0030223 | Neutrophil differentiation | Decreases phenotype | PMID:29939372 |
| GO:0030224 | Monocyte differentiation | Decreases phenotype | PMID:29939372 |
| GO:0030263 | Apoptotic chromosome condensation | Increases phenotype | PMID:18548748; PMID:29548726; PMID:32392679; PMID:32735850; PMID:34743973; PMID:35489423; PMID:38595292 |
| GO:0030279 | Negative regulation of ossification | Increases phenotype | PMID:30917596 |
| GO:0030308 | Negative regulation of cell growth | Increases phenotype | PMID:26365678 |
| GO:0030316 | Osteoclast differentiation | Increases phenotype | PMID:31793751; PMID:32522522 |
| GO:0030335 | Positive regulation of cell migration | Increases phenotype | PMID:28527916; PMID:31120230; PMID:33129824; PMID:38382870; PMID:39722890 |
| GO:0030431 | Sleep | Affects phenotype | PMID:23349044 |
| GO:0031175 | Neuron projection development | Decreases phenotype | PMID:36114956 |
| GO:0031324 | Negative regulation of cellular metabolic process | Increases phenotype | PMID:35122928 |
| GO:0031394 | Positive regulation of prostaglandin biosynthetic process | Increases phenotype | PMID:31120230 |
| GO:0031589 | Cell-substrate adhesion | Decreases phenotype | PMID:33422613 |
| GO:0031966 | Mitochondrial membrane | Affects phenotype | PMID:33038468 |
| GO:0031987 | Locomotion involved in locomotory behavior | Decreases phenotype | PMID:23349044; PMID:31166132; PMID:32735850; PMID:35489423 |
| GO:0032024 | Positive regulation of insulin secretion | Increases phenotype | PMID:38284084 |
| GO:0032053 | Ciliary basal body organization | Decreases phenotype | PMID:30572105 |
| GO:0032114 | Regulation of glucose-6-phosphatase activity | Affects phenotype | PMID:26235813 |
| GO:0032125 | Micronucleus organization | Increases phenotype | PMID:28464991; PMID:29502740; PMID:31639282 |
| GO:0032148 | Activation of protein kinase b activity | Increases phenotype | PMID:26385184; PMID:27634459; PMID:33129824 |
| GO:0032286 | Central nervous system myelin maintenance | Decreases phenotype | PMID:23680456 |
| GO:0032471 | Negative regulation of endoplasmic reticulum calcium ion concentration | Increases phenotype | PMID:37300854 |
| GO:0032775 | Dna methylation on adenine | Decreases phenotype | PMID:33865896 |
| GO:0032868 | Response to insulin | Affects phenotype | PMID:33259630 |
| GO:0032922 | Circadian regulation of gene expression | Affects phenotype | PMID:23085516 |
| GO:0032956 | Regulation of actin cytoskeleton organization | Decreases phenotype | PMID:25882684; PMID:36928142 |
| GO:0032964 | Collagen biosynthetic process | Increases phenotype | PMID:30912652 |
| GO:0032981 | Mitochondrial respiratory chain complex i assembly | Decreases phenotype | PMID:27803291 |
| GO:0033023 | Mast cell homeostasis | Affects phenotype | PMID:38712533 |
| GO:0033141 | Positive regulation of peptidyl-serine phosphorylation of stat protein | Increases phenotype | PMID:33813002 |
| GO:0033554 | Cellular response to stress | Increases phenotype | PMID:29116755; PMID:9559875 |
| GO:0033685 | Negative regulation of luteinizing hormone secretion | Increases phenotype | PMID:31496657; PMID:37972751 |
| GO:0033686 | Positive regulation of luteinizing hormone secretion | Increases phenotype | PMID:37967787 |
| GO:0033754 | Indoleamine 2,3-dioxygenase activity | Increases phenotype | PMID:35489423 |
| GO:0033864 | Positive regulation of nad(p)h oxidase activity | Increases phenotype | PMID:25446860; PMID:30399392 |
| GO:0034418 | Urate biosynthetic process | Affects phenotype | PMID:21284339 |
| GO:0034440 | Lipid oxidation | Increases phenotype | PMID:106178; PMID:25409916; PMID:26070417; PMID:26089033; PMID:27803291; PMID:27803291; PMID:30973085; PMID:28422390; PMID:29286200; PMID:30399392; PMID:30506660; PMID:30973085; PMID:31876186; PMID:32738273; PMID:34405727; PMID:35122928; PMID:36356678; PMID:36718047; PMID:36868496; PMID:38595292 |
| GO:0034728 | Nucleosome organization | Affects phenotype | PMID:23673518 |
| GO:0035358 | Regulation of peroxisome proliferator activated receptor signaling pathway | Affects phenotype | PMID:37482320 |
| GO:0035640 | Exploration behavior | Affects phenotype | PMID:35489423 |
| GO:0035752 | Lysosomal lumen ph elevation | Increases phenotype | PMID:34516972 |
| GO:0035855 | Megakaryocyte development | Decreases phenotype | PMID:35134237 |
| GO:0035934 | Corticosterone secretion | Increases phenotype | PMID:35384129; PMID:37972751 |
| GO:0035936 | Testosterone secretion | Increases phenotype | PMID:31014900; PMID:31654709; PMID:32199951 |
| GO:0036394 | Amylase secretion | Increases phenotype | PMID:38284084 |
| GO:0036499 | Perk-mediated unfolded protein response | Increases phenotype | PMID:29373603 |
| GO:0040015 | Negative regulation of multicellular organism growth | Increases phenotype | PMID:32738273; PMID:33338565 |
| GO:0040038 | Polar body extrusion after meiotic divisions | Decreases phenotype | PMID:29287790 |
| GO:0042110 | T cell activation | Affects phenotype | PMID:39396604 |
| GO:0042116 | Macrophage activation | Increases phenotype | PMID:32917723; PMID:33359024 |
| GO:0042126 | Nitrate metabolic process | Increases phenotype | PMID:24662163 |
| GO:0042127 | Regulation of cell population proliferation | Affects phenotype | PMID:34662668; PMID:35650140 |
| GO:0042167 | Heme catabolic process | Increases phenotype | PMID:37336463 |
| GO:0042307 | Positive regulation of protein import into nucleus | Increases phenotype | PMID:28229933 |
| GO:0042360 | Vitamin e metabolic process | Affects phenotype | PMID:26089033 |
| GO:0042403 | Thyroid hormone metabolic process | Affects phenotype | PMID:38712533 |
| GO:0042532 | Negative regulation of tyrosine phosphorylation of stat protein | Increases phenotype | PMID:33813002 |
| GO:0042551 | Neuron maturation | Decreases phenotype | PMID:36114956 |
| GO:0042554 | Superoxide anion generation | Increases phenotype | PMID:18548748; PMID:24662163; PMID:24662163; PMID:25502771; PMID:25502771; PMID:34952138 |
| GO:0042593 | Glucose homeostasis | Decreases phenotype | PMID:27814245; PMID:30629257; PMID:33259630; PMID:35172228; PMID:37482320; PMID:38284084 |
| GO:0042632 | Cholesterol homeostasis | Decreases phenotype | PMID:37482320 |
| GO:0042701 | Progesterone secretion | Affects phenotype | PMID:31654709 |
| GO:0042743 | Hydrogen peroxide metabolic process | Increases phenotype | PMID:26089033; PMID:31876186; PMID:36731763; PMID:37336463 |
| GO:0042756 | Drinking behavior | Decreases phenotype | PMID:32738273 |
| GO:0043029 | T cell homeostasis | Affects phenotype | PMID:39396604 |
| GO:0043046 | Dna methylation involved in gamete generation | Affects phenotype | PMID:33483743 |
| GO:0043065 | Positive regulation of apoptotic process | Increases phenotype | PMID:23680456; PMID:24291162; PMID:24419708; PMID:26046303; PMID:27558804; PMID:28651161; PMID:29444456; PMID:30399392; PMID:31348969; PMID:31676320; PMID:33813002; PMID:34662668; PMID:37244046; PMID:37660740; PMID:37972751; PMID:38174414; PMID:38242296; PMID:38401882; PMID:38565259; PMID:39778856 |
| GO:0043066 | Negative regulation of apoptotic process | Increases phenotype | PMID:25448810; PMID:32512071; PMID:34520792 |
| GO:0043123 | Positive regulation of i-kappab kinase/nf-kappab signaling | Increases phenotype | PMID:39778856 |
| GO:0043149 | Stress fiber assembly | Increases phenotype | PMID:28302721; PMID:28341147 |
| GO:0043181 | Vacuolar sequestering | Increases phenotype | PMID:31053883 |
| GO:0043217 | Myelin maintenance | Decreases phenotype | PMID:27389774 |
| GO:0043408 | Regulation of mapk cascade | Increases phenotype | PMID:32512071 |
| GO:0043491 | Protein kinase b signaling | Affects phenotype | PMID:23673518 |
| GO:0043525 | Positive regulation of neuron apoptotic process | Increases phenotype | PMID:26046303 |
| GO:0043651 | Linoleic acid metabolic process | Decreases phenotype | PMID:37482320 |
| GO:0043966 | Histone h3 acetylation | Decreases phenotype | PMID:26314618 |
| GO:0043967 | Histone h4 acetylation | Decreases phenotype | PMID:26314618 |
| GO:0043981 | Histone h4-k5 acetylation | Decreases phenotype | PMID:29653258 |
| GO:0043983 | Histone h4-k12 acetylation | Decreases phenotype | PMID:29653258 |
| GO:0044026 | Dna hypermethylation | Affects phenotype | PMID:33865896 |
| GO:0044027 | Hypermethylation of cpg island | Increases phenotype | PMID:37972751 |
| GO:0044028 | Dna hypomethylation | Affects phenotype | PMID:33865896 |
| GO:0044030 | Regulation of dna methylation | Affects phenotype | PMID:33338565; PMID:35525383 |
| GO:0044237 | Cellular metabolic process | Increases phenotype | PMID:28176351; PMID:28302721; PMID:28314151; PMID:28464991; PMID:28949029; PMID:29253600; PMID:29298499; PMID:29957541; PMID:30478740; PMID:30614199; PMID:30796935; PMID:30796935; PMID:32199951; PMID:30804470; PMID:31166132; PMID:31319114; PMID:31433112; PMID:31468104; PMID:31614173; PMID:32142837; PMID:33031904; PMID:33127495; PMID:33188856; PMID:33309878; PMID:33387572; PMID:33617915; PMID:33774064; PMID:37300869; PMID:34510229; PMID:34558789; PMID:34558789; PMID:34767868; PMID:36527706; PMID:34695510; PMID:34767868; PMID:34822840; PMID:34905088; PMID:34952138; PMID:35027733; PMID:35183672; PMID:35301059; PMID:35384129; PMID:35384129; PMID:35908931; PMID:35457000; PMID:36336208; PMID:36527706; PMID:36602393; PMID:37236586; PMID:37300854; PMID:37300869; PMID:38001299; PMID:38156290; PMID:39038763; PMID:39587603 |
| GO:0044242 | Cellular lipid catabolic process | Increases phenotype | PMID:23750309; PMID:9545559 |
| GO:0044272 | Sulfur compound biosynthetic process | Increases phenotype | PMID:29116755 |
| GO:0044308 | Axonal spine | Decreases phenotype | PMID:30614199 |
| GO:0044319 | Wound healing, spreading of cells | Increases phenotype | PMID:28302721; PMID:31319114; PMID:34481905; PMID:34481905; PMID:36336208; PMID:36336208 |
| GO:0044754 | Autolysosome | Increases phenotype | PMID:34481905 |
| GO:0045023 | G0 to g1 transition | Affects phenotype | PMID:28176351; PMID:31689473 |
| GO:0045165 | Cell fate commitment | Decreases phenotype | PMID:36114956 |
| GO:0045217 | Cell-cell junction maintenance | Decreases phenotype | PMID:25882684 |
| GO:0045329 | Carnitine biosynthetic process | Increases phenotype | PMID:30529385 |
| GO:0045333 | Cellular respiration | Decreases phenotype | PMID:30973085; PMID:33038468 |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | Increases phenotype | PMID:27803291 |
| GO:0045444 | Fat cell differentiation | Increases phenotype | PMID:31793751; PMID:36453845 |
| GO:0045453 | Bone resorption | Increases phenotype | PMID:31793751 |
| GO:0045454 | Cell redox homeostasis | Decreases phenotype | PMID:28422390; PMID:30506660; PMID:30572105; PMID:32738273; PMID:37244046 |
| GO:0045653 | Negative regulation of megakaryocyte differentiation | Increases phenotype | PMID:35134237 |
| GO:0045672 | Positive regulation of osteoclast differentiation | Increases phenotype | PMID:35843418 |
| GO:0045721 | Negative regulation of gluconeogenesis | Increases phenotype | PMID:26235813 |
| GO:0045722 | Positive regulation of gluconeogenesis | Increases phenotype | PMID:38284084 |
| GO:0045723 | Positive regulation of fatty acid biosynthetic process | Increases phenotype | PMID:39701214 |
| GO:0045764 | Positive regulation of amino acid metabolic process | Increases phenotype | PMID:38241915 |
| GO:0045766 | Positive regulation of angiogenesis | Increases phenotype | PMID:32783891 |
| GO:0045792 | Negative regulation of cell size | Increases phenotype | PMID:38712533 |
| GO:0045834 | Positive regulation of lipid metabolic process | Increases phenotype | PMID:38241915 |
| GO:0045880 | Positive regulation of smoothened signaling pathway | Increases phenotype | PMID:30506660 |
| GO:0045907 | Positive regulation of vasoconstriction | Increases phenotype | PMID:32738273 |
| GO:0045912 | Negative regulation of carbohydrate metabolic process | Increases phenotype | PMID:38284084 |
| GO:0045919 | Positive regulation of cytolysis | Increases phenotype | PMID:34662668 |
| GO:0045930 | Negative regulation of mitotic cell cycle | Affects phenotype | PMID:23941782; PMID:24782466; PMID:29179951; PMID:31614173; PMID:9822662 |
| GO:0045931 | Positive regulation of mitotic cell cycle | Affects phenotype | PMID:26385184; PMID:26562325; PMID:32512071; PMID:34520792 |
| GO:0046031 | Adp metabolic process | Increases phenotype | PMID:25064450 |
| GO:0046034 | Atp metabolic process | Increases phenotype | PMID:25064450; PMID:33038468; PMID:33497711; PMID:34952138; PMID:36527706 |
| GO:0046083 | Adenine metabolic process | Affects phenotype | PMID:35301059 |
| GO:0046209 | Nitric oxide metabolic process | Increases phenotype | PMID:26070417; PMID:26089033; PMID:31639282; PMID:37336463 |
| GO:0046323 | Glucose import | Increases phenotype | PMID:30615929; PMID:34481905 |
| GO:0046325 | Negative regulation of glucose import | Increases phenotype | PMID:39701214 |
| GO:0046330 | Positive regulation of jnk cascade | Increases phenotype | PMID:23876460; PMID:24419708; PMID:24481447; PMID:27634459 |
| GO:0046415 | Urate metabolic process | Affects phenotype | PMID:29286200; PMID:35122928 |
| GO:0046449 | Creatinine metabolic process | Increases phenotype | PMID:21284339; PMID:21284339; PMID:29421648; PMID:33127495; PMID:26815315; PMID:29286200; PMID:29421648; PMID:31639282; PMID:31639282; PMID:35384154; PMID:32738273; PMID:33127495; PMID:35122928; PMID:35384154 |
| GO:0046466 | Membrane lipid catabolic process | Increases phenotype | PMID:16806632; PMID:17897638; PMID:20643113; PMID:21620867; PMID:35844137; PMID:37244046; PMID:39414706 |
| GO:0046622 | Positive regulation of organ growth | Decreases phenotype | PMID:29214744 |
| GO:0046676 | Negative regulation of insulin secretion | Increases phenotype | PMID:35172228 |
| GO:0046686 | Response to cadmium ion | Increases phenotype | PMID:23503628; PMID:37941438 |
| GO:0046722 | Lactic acid secretion | Increases phenotype | PMID:30615929; PMID:32917723; PMID:38241915 |
| GO:0046882 | Negative regulation of follicle-stimulating hormone secretion | Increases phenotype | PMID:31496657 |
| GO:0046902 | Regulation of mitochondrial membrane permeability | Affects phenotype | PMID:18956708 |
| GO:0047823 | D-glutamyltransferase activity | Increases phenotype | PMID:26260164 |
| GO:0048143 | Astrocyte activation | Increases phenotype | PMID:26396915 |
| GO:0048469 | Cell maturation | Decreases phenotype | PMID:24583143 |
| GO:0048708 | Astrocyte differentiation | Increases phenotype | PMID:33387572 |
| GO:0050665 | Hydrogen peroxide biosynthetic process | Increases phenotype | PMID:21337715; PMID:22356231; PMID:29253600 |
| GO:0050729 | Positive regulation of inflammatory response | Increases phenotype | PMID:30529385; PMID:37967787; PMID:38241915; PMID:38241915; PMID:39418721; PMID:39414706 |
| GO:0050890 | Cognition | Decreases phenotype | PMID:31626305; PMID:32735850 |
| GO:0051091 | Positive regulation of dna-binding transcription factor activity | Increases phenotype | PMID:28527916 |
| GO:0051092 | Positive regulation of nf-kappab transcription factor activity | Increases phenotype | PMID:35122928 |
| GO:0051238 | Sequestering of metal ion | Increases phenotype | PMID:27984135 |
| GO:0051280 | Negative regulation of release of sequestered calcium ion into cytosol | Increases phenotype | PMID:28666365 |
| GO:0051343 | Positive regulation of cyclic-nucleotide phosphodiesterase activity | Increases phenotype | PMID:27558804 |
| GO:0051353 | Positive regulation of oxidoreductase activity | Increases phenotype | PMID:32738273 |
| GO:0051448 | Gonadotropin-releasing hormone binding | Decreases phenotype | PMID:37972751 |
| GO:0051452 | Intracellular ph reduction | Increases phenotype | PMID:25639782 |
| GO:0051493 | Regulation of cytoskeleton organization | Increases phenotype | PMID:28527916 |
| GO:0051572 | Negative regulation of histone h3-k4 methylation | Increases phenotype | PMID:26314618 |
| GO:0051573 | Negative regulation of histone h3-k9 methylation | Increases phenotype | PMID:26314618 |
| GO:0051646 | Mitochondrion localization | Affects phenotype | PMID:33617915 |
| GO:0051881 | Regulation of mitochondrial membrane potential | Affects phenotype | PMID:18956708; PMID:23405080; PMID:25159133; PMID:27389774; PMID:30030080; PMID:32142837; PMID:33038468; PMID:33309878; PMID:33617915; PMID:34558789; PMID:34558789; PMID:36527706; PMID:34952138; PMID:36527706; PMID:39587603 |
| GO:0051882 | Mitochondrial depolarization | Increases phenotype | PMID:33497711; PMID:34481905; PMID:34767868; PMID:36527706; PMID:36731763 |
| GO:0051896 | Regulation of protein kinase b signaling | Affects phenotype | PMID:23673518 |
| GO:0051897 | Positive regulation of protein kinase b signaling | Increases phenotype | PMID:29444456 |
| GO:0051898 | Negative regulation of protein kinase b signaling | Increases phenotype | PMID:29444456 |
| GO:0051899 | Membrane depolarization | Affects phenotype | PMID:36527706 |
| GO:0051901 | Positive regulation of mitochondrial depolarization | Increases phenotype | PMID:31676320 |
| GO:0055070 | Copper ion homeostasis | Affects phenotype | PMID:37022104 |
| GO:0055071 | Manganese ion homeostasis | Affects phenotype | PMID:37022104 |
| GO:0055072 | Iron ion homeostasis | Affects phenotype | PMID:34558789; PMID:37022104 |
| GO:0055073 | Cadmium ion homeostasis | Affects phenotype | PMID:37022104 |
| GO:0055088 | Lipid homeostasis | Affects phenotype | PMID:30529385 |
| GO:0055089 | Fatty acid homeostasis | Affects phenotype | PMID:30529385 |
| GO:0060080 | Inhibitory postsynaptic potential | Decreases phenotype | PMID:26993829 |
| GO:0060218 | Hematopoietic stem cell differentiation | Decreases phenotype | PMID:29939372 |
| GO:0060242 | Contact inhibition | Decreases phenotype | PMID:27432484 |
| GO:0060278 | Regulation of ovulation | Affects phenotype | PMID:1238902 |
| GO:0060326 | Cell chemotaxis | Affects phenotype | PMID:31319114; PMID:33188856; PMID:33422613; PMID:34687772 |
| GO:0060348 | Bone development | Decreases phenotype | PMID:31793751 |
| GO:0060408 | Regulation of acetylcholine metabolic process | Affects phenotype | PMID:38241915 |
| GO:0060419 | Heart growth | Affects phenotype | PMID:35770551 |
| GO:0060437 | Lung growth | Affects phenotype | PMID:35770551 |
| GO:0060444 | Branching involved in mammary gland duct morphogenesis | Decreases phenotype | PMID:29741670 |
| GO:0060545 | Positive regulation of necroptotic process | Increases phenotype | PMID:35844137 |
| GO:0060612 | Adipose tissue development | Increases phenotype | PMID:27634282; PMID:30629257 |
| GO:0060674 | Placenta blood vessel development | Decreases phenotype | PMID:35384129; PMID:37941438 |
| GO:0060711 | Labyrinthine layer development | Increases phenotype | PMID:35770551 |
| GO:0060723 | Regulation of cell proliferation involved in embryonic placenta development | Affects phenotype | PMID:29373603 |
| GO:0060734 | Regulation of endoplasmic reticulum stress-induced eif2 alpha phosphorylation | Affects phenotype | PMID:30375035 |
| GO:0061075 | Positive regulation of neural retina development | Decreases phenotype | PMID:23680456 |
| GO:0061085 | Regulation of histone h3-k27 methylation | Affects phenotype | PMID:26562325 |
| GO:0061179 | Negative regulation of insulin secretion involved in cellular response to glucose stimulus | Increases phenotype | PMID:31348969 |
| GO:0061370 | Testosterone biosynthetic process | Decreases phenotype | PMID:22356231; PMID:29527696; PMID:29527696; PMID:31654709; PMID:36356678; PMID:29527696; PMID:36356678; PMID:31654709; PMID:32781062; PMID:35870590; PMID:36356678; PMID:37967787 |
| GO:0061564 | Axon development | Decreases phenotype | PMID:23680456 |
| GO:0061709 | Reticulophagy | Increases phenotype | PMID:24299490 |
| GO:0061739 | Protein lipidation involved in autophagosome assembly | Increases phenotype | PMID:34580807 |
| GO:0061909 | Autophagosome-lysosome fusion | Affects phenotype | PMID:25639782; PMID:31862506; PMID:34481905; PMID:34695510 |
| GO:0070091 | Glucagon secretion | Decreases phenotype | PMID:36674557 |
| GO:0070265 | Necrotic cell death | Increases phenotype | PMID:28949029; PMID:34405727; PMID:36868496 |
| GO:0070269 | Pyroptosis | Increases phenotype | PMID:26809137; PMID:30796460; PMID:37300869 |
| GO:0070328 | Triglyceride homeostasis | Decreases phenotype | PMID:33259630; PMID:37482320; PMID:38284084 |
| GO:0070341 | Fat cell proliferation | Decreases phenotype | PMID:38712533 |
| GO:0070345 | Negative regulation of fat cell proliferation | Increases phenotype | PMID:39701214 |
| GO:0070374 | Positive regulation of erk1 and erk2 cascade | Increases phenotype | PMID:23876460; PMID:24481447; PMID:27071941; PMID:27558804; PMID:28527916; PMID:32512071 |
| GO:0070507 | Regulation of microtubule cytoskeleton organization | Decreases phenotype | PMID:36928142 |
| GO:0070509 | Calcium ion import | Increases phenotype | PMID:29100878 |
| GO:0070782 | Phosphatidylserine exposure on apoptotic cell surface | Affects phenotype | PMID:24291162 |
| GO:0070994 | Detection of oxidative stress | Increases phenotype | PMID:23349044; PMID:30973085; PMID:23961183; PMID:24184865; PMID:24299490; PMID:26089033; PMID:29527696; PMID:29527696; PMID:38712533; PMID:32392679; PMID:32781062; PMID:34767868; PMID:35384154; PMID:35870590; PMID:36527706; PMID:36646412; PMID:37022104; PMID:37300854; PMID:37336463; PMID:38712533 |
| GO:0071276 | Cellular response to cadmium ion | Increases phenotype | PMID:29116755 |
| GO:0071712 | Er-associated misfolded protein catabolic process | Increases phenotype | PMID:25374377 |
| GO:0071929 | Alpha-tubulin acetylation | Decreases phenotype | PMID:29653258; PMID:30572105 |
| GO:0072520 | Seminiferous tubule development | Decreases phenotype | PMID:37972751 |
| GO:0072593 | Reactive oxygen species metabolic process | Increases phenotype | PMID:10506578; PMID:23405080; PMID:23948867; PMID:24299490; PMID:24412756; PMID:25106854; PMID:25980575; PMID:31860779; PMID:32142837; PMID:32917723; PMID:33031904; PMID:33309878; PMID:33497711; PMID:34405727; PMID:34510229; PMID:34558789; PMID:34558789; PMID:34767868; PMID:34687772; PMID:34695510; PMID:34767868; PMID:36493885; PMID:36602393; PMID:36602393; PMID:37300854; PMID:36731763; PMID:36868496; PMID:37300854; PMID:37300869; PMID:37336463; PMID:38001299; PMID:39587603 |
| GO:0072595 | Maintenance of protein localization in organelle | Affects phenotype | PMID:30030080 |
| GO:0072672 | Neutrophil extravasation | Increases phenotype | PMID:35844137; PMID:35983679; PMID:35983679 |
| GO:0072677 | Eosinophil migration | Increases phenotype | PMID:39396604 |
| GO:0080009 | Mrna methylation | Decreases phenotype | PMID:37236586 |
| GO:0080020 | Regulation of coenzyme a biosynthetic process | Increases phenotype | PMID:30529385 |
| GO:0090024 | Negative regulation of neutrophil chemotaxis | Increases phenotype | PMID:28666365 |
| GO:0090116 | C-5 methylation of cytosine | Affects phenotype | PMID:33865896 |
| GO:0090263 | Positive regulation of canonical wnt signaling pathway | Increases phenotype | PMID:28527916 |
| GO:0090303 | Positive regulation of wound healing | Increases phenotype | PMID:31120230 |
| GO:0090327 | Negative regulation of locomotion involved in locomotory behavior | Increases phenotype | PMID:30506660 |
| GO:0090398 | Cellular senescence | Increases phenotype | PMID:36493885 |
| GO:0090523 | Cytochrome-b5 reductase activity, acting on nadph | Increases phenotype | PMID:37336463 |
| GO:0097189 | Apoptotic body | Increases phenotype | PMID:33652105 |
| GO:0097202 | Activation of cysteine-type endopeptidase activity | Increases phenotype | PMID:34905088 |
| GO:0097212 | Lysosomal membrane organization | Affects phenotype | PMID:34695510 |
| GO:0097213 | Regulation of lysosomal membrane permeability | Affects phenotype | PMID:30030080; PMID:34695510 |
| GO:0097298 | Regulation of nucleus size | Affects phenotype | PMID:38712533 |
| GO:0097707 | Ferroptosis | Increases phenotype | PMID:34558789 |
| GO:0097722 | Sperm motility | Decreases phenotype | PMID:27279585; PMID:29158198; PMID:29527696; PMID:31496657; PMID:32781062; PMID:34791780; PMID:35870590; PMID:37972751 |
| GO:0099004 | Calmodulin dependent kinase signaling pathway | Increases phenotype | PMID:27558804 |
| GO:0106292 | Superoxide-generating nadph oxidase activity | Increases phenotype | PMID:32738273 |
| GO:0106295 | Resolvin biosynthetic process | Affects phenotype | PMID:34405727 |
| GO:0110081 | Negative regulation of placenta blood vessel development | Increases phenotype | PMID:29373603 |
| GO:0110090 | Positive regulation of hippocampal neuron apoptotic process | Increases phenotype | PMID:31271426 |
| GO:0120193 | Tight junction organization | Decreases phenotype | PMID:31390532 |
| GO:0140042 | Lipid droplet formation | Affects phenotype | PMID:32892022; PMID:35183672; PMID:35183672; PMID:39418721; PMID:36602393; PMID:37236586 |
| GO:0140639 | Positive regulation of pyroptosis | Increases phenotype | PMID:35650140 |
| GO:0150078 | Positive regulation of neuroinflammatory response | Increases phenotype | PMID:38595292 |
| GO:0160024 | Leydig cell proliferation | Decreases phenotype | PMID:37972751 |
| GO:1900017 | Positive regulation of cytokine production involved in inflammatory response | Increases phenotype | PMID:26396915 |
| GO:1900034 | Regulation of cellular response to heat | Affects phenotype | PMID:24291162 |
| GO:1900182 | Positive regulation of protein localization to nucleus | Increases phenotype | PMID:35122928 |
| GO:1900227 | Positive regulation of nlrp3 inflammasome complex assembly | Increases phenotype | PMID:26809137; PMID:35650140 |
| GO:1900409 | Positive regulation of cellular response to oxidative stress | Increases phenotype | PMID:30375035 |
| GO:1900745 | Positive regulation of p38mapk cascade | Increases phenotype | PMID:26396915; PMID:27634459; PMID:31152847; PMID:35122928; PMID:39778856 |
| GO:1901098 | Positive regulation of autophagosome maturation | Increases phenotype | PMID:29179951 |
| GO:1901668 | Regulation of superoxide dismutase activity | Affects phenotype | PMID:30399392 |
| GO:1901670 | Negative regulation of superoxide dismutase activity | Increases phenotype | PMID:27803291; PMID:28422390; PMID:31496657; PMID:38595292; PMID:39414706 |
| GO:1901671 | Positive regulation of superoxide dismutase activity | Affects phenotype | PMID:25409916; PMID:26070417; PMID:39701214 |
| GO:1901687 | Glutathione derivative biosynthetic process | Decreases phenotype | PMID:28422390; PMID:30606898 |
| GO:1901896 | Positive regulation of atpase-coupled calcium transmembrane transporter activity | Decreases phenotype | PMID:28721440 |
| GO:1901988 | Negative regulation of cell cycle phase transition | Increases phenotype | PMID:38174414 |
| GO:1902071 | Regulation of hypoxia-inducible factor-1alpha signaling pathway | Affects phenotype | PMID:29408318 |
| GO:1902117 | Positive regulation of organelle assembly | Increases phenotype | PMID:34580807 |
| GO:1902177 | Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | Increases phenotype | PMID:28422390 |
| GO:1902237 | Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Increases phenotype | PMID:37261864 |
| GO:1902512 | Positive regulation of apoptotic dna fragmentation | Increases phenotype | PMID:26396915 |
| GO:1902531 | Regulation of intracellular signal transduction | Affects phenotype | PMID:23135549 |
| GO:1902552 | Negative regulation of catalase activity | Increases phenotype | PMID:27803291; PMID:31496657; PMID:37244046; PMID:39414706; PMID:39701214 |
| GO:1902600 | Proton transmembrane transport | Affects phenotype | PMID:33038468 |
| GO:1902893 | Regulation of mirna transcription | Affects phenotype | PMID:35525383 |
| GO:1902943 | Positive regulation of voltage-gated chloride channel activity | Decreases phenotype | PMID:12843258 |
| GO:1903047 | Mitotic cell cycle process | Affects phenotype | PMID:29502740; PMID:31468104 |
| GO:1903283 | Negative regulation of glutathione peroxidase activity | Increases phenotype | PMID:27803291; PMID:31496657; PMID:37244046 |
| GO:1903284 | Positive regulation of glutathione peroxidase activity | Increases phenotype | PMID:25409916 |
| GO:1903303 | Negative regulation of pyruvate kinase activity | Increases phenotype | PMID:26235813 |
| GO:1903409 | Reactive oxygen species biosynthetic process | Increases phenotype | PMID:18548748; PMID:25993096; PMID:26663770; PMID:27389774; PMID:29158198; PMID:29179951; PMID:30359721; PMID:30796935; PMID:31433112; PMID:35844137 |
| GO:1903428 | Positive regulation of reactive oxygen species biosynthetic process | Increases phenotype | PMID:24782466; PMID:25409916; PMID:26365678; PMID:26365678; PMID:28422390; PMID:26809137; PMID:27599793; PMID:28110594; PMID:28422390; PMID:29408318; PMID:29444456; PMID:29486218; PMID:30399392; PMID:30506660; PMID:31120230; PMID:31676320; PMID:32738273; PMID:35122928; PMID:35650140; PMID:37967787; PMID:38185225; PMID:38595292; PMID:39701214; PMID:39778856 |
| GO:1903537 | Meiotic cell cycle process involved in oocyte maturation | Decreases phenotype | PMID:29287790 |
| GO:1903580 | Positive regulation of atp metabolic process | Increases phenotype | PMID:26235813 |
| GO:1903787 | Negative regulation of glutathione biosynthetic process | Increases phenotype | PMID:38595292; PMID:39414706 |
| GO:1903788 | Positive regulation of glutathione biosynthetic process | Increases phenotype | PMID:29486218 |
| GO:1903999 | Negative regulation of eating behavior | Increases phenotype | PMID:32738273 |
| GO:1904141 | Positive regulation of microglial cell migration | Increases phenotype | PMID:38595292 |
| GO:1904179 | Positive regulation of adipose tissue development | Increases phenotype | PMID:27814245 |
| GO:1904230 | Negative regulation of succinate dehydrogenase activity | Increases phenotype | PMID:27803291 |
| GO:1904445 | Negative regulation of establishment of sertoli cell barrier | Increases phenotype | PMID:38565259 |
| GO:1904598 | Positive regulation of connective tissue replacement involved in inflammatory response wound healing | Increases phenotype | PMID:39938575 |
| GO:1904659 | Glucose transmembrane transport | Increases phenotype | PMID:39427783 |
| GO:1905037 | Autophagosome organization | Increases phenotype | PMID:34695510 |
| GO:1905075 | Positive regulation of tight junction disassembly | Increases phenotype | PMID:36928142; PMID:39722890 |
| GO:1905146 | Lysosomal protein catabolic process | Decreases phenotype | PMID:34695510 |
| GO:1905220 | Negative regulation of platelet formation | Increases phenotype | PMID:35134237 |
| GO:1905376 | Negative regulation of cytochrome-c oxidase activity | Increases phenotype | PMID:27803291 |
| GO:1905517 | Macrophage migration | Increases phenotype | PMID:39396604 |
| GO:1905523 | Positive regulation of macrophage migration | Increases phenotype | PMID:38565259 |
| GO:1905643 | Positive regulation of dna methylation | Increases phenotype | PMID:27984135 |
| GO:1905898 | Positive regulation of response to endoplasmic reticulum stress | Increases phenotype | PMID:29444456; PMID:30375035; PMID:37261864 |
| GO:1990266 | Neutrophil migration | Increases phenotype | PMID:39396604 |
| GO:1990349 | Gap junction-mediated intercellular transport | Increases phenotype | PMID:29444456 |
| GO:2000052 | Positive regulation of non-canonical wnt signaling pathway | Affects phenotype | PMID:29939372 |
| GO:2000134 | Negative regulation of g1/s transition of mitotic cell cycle | Increases phenotype | PMID:24782466; PMID:28651161 |
| GO:2000225 | Negative regulation of testosterone biosynthetic process | Increases phenotype | PMID:37972751 |
| GO:2000324 | Positive regulation of glucocorticoid receptor signaling pathway | Increases phenotype | PMID:2298732 |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | Affects phenotype | PMID:24291162 |
| GO:2000386 | Positive regulation of ovarian follicle development | Decreases phenotype | PMID:28801138 |
| GO:2000390 | Negative regulation of neutrophil extravasation | Increases phenotype | PMID:28666365 |
| GO:2000409 | Positive regulation of t cell extravasation | Increases phenotype | PMID:39418721 |
| GO:2000774 | Positive regulation of cellular senescence | Increases phenotype | PMID:24782466 |
| GO:2000786 | Positive regulation of autophagosome assembly | Increases phenotype | PMID:34580807 |
| GO:2000838 | Negative regulation of androstenedione secretion | Increases phenotype | PMID:29214744 |
| GO:2000844 | Negative regulation of testosterone secretion | Increases phenotype | PMID:29214744; PMID:31496657; PMID:31496657; PMID:32497820; PMID:37482142 |
| GO:2000845 | Positive regulation of testosterone secretion | Decreases phenotype | PMID:25981801 |
| GO:2000870 | Regulation of progesterone secretion | Affects phenotype | PMID:29214744 |
| GO:2000872 | Positive regulation of progesterone secretion | Increases phenotype | PMID:32892022 |
| GO:2001022 | Positive regulation of response to dna damage stimulus | Increases phenotype | PMID:37451666 |
| GO:2001046 | Positive regulation of integrin-mediated signaling pathway | Increases phenotype | PMID:28527916 |
| GO:2001057 | Reactive nitrogen species metabolic process | Affects phenotype | PMID:31639282; PMID:37336463 |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | Affects phenotype | PMID:24291162 |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | Affects phenotype | PMID:24291162 |
| GO:2001279 | Regulation of unsaturated fatty acid biosynthetic process | Decreases phenotype | PMID:37482320 |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.