2,4,5,2',4',5'-Hexachlorobiphenyl


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000723 Telomere maintenance Affects phenotype PMID:33022284
GO:0001573 Ganglioside metabolic process Affects phenotype PMID:34627992
GO:0001755 Neural crest cell migration Decreases phenotype PMID:26238599
GO:0002440 Production of molecular mediator of immune response Increases phenotype PMID:18995849
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:24726520
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:24726520
GO:0005243 Gap junction channel activity Decreases phenotype PMID:26023933
GO:0006119 Oxidative phosphorylation Increases phenotype PMID:34311058
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:33677009
GO:0006306 Dna methylation Decreases phenotype PMID:20064773
GO:0006325 Chromatin organization Affects phenotype PMID:15687046
GO:0006670 Sphingosine metabolic process Affects phenotype PMID:34627992
GO:0006749 Glutathione metabolic process Affects phenotype PMID:32352317
GO:0006879 Cellular iron ion homeostasis Decreases phenotype PMID:25686467
GO:0006897 Endocytosis Increases phenotype PMID:26141388
GO:0006898 Receptor-mediated endocytosis Increases phenotype PMID:29329451
GO:0006915 Apoptotic process Increases phenotype PMID:15201435; PMID:24954032
GO:0006973 Intracellular accumulation of glycerol Increases phenotype PMID:39793953
GO:0007005 Mitochondrion organization Increases phenotype PMID:34311058
GO:0007173 Epidermal growth factor receptor signaling pathway Increases phenotype PMID:29329451
GO:0007283 Spermatogenesis Decreases phenotype PMID:15687046; PMID:20137407
GO:0007612 Learning Affects phenotype PMID:32521479
GO:0007616 Long-term memory Decreases phenotype PMID:26480858
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:23756648
GO:0008210 Estrogen metabolic process Affects phenotype PMID:34929288
GO:0008219 Cell death Increases phenotype PMID:30075218
GO:0008283 Cell population proliferation Increases phenotype PMID:15201435; PMID:24726520; PMID:25659934; PMID:38185387
GO:0009749 Response to glucose Decreases phenotype PMID:29175711
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:39793953
GO:0010918 Positive regulation of mitochondrial membrane potential Increases phenotype PMID:34311058
GO:0014046 Dopamine secretion Affects phenotype PMID:29233657
GO:0016049 Cell growth Decreases phenotype PMID:29704545
GO:0016477 Cell migration Increases phenotype PMID:33571556
GO:0019432 Triglyceride biosynthetic process Affects phenotype PMID:23756648; PMID:28433925; PMID:30722647
GO:0019766 Iga receptor activity Decreases phenotype PMID:26649893
GO:0019770 Igg receptor activity Decreases phenotype PMID:26649893
GO:0030218 Erythrocyte differentiation Affects phenotype PMID:32352317
GO:0030224 Monocyte differentiation Increases phenotype PMID:26330309
GO:0030851 Granulocyte differentiation Increases phenotype PMID:26330309
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35413382
GO:0032204 Regulation of telomere maintenance Affects phenotype PMID:32300848
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25686467
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:19750101
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:29233657
GO:0042420 Dopamine catabolic process Increases phenotype PMID:26215117; PMID:29233657
GO:0042429 Serotonin catabolic process Increases phenotype PMID:26215117
GO:0042445 Hormone metabolic process Affects phenotype PMID:17938741
GO:0042448 Progesterone metabolic process Affects phenotype PMID:34929288
GO:0042701 Progesterone secretion Affects phenotype PMID:34311058
GO:0044027 Hypermethylation of cpg island Affects phenotype PMID:25585924
GO:0044237 Cellular metabolic process Affects phenotype PMID:34311058; PMID:34929288
GO:0044255 Cellular lipid metabolic process Increases phenotype PMID:24978599
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:30821169
GO:0046034 Atp metabolic process Affects phenotype PMID:34311058
GO:0046323 Glucose import Decreases phenotype PMID:34311058
GO:0046513 Ceramide biosynthetic process Affects phenotype PMID:34627992
GO:0048589 Developmental growth Decreases phenotype PMID:21851983; PMID:25742056
GO:0050890 Cognition Increases phenotype PMID:28270159
GO:0060326 Cell chemotaxis Affects phenotype PMID:33571556; PMID:38185387
GO:0060443 Mammary gland morphogenesis Affects phenotype PMID:26903627
GO:0061028 Establishment of endothelial barrier Decreases phenotype PMID:33571556
GO:0070341 Fat cell proliferation Increases phenotype PMID:25909471
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:29329451
GO:0070994 Detection of oxidative stress Increases phenotype PMID:25659934
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30821169
GO:1990349 Gap junction-mediated intercellular transport Decreases phenotype PMID:35413382
GO:2000045 Regulation of g1/s transition of mitotic cell cycle Affects phenotype PMID:26330309
GO:2000253 Positive regulation of feeding behavior Increases phenotype PMID:32784060
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.