Apigenin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001516 Prostaglandin biosynthetic process Affects phenotype PMID:16552572
GO:0001525 Angiogenesis Decreases phenotype PMID:35513012
GO:0002232 Leukocyte chemotaxis involved in inflammatory response Increases phenotype PMID:25935278
GO:0002296 T-helper 1 cell lineage commitment Decreases phenotype PMID:36350155
GO:0002297 T-helper 2 cell lineage commitment Increases phenotype PMID:36350155
GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response Increases phenotype PMID:36350155
GO:0002441 Histamine secretion involved in inflammatory response Increases phenotype PMID:36350155
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:28422384
GO:0003376 Sphingosine-1-phosphate receptor signaling pathway Increases phenotype PMID:25557508
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33845614
GO:0004096 Catalase activity Decreases phenotype PMID:37730986
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:28389404
GO:0004407 Histone deacetylase activity Decreases phenotype PMID:26872304
GO:0004449 Isocitrate dehydrogenase (nad+) activity Decreases phenotype PMID:26961604
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:35373622
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:28025107; PMID:28389404; PMID:33845614
GO:0004705 Jun kinase activity Increases phenotype PMID:28025107
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:28389404; PMID:35373622; PMID:37730986
GO:0005388 P-type calcium transporter activity Decreases phenotype PMID:28389404
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:28389404
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:29247770
GO:0006749 Glutathione metabolic process Increases phenotype PMID:30152906; PMID:31201582; PMID:35500696; PMID:37730986
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:28389404; PMID:28803762
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:28389404
GO:0006914 Autophagy Decreases phenotype PMID:29191453
GO:0006915 Apoptotic process Increases phenotype PMID:15670648; PMID:19142175; PMID:19885610; PMID:20493918; PMID:24148603; PMID:26408079; PMID:29191453; PMID:29247770
GO:0006979 Response to oxidative stress Increases phenotype PMID:20493918; PMID:24070738
GO:0007049 Cell cycle Decreases phenotype PMID:15670648; PMID:19142175
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:25557508
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:28389404
GO:0008219 Cell death Increases phenotype PMID:28389404
GO:0008283 Cell population proliferation Decreases phenotype PMID:19142175; PMID:19142175; PMID:24148603; PMID:19885610; PMID:19958256; PMID:24144774; PMID:24148603; PMID:25058688; PMID:26872304; PMID:29191453; PMID:29247770
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:28396216; PMID:31930969
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30152906; PMID:35500696; PMID:36350155
GO:0008306 Associative learning Increases phenotype PMID:24284476
GO:0008343 Adult feeding behavior Affects phenotype PMID:30107153
GO:0008637 Apoptotic mitochondrial changes Increases phenotype PMID:24120900
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:30152906; PMID:31930969
GO:0010942 Positive regulation of cell death Decreases phenotype PMID:22683914
GO:0010976 Positive regulation of neuron projection development Increases phenotype PMID:28396216
GO:0016042 Lipid catabolic process Increases phenotype PMID:28025107; PMID:28389404; PMID:28803762
GO:0016477 Cell migration Affects phenotype PMID:15231453; PMID:26408079; PMID:30016632
GO:0018108 Peptidyl-tyrosine phosphorylation Increases phenotype PMID:19814731
GO:0030218 Erythrocyte differentiation Increases phenotype PMID:25058688
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:31930969
GO:0030335 Positive regulation of cell migration Decreases phenotype PMID:27468969
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:37437745
GO:0031334 Positive regulation of protein-containing complex assembly Increases phenotype PMID:29960001
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:35373622
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:27468969
GO:0032464 Positive regulation of protein homooligomerization Increases phenotype PMID:29960001
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:28396216
GO:0034440 Lipid oxidation Affects phenotype PMID:28422384; PMID:30152906; PMID:35500696; PMID:37730986
GO:0034614 Cellular response to reactive oxygen species Decreases phenotype PMID:22683914
GO:0035148 Tube formation Decreases phenotype PMID:35513012
GO:0036164 Cell-abiotic substrate adhesion Decreases phenotype PMID:35513012
GO:0036343 Psychomotor behavior Affects phenotype PMID:28389404
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:31930969
GO:0042118 Endothelial cell activation Increases phenotype PMID:17313705
GO:0042133 Neurotransmitter metabolic process Affects phenotype PMID:35373622
GO:0042161 Lipoprotein oxidation Increases phenotype PMID:17313705
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:24070738; PMID:28422384; PMID:30152906; PMID:36350155; PMID:37437745
GO:0043123 Positive regulation of i-kappab kinase/nf-kappab signaling Increases phenotype PMID:30152906
GO:0043217 Myelin maintenance Affects phenotype PMID:35373622
GO:0043966 Histone h3 acetylation Increases phenotype PMID:26872304
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31412289; PMID:36055550; PMID:37730986
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:35513012
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:30152906
GO:0045823 Positive regulation of heart contraction Increases phenotype PMID:31930969
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:26872304; PMID:26961604
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:37390879; PMID:37730986
GO:0046323 Glucose import Affects phenotype PMID:35151640
GO:0046325 Negative regulation of glucose import Increases phenotype PMID:37437745
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:25557508
GO:0046415 Urate metabolic process Affects phenotype PMID:30107153
GO:0046449 Creatinine metabolic process Affects phenotype PMID:30107153; PMID:33845614
GO:0046961 Proton-transporting atpase activity, rotational mechanism Decreases phenotype PMID:10882397
GO:0050890 Cognition Affects phenotype PMID:35373622
GO:0050905 Neuromuscular process Decreases phenotype PMID:35373622
GO:0051092 Positive regulation of nf-kappab transcription factor activity Decreases phenotype PMID:22683914
GO:0051209 Release of sequestered calcium ion into cytosol Increases phenotype PMID:19814731
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:20493918; PMID:30107153
GO:0055072 Iron ion homeostasis Decreases phenotype PMID:35500696
GO:0060326 Cell chemotaxis Decreases phenotype PMID:35513012
GO:0061368 Behavioral response to formalin induced pain Increases phenotype PMID:28422384
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30591588
GO:0070265 Necrotic cell death Increases phenotype PMID:35513012
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:25557508
GO:0070527 Platelet aggregation Increases phenotype PMID:19814731
GO:0070994 Detection of oxidative stress Affects phenotype PMID:33845614; PMID:35373622
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24070738; PMID:24120900; PMID:36055550; PMID:37730986
GO:0072682 Eosinophil extravasation Increases phenotype PMID:36350155
GO:0097193 Intrinsic apoptotic signaling pathway Increases phenotype PMID:31930969
GO:0098609 Cell-cell adhesion Increases phenotype PMID:17313705
GO:0160020 Positive regulation of ferroptosis Increases phenotype PMID:35500696
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:36350155
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:29960001
GO:1900745 Positive regulation of p38mapk cascade Affects phenotype PMID:22683914; PMID:25557508
GO:1901224 Positive regulation of nik/nf-kappab signaling Decreases phenotype PMID:22683914
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30152906; PMID:35500696
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:28422384
GO:1901687 Glutathione derivative biosynthetic process Increases phenotype PMID:10647909
GO:1902459 Positive regulation of stem cell population maintenance Decreases phenotype PMID:27468969
GO:1902512 Positive regulation of apoptotic dna fragmentation Affects phenotype PMID:24070738
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:30152906
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:19958256; PMID:29247770
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:30152906; PMID:35500696
GO:1903595 Positive regulation of histamine secretion by mast cell Increases phenotype PMID:36350155
GO:1903709 Uterine gland development Increases phenotype PMID:24487097
GO:1904404 Response to formaldehyde Decreases phenotype PMID:28422384
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:29960001
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:29960001
GO:2000648 Positive regulation of stem cell proliferation Decreases phenotype PMID:27468969
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.