Genistein


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:33347704
GO:0000087 Mitotic m phase Decreases phenotype PMID:31593742
GO:0000165 Mapk cascade Increases phenotype PMID:9371707
GO:0000255 Allantoin metabolic process Affects phenotype PMID:39954026
GO:0001503 Ossification Increases phenotype PMID:24872432
GO:0001516 Prostaglandin biosynthetic process Affects phenotype PMID:21341175; PMID:25447760
GO:0001541 Ovarian follicle development Affects phenotype PMID:31747621
GO:0001547 Antral ovarian follicle growth Decreases phenotype PMID:26792615
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:31747621
GO:0001556 Oocyte maturation Increases phenotype PMID:30266436
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:24872432
GO:0001824 Blastocyst development Affects phenotype PMID:22553218
GO:0002639 Positive regulation of immunoglobulin production Affects phenotype PMID:22553218
GO:0002830 Positive regulation of type 2 immune response Increases phenotype PMID:32798538
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:35986755
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28552514
GO:0004402 Histone acetyltransferase activity Decreases phenotype PMID:30684530
GO:0004407 Histone deacetylase activity Increases phenotype PMID:30684530
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:28552514; PMID:29328408
GO:0004672 Protein kinase activity Decreases phenotype PMID:10556937
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:28552514; PMID:29259978; PMID:29328408
GO:0004972 Nmda glutamate receptor activity Increases phenotype PMID:27238724
GO:0006012 Galactose metabolic process Affects phenotype PMID:39954026
GO:0006020 Inositol metabolic process Affects phenotype PMID:39954026
GO:0006089 Lactate metabolic process Affects phenotype PMID:23333575; PMID:39954026
GO:0006108 Malate metabolic process Affects phenotype PMID:39954026
GO:0006304 Dna modification Increases phenotype PMID:10647909
GO:0006306 Dna methylation Increases phenotype PMID:27539829
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:11093795; PMID:12791511; PMID:19723084
GO:0006355 Regulation of dna-templated transcription Increases phenotype PMID:32827888
GO:0006357 Regulation of transcription by rna polymerase ii Increases phenotype PMID:27478869
GO:0006520 Amino acid metabolic process Affects phenotype PMID:39954026
GO:0006629 Lipid metabolic process Affects phenotype PMID:39954026
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:39954026
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:34942354
GO:0006695 Cholesterol biosynthetic process Increases phenotype PMID:31747621
GO:0006701 Progesterone biosynthetic process Increases phenotype PMID:26792615
GO:0006703 Estrogen biosynthetic process Decreases phenotype PMID:26792615
GO:0006711 Estrogen catabolic process Increases phenotype PMID:28985473
GO:0006743 Ubiquinone metabolic process Affects phenotype PMID:39954026
GO:0006749 Glutathione metabolic process Increases phenotype PMID:21205217; PMID:24967385; PMID:28688900; PMID:29259978; PMID:34214573
GO:0006750 Glutathione biosynthetic process Affects phenotype PMID:23295412; PMID:25620059; PMID:28259689; PMID:28552514
GO:0006805 Xenobiotic metabolic process Increases phenotype PMID:29162470
GO:0006809 Nitric oxide biosynthetic process Affects phenotype PMID:25447760
GO:0006811 Monoatomic ion transport Increases phenotype PMID:18651719
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:21205217
GO:0006915 Apoptotic process Increases phenotype PMID:10572627; PMID:11093795; PMID:11377554; PMID:12791511; PMID:15896711; PMID:15907805; PMID:24884420; PMID:25620059; PMID:27876602; PMID:26797587; PMID:27238724; PMID:29259978; PMID:33347704; PMID:9247148; PMID:9677421
GO:0006954 Inflammatory response Affects phenotype PMID:29982808
GO:0006955 Immune response Affects phenotype PMID:22553218
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:33347704
GO:0006979 Response to oxidative stress Increases phenotype PMID:15896711; PMID:23333575
GO:0007009 Plasma membrane organization Affects phenotype PMID:21205217
GO:0007049 Cell cycle Decreases phenotype PMID:12791511; PMID:18444173
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:23363563
GO:0007267 Cell-cell signaling Decreases phenotype PMID:11488454
GO:0007283 Spermatogenesis Decreases phenotype PMID:28938591; PMID:29328408; PMID:32827888
GO:0007346 Regulation of mitotic cell cycle Affects phenotype PMID:22228119
GO:0007566 Embryo implantation Decreases phenotype PMID:32186404
GO:0008202 Steroid metabolic process Affects phenotype PMID:39954026
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:39954026
GO:0008216 Spermidine metabolic process Affects phenotype PMID:39954026
GO:0008219 Cell death Increases phenotype PMID:24685904; PMID:26797587; PMID:30468814
GO:0008283 Cell population proliferation Increases phenotype PMID:10376965; PMID:12791511; PMID:15896711; PMID:18025287; PMID:18444173; PMID:21513275; PMID:19549922; PMID:19723084; PMID:21513275; PMID:21513275; PMID:24299158; PMID:21513275; PMID:9381980; PMID:22649256; PMID:24062438; PMID:24213142; PMID:27026707; PMID:28763032; PMID:24213142; PMID:24884420; PMID:25447760; PMID:25462787; PMID:25756279; PMID:27026707; PMID:28855101; PMID:29259978; PMID:29624291; PMID:30684530; PMID:32926937; PMID:7588483; PMID:9381980
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:23756170; PMID:25661160; PMID:26768552; PMID:28396216; PMID:35307500
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:22228119; PMID:23526725; PMID:29899271
GO:0008584 Male gonad development Affects phenotype PMID:23959011; PMID:29328408
GO:0009008 Dna-methyltransferase activity Increases phenotype PMID:30684530
GO:0009308 Amine metabolic process Affects phenotype PMID:39954026
GO:0009812 Flavonoid metabolic process Affects phenotype PMID:38729284; PMID:39842396
GO:0010694 Positive regulation of alkaline phosphatase activity Increases phenotype PMID:24102669
GO:0010712 Regulation of collagen metabolic process Affects phenotype PMID:21704028
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:25144547
GO:0010942 Positive regulation of cell death Affects phenotype PMID:23452621
GO:0010976 Positive regulation of neuron projection development Increases phenotype PMID:28396216
GO:0016042 Lipid catabolic process Increases phenotype PMID:28259689; PMID:28552514; PMID:30734460
GO:0016477 Cell migration Increases phenotype PMID:26407941
GO:0016887 Atp hydrolysis activity Increases phenotype PMID:34217736
GO:0017015 Regulation of transforming growth factor beta receptor signaling pathway Affects phenotype PMID:22228119
GO:0019472 4-hydroxyproline biosynthetic process Affects phenotype PMID:21704028
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:39954026
GO:0019860 Uracil metabolic process Affects phenotype PMID:39954026
GO:0030036 Actin cytoskeleton organization Affects phenotype PMID:32963737
GO:0030154 Cell differentiation Increases phenotype PMID:7588483
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:28552514
GO:0030520 Intracellular estrogen receptor signaling pathway Increases phenotype PMID:24284790; PMID:36513145
GO:0031175 Neuron projection development Increases phenotype PMID:25048912
GO:0031941 Filamentous actin Affects phenotype PMID:32963737
GO:0032088 Negative regulation of nf-kappab transcription factor activity Affects phenotype PMID:23452621
GO:0032148 Activation of protein kinase b activity Increases phenotype PMID:29217487
GO:0032310 Prostaglandin secretion Affects phenotype PMID:34942354
GO:0033146 Regulation of intracellular estrogen receptor signaling pathway Affects phenotype PMID:26865669
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:23756170; PMID:25661160; PMID:26139245; PMID:28396216
GO:0033993 Response to lipid Decreases phenotype PMID:27171397
GO:0034440 Lipid oxidation Increases phenotype PMID:10647909; PMID:24967385; PMID:28688900; PMID:29259978; PMID:29328408; PMID:34214573
GO:0034504 Protein localization to nucleus Increases phenotype PMID:21704028
GO:0034614 Cellular response to reactive oxygen species Decreases phenotype PMID:22683914
GO:0035176 Social behavior Affects phenotype PMID:32297422
GO:0035847 Uterine epithelium development Increases phenotype PMID:24487097
GO:0035936 Testosterone secretion Affects phenotype PMID:35722060
GO:0035938 Estradiol secretion Increases phenotype PMID:31747621
GO:0036211 Protein modification process Increases phenotype PMID:27876602; PMID:30734460; PMID:34214573
GO:0036474 Cell death in response to hydrogen peroxide Affects phenotype PMID:23526725
GO:0040016 Embryonic cleavage Affects phenotype PMID:22553218
GO:0042054 Histone methyltransferase activity Decreases phenotype PMID:29899271
GO:0042360 Vitamin e metabolic process Affects phenotype PMID:39954026
GO:0042415 Norepinephrine metabolic process Affects phenotype PMID:39954026
GO:0042431 Indole metabolic process Affects phenotype PMID:39954026
GO:0042445 Hormone metabolic process Affects phenotype PMID:39954026
GO:0042552 Myelination Decreases phenotype PMID:30468814
GO:0042554 Superoxide anion generation Increases phenotype PMID:10708546; PMID:10708546; PMID:9437538
GO:0042632 Cholesterol homeostasis Decreases phenotype PMID:27171397
GO:0042853 L-alanine catabolic process Affects phenotype PMID:23333575
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:23363563; PMID:25144547; PMID:25756279; PMID:26768552; PMID:29899271
GO:0043124 Negative regulation of i-kappab kinase/nf-kappab signaling Affects phenotype PMID:23452621
GO:0043406 Positive regulation of map kinase activity Increases phenotype PMID:23363563
GO:0043410 Positive regulation of mapk cascade Increases phenotype PMID:23363563
GO:0043603 Amide metabolic process Affects phenotype PMID:39954026
GO:0043966 Histone h3 acetylation Increases phenotype PMID:26768552
GO:0043970 Histone h3-k9 acetylation Decreases phenotype PMID:30684530
GO:0043973 Histone h3-k4 acetylation Decreases phenotype PMID:30684530
GO:0044237 Cellular metabolic process Decreases phenotype PMID:21205217; PMID:31201582; PMID:33347704; PMID:33396024; PMID:34942354; PMID:35986755
GO:0044319 Wound healing, spreading of cells Affects phenotype PMID:33396024
GO:0044553 Modulation of biological quality in another organism Increases phenotype PMID:32827888
GO:0045023 G0 to g1 transition Affects phenotype PMID:33347704
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:15832817
GO:0045444 Fat cell differentiation Affects phenotype PMID:21877759; PMID:30920877
GO:0045793 Positive regulation of cell size Increases phenotype PMID:24361872
GO:0045930 Negative regulation of mitotic cell cycle Affects phenotype PMID:31593742
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:35307500
GO:0046108 Uridine metabolic process Affects phenotype PMID:39954026
GO:0046110 Xanthine metabolic process Affects phenotype PMID:39954026
GO:0046326 Positive regulation of glucose import Decreases phenotype PMID:25719685
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:29217487; PMID:32186404
GO:0046697 Decidualization Increases phenotype PMID:32186404
GO:0046827 Positive regulation of protein export from nucleus Increases phenotype PMID:27393035; PMID:28688900
GO:0046961 Proton-transporting atpase activity, rotational mechanism Decreases phenotype PMID:10882397
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:24872432
GO:0050679 Positive regulation of epithelial cell proliferation Increases phenotype PMID:26260748
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:18499367
GO:0050731 Positive regulation of peptidyl-tyrosine phosphorylation Increases phenotype PMID:10025724
GO:0050916 Sensory perception of sweet taste Affects phenotype PMID:23410115
GO:0051091 Positive regulation of dna-binding transcription factor activity Increases phenotype PMID:22387535; PMID:29688519
GO:0051092 Positive regulation of nf-kappab transcription factor activity Affects phenotype PMID:15832817; PMID:22683914
GO:0051209 Release of sequestered calcium ion into cytosol Increases phenotype PMID:19814731
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:29899271
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:21205217; PMID:33347704
GO:0052697 Xenobiotic glucuronidation Increases phenotype PMID:23333575
GO:0055001 Muscle cell development Decreases phenotype PMID:24361872
GO:0060135 Maternal process involved in female pregnancy Affects phenotype PMID:22553218
GO:0060206 Estrous cycle phase Affects phenotype PMID:31747621
GO:0060209 Estrus Affects phenotype PMID:28964809; PMID:31747621
GO:0060210 Metestrus Affects phenotype PMID:28964809
GO:0060444 Branching involved in mammary gland duct morphogenesis Increases phenotype PMID:27178563
GO:0060526 Prostate glandular acinus morphogenesis Affects phenotype PMID:26260748
GO:0060612 Adipose tissue development Increases phenotype PMID:24361872
GO:0060741 Prostate gland stromal morphogenesis Affects phenotype PMID:26260748
GO:0060754 Positive regulation of mast cell chemotaxis Increases phenotype PMID:25031359
GO:0060763 Mammary duct terminal end bud growth Increases phenotype PMID:27178563
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:23959011; PMID:26792615
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30591588
GO:0070063 Rna polymerase binding Decreases phenotype PMID:30684530
GO:0070265 Necrotic cell death Increases phenotype PMID:28552514; PMID:29259978
GO:0070327 Thyroid hormone transport Decreases phenotype PMID:28119167
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:27171397
GO:0070343 White fat cell proliferation Increases phenotype PMID:24361872
GO:0070527 Platelet aggregation Increases phenotype PMID:19814731
GO:0071364 Cellular response to epidermal growth factor stimulus Decreases phenotype PMID:22387535
GO:0071391 Cellular response to estrogen stimulus Increases phenotype PMID:24284790
GO:0071456 Cellular response to hypoxia Affects phenotype PMID:23452621
GO:0071479 Cellular response to ionizing radiation Affects phenotype PMID:23452621
GO:0071625 Vocalization behavior Affects phenotype PMID:32297422
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:21205217; PMID:24491678; PMID:29259978
GO:0090240 Positive regulation of histone h4 acetylation Increases phenotype PMID:26768552
GO:0090398 Cellular senescence Increases phenotype PMID:31593742
GO:0140042 Lipid droplet formation Increases phenotype PMID:30920877
GO:1900086 Positive regulation of peptidyl-tyrosine autophosphorylation Increases phenotype PMID:22387535
GO:1900409 Positive regulation of cellular response to oxidative stress Affects phenotype PMID:23333575
GO:1900745 Positive regulation of p38mapk cascade Decreases phenotype PMID:22683914
GO:1901224 Positive regulation of nik/nf-kappab signaling Decreases phenotype PMID:22683914; PMID:23452621
GO:1901554 Response to paracetamol Decreases phenotype PMID:23333575
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:28688900
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:10647909; PMID:24967385; PMID:25144547; PMID:25448286
GO:1901687 Glutathione derivative biosynthetic process Increases phenotype PMID:10647909
GO:1901726 Negative regulation of histone deacetylase activity Increases phenotype PMID:29899271
GO:1901991 Negative regulation of mitotic cell cycle phase transition Increases phenotype PMID:29899271
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:33347704
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:28688900
GO:1903284 Positive regulation of glutathione peroxidase activity Decreases phenotype PMID:10647909; PMID:24967385; PMID:25448286
GO:1903409 Reactive oxygen species biosynthetic process Affects phenotype PMID:11896666; PMID:20673057; PMID:26797587; PMID:30734460
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25144547; PMID:28688900
GO:1903709 Uterine gland development Affects phenotype PMID:24487097; PMID:29217487; PMID:32186404
GO:1903721 Positive regulation of i-kappab phosphorylation Affects phenotype PMID:23452621
GO:1903762 Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Increases phenotype PMID:17303647
GO:1903925 Response to bisphenol a Affects phenotype PMID:27178563
GO:2000225 Negative regulation of testosterone biosynthetic process Increases phenotype PMID:32827888
GO:2000421 Positive regulation of eosinophil extravasation Increases phenotype PMID:32798538
GO:2000424 Positive regulation of eosinophil chemotaxis Increases phenotype PMID:32798538
GO:2000519 Positive regulation of t-helper 1 cell activation Increases phenotype PMID:18499367
GO:2000556 Positive regulation of t-helper 1 cell cytokine production Increases phenotype PMID:18499367
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:25144547
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:32566080
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:26316063
GO:2000866 Positive regulation of estradiol secretion Decreases phenotype PMID:28964809
GO:2000872 Positive regulation of progesterone secretion Decreases phenotype PMID:28964809
GO:2001025 Positive regulation of response to drug Increases phenotype PMID:32798538
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.