Zearalenone


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000240 Diplotene Decreases phenotype PMID:28552778
GO:0001544 Initiation of primordial ovarian follicle growth Decreases phenotype PMID:28089945
GO:0001551 Ovarian follicle endowment Decreases phenotype PMID:28552778
GO:0001675 Acrosome assembly Decreases phenotype PMID:31419471
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:24530352; PMID:30600648
GO:0001890 Placenta development Affects phenotype PMID:32858132
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:39053873
GO:0003993 Acid phosphatase activity Decreases phenotype PMID:34723416
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:31733320; PMID:34723416; PMID:35986755
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:36161741; PMID:36161741; PMID:39053873; PMID:39053873
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:25682699; PMID:34723416
GO:0004457 Lactate dehydrogenase activity Decreases phenotype PMID:34723416
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:25682699; PMID:34723416; PMID:35090964
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:17385802; PMID:26231423; PMID:34723416; PMID:35090964
GO:0005243 Gap junction channel activity Decreases phenotype PMID:27473017
GO:0006089 Lactate metabolic process Affects phenotype PMID:39053873
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:14580790
GO:0006497 Protein lipidation Increases phenotype PMID:31982503
GO:0006629 Lipid metabolic process Affects phenotype PMID:38159578
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:26231423
GO:0006650 Glycerophospholipid metabolic process Affects phenotype PMID:34537261
GO:0006703 Estrogen biosynthetic process Increases phenotype PMID:29627501
GO:0006749 Glutathione metabolic process Affects phenotype PMID:28477956; PMID:34723416
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:17385802; PMID:25682699
GO:0006754 Atp biosynthetic process Increases phenotype PMID:25058043
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:31982503
GO:0006915 Apoptotic process Increases phenotype PMID:14580790; PMID:24530352; PMID:27757495; PMID:27862621; PMID:30600648; PMID:35090964
GO:0006954 Inflammatory response Increases phenotype PMID:35090964; PMID:38159578
GO:0006979 Response to oxidative stress Affects phenotype PMID:24412706
GO:0007029 Endoplasmic reticulum organization Affects phenotype PMID:35504548
GO:0007030 Golgi organization Affects phenotype PMID:35504548
GO:0007033 Vacuole organization Increases phenotype PMID:39053873
GO:0007049 Cell cycle Decreases phenotype PMID:14580790; PMID:27473017
GO:0007162 Negative regulation of cell adhesion Increases phenotype PMID:36288102
GO:0007283 Spermatogenesis Decreases phenotype PMID:31419471; PMID:34723416
GO:0007286 Spermatid development Affects phenotype PMID:34723416
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:34537261
GO:0008152 Metabolic process Affects phenotype PMID:34537261
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:34537261
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:26231423
GO:0008219 Cell death Increases phenotype PMID:25058043; PMID:27757495
GO:0008283 Cell population proliferation Affects phenotype PMID:17385802; PMID:24530352; PMID:25058043; PMID:27757495; PMID:29627501; PMID:33419253
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:27401186; PMID:27473017; PMID:28396216; PMID:28935499; PMID:28965971; PMID:34716709
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30394307; PMID:30717214; PMID:31586597; PMID:35650142
GO:0008585 Female gonad development Decreases phenotype PMID:30138655
GO:0008653 Lipopolysaccharide metabolic process Affects phenotype PMID:39053873
GO:0009636 Response to toxic substance Decreases phenotype PMID:30270565
GO:0010508 Positive regulation of autophagy Increases phenotype PMID:30394307
GO:0010694 Positive regulation of alkaline phosphatase activity Increases phenotype PMID:27401186
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:24412706; PMID:35650142
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:28935499; PMID:34716709
GO:0010942 Positive regulation of cell death Affects phenotype PMID:28935499; PMID:31586597
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Decreases phenotype PMID:34716709
GO:0015562 Efflux transmembrane transporter activity Decreases phenotype PMID:30610963
GO:0016042 Lipid catabolic process Increases phenotype PMID:17385802; PMID:32858132; PMID:34723416
GO:0016049 Cell growth Decreases phenotype PMID:30668976
GO:0018158 Protein oxidation Increases phenotype PMID:26231423
GO:0019432 Triglyceride biosynthetic process Decreases phenotype PMID:17385802
GO:0019674 Nad metabolic process Affects phenotype PMID:38159578
GO:0030284 Nuclear estrogen receptor activity Increases phenotype PMID:27481073
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:39306225
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:31586597
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:31419471; PMID:32119988
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:25645597; PMID:28396216; PMID:28807876
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:29669061
GO:0034440 Lipid oxidation Increases phenotype PMID:26231423; PMID:36161741
GO:0036124 Histone h3-k9 trimethylation Increases phenotype PMID:32119988
GO:0036126 Sperm flagellum Affects phenotype PMID:34723416
GO:0036146 Cellular response to mycotoxin Affects phenotype PMID:24412706
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:31586597
GO:0042541 Hemoglobin biosynthetic process Increases phenotype PMID:17385802
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:24412706; PMID:28089945; PMID:28935499; PMID:29758222; PMID:30394307; PMID:30394307; PMID:35650142
GO:0043066 Negative regulation of apoptotic process Increases phenotype PMID:27473017
GO:0043970 Histone h3-k9 acetylation Increases phenotype PMID:32119988
GO:0044027 Hypermethylation of cpg island Increases phenotype PMID:28089945
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30610963; PMID:32119988; PMID:35090964; PMID:34723416; PMID:35090964; PMID:35986755
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:33419253
GO:0045333 Cellular respiration Decreases phenotype PMID:34537261
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:35650142
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:27862621; PMID:30138655
GO:0045931 Positive regulation of mitotic cell cycle Increases phenotype PMID:28965971
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:34723416
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:17385802
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:31586597
GO:0051321 Meiotic cell cycle Decreases phenotype PMID:31419471; PMID:35504548
GO:0051331 Meiotic g2 phase Affects phenotype PMID:35504548
GO:0051447 Negative regulation of meiotic cell cycle Affects phenotype PMID:28552778
GO:0051646 Mitochondrion localization Affects phenotype PMID:35504548
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:24512812; PMID:25058043; PMID:30600648
GO:0051900 Regulation of mitochondrial depolarization Affects phenotype PMID:34716709
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:24512812; PMID:29627501; PMID:34723416
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:30394307
GO:0061827 Sperm head Affects phenotype PMID:34723416
GO:0070269 Pyroptosis Increases phenotype PMID:31586597
GO:0070661 Leukocyte proliferation Increases phenotype PMID:17385802
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24412706; PMID:25058043; PMID:34015425; PMID:35090964; PMID:38159578
GO:0097225 Sperm midpiece Affects phenotype PMID:34723416
GO:0097722 Sperm motility Decreases phenotype PMID:31419471
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:31419471; PMID:32119988
GO:0120183 Positive regulation of focal adhesion disassembly Increases phenotype PMID:36288102
GO:0140042 Lipid droplet formation Increases phenotype PMID:39053873
GO:0140115 Export across plasma membrane Decreases phenotype PMID:30610963
GO:1900227 Positive regulation of nlrp3 inflammasome complex assembly Increases phenotype PMID:31586597
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:28477956
GO:1903284 Positive regulation of glutathione peroxidase activity Increases phenotype PMID:28477956
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26783879
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28477956; PMID:34716709; PMID:35650142
GO:1903537 Meiotic cell cycle process involved in oocyte maturation Decreases phenotype PMID:35504548
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:30394307
GO:2000180 Negative regulation of androgen biosynthetic process Increases phenotype PMID:29669061
GO:2000573 Positive regulation of dna biosynthetic process Increases phenotype PMID:28965971
GO:2000786 Positive regulation of autophagosome assembly Increases phenotype PMID:31586597
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:29669061
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.