DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Arsenic

Curated chemical-phenotype interactions from CTD

GO ID	GO name	Interaction type	Reference
GO:0000045	Autophagosome assembly	Increases phenotype	PMID:31844926; PMID:32525701
GO:0000080	Mitotic g1 phase	Affects phenotype	PMID:34364923
GO:0000084	Mitotic s phase	Affects phenotype	PMID:31822296; PMID:34364923; PMID:35809665
GO:0000086	G2/m transition of mitotic cell cycle	Affects phenotype	PMID:34364923; PMID:35809665; PMID:36162444
GO:0000104	Succinate dehydrogenase activity	Decreases phenotype	PMID:36947368
GO:0000278	Mitotic cell cycle	Affects phenotype	PMID:31822296
GO:0000381	Regulation of alternative mrna splicing, via spliceosome	Affects phenotype	PMID:35072517
GO:0000723	Telomere maintenance	Decreases phenotype	PMID:27084675
GO:0000737	Dna catabolic process, endonucleolytic	Increases phenotype	PMID:25062976; PMID:35513056; PMID:35809665; PMID:38723480
GO:0000932	P-body	Increases phenotype	PMID:34952004
GO:0001510	Rna methylation	Affects phenotype	PMID:37061066
GO:0001552	Ovarian follicle atresia	Increases phenotype	PMID:36068745
GO:0001568	Blood vessel development	Affects phenotype	PMID:23757599
GO:0001692	Histamine metabolic process	Affects phenotype	PMID:37888683
GO:0001774	Microglial cell activation	Increases phenotype	PMID:35777461
GO:0001780	Neutrophil homeostasis	Affects phenotype	PMID:38310360
GO:0001819	Positive regulation of cytokine production	Increases phenotype	PMID:17267001
GO:0001825	Blastocyst formation	Decreases phenotype	PMID:9820195
GO:0001836	Release of cytochrome c from mitochondria	Increases phenotype	PMID:36117518; PMID:36947368
GO:0001837	Epithelial to mesenchymal transition	Increases phenotype	PMID:32645460; PMID:33396024; PMID:39818140
GO:0001887	Selenium compound metabolic process	Affects phenotype	PMID:29398653
GO:0001890	Placenta development	Affects phenotype	PMID:25304211
GO:0001894	Tissue homeostasis	Decreases phenotype	PMID:31309260
GO:0001951	Intestinal d-glucose absorption	Increases phenotype	PMID:22354675
GO:0001954	Positive regulation of cell-matrix adhesion	Decreases phenotype	PMID:28829631
GO:0002027	Regulation of heart rate	Affects phenotype	PMID:26988683
GO:0002381	Immunoglobulin production involved in immunoglobulin-mediated immune response	Decreases phenotype	PMID:31051324
GO:0002455	Humoral immune response mediated by circulating immunoglobulin	Decreases phenotype	PMID:31051324
GO:0002523	Leukocyte migration involved in inflammatory response	Increases phenotype	PMID:25062976; PMID:25062976; PMID:36528894; PMID:30889423; PMID:35598369; PMID:36528894; PMID:36689145; PMID:36822304; PMID:38229313; PMID:38881217; PMID:38909693; PMID:38945390; PMID:39317010; PMID:39657381
GO:0002534	Cytokine production involved in inflammatory response	Affects phenotype	PMID:31775542
GO:0002681	Somatic recombination of t cell receptor gene segments	Decreases phenotype	PMID:29757418
GO:0002698	Negative regulation of immune effector process	Increases phenotype	PMID:34953898
GO:0002923	Regulation of humoral immune response mediated by circulating immunoglobulin	Affects phenotype	PMID:32276596
GO:0003073	Regulation of systemic arterial blood pressure	Affects phenotype	PMID:28270149
GO:0003094	Glomerular filtration	Decreases phenotype	PMID:33603096
GO:0003104	Positive regulation of glomerular filtration	Increases phenotype	PMID:31326826
GO:0003330	Regulation of extracellular matrix constituent secretion	Affects phenotype	PMID:32647881
GO:0003993	Acid phosphatase activity	Increases phenotype	PMID:35307918
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:38676876
GO:0004035	Alkaline phosphatase activity	Affects phenotype	PMID:21740555; PMID:25062976; PMID:25062976; PMID:30324125; PMID:30324125; PMID:33026618; PMID:35307918
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	Increases phenotype	PMID:25062976; PMID:25062976; PMID:30324125; PMID:30324125; PMID:31584213; PMID:31584213; PMID:32402895; PMID:33026618; PMID:38229313; PMID:32402895; PMID:33026618; PMID:33609566; PMID:36689145; PMID:38229313; PMID:39079579
GO:0004096	Catalase activity	Decreases phenotype	PMID:37730986; PMID:38881217
GO:0004111	Creatine kinase activity	Increases phenotype	PMID:31584213
GO:0004126	Cytidine deaminase activity	Increases phenotype	PMID:34998823
GO:0004197	Cysteine-type endopeptidase activity	Increases phenotype	PMID:33497711
GO:0004198	Calcium-dependent cysteine-type endopeptidase activity	Decreases phenotype	PMID:31398423
GO:0004364	Glutathione transferase activity	Affects phenotype	PMID:25062976; PMID:31350662; PMID:31350662; PMID:33410021; PMID:32270456; PMID:33171135; PMID:36757007; PMID:33410021; PMID:36528894; PMID:36757007
GO:0004457	Lactate dehydrogenase activity	Affects phenotype	PMID:25062976; PMID:31584213; PMID:31584213; PMID:32402895; PMID:32402895; PMID:35714946
GO:0004601	Peroxidase activity	Decreases phenotype	PMID:36850985
GO:0004602	Glutathione peroxidase activity	Decreases phenotype	PMID:25062976; PMID:31584213; PMID:31584213; PMID:37906532; PMID:32270456; PMID:32402895; PMID:33127376; PMID:35714946; PMID:36689145; PMID:36813806; PMID:36822304; PMID:37906532; PMID:38945390
GO:0004611	Phosphoenolpyruvate carboxykinase activity	Increases phenotype	PMID:32226249
GO:0004784	Superoxide dismutase activity	Increases phenotype	PMID:25062976; PMID:25062976; PMID:36850985; PMID:27289040; PMID:29741077; PMID:30324125; PMID:31350662; PMID:31350662; PMID:33148380; PMID:31584213; PMID:31584213; PMID:37906532; PMID:31739468; PMID:32270456; PMID:32402895; PMID:33127376; PMID:33171135; PMID:33410021; PMID:35307918; PMID:35714946; PMID:35809665; PMID:36528894; PMID:36689145; PMID:36757007; PMID:36813806; PMID:36822304; PMID:36850985; PMID:37084658; PMID:37730986; PMID:37879473; PMID:37906532; PMID:38881217; PMID:38909693
GO:0005388	P-type calcium transporter activity	Decreases phenotype	PMID:25062976
GO:0005391	P-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:25062976
GO:0005776	Autophagosome	Increases phenotype	PMID:38734222
GO:0005975	Carbohydrate metabolic process	Affects phenotype	PMID:37888683
GO:0005977	Glycogen metabolic process	Affects phenotype	PMID:38945390
GO:0005988	Lactose metabolic process	Affects phenotype	PMID:38945390
GO:0006006	Glucose metabolic process	Affects phenotype	PMID:33736254; PMID:36509832; PMID:38945390; PMID:39098089
GO:0006071	Glycerol metabolic process	Affects phenotype	PMID:33736254
GO:0006089	Lactate metabolic process	Affects phenotype	PMID:32006662
GO:0006096	Glycolytic process	Increases phenotype	PMID:35625704
GO:0006099	Tricarboxylic acid cycle	Affects phenotype	PMID:25577196
GO:0006102	Isocitrate metabolic process	Decreases phenotype	PMID:24295472
GO:0006119	Oxidative phosphorylation	Affects phenotype	PMID:35625704; PMID:36947368
GO:0006260	Dna replication	Decreases phenotype	PMID:35714946
GO:0006264	Mitochondrial dna replication	Affects phenotype	PMID:38676876
GO:0006281	Dna repair	Decreases phenotype	PMID:16882524; PMID:17450239; PMID:31769258
GO:0006304	Dna modification	Increases phenotype	PMID:34998823; PMID:35490796; PMID:35809665; PMID:36689145; PMID:36947368; PMID:39922519
GO:0006306	Dna methylation	Decreases phenotype	PMID:26771251; PMID:28436716; PMID:29940200
GO:0006308	Dna catabolic process	Increases phenotype	PMID:34998823; PMID:35821281
GO:0006355	Regulation of dna-templated transcription	Affects phenotype	PMID:28927277; PMID:31864032
GO:0006417	Regulation of translation	Affects phenotype	PMID:28927277
GO:0006493	Protein o-linked glycosylation	Increases phenotype	PMID:38734222
GO:0006497	Protein lipidation	Increases phenotype	PMID:32645460
GO:0006518	Peptide metabolic process	Affects phenotype	PMID:37888683
GO:0006520	Amino acid metabolic process	Affects phenotype	PMID:37759824; PMID:37888683
GO:0006534	Cysteine metabolic process	Affects phenotype	PMID:38676876
GO:0006544	Glycine metabolic process	Affects phenotype	PMID:33736254
GO:0006606	Protein import into nucleus	Affects phenotype	PMID:32062438
GO:0006631	Fatty acid metabolic process	Affects phenotype	PMID:39317010
GO:0006641	Triglyceride metabolic process	Affects phenotype	PMID:33736254; PMID:36463740; PMID:36813806; PMID:37906532; PMID:38945390
GO:0006644	Phospholipid metabolic process	Increases phenotype	PMID:37759824; PMID:37906532
GO:0006739	Nadp metabolic process	Affects phenotype	PMID:38945390
GO:0006749	Glutathione metabolic process	Affects phenotype	PMID:24295472; PMID:25062976; PMID:25062976; PMID:36850985; PMID:31350662; PMID:31584213; PMID:37906532; PMID:33026618; PMID:33026618; PMID:36822304; PMID:33410021; PMID:33497711; PMID:33736254; PMID:35307918; PMID:35598369; PMID:35809665; PMID:36528894; PMID:36813806; PMID:36822304; PMID:36850985; PMID:37482551; PMID:37676925; PMID:37730986; PMID:37879473; PMID:37906532; PMID:38881217; PMID:39317010
GO:0006750	Glutathione biosynthetic process	Decreases phenotype	PMID:26989453; PMID:27289040; PMID:29741077; PMID:30324125
GO:0006801	Superoxide metabolic process	Decreases phenotype	PMID:38229313
GO:0006805	Xenobiotic metabolic process	Affects phenotype	PMID:25194983
GO:0006809	Nitric oxide biosynthetic process	Increases phenotype	PMID:27289040
GO:0006879	Cellular iron ion homeostasis	Affects phenotype	PMID:37879473
GO:0006887	Exocytosis	Affects phenotype	PMID:37527016
GO:0006909	Phagocytosis	Affects phenotype	PMID:33063558; PMID:35777461
GO:0006911	Phagocytosis, engulfment	Increases phenotype	PMID:35351628
GO:0006914	Autophagy	Increases phenotype	PMID:32645460
GO:0006915	Apoptotic process	Increases phenotype	PMID:23600209; PMID:23600209; PMID:39693001; PMID:24212999; PMID:25227780; PMID:27289040; PMID:31822296; PMID:32179164; PMID:32188015; PMID:32802178; PMID:33921748; PMID:34364923; PMID:35714946; PMID:36117518; PMID:36861143; PMID:37906532; PMID:38299738
GO:0006954	Inflammatory response	Increases phenotype	PMID:29741077; PMID:30889423; PMID:31309260; PMID:37906532; PMID:39317010
GO:0006974	Cellular response to dna damage stimulus	Increases phenotype	PMID:20547570; PMID:23301828; PMID:30324125; PMID:31350662; PMID:32031413; PMID:32031413; PMID:33378118; PMID:32402895; PMID:33378118; PMID:33410021
GO:0006979	Response to oxidative stress	Increases phenotype	PMID:18053222; PMID:21219961
GO:0006997	Nucleus organization	Decreases phenotype	PMID:36689145
GO:0007005	Mitochondrion organization	Decreases phenotype	PMID:37879473; PMID:38157908
GO:0007009	Plasma membrane organization	Decreases phenotype	PMID:35714946
GO:0007029	Endoplasmic reticulum organization	Affects phenotype	PMID:39317010
GO:0007033	Vacuole organization	Increases phenotype	PMID:25062976; PMID:32735129; PMID:38157908
GO:0007042	Lysosomal lumen acidification	Affects phenotype	PMID:35809665
GO:0007281	Germ cell development	Decreases phenotype	PMID:36068745
GO:0007283	Spermatogenesis	Decreases phenotype	PMID:22776062; PMID:33127376; PMID:36757007; PMID:36813806; PMID:37084658; PMID:38798119
GO:0007286	Spermatid development	Affects phenotype	PMID:34352348; PMID:38798119
GO:0007346	Regulation of mitotic cell cycle	Increases phenotype	PMID:32159786
GO:0007420	Brain development	Decreases phenotype	PMID:20829427
GO:0007567	Parturition	Affects phenotype	PMID:25304211
GO:0007610	Behavior	Affects phenotype	PMID:33154986
GO:0007611	Learning or memory	Decreases phenotype	PMID:28903487
GO:0007612	Learning	Decreases phenotype	PMID:29233033; PMID:35351628; PMID:35993674
GO:0007613	Memory	Decreases phenotype	PMID:26713676; PMID:29233033; PMID:35351628; PMID:35993674; PMID:37482551
GO:0007625	Grooming behavior	Increases phenotype	PMID:38056122
GO:0007631	Feeding behavior	Affects phenotype	PMID:37676925
GO:0008016	Regulation of heart contraction	Affects phenotype	PMID:17520054
GO:0008065	Establishment of blood-nerve barrier	Affects phenotype	PMID:33739591
GO:0008121	Ubiquinol-cytochrome-c reductase activity	Increases phenotype	PMID:37906532
GO:0008137	Nadh dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:37906532
GO:0008152	Metabolic process	Affects phenotype	PMID:20670920; PMID:29329102; PMID:31309260; PMID:37131019
GO:0008177	Succinate dehydrogenase (ubiquinone) activity	Decreases phenotype	PMID:37906532
GO:0008202	Steroid metabolic process	Affects phenotype	PMID:37888683
GO:0008203	Cholesterol metabolic process	Increases phenotype	PMID:33127376; PMID:36813806; PMID:37906532; PMID:38945390; PMID:39317010
GO:0008206	Bile acid metabolic process	Affects phenotype	PMID:38945390; PMID:39317010
GO:0008210	Estrogen metabolic process	Affects phenotype	PMID:36068745
GO:0008217	Regulation of blood pressure	Affects phenotype	PMID:17164464; PMID:33488031; PMID:21878420; PMID:23222207; PMID:24218149; PMID:26220686; PMID:35598369
GO:0008219	Cell death	Increases phenotype	PMID:31542844; PMID:33497711; PMID:39720976
GO:0008270	Zinc ion binding	Decreases phenotype	PMID:33149232
GO:0008283	Cell population proliferation	Increases phenotype	PMID:23942117; PMID:27289040; PMID:32802178; PMID:33047385; PMID:34364923; PMID:35378173; PMID:35523338; PMID:35714946; PMID:37061066; PMID:38299738; PMID:38881217; PMID:38909693
GO:0008284	Positive regulation of cell population proliferation	Increases phenotype	PMID:23100159; PMID:25273566; PMID:25586904; PMID:25868784
GO:0008286	Insulin receptor signaling pathway	Decreases phenotype	PMID:39657381
GO:0008291	Acetylcholine metabolic process	Affects phenotype	PMID:29233033
GO:0008483	Transaminase activity	Increases phenotype	PMID:21740555; PMID:29334960
GO:0009060	Aerobic respiration	Decreases phenotype	PMID:24295472; PMID:32045263
GO:0009235	Cobalamin metabolic process	Affects phenotype	PMID:32402895
GO:0009299	Mrna transcription	Affects phenotype	PMID:27838757; PMID:28927277
GO:0009308	Amine metabolic process	Affects phenotype	PMID:37759824; PMID:37888683
GO:0010424	Dna methylation on cytosine within a cg sequence	Increases phenotype	PMID:23073540; PMID:31135185; PMID:25304211; PMID:25325195; PMID:26771251; PMID:29247444; PMID:32603190; PMID:35747940; PMID:39425535
GO:0010467	Gene expression	Decreases phenotype	PMID:17450239; PMID:17938729; PMID:18288317; PMID:18414638; PMID:24936443; PMID:25759245; PMID:28069514; PMID:30819207; PMID:31752878
GO:0010468	Regulation of gene expression	Affects phenotype	PMID:18039032; PMID:35646058; PMID:36428691; PMID:36617169
GO:0010507	Negative regulation of autophagy	Increases phenotype	PMID:29248574
GO:0010508	Positive regulation of autophagy	Increases phenotype	PMID:25868784
GO:0010718	Positive regulation of epithelial to mesenchymal transition	Increases phenotype	PMID:25586904
GO:0010833	Telomere maintenance via telomere lengthening	Increases phenotype	PMID:22917110
GO:0010866	Regulation of triglyceride biosynthetic process	Affects phenotype	PMID:39098089
GO:0010918	Positive regulation of mitochondrial membrane potential	Decreases phenotype	PMID:24295472
GO:0010942	Positive regulation of cell death	Increases phenotype	PMID:29248574
GO:0014002	Astrocyte development	Decreases phenotype	PMID:20829427
GO:0014005	Microglia development	Affects phenotype	PMID:35777461
GO:0015444	P-type magnesium transporter activity	Decreases phenotype	PMID:25062976
GO:0015700	Arsenite transport	Increases phenotype	PMID:29864931
GO:0015723	Bilirubin transport	Decreases phenotype	PMID:36720308
GO:0016042	Lipid catabolic process	Increases phenotype	PMID:27289040; PMID:29741077; PMID:30324125; PMID:31350662; PMID:31350662; PMID:33148380; PMID:31584213; PMID:31739468; PMID:32270456; PMID:32402895; PMID:33026618; PMID:33127376; PMID:33148380; PMID:33410021; PMID:35307918; PMID:35714946; PMID:39098089
GO:0016049	Cell growth	Affects phenotype	PMID:31822296; PMID:32045263
GO:0016477	Cell migration	Affects phenotype	PMID:25559853; PMID:36861143; PMID:38157908
GO:0018119	Peptidyl-cysteine s-nitrosylation	Decreases phenotype	PMID:25110733
GO:0018126	Protein hydroxylation	Increases phenotype	PMID:33026618
GO:0018158	Protein oxidation	Affects phenotype	PMID:24348802; PMID:25062976; PMID:31584213; PMID:33410021; PMID:36757007
GO:0019530	Taurine metabolic process	Affects phenotype	PMID:33736254
GO:0019627	Urea metabolic process	Affects phenotype	PMID:33026618; PMID:33026618; PMID:36822304; PMID:36822304; PMID:37879473; PMID:38945390
GO:0019752	Carboxylic acid metabolic process	Affects phenotype	PMID:37888683
GO:0019852	L-ascorbic acid metabolic process	Affects phenotype	PMID:25062976; PMID:31584213; PMID:33736254
GO:0020027	Hemoglobin metabolic process	Affects phenotype	PMID:37759824
GO:0022602	Ovulation cycle process	Affects phenotype	PMID:36068745
GO:0030097	Hemopoiesis	Affects phenotype	PMID:38945390
GO:0030154	Cell differentiation	Affects phenotype	PMID:37999580; PMID:38299738
GO:0030199	Collagen fibril organization	Affects phenotype	PMID:33026618; PMID:37999580; PMID:38676876
GO:0030218	Erythrocyte differentiation	Affects phenotype	PMID:33149232
GO:0030219	Megakaryocyte differentiation	Decreases phenotype	PMID:33149232
GO:0030220	Platelet formation	Decreases phenotype	PMID:31991237
GO:0030263	Apoptotic chromosome condensation	Increases phenotype	PMID:36822304; PMID:39693001
GO:0030335	Positive regulation of cell migration	Increases phenotype	PMID:23100159; PMID:25273566
GO:0030578	Pml body organization	Decreases phenotype	PMID:36880596
GO:0030877	Beta-catenin destruction complex	Affects phenotype	PMID:39818140
GO:0031012	Extracellular matrix	Increases phenotype	PMID:37999580
GO:0031987	Locomotion involved in locomotory behavior	Decreases phenotype	PMID:29233033; PMID:29233033; PMID:38056122
GO:0032042	Mitochondrial dna metabolic process	Affects phenotype	PMID:29940200
GO:0032060	Bleb assembly	Increases phenotype	PMID:36117518
GO:0032125	Micronucleus organization	Increases phenotype	PMID:31350662
GO:0032259	Methylation	Affects phenotype	PMID:18288317
GO:0032350	Regulation of hormone metabolic process	Affects phenotype	PMID:18414639
GO:0032507	Maintenance of protein location in cell	Affects phenotype	PMID:31309260
GO:0032611	Interleukin-1 beta production	Affects phenotype	PMID:20940111
GO:0032636	Interleukin-7 production	Decreases phenotype	PMID:19167470
GO:0032680	Regulation of tumor necrosis factor production	Affects phenotype	PMID:31652851
GO:0032729	Positive regulation of type ii interferon production	Affects phenotype	PMID:20940111
GO:0032760	Positive regulation of tumor necrosis factor production	Increases phenotype	PMID:20940111; PMID:29028684; PMID:31652851; PMID:7537211
GO:0032930	Positive regulation of superoxide anion generation	Increases phenotype	PMID:7537211
GO:0032964	Collagen biosynthetic process	Increases phenotype	PMID:31238026
GO:0033209	Tumor necrosis factor-mediated signaling pathway	Affects phenotype	PMID:24675094
GO:0033327	Leydig cell differentiation	Affects phenotype	PMID:33171135
GO:0033590	Response to cobalamin	Increases phenotype	PMID:29459232
GO:0033962	P-body assembly	Increases phenotype	PMID:34952004
GO:0034109	Homotypic cell-cell adhesion	Increases phenotype	PMID:36504884
GO:0034440	Lipid oxidation	Increases phenotype	PMID:24295472; PMID:24348802; PMID:25062976; PMID:25062976; PMID:36850985; PMID:35598369; PMID:35809665; PMID:36669534; PMID:36689145; PMID:36822304; PMID:36850985; PMID:36947368; PMID:37676925; PMID:37730986; PMID:37759824; PMID:37879473; PMID:37906532; PMID:38229313; PMID:38723480; PMID:38881217; PMID:38909693; PMID:38945390; PMID:39317010; PMID:39922519
GO:0034599	Cellular response to oxidative stress	Affects phenotype	PMID:20940111
GO:0035459	Vesicle cargo loading	Affects phenotype	PMID:30169766
GO:0035640	Exploration behavior	Decreases phenotype	PMID:29233033; PMID:29233033; PMID:38056122
GO:0035641	Locomotory exploration behavior	Affects phenotype	PMID:33609566
GO:0035733	Hepatic stellate cell activation	Increases phenotype	PMID:37999580
GO:0035773	Insulin secretion involved in cellular response to glucose stimulus	Decreases phenotype	PMID:23349674
GO:0035794	Positive regulation of mitochondrial membrane permeability	Increases phenotype	PMID:24295472
GO:0035855	Megakaryocyte development	Increases phenotype	PMID:33149232
GO:0035934	Corticosterone secretion	Increases phenotype	PMID:24218149
GO:0035936	Testosterone secretion	Decreases phenotype	PMID:33171135
GO:0035937	Estrogen secretion	Affects phenotype	PMID:36068745
GO:0036123	Histone h3-k9 dimethylation	Affects phenotype	PMID:32062438; PMID:33378118
GO:0036126	Sperm flagellum	Affects phenotype	PMID:38798119
GO:0036145	Dendritic cell homeostasis	Affects phenotype	PMID:30889423
GO:0036211	Protein modification process	Increases phenotype	PMID:38676876
GO:0036374	Glutathione hydrolase activity	Increases phenotype	PMID:25062976
GO:0038001	Paracrine signaling	Affects phenotype	PMID:37527016
GO:0040018	Positive regulation of multicellular organism growth	Decreases phenotype	PMID:24348802
GO:0040029	Epigenetic regulation of gene expression	Affects phenotype	PMID:38030093
GO:0042116	Macrophage activation	Affects phenotype	PMID:36617169
GO:0042310	Vasoconstriction	Increases phenotype	PMID:35598369
GO:0042311	Vasodilation	Increases phenotype	PMID:35598369
GO:0042332	Gravitaxis	Affects phenotype	PMID:33609566
GO:0042360	Vitamin e metabolic process	Affects phenotype	PMID:25062976
GO:0042403	Thyroid hormone metabolic process	Affects phenotype	PMID:38797200
GO:0042428	Serotonin metabolic process	Affects phenotype	PMID:37888683
GO:0042431	Indole metabolic process	Affects phenotype	PMID:37888683
GO:0042554	Superoxide anion generation	Increases phenotype	PMID:33026618
GO:0042593	Glucose homeostasis	Decreases phenotype	PMID:22354675; PMID:27623387
GO:0042696	Menarche	Affects phenotype	PMID:36729392
GO:0042742	Defense response to bacterium	Increases phenotype	PMID:33063558
GO:0042743	Hydrogen peroxide metabolic process	Affects phenotype	PMID:35714946; PMID:36850985
GO:0042755	Eating behavior	Affects phenotype	PMID:25062976
GO:0042756	Drinking behavior	Affects phenotype	PMID:25062976; PMID:29741077; PMID:37676925
GO:0043005	Neuron projection	Decreases phenotype	PMID:37624150
GO:0043045	Dna methylation involved in embryo development	Affects phenotype	PMID:24525453
GO:0043065	Positive regulation of apoptotic process	Increases phenotype	PMID:20829427; PMID:24028894; PMID:25868784
GO:0043373	Cd4-positive, alpha-beta t cell lineage commitment	Decreases phenotype	PMID:24525453
GO:0043374	Cd8-positive, alpha-beta t cell differentiation	Increases phenotype	PMID:23757598
GO:0043375	Cd8-positive, alpha-beta t cell lineage commitment	Increases phenotype	PMID:24525453
GO:0043403	Skeletal muscle tissue regeneration	Decreases phenotype	PMID:37527016
GO:0043473	Pigmentation	Increases phenotype	PMID:27966667
GO:0043525	Positive regulation of neuron apoptotic process	Increases phenotype	PMID:28903487
GO:0043588	Skin development	Affects phenotype	PMID:38299738
GO:0043616	Keratinocyte proliferation	Decreases phenotype	PMID:38299738
GO:0043970	Histone h3-k9 acetylation	Increases phenotype	PMID:39617304
GO:0043971	Histone h3-k18 acetylation	Affects phenotype	PMID:27068294; PMID:32031413; PMID:37999580
GO:0043984	Histone h4-k16 acetylation	Decreases phenotype	PMID:32735129
GO:0044026	Dna hypermethylation	Increases phenotype	PMID:25598836
GO:0044027	Hypermethylation of cpg island	Increases phenotype	PMID:28242323; PMID:38030093
GO:0044028	Dna hypomethylation	Increases phenotype	PMID:28270149
GO:0044030	Regulation of dna methylation	Affects phenotype	PMID:22466225; PMID:22551203; PMID:25304211; PMID:27838757; PMID:28927277
GO:0044237	Cellular metabolic process	Increases phenotype	PMID:31542844; PMID:31739468; PMID:31739468; PMID:33736254; PMID:32031413; PMID:32188015; PMID:32188015; PMID:32735129; PMID:32930475; PMID:33049506; PMID:33396024; PMID:33736254; PMID:34998823; PMID:35714946; PMID:35809665; PMID:36669534; PMID:36861143; PMID:37730986; PMID:37879473; PMID:38056122; PMID:38157908; PMID:38299738; PMID:38723480; PMID:39693001
GO:0044319	Wound healing, spreading of cells	Increases phenotype	PMID:33396024; PMID:34364923; PMID:38299738; PMID:39818140; PMID:39922519
GO:0044381	Glucose import in response to insulin stimulus	Decreases phenotype	PMID:39098089
GO:0044403	Biological process involved in symbiotic interaction	Affects phenotype	PMID:31309260
GO:0044546	Nlrp3 inflammasome complex assembly	Increases phenotype	PMID:39657381
GO:0044648	Histone h3-k4 dimethylation	Increases phenotype	PMID:21385672
GO:0044754	Autolysosome	Increases phenotype	PMID:38734222
GO:0045023	G0 to g1 transition	Affects phenotype	PMID:31822296; PMID:35809665
GO:0045066	Regulatory t cell differentiation	Increases phenotype	PMID:32735129
GO:0045087	Innate immune response	Affects phenotype	PMID:31703545
GO:0045088	Regulation of innate immune response	Affects phenotype	PMID:32514536
GO:0045429	Positive regulation of nitric oxide biosynthetic process	Increases phenotype	PMID:24295472
GO:0045444	Fat cell differentiation	Decreases phenotype	PMID:36989998
GO:0045445	Myoblast differentiation	Decreases phenotype	PMID:32159786
GO:0045454	Cell redox homeostasis	Affects phenotype	PMID:25868784; PMID:31309260
GO:0045739	Positive regulation of dna repair	Decreases phenotype	PMID:24473091
GO:0045747	Positive regulation of notch signaling pathway	Increases phenotype	PMID:32647881
GO:0045793	Positive regulation of cell size	Increases phenotype	PMID:39098089
GO:0045930	Negative regulation of mitotic cell cycle	Increases phenotype	PMID:25868784
GO:0046007	Negative regulation of activated t cell proliferation	Increases phenotype	PMID:28823652
GO:0046034	Atp metabolic process	Affects phenotype	PMID:25062976; PMID:31584213; PMID:33497711
GO:0046085	Adenosine metabolic process	Affects phenotype	PMID:37888683
GO:0046108	Uridine metabolic process	Affects phenotype	PMID:33736254
GO:0046209	Nitric oxide metabolic process	Affects phenotype	PMID:25062976; PMID:31584213; PMID:35351628; PMID:35351628; PMID:35777461; PMID:35777461; PMID:37676925; PMID:37730986
GO:0046323	Glucose import	Increases phenotype	PMID:32006662
GO:0046415	Urate metabolic process	Decreases phenotype	PMID:24348802; PMID:33026618
GO:0046449	Creatinine metabolic process	Decreases phenotype	PMID:24348802; PMID:32270456; PMID:32402895; PMID:32402895; PMID:33026618; PMID:36822304; PMID:33026618; PMID:33026618; PMID:36822304; PMID:36822304; PMID:37879473; PMID:38945390
GO:0046466	Membrane lipid catabolic process	Increases phenotype	PMID:21219961
GO:0046483	Heterocycle metabolic process	Affects phenotype	PMID:37888683
GO:0046618	Xenobiotic export from cell	Decreases phenotype	PMID:28458011
GO:0046655	Folic acid metabolic process	Affects phenotype	PMID:32402895
GO:0046685	Response to arsenic-containing substance	Increases phenotype	PMID:27561292; PMID:27713174; PMID:28494415; PMID:30889423; PMID:34272803; PMID:36399430; PMID:36850985; PMID:37797956; PMID:39675543
GO:0046902	Regulation of mitochondrial membrane permeability	Affects phenotype	PMID:36117518
GO:0048143	Astrocyte activation	Increases phenotype	PMID:39693001
GO:0048266	Behavioral response to pain	Decreases phenotype	PMID:33739591
GO:0048538	Thymus development	Decreases phenotype	PMID:19167470
GO:0048589	Developmental growth	Decreases phenotype	PMID:35646058
GO:0048666	Neuron development	Affects phenotype	PMID:37624150
GO:0048864	Stem cell development	Increases phenotype	PMID:33047385
GO:0048866	Stem cell fate specification	Increases phenotype	PMID:32062438
GO:0050691	Regulation of defense response to virus by host	Affects phenotype	PMID:32514536
GO:0050729	Positive regulation of inflammatory response	Increases phenotype	PMID:20940111; PMID:25288670
GO:0050890	Cognition	Decreases phenotype	PMID:17450237; PMID:17805430; PMID:25288670; PMID:26968381
GO:0050966	Detection of mechanical stimulus involved in sensory perception of pain	Decreases phenotype	PMID:33739591
GO:0050996	Positive regulation of lipid catabolic process	Increases phenotype	PMID:38423337
GO:0051027	Dna transport	Increases phenotype	PMID:33063558
GO:0051148	Negative regulation of muscle cell differentiation	Increases phenotype	PMID:32647881
GO:0051450	Myoblast proliferation	Increases phenotype	PMID:32159786
GO:0051452	Intracellular ph reduction	Decreases phenotype	PMID:32525701
GO:0051480	Regulation of cytosolic calcium ion concentration	Affects phenotype	PMID:28823652
GO:0051562	Negative regulation of mitochondrial calcium ion concentration	Increases phenotype	PMID:24295472
GO:0051593	Response to folic acid	Decreases phenotype	PMID:25885259
GO:0051881	Regulation of mitochondrial membrane potential	Affects phenotype	PMID:27289040; PMID:32006662; PMID:32159786; PMID:35809665; PMID:36813806; PMID:38723480
GO:0051882	Mitochondrial depolarization	Increases phenotype	PMID:31739468; PMID:33497711
GO:0051897	Positive regulation of protein kinase b signaling	Increases phenotype	PMID:25586904
GO:0051899	Membrane depolarization	Increases phenotype	PMID:36117518
GO:0055001	Muscle cell development	Decreases phenotype	PMID:37527016
GO:0055072	Iron ion homeostasis	Affects phenotype	PMID:37879473; PMID:38676876
GO:0055088	Lipid homeostasis	Decreases phenotype	PMID:24295472
GO:0060013	Righting reflex	Affects phenotype	PMID:33609566
GO:0060208	Proestrus	Affects phenotype	PMID:36068745
GO:0060307	Regulation of ventricular cardiac muscle cell membrane repolarization	Affects phenotype	PMID:19957052
GO:0060322	Head development	Decreases phenotype	PMID:25304211; PMID:25971349; PMID:26955061
GO:0060326	Cell chemotaxis	Increases phenotype	PMID:32645460; PMID:33047385; PMID:34364923; PMID:39818140; PMID:39922519
GO:0060348	Bone development	Decreases phenotype	PMID:30696509
GO:0060574	Intestinal epithelial cell maturation	Affects phenotype	PMID:38310360
GO:0060612	Adipose tissue development	Increases phenotype	PMID:32045263; PMID:39098089
GO:0061370	Testosterone biosynthetic process	Affects phenotype	PMID:33127376; PMID:36813806
GO:0061518	Microglial cell proliferation	Increases phenotype	PMID:35777461
GO:0061827	Sperm head	Affects phenotype	PMID:38798119
GO:0070265	Necrotic cell death	Increases phenotype	PMID:25062976; PMID:25062976; PMID:36528894; PMID:32270456; PMID:36528894; PMID:37906532; PMID:38229313; PMID:39317010; PMID:39657381
GO:0070577	Lysine-acetylated histone binding	Affects phenotype	PMID:32031413; PMID:37999580
GO:0070584	Mitochondrion morphogenesis	Affects phenotype	PMID:32647881
GO:0070814	Hydrogen sulfide biosynthetic process	Affects phenotype	PMID:37482551
GO:0070885	Negative regulation of calcineurin-nfat signaling cascade	Increases phenotype	PMID:28823652
GO:0070994	Detection of oxidative stress	Affects phenotype	PMID:20587388; PMID:20587388; PMID:25062976; PMID:24936443; PMID:25062976; PMID:31309260; PMID:35598369; PMID:35821281; PMID:36813806; PMID:36822304; PMID:37084658; PMID:37759824; PMID:38229313; PMID:38676876; PMID:38723480; PMID:38881217; PMID:38909693
GO:0070995	Nadph oxidation	Decreases phenotype	PMID:24295472
GO:0071243	Cellular response to arsenic-containing substance	Increases phenotype	PMID:23070617; PMID:24239724; PMID:27056082; PMID:28615018; PMID:35547012; PMID:37759824
GO:0071442	Positive regulation of histone h3-k14 acetylation	Increases phenotype	PMID:27068294
GO:0071480	Cellular response to gamma radiation	Affects phenotype	PMID:31769258
GO:0071722	Detoxification of arsenic-containing substance	Increases phenotype	PMID:23070617; PMID:24845704; PMID:27056082; PMID:35088608
GO:0071897	Dna biosynthetic process	Decreases phenotype	PMID:17450239
GO:0072089	Stem cell proliferation	Decreases phenotype	PMID:38299738
GO:0072520	Seminiferous tubule development	Affects phenotype	PMID:33127376; PMID:33127376; PMID:33171135
GO:0072593	Reactive oxygen species metabolic process	Increases phenotype	PMID:31350662; PMID:31584213; PMID:31739468; PMID:31739468; PMID:33736254; PMID:31822296; PMID:32006662; PMID:32525701; PMID:33063558; PMID:33497711; PMID:33736254; PMID:35351628; PMID:35351628; PMID:35777461; PMID:35714946; PMID:35821281; PMID:36117518; PMID:37730986; PMID:37879473; PMID:38065500
GO:0072660	Maintenance of protein location in plasma membrane	Affects phenotype	PMID:31398423
GO:0072676	Lymphocyte migration	Increases phenotype	PMID:39317010
GO:0080009	Mrna methylation	Increases phenotype	PMID:38723480
GO:0080182	Histone h3-k4 trimethylation	Increases phenotype	PMID:38299738
GO:0090136	Epithelial cell-cell adhesion	Decreases phenotype	PMID:38881217
GO:0090181	Regulation of cholesterol metabolic process	Affects phenotype	PMID:26068977
GO:0090207	Regulation of triglyceride metabolic process	Affects phenotype	PMID:26068977
GO:0097198	Histone h3-k36 trimethylation	Decreases phenotype	PMID:29499398
GO:0097215	Negative regulation of lysosomal membrane permeability	Increases phenotype	PMID:36117518
GO:0097368	Establishment of sertoli cell barrier	Affects phenotype	PMID:37084658
GO:0097676	Histone h3-k36 dimethylation	Affects phenotype	PMID:26967670
GO:0097722	Sperm motility	Decreases phenotype	PMID:33410021; PMID:34352348; PMID:36757007; PMID:36813806; PMID:38798119
GO:0098532	Histone h3-k27 trimethylation	Decreases phenotype	PMID:38299738
GO:0098609	Cell-cell adhesion	Increases phenotype	PMID:33047385
GO:0099156	Cell-cell signaling via exosome	Increases phenotype	PMID:30169766
GO:0106106	Cold-induced thermogenesis	Decreases phenotype	PMID:32045263
GO:0110090	Positive regulation of hippocampal neuron apoptotic process	Increases phenotype	PMID:35993674
GO:0120327	Telopode	Decreases phenotype	PMID:35378173
GO:0140042	Lipid droplet formation	Affects phenotype	PMID:33736254; PMID:36463740; PMID:37879473; PMID:39317010
GO:0140059	Dendrite arborization	Decreases phenotype	PMID:35993674
GO:0140409	Positive regulation of mrna alternative polyadenylation	Increases phenotype	PMID:37021545
GO:0140644	Neutrophil extracellular trap	Increases phenotype	PMID:33063558
GO:0140657	Atp-dependent activity	Decreases phenotype	PMID:25062976; PMID:36947368
GO:1900111	Positive regulation of histone h3-k9 dimethylation	Increases phenotype	PMID:27068294
GO:1901052	Sarcosine metabolic process	Affects phenotype	PMID:33736254
GO:1901605	Alpha-amino acid metabolic process	Affects phenotype	PMID:25577196
GO:1901671	Positive regulation of superoxide dismutase activity	Decreases phenotype	PMID:24295472
GO:1901687	Glutathione derivative biosynthetic process	Decreases phenotype	PMID:24295472
GO:1901896	Positive regulation of atpase-coupled calcium transmembrane transporter activity	Decreases phenotype	PMID:24295472
GO:1902465	Negative regulation of histone h3-k27 trimethylation	Increases phenotype	PMID:22843710
GO:1902512	Positive regulation of apoptotic dna fragmentation	Increases phenotype	PMID:24295472
GO:1902958	Positive regulation of mitochondrial electron transport, nadh to ubiquinone	Decreases phenotype	PMID:24295472
GO:1903047	Mitotic cell cycle process	Affects phenotype	PMID:34364923; PMID:35809665; PMID:36162444
GO:1903220	Positive regulation of malate dehydrogenase (decarboxylating) (nadp+) activity	Decreases phenotype	PMID:24295472
GO:1903283	Negative regulation of glutathione peroxidase activity	Increases phenotype	PMID:38423337
GO:1903284	Positive regulation of glutathione peroxidase activity	Decreases phenotype	PMID:24295472
GO:1903408	Positive regulation of p-type sodium:potassium-exchanging transporter activity	Decreases phenotype	PMID:24295472
GO:1903409	Reactive oxygen species biosynthetic process	Increases phenotype	PMID:29741077
GO:1903428	Positive regulation of reactive oxygen species biosynthetic process	Increases phenotype	PMID:24295472; PMID:24348802; PMID:32007923; PMID:32159786
GO:1903543	Positive regulation of exosomal secretion	Increases phenotype	PMID:30169766
GO:1903561	Extracellular vesicle	Increases phenotype	PMID:34044057
GO:1903841	Cellular response to arsenite(3-)	Increases phenotype	PMID:21560223
GO:1903936	Cellular response to sodium arsenite	Decreases phenotype	PMID:36504884
GO:1904026	Regulation of collagen fibril organization	Affects phenotype	PMID:38310360
GO:1904231	Positive regulation of succinate dehydrogenase activity	Decreases phenotype	PMID:24295472
GO:1904263	Positive regulation of torc1 signaling	Increases phenotype	PMID:29248574
GO:1904356	Regulation of telomere maintenance via telomere lengthening	Affects phenotype	PMID:29757418
GO:1904358	Positive regulation of telomere maintenance via telomere lengthening	Increases phenotype	PMID:25460668
GO:1904960	Positive regulation of cytochrome-c oxidase activity	Decreases phenotype	PMID:24295472
GO:1905517	Macrophage migration	Increases phenotype	PMID:30889423
GO:1905603	Regulation of blood-brain barrier permeability	Decreases phenotype	PMID:20829427
GO:1905867	Epididymis development	Affects phenotype	PMID:33171135
GO:1990773	Matrix metallopeptidase secretion	Increases phenotype	PMID:23232971; PMID:26637202
GO:2000147	Positive regulation of cell motility	Decreases phenotype	PMID:25868784
GO:2000555	Negative regulation of t-helper 1 cell cytokine production	Increases phenotype	PMID:24924402
GO:2000617	Positive regulation of histone h3-k9 acetylation	Increases phenotype	PMID:21385672
GO:2001162	Positive regulation of histone h3-k79 methylation	Increases phenotype	PMID:29161537
GO:2001255	Positive regulation of histone h3-k36 trimethylation	Increases phenotype	PMID:27068294
GO:2001272	Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	Increases phenotype	PMID:35993674

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.