3-Nitropropionic acid


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:27206696; PMID:27206696; PMID:37116597; PMID:37116597
GO:0001774 Microglial cell activation Increases phenotype PMID:37308051
GO:0001825 Blastocyst formation Decreases phenotype PMID:39832703
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:21945202
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:39326639
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:37116597
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:27206696; PMID:27206696; PMID:37116597
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:21945202; PMID:27206696; PMID:27206696; PMID:37116597; PMID:37116597
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:21945202; PMID:27206696; PMID:27206696; PMID:37116597; PMID:39326639; PMID:29753867; PMID:37116597; PMID:39326639
GO:0006120 Mitochondrial electron transport, nadh to ubiquinone Decreases phenotype PMID:25445565
GO:0006121 Mitochondrial electron transport, succinate to ubiquinone Decreases phenotype PMID:25445565
GO:0006123 Mitochondrial electron transport, cytochrome c to oxygen Decreases phenotype PMID:25445565
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:11211235
GO:0006537 Glutamate biosynthetic process Increases phenotype PMID:29753867
GO:0006541 Glutamine metabolic process Affects phenotype PMID:36509115
GO:0006749 Glutathione metabolic process Affects phenotype PMID:39326639
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:21945202; PMID:27206696; PMID:29753867
GO:0006809 Nitric oxide biosynthetic process Increases phenotype PMID:27206696
GO:0006811 Monoatomic ion transport Increases phenotype PMID:11211235
GO:0006915 Apoptotic process Increases phenotype PMID:11080188; PMID:11211235; PMID:11573988; PMID:15571979
GO:0006979 Response to oxidative stress Increases phenotype PMID:11211235; PMID:15541418; PMID:36509115; PMID:38513929
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:37116597
GO:0008177 Succinate dehydrogenase (ubiquinone) activity Decreases phenotype PMID:37116597
GO:0008219 Cell death Increases phenotype PMID:12930891; PMID:19046382; PMID:20561156; PMID:21219333
GO:0008344 Adult locomotory behavior Decreases phenotype PMID:29753867
GO:0008542 Visual learning Affects phenotype PMID:36509115
GO:0009449 Gamma-aminobutyric acid biosynthetic process Decreases phenotype PMID:29753867
GO:0009790 Embryo development Affects phenotype PMID:39832703
GO:0010189 Vitamin e biosynthetic process Decreases phenotype PMID:27206696
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:19306371
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:19306371
GO:0010942 Positive regulation of cell death Increases phenotype PMID:37634662
GO:0014049 Positive regulation of glutamate secretion Increases phenotype PMID:29045497
GO:0016042 Lipid catabolic process Increases phenotype PMID:21945202; PMID:27206696; PMID:29753867
GO:0018158 Protein oxidation Increases phenotype PMID:27206696
GO:0019228 Neuronal action potential Affects phenotype PMID:16919272
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:27206696
GO:0031987 Locomotion involved in locomotory behavior Decreases phenotype PMID:19046382; PMID:19046382; PMID:28853159; PMID:28853159; PMID:39326639
GO:0034440 Lipid oxidation Increases phenotype PMID:25445565; PMID:39326639
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:29753867
GO:0036124 Histone h3-k9 trimethylation Increases phenotype PMID:39832703
GO:0036211 Protein modification process Increases phenotype PMID:21945202
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:29753867
GO:0042417 Dopamine metabolic process Affects phenotype PMID:36509115
GO:0042756 Drinking behavior Increases phenotype PMID:31550440
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:19306371
GO:0045333 Cellular respiration Decreases phenotype PMID:37116597
GO:0045448 Mitotic cell cycle, embryonic Decreases phenotype PMID:39832703
GO:0046034 Atp metabolic process Affects phenotype PMID:39832703
GO:0046058 Camp metabolic process Affects phenotype PMID:36509115
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:39326639
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:15541418; PMID:19476553
GO:0048143 Astrocyte activation Affects phenotype PMID:36509115
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:22871521
GO:0050885 Neuromuscular process controlling balance Affects phenotype PMID:36509115
GO:0050890 Cognition Decreases phenotype PMID:39326639
GO:0051402 Neuron apoptotic process Increases phenotype PMID:39326639
GO:0051659 Maintenance of mitochondrion location Affects phenotype PMID:39832703
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:11080188; PMID:39832703
GO:0061744 Motor behavior Affects phenotype PMID:36509115
GO:0070265 Necrotic cell death Increases phenotype PMID:29753867
GO:0070994 Detection of oxidative stress Increases phenotype PMID:37116597; PMID:39832703
GO:0070997 Neuron death Increases phenotype PMID:37308051
GO:0090461 Cellular glutamate homeostasis Decreases phenotype PMID:29045497
GO:0098532 Histone h3-k27 trimethylation Increases phenotype PMID:39832703
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:39832703
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:29205955; PMID:37634662
GO:1904230 Negative regulation of succinate dehydrogenase activity Increases phenotype PMID:38513929
GO:1904960 Positive regulation of cytochrome-c oxidase activity Increases phenotype PMID:19306371
GO:1905376 Negative regulation of cytochrome-c oxidase activity Increases phenotype PMID:19306371
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.