Diclofenac


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000050 Urea cycle Increases phenotype PMID:31042592; PMID:31332906
GO:0000086 G2/m transition of mitotic cell cycle Increases phenotype PMID:32087850
GO:0001516 Prostaglandin biosynthetic process Increases phenotype PMID:31048000
GO:0002232 Leukocyte chemotaxis involved in inflammatory response Increases phenotype PMID:25935278
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:27671914; PMID:38945390
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:25450234
GO:0002863 Positive regulation of inflammatory response to antigenic stimulus Increases phenotype PMID:25450234
GO:0003094 Glomerular filtration Decreases phenotype PMID:18576898
GO:0004035 Alkaline phosphatase activity Decreases phenotype PMID:26934552
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:26934552
GO:0004467 Long-chain fatty acid-coa ligase activity Decreases phenotype PMID:19391105
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23994749; PMID:38945390
GO:0004623 Phospholipase a2 activity Decreases phenotype PMID:32220568
GO:0004666 Prostaglandin-endoperoxide synthase activity Decreases phenotype PMID:32220568
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:23994749; PMID:31332906
GO:0004855 Xanthine oxidase activity Increases phenotype PMID:28400101
GO:0005977 Glycogen metabolic process Affects phenotype PMID:38945390
GO:0005978 Glycogen biosynthetic process Affects phenotype PMID:26934552
GO:0005988 Lactose metabolic process Affects phenotype PMID:38945390
GO:0006006 Glucose metabolic process Affects phenotype PMID:38945390
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:15492235
GO:0006636 Unsaturated fatty acid biosynthetic process Affects phenotype PMID:32220568
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:38945390
GO:0006693 Prostaglandin metabolic process Affects phenotype PMID:32220568
GO:0006739 Nadp metabolic process Affects phenotype PMID:38945390
GO:0006749 Glutathione metabolic process Affects phenotype PMID:12763371; PMID:26921665; PMID:28754375
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:23208430; PMID:23994749; PMID:25014874; PMID:31042592; PMID:31332906
GO:0006805 Xenobiotic metabolic process Decreases phenotype PMID:12763371; PMID:31145889
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:26609140
GO:0006915 Apoptotic process Increases phenotype PMID:12826271; PMID:12894507; PMID:14599462; PMID:14609740; PMID:14609740; PMID:15361550; PMID:15492235; PMID:15555568; PMID:20237495; PMID:21427588; PMID:27313093; PMID:9192825
GO:0006919 Activation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:9851595
GO:0006954 Inflammatory response Increases phenotype PMID:33171190
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:29777724; PMID:30842367
GO:0006979 Response to oxidative stress Affects phenotype PMID:14599462; PMID:14609740; PMID:14609740; PMID:21427588
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:28762043
GO:0007286 Spermatid development Decreases phenotype PMID:37844793
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:38945390
GO:0008206 Bile acid metabolic process Affects phenotype PMID:38815664; PMID:38945390
GO:0008217 Regulation of blood pressure Increases phenotype PMID:14716214; PMID:18576898
GO:0008219 Cell death Increases phenotype PMID:15492235; PMID:16388830; PMID:18191430; PMID:24104198; PMID:9232694
GO:0008283 Cell population proliferation Affects phenotype PMID:12826271; PMID:15492235; PMID:15555568; PMID:16793607; PMID:27313093; PMID:17351657; PMID:21427588
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:33785417
GO:0009408 Response to heat Increases phenotype PMID:31926916
GO:0009636 Response to toxic substance Decreases phenotype PMID:21319177
GO:0010637 Negative regulation of mitochondrial fusion Increases phenotype PMID:27792760
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:15273253
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:27792760
GO:0010918 Positive regulation of mitochondrial membrane potential Decreases phenotype PMID:28754375; PMID:28762043
GO:0010942 Positive regulation of cell death Increases phenotype PMID:19192274; PMID:23397584; PMID:24770551; PMID:25860621; PMID:27590069; PMID:27792760; PMID:28754375; PMID:28762043
GO:0016042 Lipid catabolic process Increases phenotype PMID:22653900; PMID:23994749; PMID:28400101; PMID:28535741; PMID:31042592; PMID:31332906
GO:0016049 Cell growth Affects phenotype PMID:30659321
GO:0019395 Fatty acid oxidation Affects phenotype PMID:38676573
GO:0019627 Urea metabolic process Affects phenotype PMID:38945390
GO:0019646 Aerobic electron transport chain Affects phenotype PMID:38676573
GO:0019722 Calcium-mediated signaling Affects phenotype PMID:21427588
GO:0022604 Regulation of cell morphogenesis Affects phenotype PMID:27792760
GO:0030097 Hemopoiesis Affects phenotype PMID:38945390
GO:0030154 Cell differentiation Decreases phenotype PMID:12826271
GO:0030277 Maintenance of gastrointestinal epithelium Decreases phenotype PMID:28733234
GO:0030595 Leukocyte chemotaxis Decreases phenotype PMID:6845886
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:35537566
GO:0031394 Positive regulation of prostaglandin biosynthetic process Increases phenotype PMID:24609059
GO:0032125 Micronucleus organization Increases phenotype PMID:30842367; PMID:32087850
GO:0032930 Positive regulation of superoxide anion generation Increases phenotype PMID:28762043; PMID:28899749
GO:0034418 Urate biosynthetic process Increases phenotype PMID:31042592
GO:0034440 Lipid oxidation Increases phenotype PMID:28733234; PMID:38945390
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:31813902
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:31926916
GO:0040018 Positive regulation of multicellular organism growth Increases phenotype PMID:37844793
GO:0042311 Vasodilation Increases phenotype PMID:28899749
GO:0042391 Regulation of membrane potential Affects phenotype PMID:16806078
GO:0042775 Mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:25746382
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:24752500; PMID:24752500; PMID:28762043; PMID:26609140; PMID:28762043; PMID:37844793
GO:0044237 Cellular metabolic process Decreases phenotype PMID:32087850; PMID:32220568; PMID:34762139
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:38582345
GO:0045851 Ph reduction Increases phenotype PMID:28733234
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:32087850
GO:0046034 Atp metabolic process Affects phenotype PMID:34762139
GO:0046330 Positive regulation of jnk cascade Increases phenotype PMID:26609140
GO:0046449 Creatinine metabolic process Affects phenotype PMID:31042592; PMID:31332906; PMID:38945390
GO:0046466 Membrane lipid catabolic process Affects phenotype PMID:19948161; PMID:2116696
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:37844793
GO:0047760 Butyrate-coa ligase activity Decreases phenotype PMID:19391105
GO:0048266 Behavioral response to pain Increases phenotype PMID:31926916
GO:0050901 Leukocyte tethering or rolling Decreases phenotype PMID:14716214; PMID:18460984
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:38582345
GO:0051092 Positive regulation of nf-kappab transcription factor activity Increases phenotype PMID:12763371
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:16388830; PMID:21427588; PMID:22653900
GO:0051899 Membrane depolarization Increases phenotype PMID:36941454
GO:0052697 Xenobiotic glucuronidation Decreases phenotype PMID:27071666
GO:0060326 Cell chemotaxis Increases phenotype PMID:9232694
GO:0061367 Behavioral response to acetic acid induced pain Decreases phenotype PMID:28193520; PMID:28962077; PMID:31857126; PMID:31857126; PMID:33171190
GO:0070265 Necrotic cell death Increases phenotype PMID:27671914
GO:0070365 Hepatocyte differentiation Increases phenotype PMID:27313093
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:26609140
GO:0071674 Mononuclear cell migration Increases phenotype PMID:31332906
GO:0072520 Seminiferous tubule development Affects phenotype PMID:37844793
GO:0072719 Cellular response to cisplatin Increases phenotype PMID:33785417
GO:0098743 Cell aggregation Decreases phenotype PMID:33785417
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:9851595
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27313093
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:12763371; PMID:26921665; PMID:28762043
GO:1903578 Regulation of atp metabolic process Decreases phenotype PMID:24770551; PMID:25746382
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:38582345
GO:1904000 Positive regulation of eating behavior Decreases phenotype PMID:28733234
GO:1905792 Positive regulation of mechanosensory behavior Increases phenotype PMID:31926916
GO:1990961 Xenobiotic detoxification by transmembrane export across the plasma membrane Decreases phenotype PMID:30659321
GO:2000242 Negative regulation of reproductive process Increases phenotype PMID:37844793
GO:2000375 Negative regulation of oxygen metabolic process Increases phenotype PMID:35748891
GO:2000782 Regulation of establishment of cell polarity regulating cell shape Affects phenotype PMID:27792760
GO:2001170 Negative regulation of atp biosynthetic process Increases phenotype PMID:27792760
GO:2001171 Positive regulation of atp biosynthetic process Decreases phenotype PMID:26921665; PMID:28754375
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.