Phenol, 4,4'-(9H-fluoren-9-ylidene)bis-


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:38211720
GO:0000212 Meiotic spindle organization Affects phenotype PMID:31082581
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:39986567
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:31082581
GO:0001553 Luteinization Decreases phenotype PMID:28248286
GO:0001825 Blastocyst formation Decreases phenotype PMID:39986567
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:33989918
GO:0004016 Adenylate cyclase activity Increases phenotype PMID:35987080
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33989918
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:33989918
GO:0006171 Camp biosynthetic process Increases phenotype PMID:35987080
GO:0006754 Atp biosynthetic process Affects phenotype PMID:35435491
GO:0006915 Apoptotic process Increases phenotype PMID:31082581
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:31082581
GO:0007033 Vacuole organization Increases phenotype PMID:33989918
GO:0007283 Spermatogenesis Decreases phenotype PMID:35764126
GO:0008219 Cell death Increases phenotype PMID:35987080
GO:0008283 Cell population proliferation Decreases phenotype PMID:35987080
GO:0009299 Mrna transcription Decreases phenotype PMID:39986567
GO:0009790 Embryo development Decreases phenotype PMID:39986567
GO:0030283 Testosterone dehydrogenase [nad(p)] activity Decreases phenotype PMID:39313105
GO:0032342 Aldosterone biosynthetic process Affects phenotype PMID:35987080
GO:0034651 Cortisol biosynthetic process Affects phenotype PMID:35987080
GO:0035936 Testosterone secretion Affects phenotype PMID:35764126
GO:0036124 Histone h3-k9 trimethylation Decreases phenotype PMID:39986567
GO:0040038 Polar body extrusion after meiotic divisions Decreases phenotype PMID:31082581
GO:0042311 Vasodilation Increases phenotype PMID:33989918
GO:0042554 Superoxide anion generation Increases phenotype PMID:39986567
GO:0042701 Progesterone secretion Affects phenotype PMID:39313105
GO:0043970 Histone h3-k9 acetylation Decreases phenotype PMID:39986567
GO:0043974 Histone h3-k27 acetylation Decreases phenotype PMID:39986567
GO:0044237 Cellular metabolic process Decreases phenotype PMID:31327139; PMID:33989918; PMID:38211720
GO:0044319 Wound healing, spreading of cells Decreases phenotype PMID:31327139
GO:0046034 Atp metabolic process Affects phenotype PMID:39986567
GO:0048863 Stem cell differentiation Affects phenotype PMID:37964943
GO:0050000 Chromosome localization Affects phenotype PMID:31082581
GO:0051646 Mitochondrion localization Affects phenotype PMID:39986567
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:31082581; PMID:39986567
GO:0060065 Uterus development Affects phenotype PMID:28248286
GO:0060135 Maternal process involved in female pregnancy Decreases phenotype PMID:28248286
GO:0061085 Regulation of histone h3-k27 methylation Affects phenotype PMID:39986567
GO:0061107 Seminal vesicle development Increases phenotype PMID:28248286
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:35764126; PMID:35987080
GO:0070994 Detection of oxidative stress Increases phenotype PMID:39986567
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:38211720
GO:0098532 Histone h3-k27 trimethylation Decreases phenotype PMID:39986567
GO:0160024 Leydig cell proliferation Increases phenotype PMID:35764126
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:38211720
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:31082581
GO:1905867 Epididymis development Increases phenotype PMID:28248286
GO:2000386 Positive regulation of ovarian follicle development Decreases phenotype PMID:28248286
GO:2000480 Negative regulation of camp-dependent protein kinase activity Increases phenotype PMID:35987080
GO:2000481 Positive regulation of camp-dependent protein kinase activity Increases phenotype PMID:35987080
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.