Triptolide


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:26990902
GO:0000084 Mitotic s phase Affects phenotype PMID:36990132
GO:0000122 Negative regulation of transcription by rna polymerase ii Increases phenotype PMID:31218727
GO:0001541 Ovarian follicle development Decreases phenotype PMID:38735593
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:27022166
GO:0001820 Serotonin secretion Increases phenotype PMID:36539404
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:26990902; PMID:36520315
GO:0001954 Positive regulation of cell-matrix adhesion Decreases phenotype PMID:26420756
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:34758665; PMID:36520315; PMID:36990132; PMID:36328986; PMID:36520315
GO:0002724 Regulation of t cell cytokine production Affects phenotype PMID:36520315
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:33832337
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:33832337; PMID:34758665
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:26277538; PMID:38735593
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:26134275; PMID:26277538; PMID:30682494; PMID:34758665; PMID:38735593
GO:0005634 Nucleus Decreases phenotype PMID:32061799
GO:0005739 Mitochondrion Decreases phenotype PMID:36436616
GO:0006006 Glucose metabolic process Decreases phenotype PMID:23639586; PMID:29723566; PMID:31618665
GO:0006264 Mitochondrial dna replication Affects phenotype PMID:29723566; PMID:36436616
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:26990902
GO:0006520 Amino acid metabolic process Affects phenotype PMID:33832337
GO:0006606 Protein import into nucleus Affects phenotype PMID:31618665
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:32987112; PMID:32987112; PMID:36520315; PMID:36520315
GO:0006644 Phospholipid metabolic process Affects phenotype PMID:32519852
GO:0006665 Sphingolipid metabolic process Affects phenotype PMID:32519852
GO:0006749 Glutathione metabolic process Affects phenotype PMID:34758665
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:30682494; PMID:30836114; PMID:30926361
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:29723566; PMID:31618665
GO:0006914 Autophagy Increases phenotype PMID:26990902
GO:0006915 Apoptotic process Increases phenotype PMID:18922616; PMID:26277538; PMID:26990902; PMID:30836114; PMID:30926361; PMID:31557070; PMID:31618665; PMID:32987112; PMID:36520315; PMID:36328986; PMID:36436616; PMID:36520315; PMID:38735593; PMID:38960301
GO:0006954 Inflammatory response Increases phenotype PMID:32987112
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:30836114
GO:0007049 Cell cycle Affects phenotype PMID:23639586
GO:0007283 Spermatogenesis Decreases phenotype PMID:30836114; PMID:38960301
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:32987112; PMID:32987112; PMID:36520315; PMID:36520315
GO:0008206 Bile acid metabolic process Increases phenotype PMID:30633930; PMID:36328986
GO:0008219 Cell death Increases phenotype PMID:29723566; PMID:29902661
GO:0008283 Cell population proliferation Affects phenotype PMID:32061799; PMID:32987112
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:12533674; PMID:30009776; PMID:30394310; PMID:34087332; PMID:35678845
GO:0008343 Adult feeding behavior Affects phenotype PMID:33600922
GO:0008584 Male gonad development Decreases phenotype PMID:29723566; PMID:38960301
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:32519852
GO:0009112 Nucleobase metabolic process Affects phenotype PMID:32519852
GO:0009437 Carnitine metabolic process Affects phenotype PMID:31241159
GO:0009611 Response to wounding Increases phenotype PMID:30009776
GO:0010918 Positive regulation of mitochondrial membrane potential Affects phenotype PMID:25169008; PMID:30009776; PMID:30009776; PMID:31218727
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:25169008; PMID:37944651
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26420756; PMID:27554044
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:26420756
GO:0014889 Muscle atrophy Increases phenotype PMID:32061799
GO:0014906 Myotube cell development involved in skeletal muscle regeneration Decreases phenotype PMID:32061799
GO:0016042 Lipid catabolic process Increases phenotype PMID:26134275; PMID:29723566; PMID:30836114
GO:0016049 Cell growth Decreases phenotype PMID:29723566; PMID:29902661; PMID:30682494
GO:0016477 Cell migration Increases phenotype PMID:25497111
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:29723566
GO:0019222 Regulation of metabolic process Affects phenotype PMID:32835833
GO:0019249 Lactate biosynthetic process Decreases phenotype PMID:29723566
GO:0019659 Glucose catabolic process to lactate Decreases phenotype PMID:34087332
GO:0019674 Nad metabolic process Affects phenotype PMID:36436616
GO:0030101 Natural killer cell activation Increases phenotype PMID:36520315
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Increases phenotype PMID:30633930
GO:0030335 Positive regulation of cell migration Decreases phenotype PMID:26420756
GO:0030836 Positive regulation of actin filament depolymerization Increases phenotype PMID:27554044
GO:0032114 Regulation of glucose-6-phosphatase activity Affects phenotype PMID:23639586
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:26420756; PMID:30394310
GO:0032735 Positive regulation of interleukin-12 production Increases phenotype PMID:15663903
GO:0034063 Stress granule assembly Increases phenotype PMID:34244458
GO:0034116 Positive regulation of heterotypic cell-cell adhesion Decreases phenotype PMID:27554044
GO:0034440 Lipid oxidation Increases phenotype PMID:34758665; PMID:38960301
GO:0035359 Negative regulation of peroxisome proliferator activated receptor signaling pathway Increases phenotype PMID:31241159
GO:0035930 Corticosteroid hormone secretion Increases phenotype PMID:31557376
GO:0035934 Corticosterone secretion Increases phenotype PMID:31557376
GO:0035936 Testosterone secretion Increases phenotype PMID:31557376
GO:0035938 Estradiol secretion Increases phenotype PMID:31557376
GO:0036145 Dendritic cell homeostasis Affects phenotype PMID:36520315
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:30009776
GO:0042593 Glucose homeostasis Decreases phenotype PMID:23639586; PMID:30633930
GO:0042701 Progesterone secretion Increases phenotype PMID:31557376
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:12533674; PMID:23639586; PMID:25169008; PMID:27022166; PMID:30009776; PMID:30394310; PMID:30394310; PMID:32835833; PMID:30633930; PMID:37944651
GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:12533674
GO:0043400 Cortisol secretion Increases phenotype PMID:31557376
GO:0044237 Cellular metabolic process Decreases phenotype PMID:30926361; PMID:32061799; PMID:33600922; PMID:36436616; PMID:36990132; PMID:38735593; PMID:38960301
GO:0044849 Estrous cycle Affects phenotype PMID:27022166
GO:0045333 Cellular respiration Affects phenotype PMID:36436616
GO:0045454 Cell redox homeostasis Affects phenotype PMID:23639586
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:34087332
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:26990902
GO:0046034 Atp metabolic process Affects phenotype PMID:36436616
GO:0046323 Glucose import Decreases phenotype PMID:31618665
GO:0046330 Positive regulation of jnk cascade Decreases phenotype PMID:26420756
GO:0046415 Urate metabolic process Decreases phenotype PMID:32519852
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:32519852
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:34087332
GO:0050714 Positive regulation of protein secretion Increases phenotype PMID:30009776
GO:0051092 Positive regulation of nf-kappab transcription factor activity Decreases phenotype PMID:26420756
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:26277538; PMID:26990902; PMID:29723566; PMID:36436616; PMID:36990132
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:36436616
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:26990902
GO:0060112 Generation of ovulation cycle rhythm Affects phenotype PMID:38735593
GO:0060207 Diestrus Affects phenotype PMID:38735593
GO:0060208 Proestrus Affects phenotype PMID:38735593
GO:0060209 Estrus Affects phenotype PMID:38735593
GO:0060210 Metestrus Affects phenotype PMID:38735593
GO:0060280 Negative regulation of ovulation Increases phenotype PMID:27022166
GO:0060545 Positive regulation of necroptotic process Increases phenotype PMID:30633930
GO:0061951 Establishment of protein localization to plasma membrane Increases phenotype PMID:30591588
GO:0070265 Necrotic cell death Increases phenotype PMID:31557070; PMID:36328986; PMID:38960301
GO:0070374 Positive regulation of erk1 and erk2 cascade Decreases phenotype PMID:26420756
GO:0070534 Protein k63-linked ubiquitination Increases phenotype PMID:38960301
GO:0070585 Protein localization to mitochondrion Affects phenotype PMID:30009776
GO:0070873 Regulation of glycogen metabolic process Affects phenotype PMID:30633930
GO:0070994 Detection of oxidative stress Increases phenotype PMID:38960301
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:26277538; PMID:31218727; PMID:34758665; PMID:38735593
GO:0080135 Regulation of cellular response to stress Increases phenotype PMID:31218727
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:25169008; PMID:30009776; PMID:30009776
GO:0097368 Establishment of sertoli cell barrier Decreases phenotype PMID:30836114
GO:0140042 Lipid droplet formation Increases phenotype PMID:32987112; PMID:36520315
GO:1900039 Positive regulation of cellular response to hypoxia Increases phenotype PMID:24842335
GO:1900181 Negative regulation of protein localization to nucleus Increases phenotype PMID:34087332
GO:1900409 Positive regulation of cellular response to oxidative stress Affects phenotype PMID:23639586
GO:1900745 Positive regulation of p38mapk cascade Increases phenotype PMID:26420756
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:25169008
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:27554044
GO:1902679 Negative regulation of rna biosynthetic process Increases phenotype PMID:31218727
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:36990132
GO:1903393 Positive regulation of adherens junction organization Decreases phenotype PMID:27554044
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:26990902; PMID:30682494; PMID:30926361
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25169008; PMID:25169008; PMID:30009776; PMID:30009776; PMID:30394310
GO:1905710 Positive regulation of membrane permeability Increases phenotype PMID:31218727
GO:1990266 Neutrophil migration Increases phenotype PMID:24949944
GO:2000279 Negative regulation of dna biosynthetic process Increases phenotype PMID:31218727
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:27022166
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:30633930
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.