Zinc Sulfate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002678 Positive regulation of chronic inflammatory response Increases phenotype PMID:35526705
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:22422511
GO:0004053 Arginase activity Increases phenotype PMID:32864810
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:32864810
GO:0004602 Glutathione peroxidase activity Affects phenotype PMID:25724285; PMID:32864810
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:22422511; PMID:25724285; PMID:32864810
GO:0005391 P-type sodium:potassium-exchanging transporter activity Decreases phenotype PMID:32864810
GO:0006004 Fucose metabolic process Affects phenotype PMID:32864810
GO:0006054 N-acetylneuraminate metabolic process Affects phenotype PMID:32864810
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:7673702
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25724285; PMID:29408668
GO:0006882 Cellular zinc ion homeostasis Affects phenotype PMID:32661532
GO:0006909 Phagocytosis Affects phenotype PMID:32712770
GO:0006915 Apoptotic process Increases phenotype PMID:27017951; PMID:29408668; PMID:32712770; PMID:36450499; PMID:7673702
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27017951
GO:0006979 Response to oxidative stress Increases phenotype PMID:16959597
GO:0007283 Spermatogenesis Decreases phenotype PMID:39106537
GO:0007614 Short-term memory Decreases phenotype PMID:36265761
GO:0007625 Grooming behavior Decreases phenotype PMID:35526705
GO:0007628 Adult walking behavior Decreases phenotype PMID:35526705
GO:0008219 Cell death Increases phenotype PMID:26865462; PMID:32712770
GO:0008283 Cell population proliferation Decreases phenotype PMID:24962574
GO:0009725 Response to hormone Increases phenotype PMID:35526705
GO:0010035 Response to inorganic substance Increases phenotype PMID:35526705
GO:0010259 Multicellular organism aging Increases phenotype PMID:35526705
GO:0010424 Dna methylation on cytosine within a cg sequence Decreases phenotype PMID:27017951
GO:0016042 Lipid catabolic process Increases phenotype PMID:25724285; PMID:27270452
GO:0016049 Cell growth Decreases phenotype PMID:29408668
GO:0018158 Protein oxidation Increases phenotype PMID:32864810
GO:0019318 Hexose metabolic process Affects phenotype PMID:32864810
GO:0019627 Urea metabolic process Increases phenotype PMID:35526705
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:35526705
GO:0030317 Flagellated sperm motility Decreases phenotype PMID:39106537
GO:0032275 Luteinizing hormone secretion Decreases phenotype PMID:39106537
GO:0033484 Cellular nitric oxide homeostasis Decreases phenotype PMID:35526705
GO:0034440 Lipid oxidation Increases phenotype PMID:35526705
GO:0035640 Exploration behavior Decreases phenotype PMID:35526705
GO:0035936 Testosterone secretion Decreases phenotype PMID:39106537
GO:0042133 Neurotransmitter metabolic process Increases phenotype PMID:35526705
GO:0044237 Cellular metabolic process Decreases phenotype PMID:32712770; PMID:36450499
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:35526705
GO:0045930 Negative regulation of mitotic cell cycle Increases phenotype PMID:27017951
GO:0046449 Creatinine metabolic process Increases phenotype PMID:35526705
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:16865776
GO:0046884 Follicle-stimulating hormone secretion Decreases phenotype PMID:39106537
GO:0055070 Copper ion homeostasis Decreases phenotype PMID:24368744
GO:0070265 Necrotic cell death Increases phenotype PMID:32712770
GO:0070459 Prolactin secretion Increases phenotype PMID:39106537
GO:0071578 Zinc ion import across plasma membrane Decreases phenotype PMID:30635848
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:24412756; PMID:25724285; PMID:32712770
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:35526705; PMID:39106537
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:24368744
GO:1901687 Glutathione derivative biosynthetic process Decreases phenotype PMID:24368744
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:39106537
GO:1902553 Positive regulation of catalase activity Decreases phenotype PMID:24368744
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:27017951; PMID:29408668
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.