Potassium dichromate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000104 Succinate dehydrogenase activity Decreases phenotype PMID:25245570
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:35547012; PMID:36849043; PMID:39177155
GO:0001541 Ovarian follicle development Increases phenotype PMID:26348139
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:23470461; PMID:23470461; PMID:25568306; PMID:26348139
GO:0001916 Positive regulation of t cell mediated cytotoxicity Decreases phenotype PMID:28899767
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:30974164; PMID:36880428
GO:0003876 Amp deaminase activity Increases phenotype PMID:29665407
GO:0003954 Nadh dehydrogenase activity Decreases phenotype PMID:25245570
GO:0003993 Acid phosphatase activity Increases phenotype PMID:28988497
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:28988497
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28988497; PMID:28988497; PMID:30974164; PMID:31756458
GO:0004096 Catalase activity Increases phenotype PMID:39177155
GO:0004129 Cytochrome-c oxidase activity Decreases phenotype PMID:25245570
GO:0004364 Glutathione transferase activity Affects phenotype PMID:23470461; PMID:25245570; PMID:29665407; PMID:30578656; PMID:39177155
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:28988497; PMID:29665407
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:23470461; PMID:25245570; PMID:28988497
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:23470461; PMID:25245570; PMID:28988497; PMID:31756458; PMID:35547012; PMID:36849043; PMID:39177155
GO:0006089 Lactate metabolic process Increases phenotype PMID:29665407
GO:0006119 Oxidative phosphorylation Decreases phenotype PMID:36473502
GO:0006749 Glutathione metabolic process Increases phenotype PMID:28988497; PMID:29665407; PMID:30578656; PMID:35547012; PMID:39177155
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:25245570; PMID:31756458
GO:0006754 Atp biosynthetic process Affects phenotype PMID:35435491
GO:0006788 Heme oxidation Increases phenotype PMID:29665407
GO:0006915 Apoptotic process Increases phenotype PMID:23470461; PMID:25245570; PMID:30974164; PMID:35307491; PMID:36849043
GO:0006954 Inflammatory response Increases phenotype PMID:31756458
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:25245570
GO:0006979 Response to oxidative stress Increases phenotype PMID:18155343
GO:0007005 Mitochondrion organization Decreases phenotype PMID:32980475; PMID:36849043
GO:0007033 Vacuole organization Increases phenotype PMID:30974164
GO:0007283 Spermatogenesis Decreases phenotype PMID:28192182; PMID:30578656; PMID:30578656
GO:0007588 Excretion Affects phenotype PMID:18331393
GO:0007613 Memory Affects phenotype PMID:30090589
GO:0008206 Bile acid metabolic process Affects phenotype PMID:30090589
GO:0008209 Androgen metabolic process Affects phenotype PMID:33675932
GO:0008210 Estrogen metabolic process Affects phenotype PMID:33675932
GO:0008219 Cell death Increases phenotype PMID:26865462
GO:0008253 5'-nucleotidase activity Decreases phenotype PMID:29665407
GO:0008283 Cell population proliferation Decreases phenotype PMID:23718831; PMID:24962574
GO:0008361 Regulation of cell size Affects phenotype PMID:30315952
GO:0008483 Transaminase activity Affects phenotype PMID:30578656
GO:0008584 Male gonad development Affects phenotype PMID:33675932
GO:0009261 Ribonucleotide catabolic process Decreases phenotype PMID:29665407
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:30578656
GO:0010923 Negative regulation of phosphatase activity Increases phenotype PMID:30578656
GO:0016042 Lipid catabolic process Increases phenotype PMID:23470461; PMID:28988497
GO:0016477 Cell migration Increases phenotype PMID:36473502
GO:0018158 Protein oxidation Increases phenotype PMID:18331393; PMID:29665407; PMID:39177155
GO:0019853 L-ascorbic acid biosynthetic process Decreases phenotype PMID:23470461
GO:0022900 Electron transport chain Decreases phenotype PMID:29665407
GO:0030199 Collagen fibril organization Increases phenotype PMID:31756458
GO:0030308 Negative regulation of cell growth Increases phenotype PMID:36931533
GO:0032099 Negative regulation of appetite Increases phenotype PMID:36416502
GO:0032148 Activation of protein kinase b activity Decreases phenotype PMID:26348139; PMID:36416502
GO:0034109 Homotypic cell-cell adhesion Decreases phenotype PMID:30315952
GO:0034440 Lipid oxidation Increases phenotype PMID:18331393; PMID:25409916; PMID:26348139; PMID:28192182; PMID:29665407; PMID:30578656; PMID:30578656; PMID:36416502; PMID:35547012; PMID:36416502; PMID:39177155
GO:0035936 Testosterone secretion Decreases phenotype PMID:23470461
GO:0035937 Estrogen secretion Decreases phenotype PMID:23470461
GO:0036211 Protein modification process Increases phenotype PMID:35547012
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:28192182
GO:0042110 T cell activation Decreases phenotype PMID:28899767
GO:0042130 Negative regulation of t cell proliferation Increases phenotype PMID:28899767
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:30090589
GO:0042701 Progesterone secretion Decreases phenotype PMID:23470461
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:32980475
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:25568306; PMID:26348139; PMID:26348139; PMID:32569804; PMID:37146930; PMID:37931768
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:29665407
GO:0045821 Positive regulation of glycolytic process Increases phenotype PMID:32569804
GO:0046033 Amp metabolic process Increases phenotype PMID:29665407
GO:0046034 Atp metabolic process Affects phenotype PMID:36849043
GO:0046415 Urate metabolic process Decreases phenotype PMID:18331393
GO:0046449 Creatinine metabolic process Decreases phenotype PMID:18331393; PMID:32980475
GO:0046622 Positive regulation of organ growth Decreases phenotype PMID:28192182
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:23470461
GO:0050801 Monoatomic ion homeostasis Affects phenotype PMID:30090589
GO:0050860 Negative regulation of t cell receptor signaling pathway Affects phenotype PMID:28899767
GO:0050879 Multicellular organismal movement Decreases phenotype PMID:36416502
GO:0051348 Negative regulation of transferase activity Affects phenotype PMID:30578656
GO:0055072 Iron ion homeostasis Decreases phenotype PMID:36416502
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:30315952
GO:0061621 Canonical glycolysis Increases phenotype PMID:36473502
GO:0061739 Protein lipidation involved in autophagosome assembly Increases phenotype PMID:32569804
GO:0070265 Necrotic cell death Increases phenotype PMID:28988497; PMID:28988497; PMID:30974164; PMID:31756458; PMID:39177155
GO:0070994 Detection of oxidative stress Increases phenotype PMID:36849043
GO:0071243 Cellular response to arsenic-containing substance Affects phenotype PMID:35547012
GO:0071674 Mononuclear cell migration Increases phenotype PMID:39177155
GO:0072582 17-beta-hydroxysteroid dehydrogenase (nadp+) activity Decreases phenotype PMID:33675932
GO:0102727 3beta-hydroxysteroid dehydrogenase activity Decreases phenotype PMID:33675932
GO:1900111 Positive regulation of histone h3-k9 dimethylation Increases phenotype PMID:29391238
GO:1900113 Negative regulation of histone h3-k9 trimethylation Increases phenotype PMID:37931768
GO:1900114 Positive regulation of histone h3-k9 trimethylation Increases phenotype PMID:29391238; PMID:37931768
GO:1901666 Positive regulation of nad+ adp-ribosyltransferase activity Increases phenotype PMID:18331393
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:30578656
GO:1901671 Positive regulation of superoxide dismutase activity Affects phenotype PMID:25409916; PMID:26348139; PMID:28192182
GO:1901687 Glutathione derivative biosynthetic process Increases phenotype PMID:29665407
GO:1902093 Positive regulation of flagellated sperm motility Decreases phenotype PMID:28192182
GO:1902465 Negative regulation of histone h3-k27 trimethylation Increases phenotype PMID:37931768
GO:1902466 Positive regulation of histone h3-k27 trimethylation Increases phenotype PMID:37931768
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:18331393; PMID:29665407; PMID:30578656
GO:1903284 Positive regulation of glutathione peroxidase activity Affects phenotype PMID:25409916; PMID:26348139; PMID:28192182
GO:1903407 Negative regulation of p-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:29665407
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:25409916; PMID:28192182; PMID:29665407; PMID:37146930
GO:1904027 Negative regulation of collagen fibril organization Increases phenotype PMID:37146930
GO:1905709 Negative regulation of membrane permeability Increases phenotype PMID:37146930
GO:1905710 Positive regulation of membrane permeability Increases phenotype PMID:37146930
GO:1990266 Neutrophil migration Increases phenotype PMID:36880428
GO:2000355 Negative regulation of ovarian follicle development Increases phenotype PMID:37931768
GO:2000510 Positive regulation of dendritic cell chemotaxis Increases phenotype PMID:24768652
GO:2000738 Positive regulation of stem cell differentiation Increases phenotype PMID:29391238
GO:2000844 Negative regulation of testosterone secretion Increases phenotype PMID:30578656
GO:2000845 Positive regulation of testosterone secretion Decreases phenotype PMID:28192182
GO:2001057 Reactive nitrogen species metabolic process Increases phenotype PMID:29665407
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.