1,2-Dichloroethane


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001809 Positive regulation of type iv hypersensitivity Decreases phenotype PMID:14631503
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:28189721; PMID:28960355; PMID:37150348
GO:0005978 Glycogen biosynthetic process Increases phenotype PMID:28189721; PMID:28960355
GO:0006094 Gluconeogenesis Affects phenotype PMID:28960355
GO:0006114 Glycerol biosynthetic process Increases phenotype PMID:28960355
GO:0006171 Camp biosynthetic process Increases phenotype PMID:28973639
GO:0006833 Water transport Increases phenotype PMID:31734271
GO:0006915 Apoptotic process Increases phenotype PMID:31520740
GO:0006955 Immune response Decreases phenotype PMID:24228488
GO:0006971 Hypotonic response Increases phenotype PMID:37028497
GO:0006997 Nucleus organization Decreases phenotype PMID:18230303
GO:0007005 Mitochondrion organization Affects phenotype PMID:37028497
GO:0007009 Plasma membrane organization Decreases phenotype PMID:18230303
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:23559643
GO:0007283 Spermatogenesis Decreases phenotype PMID:28973639
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:18230303; PMID:23559643
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:34560092
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:34560092
GO:0019432 Triglyceride biosynthetic process Increases phenotype PMID:28189721; PMID:28960355
GO:0032275 Luteinizing hormone secretion Increases phenotype PMID:28973639
GO:0034440 Lipid oxidation Increases phenotype PMID:30664321
GO:0035399 Helper t cell enhancement of b cell mediated immune response Decreases phenotype PMID:14631503
GO:0035633 Maintenance of blood-brain barrier Decreases phenotype PMID:30081051
GO:0035936 Testosterone secretion Increases phenotype PMID:28973639
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28973639
GO:0045773 Positive regulation of axon extension Decreases phenotype PMID:18230303
GO:0051613 Positive regulation of serotonin uptake Decreases phenotype PMID:16350752
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:28973639
GO:0070994 Detection of oxidative stress Increases phenotype PMID:37150348
GO:0090200 Positive regulation of release of cytochrome c from mitochondria Increases phenotype PMID:34560092
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:34560092
GO:1903406 Regulation of p-type sodium:potassium-exchanging transporter activity Affects phenotype PMID:16350752
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:23559643
GO:2001244 Positive regulation of intrinsic apoptotic signaling pathway Increases phenotype PMID:34560092
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.