Tartrazine


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:12160896; PMID:29981020
GO:0001776 Leukocyte homeostasis Affects phenotype PMID:31936188
GO:0001820 Serotonin secretion Increases phenotype PMID:36539404
GO:0001821 Histamine secretion Increases phenotype PMID:2445985; PMID:6189363
GO:0002123 Irritable aggressive behavior Increases phenotype PMID:3395307
GO:0002523 Leukocyte migration involved in inflammatory response Increases phenotype PMID:29981020; PMID:39619970
GO:0002539 Prostaglandin production involved in inflammatory response Increases phenotype PMID:29290353
GO:0002540 Leukotriene production involved in inflammatory response Increases phenotype PMID:29290353
GO:0003796 Lysozyme activity Decreases phenotype PMID:30096597
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity Increases phenotype PMID:22317828; PMID:22317828; PMID:29981020
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:22317828; PMID:22317828; PMID:28239801; PMID:29981020; PMID:28239801
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity Increases phenotype PMID:22317828; PMID:22317828; PMID:28239801; PMID:29981020; PMID:28239801
GO:0004364 Glutathione transferase activity Decreases phenotype PMID:22317828; PMID:29427609
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:28239801
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:28239801
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:22317828; PMID:26862277; PMID:28239801; PMID:31936188
GO:0005581 Collagen trimer Affects phenotype PMID:39619970
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:28239801
GO:0006690 Icosanoid metabolic process Affects phenotype PMID:29290353
GO:0006691 Leukotriene metabolic process Affects phenotype PMID:29290353
GO:0006749 Glutathione metabolic process Affects phenotype PMID:22317828; PMID:22317828; PMID:28239801; PMID:26862277; PMID:28239801; PMID:31936188
GO:0006909 Phagocytosis Decreases phenotype PMID:30096597
GO:0006915 Apoptotic process Increases phenotype PMID:39619970
GO:0006939 Smooth muscle contraction Increases phenotype PMID:7257821
GO:0006979 Response to oxidative stress Increases phenotype PMID:20678534; PMID:31032366; PMID:33316931; PMID:33748463
GO:0007283 Spermatogenesis Decreases phenotype PMID:29854586; PMID:33565293
GO:0007420 Brain development Affects phenotype PMID:28126192
GO:0007610 Behavior Affects phenotype PMID:20551163; PMID:3395307
GO:0007611 Learning or memory Decreases phenotype PMID:22417523
GO:0007612 Learning Decreases phenotype PMID:551301; PMID:7464455
GO:0007613 Memory Decreases phenotype PMID:28126192; PMID:33748463
GO:0007626 Locomotory behavior Affects phenotype PMID:551301; PMID:7464455
GO:0008146 Sulfotransferase activity Decreases phenotype PMID:28356238
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:28239801
GO:0008283 Cell population proliferation Decreases phenotype PMID:20077213
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:30847814
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:26190785
GO:0010867 Positive regulation of triglyceride biosynthetic process Increases phenotype PMID:29854586; PMID:32870427
GO:0010916 Negative regulation of very-low-density lipoprotein particle clearance Increases phenotype PMID:29854586; PMID:32870427
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:30847814
GO:0010983 Positive regulation of high-density lipoprotein particle clearance Increases phenotype PMID:29854586; PMID:32870427
GO:0010989 Negative regulation of low-density lipoprotein particle clearance Increases phenotype PMID:29854586; PMID:32870427
GO:0014009 Glial cell proliferation Affects phenotype PMID:28126192
GO:0015734 Taurine transport Decreases phenotype PMID:39341
GO:0015816 Glycine transport Decreases phenotype PMID:39341
GO:0015871 Choline transport Decreases phenotype PMID:39341
GO:0016032 Viral process Decreases phenotype PMID:31167919
GO:0016209 Antioxidant activity Affects phenotype PMID:30657462; PMID:38408527
GO:0019627 Urea metabolic process Affects phenotype PMID:22317828; PMID:22317828; PMID:28239801; PMID:28239801; PMID:32981412
GO:0030199 Collagen fibril organization Increases phenotype PMID:26862277; PMID:39619970
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:26862277; PMID:28126192; PMID:30096597; PMID:31936188
GO:0030282 Bone mineralization Decreases phenotype PMID:39619970
GO:0031175 Neuron projection development Decreases phenotype PMID:28126192
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:22323474; PMID:31936188
GO:0032099 Negative regulation of appetite Increases phenotype PMID:6146662
GO:0032125 Micronucleus organization Affects phenotype PMID:28264634
GO:0032964 Collagen biosynthetic process Increases phenotype PMID:28356238
GO:0033686 Positive regulation of luteinizing hormone secretion Increases phenotype PMID:36012044
GO:0034101 Erythrocyte homeostasis Decreases phenotype PMID:31936188; PMID:864790
GO:0034440 Lipid oxidation Increases phenotype PMID:26862277; PMID:28239801; PMID:31936188
GO:0035641 Locomotory exploration behavior Affects phenotype PMID:24937660
GO:0040013 Negative regulation of locomotion Increases phenotype PMID:6146662
GO:0042417 Dopamine metabolic process Affects phenotype PMID:26190785
GO:0042428 Serotonin metabolic process Affects phenotype PMID:26190785
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:22417523; PMID:26190785
GO:0043197 Dendritic spine Affects phenotype PMID:28126192
GO:0044237 Cellular metabolic process Increases phenotype PMID:20077213; PMID:33819548; PMID:34681664; PMID:36564854
GO:0044782 Cilium organization Affects phenotype PMID:24941295
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:28243541
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:28243541; PMID:32870427
GO:0045542 Positive regulation of cholesterol biosynthetic process Increases phenotype PMID:29854586; PMID:32870427
GO:0045926 Negative regulation of growth Increases phenotype PMID:859044
GO:0046209 Nitric oxide metabolic process Affects phenotype PMID:30096597
GO:0046415 Urate metabolic process Affects phenotype PMID:28239801
GO:0046449 Creatinine metabolic process Affects phenotype PMID:22317828; PMID:22317828; PMID:28239801; PMID:29981020; PMID:28239801; PMID:32981412
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:26190785; PMID:29427609; PMID:34972512
GO:0046959 Habituation Decreases phenotype PMID:551301
GO:0046985 Positive regulation of hemoglobin biosynthetic process Affects phenotype PMID:864790
GO:0050729 Positive regulation of inflammatory response Affects phenotype PMID:29217164; PMID:29854586; PMID:30847814
GO:0050905 Neuromuscular process Affects phenotype PMID:864790
GO:0050996 Positive regulation of lipid catabolic process Increases phenotype PMID:22417523; PMID:28243541; PMID:38408527; PMID:29854586; PMID:30657462; PMID:30847814; PMID:32870427; PMID:38408527
GO:0051612 Negative regulation of serotonin uptake Increases phenotype PMID:39341
GO:0051622 Negative regulation of norepinephrine uptake Increases phenotype PMID:39341
GO:0051782 Negative regulation of cell division Increases phenotype PMID:20667460
GO:0051938 L-glutamate import Decreases phenotype PMID:39341
GO:0051939 Gamma-aminobutyric acid import Decreases phenotype PMID:39341
GO:0055008 Cardiac muscle tissue morphogenesis Increases phenotype PMID:39619970
GO:0061326 Renal tubule development Decreases phenotype PMID:29854586
GO:0061370 Testosterone biosynthetic process Affects phenotype PMID:33565293
GO:0070265 Necrotic cell death Increases phenotype PMID:26862277; PMID:29981020; PMID:30096597
GO:0070661 Leukocyte proliferation Increases phenotype PMID:29981020
GO:0070997 Neuron death Affects phenotype PMID:28126192
GO:0072676 Lymphocyte migration Increases phenotype PMID:17505761
GO:0072677 Eosinophil migration Increases phenotype PMID:17505761
GO:0090648 Response to environmental enrichment Affects phenotype PMID:28126192
GO:0097279 Histamine secretion mediated by ige immunoglobulin Increases phenotype PMID:24153330
GO:0140042 Lipid droplet formation Increases phenotype PMID:37046073
GO:0160029 Kidney cortex tubule cell dedifferentiation Increases phenotype PMID:29854586
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:20678534; PMID:33316931; PMID:26190785; PMID:29217164; PMID:29427609; PMID:33316931; PMID:34972512
GO:1901671 Positive regulation of superoxide dismutase activity Increases phenotype PMID:30657462; PMID:38408527
GO:1902552 Negative regulation of catalase activity Increases phenotype PMID:20678534; PMID:29217164; PMID:33316931
GO:1902553 Positive regulation of catalase activity Increases phenotype PMID:30657462
GO:1903011 Negative regulation of bone development Increases phenotype PMID:39866447
GO:1903283 Negative regulation of glutathione peroxidase activity Increases phenotype PMID:33316931; PMID:38408527
GO:1903284 Positive regulation of glutathione peroxidase activity Increases phenotype PMID:29427609
GO:1903787 Negative regulation of glutathione biosynthetic process Increases phenotype PMID:30657462; PMID:30847814; PMID:32870427; PMID:38408527
GO:1990000 Amyloid fibril formation Affects phenotype PMID:29028503
GO:2000252 Negative regulation of feeding behavior Increases phenotype PMID:39619924
GO:2000439 Positive regulation of monocyte extravasation Increases phenotype PMID:30847814
GO:2000863 Positive regulation of estrogen secretion Increases phenotype PMID:36012044
GO:2000987 Positive regulation of behavioral fear response Increases phenotype PMID:22417523
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.