Dithiothreitol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0001836 Release of cytochrome c from mitochondria Increases phenotype PMID:18022205
GO:0003918 Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity Increases phenotype PMID:33760604
GO:0004725 Protein tyrosine phosphatase activity Increases phenotype PMID:32493877
GO:0005980 Glycogen catabolic process Increases phenotype PMID:8690080
GO:0006265 Dna topological change Increases phenotype PMID:29272108
GO:0006412 Translation Decreases phenotype PMID:34244458
GO:0006915 Apoptotic process Increases phenotype PMID:11779429; PMID:11783079; PMID:16118208
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:33760604
GO:0008121 Ubiquinol-cytochrome-c reductase activity Increases phenotype PMID:18022205
GO:0008137 Nadh dehydrogenase (ubiquinone) activity Decreases phenotype PMID:18022205
GO:0008219 Cell death Increases phenotype PMID:18022205; PMID:25130544; PMID:8031150; PMID:8653807
GO:0008283 Cell population proliferation Decreases phenotype PMID:19468689; PMID:25130544
GO:0008284 Positive regulation of cell population proliferation Decreases phenotype PMID:7491977
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30396169
GO:0008654 Phospholipid biosynthetic process Increases phenotype PMID:28552552
GO:0009826 Unidimensional cell growth Increases phenotype PMID:31873818
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:26124276
GO:0010942 Positive regulation of cell death Affects phenotype PMID:7743356
GO:0016049 Cell growth Decreases phenotype PMID:29150332
GO:0017148 Negative regulation of translation Increases phenotype PMID:28241074
GO:0030264 Nuclear fragmentation involved in apoptotic nuclear change Increases phenotype PMID:26124276
GO:0030968 Endoplasmic reticulum unfolded protein response Increases phenotype PMID:23123503
GO:0032464 Positive regulation of protein homooligomerization Increases phenotype PMID:29298433
GO:0032769 Negative regulation of monooxygenase activity Increases phenotype PMID:28726718
GO:0032770 Positive regulation of monooxygenase activity Increases phenotype PMID:28726718
GO:0034063 Stress granule assembly Increases phenotype PMID:34244458
GO:0034440 Lipid oxidation Increases phenotype PMID:106178
GO:0034620 Cellular response to unfolded protein Increases phenotype PMID:34244458
GO:0035794 Positive regulation of mitochondrial membrane permeability Increases phenotype PMID:22226756
GO:0042743 Hydrogen peroxide metabolic process Affects phenotype PMID:31873818
GO:0042919 Benzoate transport Decreases phenotype PMID:8140053
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:37741124
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:7966357
GO:0046902 Regulation of mitochondrial membrane permeability Affects phenotype PMID:18022205
GO:0050665 Hydrogen peroxide biosynthetic process Increases phenotype PMID:18022205
GO:0051092 Positive regulation of nf-kappab transcription factor activity Affects phenotype PMID:7476933; PMID:7491977
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:11779429; PMID:11783079; PMID:16118208
GO:0051882 Mitochondrial depolarization Affects phenotype PMID:18022205
GO:0051901 Positive regulation of mitochondrial depolarization Increases phenotype PMID:22226756
GO:0062029 Positive regulation of stress granule assembly Increases phenotype PMID:28241074
GO:0070992 Translation initiation complex Affects phenotype PMID:34244458
GO:0072593 Reactive oxygen species metabolic process Increases phenotype PMID:18022205; PMID:28214884; PMID:35840659
GO:0140042 Lipid droplet formation Increases phenotype PMID:30547786
GO:1901223 Negative regulation of nik/nf-kappab signaling Increases phenotype PMID:19509257
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Decreases phenotype PMID:28721440
GO:1903407 Negative regulation of p-type sodium:potassium-exchanging transporter activity Increases phenotype PMID:22180340
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:29150332
GO:1905538 Polysome binding Decreases phenotype PMID:34244458
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:30547786
GO:2001272 Positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Increases phenotype PMID:26124276
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.