Thapsigargin


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002115 Store-operated calcium entry Increases phenotype PMID:24990931; PMID:8759727
GO:0003994 Aconitate hydratase activity Decreases phenotype PMID:39477182
GO:0004197 Cysteine-type endopeptidase activity Increases phenotype PMID:23741617; PMID:26513129
GO:0006094 Gluconeogenesis Increases phenotype PMID:28223344
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:12198651; PMID:16357177; PMID:9541492
GO:0006412 Translation Decreases phenotype PMID:23741617
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:34516972
GO:0006749 Glutathione metabolic process Affects phenotype PMID:39477182
GO:0006811 Monoatomic ion transport Increases phenotype PMID:11788349; PMID:7691410
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:11914123; PMID:25371527; PMID:26363153; PMID:26398720; PMID:26677073; PMID:27640744; PMID:27640744; PMID:37920924; PMID:28823644; PMID:29248592; PMID:31054997; PMID:31467635; PMID:32314600; PMID:33906515; PMID:37920924; PMID:39153536
GO:0006915 Apoptotic process Increases phenotype PMID:10946849; PMID:12606818; PMID:12871656; PMID:12871656; PMID:16153637; PMID:15039469; PMID:15488331; PMID:16338971; PMID:18477628; PMID:18669601; PMID:20022965; PMID:20130848; PMID:20493918; PMID:20626587; PMID:26677073; PMID:37741535; PMID:39477182; PMID:9541492
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:32574669
GO:0006979 Response to oxidative stress Increases phenotype PMID:20493918
GO:0007005 Mitochondrion organization Affects phenotype PMID:39477182
GO:0007033 Vacuole organization Increases phenotype PMID:24898257
GO:0007049 Cell cycle Increases phenotype PMID:11754638
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:19467708; PMID:25455450; PMID:26264395; PMID:26769196; PMID:27226631; PMID:27939335; PMID:8759727
GO:0007268 Chemical synaptic transmission Increases phenotype PMID:15857686
GO:0008219 Cell death Increases phenotype PMID:16388830; PMID:25762722; PMID:28025169; PMID:29453283
GO:0008283 Cell population proliferation Decreases phenotype PMID:24892553; PMID:24898257; PMID:28161410; PMID:29453283
GO:0008284 Positive regulation of cell population proliferation Increases phenotype PMID:23544152
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:30841431
GO:0008610 Lipid biosynthetic process Affects phenotype PMID:32535746
GO:0009395 Phospholipid catabolic process Increases phenotype PMID:23041292
GO:0010729 Positive regulation of hydrogen peroxide biosynthetic process Increases phenotype PMID:19467708
GO:0010890 Positive regulation of sequestering of triglyceride Increases phenotype PMID:29414781
GO:0010942 Positive regulation of cell death Increases phenotype PMID:26124276; PMID:29793971
GO:0016049 Cell growth Decreases phenotype PMID:30243730; PMID:30508555
GO:0016477 Cell migration Increases phenotype PMID:24898257
GO:0018158 Protein oxidation Increases phenotype PMID:39477182
GO:0019395 Fatty acid oxidation Increases phenotype PMID:32535746
GO:0019722 Calcium-mediated signaling Increases phenotype PMID:10797495; PMID:12198651; PMID:12632256; PMID:15006548; PMID:15236632; PMID:15236632; PMID:15350831; PMID:15350831; PMID:15379781; PMID:17917717; PMID:19448140; PMID:20130848; PMID:21350800
GO:0030199 Collagen fibril organization Increases phenotype PMID:39477182
GO:0030262 Apoptotic nuclear changes Increases phenotype PMID:26124276
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:23544152
GO:0030968 Endoplasmic reticulum unfolded protein response Increases phenotype PMID:23123503
GO:0032057 Negative regulation of translational initiation in response to stress Increases phenotype PMID:25268112
GO:0032469 Endoplasmic reticulum calcium ion homeostasis Affects phenotype PMID:25418486
GO:0032471 Negative regulation of endoplasmic reticulum calcium ion concentration Increases phenotype PMID:26085089
GO:0034063 Stress granule assembly Affects phenotype PMID:29576526
GO:0034440 Lipid oxidation Increases phenotype PMID:39477182
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:20477944; PMID:24865413
GO:0035752 Lysosomal lumen ph elevation Increases phenotype PMID:34516972
GO:0036483 Neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:26264395
GO:0036494 Positive regulation of translation initiation in response to endoplasmic reticulum stress Increases phenotype PMID:16330322
GO:0042307 Positive regulation of protein import into nucleus Increases phenotype PMID:27587023
GO:0042310 Vasoconstriction Decreases phenotype PMID:23177664
GO:0042554 Superoxide anion generation Affects phenotype PMID:35544339
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:20477944; PMID:25341683; PMID:30215789; PMID:30841431
GO:0043303 Mast cell degranulation Increases phenotype PMID:27018130
GO:0043525 Positive regulation of neuron apoptotic process Increases phenotype PMID:35028790
GO:0044237 Cellular metabolic process Decreases phenotype PMID:26513129; PMID:27748814; PMID:35544339; PMID:37920924
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:11964372
GO:0046034 Atp metabolic process Affects phenotype PMID:35544339
GO:0046460 Neutral lipid biosynthetic process Increases phenotype PMID:32535746
GO:0050731 Positive regulation of peptidyl-tyrosine phosphorylation Increases phenotype PMID:8759727
GO:0050900 Leukocyte migration Decreases phenotype PMID:23539630
GO:0051281 Positive regulation of release of sequestered calcium ion into cytosol Increases phenotype PMID:23885834; PMID:24990931; PMID:26085089; PMID:26341291; PMID:29630867; PMID:8759727
GO:0051480 Regulation of cytosolic calcium ion concentration Affects phenotype PMID:11964372
GO:0051881 Regulation of mitochondrial membrane potential Decreases phenotype PMID:16153637; PMID:16388830; PMID:20493918; PMID:26677073; PMID:39477182
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:23530660; PMID:27060209; PMID:28347754; PMID:29883672; PMID:30056177; PMID:30243730; PMID:31709706
GO:0060012 Synaptic transmission, glycinergic Affects phenotype PMID:30439410
GO:0060402 Calcium ion transport into cytosol Increases phenotype PMID:27709270
GO:0061909 Autophagosome-lysosome fusion Decreases phenotype PMID:31862506
GO:0062029 Positive regulation of stress granule assembly Increases phenotype PMID:27030674
GO:0070509 Calcium ion import Increases phenotype PMID:30394170
GO:0070886 Positive regulation of calcineurin-nfat signaling cascade Increases phenotype PMID:24990931
GO:0071421 Manganese ion transmembrane transport Increases phenotype PMID:8759727
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:35544339
GO:0075522 Ires-dependent viral translational initiation Decreases phenotype PMID:25268112
GO:0086003 Cardiac muscle cell contraction Affects phenotype PMID:39477182
GO:0090398 Cellular senescence Affects phenotype PMID:24898257
GO:0097352 Autophagosome maturation Decreases phenotype PMID:28347754
GO:0098609 Cell-cell adhesion Increases phenotype PMID:28025169
GO:1900103 Positive regulation of endoplasmic reticulum unfolded protein response Increases phenotype PMID:32407927
GO:1901341 Positive regulation of store-operated calcium channel activity Increases phenotype PMID:19467708
GO:1901896 Positive regulation of atpase-coupled calcium transmembrane transporter activity Increases phenotype PMID:7673132
GO:1902108 Regulation of mitochondrial membrane permeability involved in apoptotic process Affects phenotype PMID:39477182
GO:1902512 Positive regulation of apoptotic dna fragmentation Increases phenotype PMID:23885834
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:28347754
GO:1903675 Negative regulation of cap-dependent translational initiation Increases phenotype PMID:25268112
GO:1903896 Positive regulation of ire1-mediated unfolded protein response Increases phenotype PMID:29414781
GO:1903899 Positive regulation of perk-mediated unfolded protein response Increases phenotype PMID:27638049
GO:1905665 Positive regulation of calcium ion import across plasma membrane Increases phenotype PMID:29476780
GO:1905692 Endoplasmic reticulum disassembly Increases phenotype PMID:37741535
GO:1905898 Positive regulation of response to endoplasmic reticulum stress Increases phenotype PMID:35028790
GO:2000676 Positive regulation of type b pancreatic cell apoptotic process Increases phenotype PMID:34588186
GO:2001214 Positive regulation of vasculogenesis Increases phenotype PMID:23544152
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.