Cannabidiol


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000045 Autophagosome assembly Increases phenotype PMID:32751388
GO:0000080 Mitotic g1 phase Affects phenotype PMID:28392768; PMID:32751388; PMID:34871667
GO:0000084 Mitotic s phase Affects phenotype PMID:28392768; PMID:34302491; PMID:34871667
GO:0000086 G2/m transition of mitotic cell cycle Affects phenotype PMID:28392768; PMID:34302491
GO:0000278 Mitotic cell cycle Affects phenotype PMID:32751388
GO:0001654 Eye development Affects phenotype PMID:31690747
GO:0001659 Temperature homeostasis Decreases phenotype PMID:28807673
GO:0001675 Acrosome assembly Increases phenotype PMID:34774840
GO:0001780 Neutrophil homeostasis Affects phenotype PMID:32345916
GO:0001894 Tissue homeostasis Decreases phenotype PMID:30825431
GO:0002121 Inter-male aggressive behavior Increases phenotype PMID:34662589
GO:0002690 Positive regulation of leukocyte chemotaxis Increases phenotype PMID:30123217
GO:0002693 Positive regulation of cellular extravasation Increases phenotype PMID:30123217
GO:0004035 Alkaline phosphatase activity Increases phenotype PMID:32656944
GO:0004197 Cysteine-type endopeptidase activity Increases phenotype PMID:29441458; PMID:34302491
GO:0004392 Heme oxygenase (decyclizing) activity Affects phenotype PMID:32033040
GO:0004565 Beta-galactosidase activity Decreases phenotype PMID:32553926
GO:0004602 Glutathione peroxidase activity Decreases phenotype PMID:32752303
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:34774840
GO:0005262 Calcium channel activity Increases phenotype PMID:32733202
GO:0006071 Glycerol metabolic process Affects phenotype PMID:30550613
GO:0006096 Glycolytic process Decreases phenotype PMID:36810933
GO:0006260 Dna replication Decreases phenotype PMID:34871667
GO:0006264 Mitochondrial dna replication Increases phenotype PMID:34269108
GO:0006265 Dna topological change Increases phenotype PMID:29272108
GO:0006306 Dna methylation Increases phenotype PMID:33407853; PMID:34015384
GO:0006309 Apoptotic dna fragmentation Increases phenotype PMID:23220503
GO:0006497 Protein lipidation Increases phenotype PMID:32751388; PMID:34302491
GO:0006544 Glycine metabolic process Affects phenotype PMID:30550613
GO:0006580 Ethanolamine metabolic process Affects phenotype PMID:30550613
GO:0006601 Creatine biosynthetic process Increases phenotype PMID:36988283
GO:0006606 Protein import into nucleus Affects phenotype PMID:32244040
GO:0006629 Lipid metabolic process Affects phenotype PMID:30550613; PMID:39233107
GO:0006749 Glutathione metabolic process Affects phenotype PMID:31052254; PMID:32752303; PMID:39233107
GO:0006754 Atp biosynthetic process Affects phenotype PMID:38182033
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:39299374
GO:0006816 Calcium ion transport Affects phenotype PMID:33629929
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:29441458
GO:0006914 Autophagy Increases phenotype PMID:33096116; PMID:34302491; PMID:38583854
GO:0006915 Apoptotic process Increases phenotype PMID:27430346; PMID:30341733; PMID:30349652; PMID:30796934; PMID:31349651; PMID:31699976; PMID:31699976; PMID:32733202; PMID:32751388; PMID:32992648; PMID:33244087; PMID:36810933; PMID:39894194
GO:0006954 Inflammatory response Increases phenotype PMID:32345916
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:30341733; PMID:32992648; PMID:34774840
GO:0007204 Positive regulation of cytosolic calcium ion concentration Increases phenotype PMID:30074247
GO:0007283 Spermatogenesis Decreases phenotype PMID:29766538; PMID:34774840
GO:0007610 Behavior Affects phenotype PMID:33407853
GO:0007611 Learning or memory Decreases phenotype PMID:30496751
GO:0007613 Memory Affects phenotype PMID:16406104; PMID:28344069; PMID:30610611; PMID:33285233; PMID:33407853
GO:0007625 Grooming behavior Decreases phenotype PMID:29624642
GO:0007631 Feeding behavior Affects phenotype PMID:31052254
GO:0008015 Blood circulation Affects phenotype PMID:32360362
GO:0008219 Cell death Affects phenotype PMID:31077084; PMID:31104297
GO:0008234 Cysteine-type peptidase activity Increases phenotype PMID:39233107
GO:0008283 Cell population proliferation Affects phenotype PMID:23220503; PMID:23220503; PMID:32049991; PMID:30349652; PMID:31699976; PMID:32049991; PMID:32752303; PMID:36810933; PMID:39894194
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:27769052; PMID:30007266; PMID:30096889
GO:0008360 Regulation of cell shape Affects phenotype PMID:32049991
GO:0008361 Regulation of cell size Affects phenotype PMID:28392768
GO:0009410 Response to xenobiotic stimulus Decreases phenotype PMID:30217539
GO:0009448 Gamma-aminobutyric acid metabolic process Affects phenotype PMID:30550613
GO:0009636 Response to toxic substance Affects phenotype PMID:23552853
GO:0010424 Dna methylation on cytosine within a cg sequence Affects phenotype PMID:30521419
GO:0010460 Positive regulation of heart rate Increases phenotype PMID:33338514
GO:0010507 Negative regulation of autophagy Increases phenotype PMID:30074247
GO:0010884 Positive regulation of lipid storage Increases phenotype PMID:30382123
GO:0010917 Negative regulation of mitochondrial membrane potential Increases phenotype PMID:38583854
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:27769052
GO:0010942 Positive regulation of cell death Increases phenotype PMID:23552853; PMID:33864076
GO:0014046 Dopamine secretion Affects phenotype PMID:31941059
GO:0014068 Positive regulation of phosphatidylinositol 3-kinase signaling Increases phenotype PMID:28025562
GO:0014823 Response to activity Affects phenotype PMID:38182033
GO:0016042 Lipid catabolic process Affects phenotype PMID:32752303; PMID:34774840
GO:0016049 Cell growth Decreases phenotype PMID:30349652; PMID:33244087
GO:0016209 Antioxidant activity Decreases phenotype PMID:36988283
GO:0016477 Cell migration Decreases phenotype PMID:24910342; PMID:33244087
GO:0016525 Negative regulation of angiogenesis Increases phenotype PMID:37567336
GO:0018158 Protein oxidation Decreases phenotype PMID:36796712
GO:0019369 Arachidonic acid metabolic process Affects phenotype PMID:33285233
GO:0019530 Taurine metabolic process Affects phenotype PMID:30550613
GO:0019627 Urea metabolic process Affects phenotype PMID:39233107
GO:0019646 Aerobic electron transport chain Decreases phenotype PMID:28013001
GO:0019722 Calcium-mediated signaling Affects phenotype PMID:29630867
GO:0019852 L-ascorbic acid metabolic process Affects phenotype PMID:32752303
GO:0023041 Neuronal signal transduction Increases phenotype PMID:32209479
GO:0030036 Actin cytoskeleton organization Decreases phenotype PMID:34871667
GO:0030154 Cell differentiation Increases phenotype PMID:31953017
GO:0030187 Melatonin biosynthetic process Increases phenotype PMID:16805813
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:29441458
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:30033591; PMID:33872753
GO:0030336 Negative regulation of cell migration Increases phenotype PMID:30713602; PMID:34575494; PMID:37567336; PMID:37625625; PMID:38342230
GO:0030431 Sleep Increases phenotype PMID:30636988
GO:0030501 Positive regulation of bone mineralization Increases phenotype PMID:28479140
GO:0030534 Adult behavior Affects phenotype PMID:31052254
GO:0031175 Neuron projection development Decreases phenotype PMID:33817834
GO:0031914 Negative regulation of synaptic plasticity Increases phenotype PMID:29669714
GO:0031987 Locomotion involved in locomotory behavior Increases phenotype PMID:30610611; PMID:30984001
GO:0032043 Mitochondrial dna catabolic process Increases phenotype PMID:29374603
GO:0032615 Interleukin-12 production Increases phenotype PMID:34740670
GO:0032793 Positive regulation of creb transcription factor activity Increases phenotype PMID:30033591
GO:0032831 Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation Increases phenotype PMID:27865421
GO:0032868 Response to insulin Increases phenotype PMID:30382123
GO:0032967 Positive regulation of collagen biosynthetic process Increases phenotype PMID:30033591; PMID:30033591; PMID:30825431; PMID:33872753
GO:0033036 Macromolecule localization Affects phenotype PMID:31054246
GO:0034109 Homotypic cell-cell adhesion Decreases phenotype PMID:32049991
GO:0034113 Heterotypic cell-cell adhesion Decreases phenotype PMID:31154070
GO:0034505 Tooth mineralization Increases phenotype PMID:33872753
GO:0034599 Cellular response to oxidative stress Increases phenotype PMID:28935932
GO:0034644 Cellular response to uv Affects phenotype PMID:33540902
GO:0034976 Response to endoplasmic reticulum stress Increases phenotype PMID:38583854
GO:0035176 Social behavior Decreases phenotype PMID:30496751; PMID:31326506; PMID:33285233
GO:0035640 Exploration behavior Decreases phenotype PMID:30538288; PMID:30610611
GO:0035902 Response to immobilization stress Affects phenotype PMID:30324842
GO:0035938 Estradiol secretion Affects phenotype PMID:31953017
GO:0040013 Negative regulation of locomotion Increases phenotype PMID:28807673
GO:0040017 Positive regulation of locomotion Increases phenotype PMID:29624642
GO:0042102 Positive regulation of t cell proliferation Increases phenotype PMID:30123217
GO:0042116 Macrophage activation Increases phenotype PMID:34537380
GO:0042311 Vasodilation Increases phenotype PMID:10570211
GO:0042415 Norepinephrine metabolic process Affects phenotype PMID:31941059
GO:0042417 Dopamine metabolic process Decreases phenotype PMID:28344069
GO:0042428 Serotonin metabolic process Affects phenotype PMID:31941059; PMID:37927177; PMID:37927177
GO:0042438 Melanin biosynthetic process Increases phenotype PMID:28601556
GO:0043032 Positive regulation of macrophage activation Increases phenotype PMID:30033591
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:28013001; PMID:30007266; PMID:30713602; PMID:34575494; PMID:36988283; PMID:37625625; PMID:38342230
GO:0043149 Stress fiber assembly Affects phenotype PMID:32049991
GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:33955754
GO:0043306 Positive regulation of mast cell degranulation Increases phenotype PMID:30033591
GO:0043589 Skin morphogenesis Increases phenotype PMID:30033591
GO:0043616 Keratinocyte proliferation Increases phenotype PMID:31518892
GO:0043687 Post-translational protein modification Increases phenotype PMID:31499052
GO:0043954 Cellular component maintenance Decreases phenotype PMID:28807673
GO:0044237 Cellular metabolic process Increases phenotype PMID:24910342; PMID:26504004; PMID:26504004; PMID:39828184; PMID:27430346; PMID:28392768; PMID:29441458; PMID:29441458; PMID:32751388; PMID:31104297; PMID:31349651; PMID:31699976; PMID:31941059; PMID:31991773; PMID:32033040; PMID:32244040; PMID:32553926; PMID:32708634; PMID:32751388; PMID:32752303; PMID:32992648; PMID:33076330; PMID:33244087; PMID:34302491; PMID:34871667; PMID:36810933; PMID:39233107; PMID:39828184
GO:0044319 Wound healing, spreading of cells Affects phenotype PMID:32049991; PMID:32656944; PMID:32751388; PMID:32992648; PMID:34302491
GO:0045023 G0 to g1 transition Affects phenotype PMID:31349651; PMID:36810933
GO:0045333 Cellular respiration Decreases phenotype PMID:31699976; PMID:36810933
GO:0045596 Negative regulation of cell differentiation Increases phenotype PMID:30825431
GO:0045600 Positive regulation of fat cell differentiation Increases phenotype PMID:30382123
GO:0045602 Negative regulation of endothelial cell differentiation Increases phenotype PMID:30825431
GO:0045793 Positive regulation of cell size Increases phenotype PMID:28807673; PMID:30382123
GO:0045907 Positive regulation of vasoconstriction Increases phenotype PMID:33338514
GO:0045919 Positive regulation of cytolysis Increases phenotype PMID:30096889
GO:0046034 Atp metabolic process Affects phenotype PMID:31104297; PMID:31699976; PMID:36810933
GO:0046676 Negative regulation of insulin secretion Increases phenotype PMID:31499052
GO:0046697 Decidualization Increases phenotype PMID:31154070
GO:0046960 Sensitization Affects phenotype PMID:29084627
GO:0048148 Behavioral response to cocaine Increases phenotype PMID:33427014
GO:0048149 Behavioral response to ethanol Affects phenotype PMID:28194850; PMID:29859012
GO:0048266 Behavioral response to pain Decreases phenotype PMID:28807673
GO:0048858 Cell projection morphogenesis Decreases phenotype PMID:28807673
GO:0050729 Positive regulation of inflammatory response Increases phenotype PMID:30074247
GO:0050890 Cognition Decreases phenotype PMID:30538288; PMID:31823199
GO:0050892 Intestinal absorption Increases phenotype PMID:27648135
GO:0051092 Positive regulation of nf-kappab transcription factor activity Affects phenotype PMID:30796934
GO:0051490 Negative regulation of filopodium assembly Increases phenotype PMID:37625625
GO:0051512 Positive regulation of unidimensional cell growth Increases phenotype PMID:33338514
GO:0051612 Negative regulation of serotonin uptake Increases phenotype PMID:38663822
GO:0051658 Maintenance of nucleus location Decreases phenotype PMID:30074247
GO:0051726 Regulation of cell cycle Increases phenotype PMID:27769052
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:29441458; PMID:31349651; PMID:31699976; PMID:38182033; PMID:39233107
GO:0051882 Mitochondrial depolarization Increases phenotype PMID:34302491; PMID:36810933
GO:0051896 Regulation of protein kinase b signaling Affects phenotype PMID:37567336
GO:0051897 Positive regulation of protein kinase b signaling Increases phenotype PMID:28025562
GO:0055118 Negative regulation of cardiac muscle contraction Increases phenotype PMID:33338514
GO:0060009 Sertoli cell development Decreases phenotype PMID:29766538
GO:0060134 Prepulse inhibition Decreases phenotype PMID:34015384
GO:0060267 Positive regulation of respiratory burst Increases phenotype PMID:28935932
GO:0060326 Cell chemotaxis Affects phenotype PMID:24910342; PMID:27769052; PMID:31991773; PMID:32656944; PMID:33244087
GO:0060391 Positive regulation of smad protein signal transduction Increases phenotype PMID:30033591
GO:0060452 Positive regulation of cardiac muscle contraction Increases phenotype PMID:33338514
GO:0061045 Negative regulation of wound healing Increases phenotype PMID:37567336
GO:0061333 Renal tubule morphogenesis Affects phenotype PMID:36988283
GO:0061366 Behavioral response to chemical pain Increases phenotype PMID:29450258
GO:0061450 Trophoblast cell migration Decreases phenotype PMID:31154070
GO:0061518 Microglial cell proliferation Decreases phenotype PMID:28807673
GO:0061739 Protein lipidation involved in autophagosome assembly Affects phenotype PMID:27769052; PMID:30074247
GO:0070189 Kynurenine metabolic process Affects phenotype PMID:31941059
GO:0070265 Necrotic cell death Increases phenotype PMID:30341733; PMID:32751388; PMID:32752303; PMID:32992648
GO:0070269 Pyroptosis Increases phenotype PMID:33955754; PMID:34269108
GO:0070328 Triglyceride homeostasis Decreases phenotype PMID:28935932; PMID:30382123
GO:0070346 Positive regulation of fat cell proliferation Increases phenotype PMID:30382123
GO:0070374 Positive regulation of erk1 and erk2 cascade Increases phenotype PMID:30033591
GO:0070509 Calcium ion import Increases phenotype PMID:31096838
GO:0070633 Transepithelial transport Increases phenotype PMID:27648135
GO:0070994 Detection of oxidative stress Affects phenotype PMID:36796712; PMID:37927177
GO:0070997 Neuron death Increases phenotype PMID:32033040
GO:0071500 Cellular response to nitrosative stress Increases phenotype PMID:28935932
GO:0071670 Smooth muscle cell chemotaxis Increases phenotype PMID:30349652
GO:0072559 Nlrp3 inflammasome complex Increases phenotype PMID:34269108
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:24910342; PMID:26504004; PMID:29441458; PMID:31349651; PMID:31518892; PMID:32553926; PMID:36810933; PMID:38583854
GO:0090116 C-5 methylation of cytosine Decreases phenotype PMID:29374603
GO:0090327 Negative regulation of locomotion involved in locomotory behavior Increases phenotype PMID:30074247
GO:0090358 Positive regulation of tryptophan metabolic process Increases phenotype PMID:38663822
GO:0090394 Negative regulation of excitatory postsynaptic potential Increases phenotype PMID:29669714
GO:0090648 Response to environmental enrichment Decreases phenotype PMID:30984001; PMID:31823199; PMID:33285233
GO:0097153 Cysteine-type endopeptidase activity involved in apoptotic process Increases phenotype PMID:31699976
GO:0097707 Ferroptosis Increases phenotype PMID:31104297; PMID:38583854
GO:0097722 Sperm motility Affects phenotype PMID:34774840
GO:0098817 Evoked excitatory postsynaptic potential Decreases phenotype PMID:29669714
GO:0099171 Presynaptic modulation of chemical synaptic transmission Increases phenotype PMID:29669714
GO:0106128 Negative regulation of store-operated calcium entry Increases phenotype PMID:29630867
GO:0140042 Lipid droplet formation Increases phenotype PMID:28935932; PMID:39233107
GO:1900156 Positive regulation of bone trabecula formation Increases phenotype PMID:28479140
GO:1900182 Positive regulation of protein localization to nucleus Increases phenotype PMID:30217539
GO:1901524 Regulation of mitophagy Affects phenotype PMID:33629929
GO:1901568 Fatty acid derivative metabolic process Increases phenotype PMID:30496751
GO:1901741 Positive regulation of myoblast fusion Increases phenotype PMID:30074247
GO:1901856 Negative regulation of cellular respiration Increases phenotype PMID:30713602
GO:1901899 Positive regulation of relaxation of cardiac muscle Increases phenotype PMID:33338514
GO:1902107 Positive regulation of leukocyte differentiation Increases phenotype PMID:30123217
GO:1903035 Negative regulation of response to wounding Increases phenotype PMID:28479140
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:28392768; PMID:31349651; PMID:34302491; PMID:34871667; PMID:36810933
GO:1903296 Positive regulation of glutamate secretion, neurotransmission Affects phenotype PMID:26283212
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30349652; PMID:33955754
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28013001; PMID:30217539; PMID:36988283
GO:1903514 Release of sequestered calcium ion into cytosol by endoplasmic reticulum Increases phenotype PMID:29630867
GO:1903626 Positive regulation of dna catabolic process Increases phenotype PMID:27769052
GO:1903752 Positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Increases phenotype PMID:33955754
GO:1903980 Positive regulation of microglial cell activation Increases phenotype PMID:30217539
GO:1904028 Positive regulation of collagen fibril organization Increases phenotype PMID:30825431
GO:1904094 Positive regulation of autophagic cell death Increases phenotype PMID:33629929
GO:1904179 Positive regulation of adipose tissue development Increases phenotype PMID:30382123
GO:1904230 Negative regulation of succinate dehydrogenase activity Increases phenotype PMID:29374603
GO:1904646 Cellular response to amyloid-beta Decreases phenotype PMID:31104297
GO:1904762 Positive regulation of myofibroblast differentiation Increases phenotype PMID:30033591
GO:1904803 Regulation of translation involved in cellular response to uv Affects phenotype PMID:34667212
GO:1905448 Positive regulation of mitochondrial atp synthesis coupled electron transport Decreases phenotype PMID:28013001
GO:1905665 Positive regulation of calcium ion import across plasma membrane Increases phenotype PMID:28945920; PMID:30235802
GO:1990138 Neuron projection extension Decreases phenotype PMID:32033040
GO:1990266 Neutrophil migration Increases phenotype PMID:29450258
GO:2000251 Positive regulation of actin cytoskeleton reorganization Increases phenotype PMID:30096889
GO:2000277 Positive regulation of oxidative phosphorylation uncoupler activity Decreases phenotype PMID:28013001
GO:2000391 Positive regulation of neutrophil extravasation Increases phenotype PMID:28935932
GO:2000409 Positive regulation of t cell extravasation Increases phenotype PMID:30033591; PMID:30123217
GO:2000774 Positive regulation of cellular senescence Increases phenotype PMID:36519830
GO:2000986 Negative regulation of behavioral fear response Increases phenotype PMID:34262461
GO:2001024 Negative regulation of response to drug Increases phenotype PMID:28807673
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.