Topiramate


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0002027 Regulation of heart rate Increases phenotype PMID:16432681
GO:0004784 Superoxide dismutase activity Decreases phenotype PMID:29753867
GO:0005975 Carbohydrate metabolic process Affects phenotype PMID:39098565
GO:0006537 Glutamate biosynthetic process Increases phenotype PMID:29753867
GO:0006749 Glutathione metabolic process Increases phenotype PMID:34266355
GO:0006750 Glutathione biosynthetic process Decreases phenotype PMID:29753867
GO:0006805 Xenobiotic metabolic process Affects phenotype PMID:25745819
GO:0006811 Monoatomic ion transport Affects phenotype PMID:12972176; PMID:15128855
GO:0006979 Response to oxidative stress Decreases phenotype PMID:18949505
GO:0007610 Behavior Affects phenotype PMID:22489711
GO:0007635 Chemosensory behavior Increases phenotype PMID:34266355
GO:0008217 Regulation of blood pressure Decreases phenotype PMID:17363756; PMID:17391164
GO:0008219 Cell death Increases phenotype PMID:15128855; PMID:17636003
GO:0008283 Cell population proliferation Decreases phenotype PMID:15591643
GO:0008344 Adult locomotory behavior Decreases phenotype PMID:29753867
GO:0009449 Gamma-aminobutyric acid biosynthetic process Decreases phenotype PMID:29753867
GO:0016042 Lipid catabolic process Increases phenotype PMID:29753867
GO:0019722 Calcium-mediated signaling Increases phenotype PMID:15128855
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:34266355
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:29753867
GO:0042311 Vasodilation Affects phenotype PMID:15980877
GO:0042416 Dopamine biosynthetic process Decreases phenotype PMID:29753867
GO:0046466 Membrane lipid catabolic process Increases phenotype PMID:15591643; PMID:18949505
GO:0051970 Negative regulation of transmission of nerve impulse Increases phenotype PMID:19417176
GO:0060079 Excitatory postsynaptic potential Decreases phenotype PMID:12972176
GO:0060080 Inhibitory postsynaptic potential Affects phenotype PMID:19417176
GO:0070265 Necrotic cell death Increases phenotype PMID:29753867; PMID:34266355
GO:0070994 Detection of oxidative stress Increases phenotype PMID:34266355
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.