| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:2423406 | IVR | 10 mg/kg | 10 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Ovarian atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Thymus atrophy | Immunological endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| PMID:30036966 | IVTH | 0.00001 M | 0.00001 M | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.