Lindane

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10467719	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Alters sperm function	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Affects calcium signaling	Metabolic endocrine-mediated perturbations
PMID:14613717	IVR	20 mg/kg/day	20 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:15253041	IVTH	0.000001 - 0.001 M	0.000075 M	Cancer phenotype	Endocrine-mediated cancer
PMID:16641539	IVR	300 mg/kg/day	300 mg/kg/day	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Changes in liver morphology in offspring	Hepatic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Atrophy of spleen	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects testosterone metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased thymus gland weights	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Changes in liver morphology in offspring	Hepatic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	-	No significant effects observed	-
PMID:17080404	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.0001 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.0001 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
PMID:17537412	IVR	15 mg/kg/day	15 mg/kg/day	Affects ovulation	Reproductive endocrine-mediated perturbations
	IVR	15 mg/kg/day	15 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	15 mg/kg/day	15 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	15 mg/kg/day	15 mg/kg/day	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	15 mg/kg/day	15 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
PMID:22240090	IVR	32.2 mg/kg/day	32.2 mg/kg/day	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVR	64.4 mg/kg/day	64.4 mg/kg/day	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVR	16.6 mg/kg/day	16.6 mg/kg/day	Induced migration capability of tumor cells	Endocrine-mediated cancer

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.