| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:7497912 | IVR | 9 mg/kg | - | No significant effects observed | - |
| IVR | 735 mg/kg | 735 mg/kg | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations | |
| IVR | 735 mg/kg | 735 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 735 mg/kg | 735 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 147 mg/kg | 147 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 147 mg/kg | 147 mg/kg | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 147 mg/kg | 147 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 147 mg/kg | 147 mg/kg | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 37 mg/kg | 37 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 37 mg/kg | 37 mg/kg | Affects calcium signaling | Metabolic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Affects calcium signaling | Metabolic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 588 mg/kg | 588 mg/kg | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 368 mg/kg | 368 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 368 mg/kg | 368 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 368 mg/kg | 368 mg/kg | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.