| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:29409581 | IVR | 5 mg/kg | - | No significant effects observed | - |
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| PMID:30844666 | IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increase in Thyrotropin-releasing hormone (TRH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.