| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:15808788 | IVR | 150 mg/L | 150 mg/L | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations |
| IVR | 150 mg/L | 150 mg/L | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/L | 150 mg/L | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/L | 50 mg/L | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 300 mg/L | 300 mg/L | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 300 mg/L | 300 mg/L | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 300 mg/L | 300 mg/L | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| PMID:9138633 | IVR | 250 mg/kg | 250 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg | 250 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.