| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:12204829 | IVH | 0.02 mg/kg/day | 0.02 mg/kg/day | Affects iodine uptake into thyroid | Metabolic endocrine-mediated perturbations |
| IVH | 0.007 mg/kg/day | - | No significant effects observed | - | |
| IVH | 0.5 mg/kg/day | 0.5 mg/kg/day | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVH | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects iodine uptake into thyroid | Metabolic endocrine-mediated perturbations | |
| PMID:18560531 | IVR | 30 mg/L | 30 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 30 mg/L | 30 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1000 mg/L | 1000 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 300 mg/L | 300 mg/L | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 300 mg/L | 300 mg/L | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:20479570 | IVTH | 0.00000001 - 0.0001 M | 0.0001 M | Affects iodine uptake into thyroid | Metabolic endocrine-mediated perturbations |
| PMID:29139221 | IVR | 35 mg/kg/day | 35 mg/kg/day | Increase in Thyrotropin-releasing hormone (TRH) levels | Metabolic endocrine-mediated perturbations |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Alters hypothalamic-pituitary-thyroid axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 35 mg/kg/day | 35 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.