Triphenyltin chloride

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:16513093	IVTH	0.000000001 - 0.00001 M	0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:17644232	IVR	2 mg/kg	-	No significant effects observed	-
	IVR	6 mg/kg	6 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
PMID:19464569	IVR	6 mg/kg	-	No significant effects observed	-
	IVR	2 mg/kg	2 mg/kg	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:20708649	IVR	2 mg/kg/day	2 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Alters aromatase activity in gonads	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:30147652	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:30223319	IVR	0.5 mg/kg	0.5 mg/kg	Affects leydig cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Affects sertoli cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Affects sertoli cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Affects leydig cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects leydig cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sertoli cells function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:6661580	IVR	20 mg/kg/day	20 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:9100293	IVR	3.1 mg/kg	-	No significant effects observed	-
	IVR	4.7 mg/kg	4.7 mg/kg	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	4.7 mg/kg	4.7 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg	25 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	6.3 mg/kg	6.3 mg/kg	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	6.3 mg/kg	6.3 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	12.5 mg/kg	12.5 mg/kg	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	12.5 mg/kg	12.5 mg/kg	Affects implantation	Reproductive endocrine-mediated perturbations

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