| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18468972 | IVR | 100 mg/kg | 100 mg/kg | Increased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 1000 mg/kg | 1000 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| PMID:22311695 | IVR | 150 mg/kg/day | - | No significant effects observed | - |
| IVR | 450 mg/kg/day | 450 mg/kg/day | Affects fertility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects fertility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.