| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:16984955 | IVTH | 0.0000125 - 0.0002 M | 0.0001 - 0.0002 M | Affects embryonic development | Developmental endocrine-mediated perturbations |
| PMID:17010207 | IVR | 600 mg/kg | 600 mg/kg | Increased oxytocin levels | Reproductive endocrine-mediated perturbations |
| IVR | 600 mg/kg | 600 mg/kg | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:17229994 | IVR | 10 mg/kg | 10 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:17558187 | IVR | 10 mg/kg | 10 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:17679765 | IVR | 10 mg/kg | 10 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| PMID:18621119 | IVR | 0.1 mg/kg | 0.1 mg/kg | Affects skeletal development in fetus | Developmental endocrine-mediated perturbations |
| PMID:18854640 | IVTH | 0.000000001 - 0.00001 M | 0.00000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:22531466 | IVTH | 0.0000001 - 0.00001 M | 0.0000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:23142789 | IVR | 3 mg/kg/day | 3 mg/kg/day | Affects calcium transport | Metabolic endocrine-mediated perturbations |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Affects calcium signaling | Metabolic endocrine-mediated perturbations | |
| IVR | 48 mg/kg/day | 48 mg/kg/day | Affects calcium transport | Metabolic endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Affects calcium signaling | Metabolic endocrine-mediated perturbations | |
| IVR | 12 mg/kg/day | 12 mg/kg/day | Affects calcium transport | Metabolic endocrine-mediated perturbations | |
| PMID:24248536 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:24684733 | IVTH | 0.0000001 - 0.00001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 100 mg/kg | 100 mg/kg | Induce tumor progression | Endocrine-mediated cancer | |
| IVR | 100 mg/kg | 100 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:28160177 | IVR | 40 mg/kg | 40 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations |
| IVR | 120 mg/kg | 120 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 360 mg/kg | 360 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 360 mg/kg | 360 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| PMID:9460178 | IVR | 0.02 mg/kg | 0.02 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVR | 0.002 mg/kg | 0.002 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.