Decabromobiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17698168	IVR	10 mg/kg/day	10 mg/kg/day	Affects morphology of hepatocytes	Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Affects morphology of hepatocytes	Hepatic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects morphology of hepatocytes	Hepatic endocrine-mediated perturbations
PMID:26602377	IVR	750 mg/kg	-	No significant effects observed	-
	IVR	950 mg/kg	950 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	950 mg/kg	950 mg/kg	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	950 mg/kg	950 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	950 mg/kg	950 mg/kg	Testicular carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	950 mg/kg	950 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	950 mg/kg	950 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:30565106	IVR	100 mg/kg	100 mg/kg	Affects blood-testis barrier (BTB) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects blood-testis barrier (BTB) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects blood-testis barrier (BTB) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
PMID:30844666	IVR	5 mg/kg/day	5 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
PMID:30849655	IVTH	0.000001 M	0.000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Affects liver function	Hepatic endocrine-mediated perturbations

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