Tributylchlorostannane


Literature identifierStudy typeTest dosageEffective dosageEndocrine-mediated endpointsSystems-level perturbations
PMID:12083789IVR0.000004 M 0.000004 MDecreased testis weightsReproductive endocrine-mediated perturbations
IVR0.000004 M 0.000004 MAffects steroid metabolismMetabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:12773765IVR10 mg/kg 10 mg/kgDecrease in T3 levelsMetabolic endocrine-mediated perturbations
IVR10 mg/kg 10 mg/kgAffects skeletal development in fetusDevelopmental endocrine-mediated perturbations
IVR10 mg/kg 10 mg/kgIncreased placental weightsReproductive endocrine-mediated perturbations
IVR10 mg/kg 10 mg/kgDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR10 mg/kg 10 mg/kgAffects anogenital distanceReproductive endocrine-mediated perturbations
IVR0.25 mg/kg 0.25 mg/kgAffects anogenital distanceReproductive endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgAffects anogenital distanceReproductive endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgAffects litter sizeReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgAffects implantationReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgDecrease in T3 levelsMetabolic endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgIncreased placental weightsReproductive endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgAffects skeletal development in fetusDevelopmental endocrine-mediated perturbations
PMID:14667468IVR0.25 mg/kg 0.25 mg/kgDecreased thymus gland weightsImmunological endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgIncreased triglycerides levelMetabolic endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgIncreased spleen weightsImmunological endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgIncrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgIncreased weights of adrenal glandMetabolic endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgDecreased thymus gland weightsImmunological endocrine-mediated perturbations
IVR2.5 mg/kg 2.5 mg/kgDecreased liver weightsHepatic endocrine-mediated perturbations
IVR0.025 mg/kg 0.025 mg/kgDecreased liver weightsHepatic endocrine-mediated perturbations
PMID:16513093IVTH0.000000001 - 0.00001 M 0.0000001 MAffects steroidogenesisReproductive endocrine-mediated perturbations
PMID:16613991IVR0.05 mg/kg 0.05 mg/kgChanges in liver morphologyHepatic endocrine-mediated perturbations
IVR0.5 mg/kg 0.5 mg/kgChanges in liver morphologyHepatic endocrine-mediated perturbations
IVR0.5 mg/kg 0.5 mg/kgLead to obesityMetabolic endocrine-mediated perturbations
IVR0.5 mg/kg 0.5 mg/kgAlteration in gonadal morphologyReproductive endocrine-mediated perturbations
IVR0.3 mg/kg 0.3 mg/kgLead to obesityMetabolic endocrine-mediated perturbations
IVR0.3 mg/kg 0.3 mg/kgAffects thyroid hormone metabolismMetabolic endocrine-mediated perturbations
IVR0.05 mg/kg 0.05 mg/kgAlteration in gonadal morphologyReproductive endocrine-mediated perturbations
IVR0.05 mg/kg 0.05 mg/kgLead to obesityMetabolic endocrine-mediated perturbations
PMID:18246498IVR2.5 mg/kg/day -No significant effects observed-
IVR0.25 mg/kg/day -No significant effects observed-
IVR10 mg/kg/day 10 mg/kg/dayDecreased liver weightsHepatic endocrine-mediated perturbations
PMID:20052771IVR0.17 mg/kg/day 0.17 mg/kg/dayDecreased testosterone levelsReproductive endocrine-mediated perturbations
IVR0.17 mg/kg/day 0.17 mg/kg/dayDecreased LH levelsReproductive endocrine-mediated perturbations
IVR0.17 mg/kg/day 0.17 mg/kg/dayDecreased estradiol levelsReproductive endocrine-mediated perturbations
IVR0.017 mg/kg/day 0.017 mg/kg/dayDecreased LH levelsReproductive endocrine-mediated perturbations
IVR0.017 mg/kg/day 0.017 mg/kg/dayDecreased estradiol levelsReproductive endocrine-mediated perturbations
PMID:22362710IVR0.001 mg/kg/day 0.001 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
IVR0.001 mg/kg/day 0.001 mg/kg/dayAlterations in vaginal openingReproductive endocrine-mediated perturbations
IVR0.01 mg/kg/day 0.01 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
IVR0.01 mg/kg/day 0.01 mg/kg/dayAlterations in vaginal openingReproductive endocrine-mediated perturbations
IVR0.1 mg/kg/day 0.1 mg/kg/dayAlterations in vaginal openingReproductive endocrine-mediated perturbations
IVR0.1 mg/kg/day 0.1 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
PMID:22972585IVR0.001 mg/kg -No significant effects observed-
IVR0.01 mg/kg 0.01 mg/kgAffects social behaviorNeurological endocrine-mediated perturbations
IVR0.1 mg/kg 0.1 mg/kgUndescended testes (or cryptorchidism)Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.1 mg/kg 0.1 mg/kgAffects social behaviorNeurological endocrine-mediated perturbations
PMID:23523586IVTH0.000000025 M 0.000000025 MAffects steroidogenesisReproductive endocrine-mediated perturbations
IVTH0.00000005 M 0.00000005 MAffects steroidogenesisReproductive endocrine-mediated perturbations
IVTH0.00000005 M 0.00000005 MAffects cytokine signalingImmunological endocrine-mediated perturbations
IVTH0.0000001 M 0.0000001 MAffects cytokine signalingImmunological endocrine-mediated perturbations
IVTH0.0000001 M 0.0000001 MAffects steroidogenesisReproductive endocrine-mediated perturbations
PMID:23913619IVR0.001 mg/kg/day 0.001 mg/kg/dayReduced sperm countsReproductive endocrine-mediated perturbations
IVR0.001 mg/kg/day 0.001 mg/kg/dayAffects sperm motilityReproductive endocrine-mediated perturbations
IVR0.01 mg/kg/day 0.01 mg/kg/dayReduced sperm countsReproductive endocrine-mediated perturbations
IVR0.01 mg/kg/day 0.01 mg/kg/dayDecreased estradiol levelsReproductive endocrine-mediated perturbations
IVR0.1 mg/kg/day 0.1 mg/kg/dayInduce apoptosis in seminiferous tubulesReproductive endocrine-mediated perturbations
IVR0.01 mg/kg/day 0.01 mg/kg/dayAffects sperm motilityReproductive endocrine-mediated perturbations
IVR0.1 mg/kg/day 0.1 mg/kg/dayAffects sperm motilityReproductive endocrine-mediated perturbations
IVR0.1 mg/kg/day 0.1 mg/kg/dayReduced sperm countsReproductive endocrine-mediated perturbations
PMID:2466803IVR5 - 60 mg/kg 10 mg/kgLymph nodes inflammationImmunological endocrine-mediated perturbations
IVR5 - 60 mg/kg 10 mg/kgDecreased thymus gland weightsImmunological endocrine-mediated perturbations
IVR5 - 60 mg/kg 35 mg/kgDecreased spleen weightsImmunological endocrine-mediated perturbations
IVR5 - 60 mg/kg 60 mg/kgDecreased spleen weightsImmunological endocrine-mediated perturbations
PMID:24895210IVR10 mg/kg 10 mg/kgAffects blood-brain barrier (BBB)Neurological endocrine-mediated perturbations
IVR10 mg/kg 10 mg/kgOxidative stress in nervous systemNeurological endocrine-mediated perturbations
IVR30 mg/kg 30 mg/kgOxidative stress in nervous systemNeurological endocrine-mediated perturbations
IVR30 mg/kg 30 mg/kgAffects blood-brain barrier (BBB)Neurological endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgAffects blood-brain barrier (BBB)Neurological endocrine-mediated perturbations
IVR20 mg/kg 20 mg/kgOxidative stress in nervous systemNeurological endocrine-mediated perturbations
PMID:25101840IVR0.05 mg/kg/day 0.05 mg/kg/dayDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR0.0005 mg/kg/day 0.0005 mg/kg/dayAlters thyroglobulin levelsMetabolic endocrine-mediated perturbations
IVR0.0005 mg/kg/day 0.0005 mg/kg/dayIncrease in Thyrotropin-releasing hormone (TRH) levelsMetabolic endocrine-mediated perturbations
IVR0.0005 mg/kg/day 0.0005 mg/kg/dayIncrease in TSH levelsMetabolic endocrine-mediated perturbations
IVR0.005 mg/kg/day 0.005 mg/kg/dayAlters thyroglobulin levelsMetabolic endocrine-mediated perturbations
IVR0.005 mg/kg/day 0.005 mg/kg/dayDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR0.005 mg/kg/day 0.005 mg/kg/dayIncrease in Thyrotropin-releasing hormone (TRH) levelsMetabolic endocrine-mediated perturbations
IVR0.005 mg/kg/day 0.005 mg/kg/dayIncrease in TSH levelsMetabolic endocrine-mediated perturbations
IVR0.05 mg/kg/day 0.05 mg/kg/dayIncrease in Thyrotropin-releasing hormone (TRH) levelsMetabolic endocrine-mediated perturbations
IVR0.05 mg/kg/day 0.05 mg/kg/dayIncrease in TSH levelsMetabolic endocrine-mediated perturbations
IVR0.05 mg/kg/day 0.05 mg/kg/dayAlters thyroglobulin levelsMetabolic endocrine-mediated perturbations
IVR0.05 mg/kg/day 0.05 mg/kg/dayDecrease in T3 levelsMetabolic endocrine-mediated perturbations
PMID:25819109IVR0.0001 mg/kg/day 0.0001 mg/kg/dayLead to obesityMetabolic endocrine-mediated perturbations
PMID:25898838IVR4 mg/kg 4 mg/kgAffects implantationReproductive endocrine-mediated perturbations
IVR4 mg/kg 4 mg/kgAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR8 mg/kg 8 mg/kgAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR8 mg/kg 8 mg/kgAffects implantationReproductive endocrine-mediated perturbations
PMID:27267847IVR0.0001 mg/kg/day 0.0001 mg/kg/dayIncreased levels of Corticotropin-releasing hormone (CRH)Neurological endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayLead to obesityMetabolic endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAlters hypothalamic-pituitary-adrenal (HPA) axisMetabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayIncrease in corticosterone levelsNeurological endocrine-mediated perturbations
PMID:27521499IVR0.0005 mg/kg/day 0.0005 mg/kg/dayDecreased estradiol levelsReproductive endocrine-mediated perturbations
IVR0.0005 mg/kg/day 0.0005 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayDecreased estradiol levelsReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
PMID:28161095IVR0.0001 mg/kg/day 0.0001 mg/kg/dayIncreased testosterone levelsReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects fertilityReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAlters hypothalamic-pituitary-gonadal axis (HPG axis)Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:28781899IVR5 mg/kg 5 mg/kgDecrease in T4 levelsMetabolic endocrine-mediated perturbations
IVR5 mg/kg 5 mg/kgIncrease in TSH levelsMetabolic endocrine-mediated perturbations
IVR5 mg/kg 5 mg/kgChanges in morphology of thyroid glandMetabolic endocrine-mediated perturbations
IVR5 mg/kg 5 mg/kgReduced glutathione levelsMetabolic endocrine-mediated perturbations
IVR5 mg/kg 5 mg/kgDecrease in T3 levelsMetabolic endocrine-mediated perturbations
PMID:30831249IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayOxidative stress in mammary glandReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects expression of estrogen receptor-alpha (ER-alpha)Reproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects steroidogenesisReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayDecreased uterine weightsReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAlters mammary gland developmentDevelopmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayIncreased mammary gland weightsReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayLead to obesityMetabolic endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayIncreased triglycerides levelMetabolic endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayDecreased ovarian weightsReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAffects lipid metabolismMetabolic endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayAbnormal estrous cyclesReproductive endocrine-mediated perturbations
IVR0.0001 mg/kg/day 0.0001 mg/kg/dayOxidative stress in liverHepatic endocrine-mediated perturbations
PMID:31821856IVR0.0001 mg/kg/day 0.0001 mg/kg/dayChanges in morphology of thyroid glandMetabolic endocrine-mediated perturbations
PMID:7900160IVR100 mg/kg 100 mg/kgAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR100 mg/kg 100 mg/kgAffects implantationReproductive endocrine-mediated perturbations
IVR25 mg/kg 25 mg/kgAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR25 mg/kg 25 mg/kgAffects implantationReproductive endocrine-mediated perturbations
IVR50 mg/kg 50 mg/kgAffects embryonic developmentDevelopmental endocrine-mediated perturbations
IVR50 mg/kg 50 mg/kgAffects implantationReproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.