t-Butyl methyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10746943	IVR	500 mg/kg/day	-	No significant effects observed	-
	IVR	250 mg/kg/day	-	No significant effects observed	-
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decreased prolactin levels	Reproductive endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1500 mg/kg/day	1500 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased prolactin levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
PMID:10966521	IVR	250 mg/day	-	No significant effects observed	-
	IVR	1500 mg/day	1500 mg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1500 mg/day	1500 mg/day	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	1500 mg/day	1500 mg/day	Affects testosterone metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1500 mg/day	1500 mg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	500 mg/day	500 mg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/day	1000 mg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/day	1000 mg/day	Affects testosterone metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/day	1000 mg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
PMID:19344668	IVR	100 %	100 %	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	100 %	100 %	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	100 %	100 %	Affects GABA-receptors	Neurological endocrine-mediated perturbations
	IVR	50 %	50 %	Affects GABA-receptors	Neurological endocrine-mediated perturbations
	IVR	50 %	50 %	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	50 %	50 %	Affects spatial memory	Neurological endocrine-mediated perturbations
PMID:19595749	IVR	1200 mg/kg	1200 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1200 mg/kg	1200 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations

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