2,3',4',6-Tetrabromodiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:11861977	IVR	1 mg/kg/day	-	No significant effects observed	-
	IVR	10 mg/kg/day	10 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:14999130	IVR	3 mg/kg	3 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Increased prolactin levels	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Alterations in preputial separation	Reproductive endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg	60 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:18313098	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects corticosterone metabolism	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVTH	0.000000005 - 0.0000005 M	0.0000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:18470304	IVR	150 mg/kg	150 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	75 mg/kg	-	No significant effects observed	-
	IVTH	0.000001 - 0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVR	50 mg/kg	50 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:22127959	IVR	3 mg/kg/day	3 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Hypertrophy in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Hyperplasia in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Hypertrophy in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Hyperplasia in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	60 mg/kg/day	60 mg/kg/day	Decreased prolactin levels	Reproductive endocrine-mediated perturbations
PMID:25060363	IVR	0.1 mg/kg	-	No significant effects observed	-
	IVR	1 mg/kg	-	No significant effects observed	-
	IVR	10 mg/kg	10 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:28644858	IVTH	0.01 - 50 mg/L	5 - 50 mg/L	Alters thyroglobulin levels	Metabolic endocrine-mediated perturbations
	IVTH	0.01 - 50 mg/L	5 - 50 mg/L	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:8134923	IVR	4 mg/kg	-	No significant effects observed	-
	IVR	0.8 mg/kg	-	No significant effects observed	-
	IVR	100 mg/kg	-	No significant effects observed	-
	IVR	20 mg/kg	-	No significant effects observed	-
	IVR	500 mg/kg	500 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations

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