| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10366543 | IVR | 0.002 - 0.032 mg/kg | 0.004 - 0.032 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.002 - 0.032 mg/kg | 0.004 - 0.032 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.002 - 0.032 mg/kg | 0.004 - 0.032 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.002 - 0.032 mg/kg | 0.004 - 0.032 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:10568697 | IVR | 0.01 mg/kg | 0.01 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Endometrial carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Endometrial carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| PMID:10919282 | IVR | 0.000046 mg/kg | 0.000046 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| PMID:11896295 | IVR | 0.001 mg/kg | 0.001 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| PMID:12128104 | IVR | 0.032 mg/kg | 0.032 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects ovulation | Reproductive endocrine-mediated perturbations | |
| PMID:12538606 | IVTH | 0.00000001 M | 0.00000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 M | 0.00000001 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:12697716 | IVR | 0.0008 mg/kg | 0.0008 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:14718648 | IVR | 0.005 mg/kg | 0.005 mg/kg | Increased prolactin levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects lactation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Decreased mammary gland weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Alters mammary gland development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:15279877 | IVR | 0.01 mg/kg | 0.01 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| PMID:15716479 | IVR | 0.001 mg/kg | 0.001 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Changes in morphology of thyroid gland in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| PMID:15758561 | IVR | 0.001 mg/kg | 0.001 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0003 mg/kg | 0.0003 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| PMID:15902423 | IVR | 0.01 mg/kg | 0.01 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:16167324 | IVR | 0.00018 mg/kg | 0.00018 mg/kg | Changes in brain morphology | Neurological endocrine-mediated perturbations |
| IVR | 0.00018 mg/kg | 0.00018 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| PMID:16177221 | IVR | 0.00005 mg/kg | 0.00005 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| PMID:17050859 | IVR | 0.000001 mg/kg | 0.000001 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000005 mg/kg | 0.000005 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:17485921 | IVR | 0.000002 mg/kg | 0.000002 mg/kg | Alters sex ratio | Reproductive endocrine-mediated perturbations |
| IVR | 0.002 mg/kg | 0.002 mg/kg | Alters sex ratio | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0000004 mg/kg | 0.0000004 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:17555868 | IVTH | 0.0000000001 - 0.00000001 M | 0.0000000001 - 0.00000001 M | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000000001 - 0.00000001 M | 0.0000000001 - 0.00000001 M | Induce cancer metastasis | Endocrine-mediated cancer | |
| IVTH | 0.0000000001 - 0.00000001 M | 0.0000000001 - 0.00000001 M | Alters estrogen-responsive genes | Reproductive endocrine-mediated perturbations | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Induce cancer metastasis | Endocrine-mediated cancer | |
| PMID:18284931 | IVR | 0.0025 mg/kg | 0.0025 mg/kg | Lead to obesity | Metabolic endocrine-mediated perturbations |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Increased estrogen levels | Reproductive endocrine-mediated perturbations | |
| PMID:19069654 | IVR | 0.005 - 0.015 mg/kg | 0.005 - 0.015 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.005 - 0.015 mg/kg | 0.005 - 0.015 mg/kg | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| PMID:19085997 | IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:19490992 | IVR | 0.000001 mg/kg | 0.000001 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.000001 mg/kg | 0.000001 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.00005 mg/kg | 0.00005 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000005 mg/kg | 0.000005 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000005 mg/kg | 0.000005 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000005 mg/kg | 0.000005 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:19490993 | IVR | 0.002 mg/kg | - | No significant effects observed | - |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | - | No significant effects observed | - | |
| IVR | 0.005 mg/kg | 0.005 mg/kg | Erectile dysfunction | Reproductive endocrine-mediated perturbations | |
| PMID:19492234 | IVR | 50 mg/kg | 50 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg | 125 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| PMID:19623578 | IVR | 0.01 mg/kg | 0.01 mg/kg | Reduced insulin levels | Metabolic endocrine-mediated perturbations |
| PMID:19762394 | IVR | 0.00001 mmol | 0.00001 mmol | Decreased spleen weights | Immunological endocrine-mediated perturbations |
| IVR | 0.00001 mmol | 0.00001 mmol | Decreased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 0.00001 mmol | 0.00001 mmol | Changes in T-cell populations | Immunological endocrine-mediated perturbations | |
| IVR | 0.00001 mmol | 0.00001 mmol | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| IVR | 0.00001 mmol | 0.00001 mmol | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| PMID:19843953 | IVR | 0.000046 mg/kg | 0.000046 mg/kg | Uterine carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| IVR | 0.00001 mg/kg | - | No significant effects observed | - | |
| IVR | 0.000003 mg/kg | - | No significant effects observed | - | |
| IVR | 0.000022 mg/kg | - | No significant effects observed | - | |
| IVR | 0.0001 mg/kg | 0.0001 mg/kg | Ovarian atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg | 0.0001 mg/kg | Uterine carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| PMID:19962423 | IVTH | 0.0000000001 - 0.00000001 M | 0.0000000001 - 0.00000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:20083559 | IVTH | 0.0000000002 - 0.000000006 M | 0.000000002 M | Oxidative stress in liver | Hepatic endocrine-mediated perturbations |
| IVTH | 0.0000000002 - 0.000000006 M | 0.000000002 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:20724799 | IVR | 0.032 mg/kg | 0.032 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.032 mg/kg | 0.032 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:20806395 | IVR | 0.0001 mg/kg | 0.0001 mg/kg | Increase in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVR | 0.0001 mg/kg | 0.0001 mg/kg | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg | 0.0001 mg/kg | Affects the biochemical composition of ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg | 0.0001 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:20807317 | IVR | 0.0007 mg/kg | 0.0007 mg/kg | Affects differentiation process | Developmental endocrine-mediated perturbations |
| IVR | 0.0007 mg/kg | 0.0007 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 0.0007 mg/kg | 0.0007 mg/kg | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:20823264 | IVTH | 0.0000000001 - 0.0000001 M | 0.00000001 - 0.0000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000000001 - 0.0000001 M | 0.00000001 - 0.0000001 M | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:20955784 | IVR | 0.01 mg/kg | 0.01 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| PMID:21414370 | IVR | 0.0004 mg/kg | 0.0004 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Affects GABA-receptors | Neurological endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Increased levels of epinephrine | Neurological endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Increased levels of norepinephrine | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased levels of norepinephrine | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Affects GABA-receptors | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased dopamine levels | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased levels of epinephrine | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Affects acetylcholinesterase activity | Neurological endocrine-mediated perturbations | |
| IVR | 0.0004 mg/kg | 0.0004 mg/kg | Increased dopamine levels | Neurological endocrine-mediated perturbations | |
| PMID:21432160 | IVR | 0.00005 mg/kg | 0.00005 mg/kg | Alters sex ratio | Reproductive endocrine-mediated perturbations |
| IVR | 0.0000125 mg/kg | 0.0000125 mg/kg | Alters sex ratio | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0000125 mg/kg | 0.0000125 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg | 0.0008 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg | 0.0002 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:21706896 | IVR | 0.001 mg/kg | - | No significant effects observed | - |
| IVR | 0.00025 mg/kg | 0.00025 mg/kg | Hyperplasia in adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.003 mg/kg | 0.003 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:22129735 | IVR | 0.000002 mg/L | 0.000002 mg/L | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 0.000002 mg/L | 0.000002 mg/L | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000002 mg/L | 0.000002 mg/L | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.000002 mg/L | 0.000002 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:22634562 | IVTH | 0.00000001 M | 0.00000001 M | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations |
| PMID:23142538 | IVR | 0.000002 mg/kg/day | - | No significant effects observed | - |
| IVR | 0.00001 mg/kg/day | 0.00001 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 0.00001 mg/kg/day | 0.00001 mg/kg/day | Alters sperm function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00001 mg/kg/day | 0.00001 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:23363575 | IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Oxidative stress in prostate | Reproductive endocrine-mediated perturbations |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Oxidative stress in seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| PMID:23727336 | IVTH | 0.000000000001 - 0.00000001 M | 0.000000001 - 0.00000001 M | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:25127480 | IVR | 0.01 mg/kg | 0.01 mg/kg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| PMID:25697571 | IVTH | 0.0000000000000031 M | 0.0000000000000031 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000000000000031 M | 0.0000000000000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000000031 M | 0.0000000000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000000031 M | 0.0000000000031 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000031 M | 0.0000000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000031 M | 0.0000000031 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:26415833 | IVR | 0.00000001 - 0.00001 mg/kg | 0.000000086 - 0.00000141 mg/kg | Decreased spleen weights | Immunological endocrine-mediated perturbations |
| IVR | 0.00000001 - 0.00001 mg/kg | 0.000000086 - 0.00000141 mg/kg | Increased thymus gland weights | Immunological endocrine-mediated perturbations | |
| IVR | 0.00000001 - 0.00001 mg/kg | 0.000000086 - 0.00000141 mg/kg | Decreased pancreas weights | Metabolic endocrine-mediated perturbations | |
| IVR | 0.00000001 - 0.00001 mg/kg | 0.000000086 - 0.00000141 mg/kg | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| PMID:27535957 | IVR | 0.01 mg/kg | 0.01 mg/kg | Affects the normal functioning of reproductive system | Reproductive endocrine-mediated perturbations |
| PMID:27613106 | IVR | 0.0005 mg/kg | 0.0005 mg/kg | Alters mammary gland development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:28774668 | IVR | 0.00014 mg/kg/day | 0.00014 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations |
| IVR | 0.00014 mg/kg/day | 0.00014 mg/kg/day | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 0.00014 mg/kg/day | 0.00014 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:29741588 | IVR | 0.01 mg/kg | 0.01 mg/kg | Affects placental function in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Epigenomic alterations in sperm in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Affects placental development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 mg/kg | 0.01 mg/kg | Induce apoptosis of spermatogenic cells in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:29778942 | IVTH | 0.00000000001 M | 0.00000000001 M | Affects embryonic development | Developmental endocrine-mediated perturbations |
| IVTH | 0.00000000001 M | 0.00000000001 M | Affects liver function | Hepatic endocrine-mediated perturbations | |
| PMID:30176550 | IVR | 0.0008 mg/kg/day | 0.0008 mg/kg/day | Affects spatial memory in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 0.0008 mg/kg/day | 0.0008 mg/kg/day | Affects spatial learning in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg/day | 0.0008 mg/kg/day | Affects social behavior in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.0008 mg/kg/day | 0.0008 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg/day | 0.0002 mg/kg/day | Affects social behavior in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:30219569 | IVTH | 2.5 mg/L | 2.5 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
| IVTH | 2.5 mg/L | 2.5 mg/L | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:31195220 | IVTH | 0.00000000001 M | 0.00000000001 M | Affects pancreas development | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVTH | 0.0000000001 M | 0.0000000001 M | Affects pancreas development | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:31629011 | IVR | 0.0005 mg/kg/day | 0.0005 mg/kg/day | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.0005 mg/kg/day | 0.0005 mg/kg/day | Decreased ovarian weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg/day | 0.0005 mg/kg/day | Affects folliculogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg/day | 0.0005 mg/kg/day | Increased LH levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0005 mg/kg/day | 0.0005 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Alterations in vaginal opening of offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0001 mg/kg/day | 0.0001 mg/kg/day | Decreased ovarian weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:7645025 | IVR | 0.001 mg/kg | 0.001 mg/kg | Changes in morphology of accessory sex organs | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Causes vaginal bleeding | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Delayed puberty | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 mg/kg | 0.001 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:9431574 | IVR | 0.001 mg/kg | 0.001 mg/kg | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| PMID:9751521 | IVTH | 0.0000000000031 M | 0.0000000000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000031 M | 0.0000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000031 M | 0.0000000031 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.