Hexabromocyclododecane

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15585367	IVTH	0.00000156 - 0.0002 M	0.00005 - 0.0002 M	Affects TR-mediated gene expression	Metabolic endocrine-mediated perturbations
PMID:16984958	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	0.3 - 200 mg/kg/day	0.3 - 200 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:19118610	IVR	3 mg/kg	3 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased brain weights	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decreased brain weights	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Decreased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
PMID:21072945	IVR	0.2 mg/kg	0.2 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
PMID:21457653	IVTH	0.00000002 - 0.00002 M	0.00000002 - 0.0000002 M	Cancer phenotype	Endocrine-mediated cancer
PMID:22179484	IVTH	0.00000002 - 0.000002 M	0.0000002 - 0.000002 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.00000002 - 0.000002 M	0.0000002 - 0.000002 M	Cancer phenotype	Endocrine-mediated cancer
PMID:26795019	IVR	3 mg/kg/day	3 mg/kg/day	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects liver function	Hepatic endocrine-mediated perturbations
PMID:26804032	IVTH	0.00000001 M	0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:26979758	IVTH	0.0001 M	0.0001 M	Altered estrogen levels	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.