| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:30586609 | IVR | 10 mg/kg | 10 mg/kg | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturba | |
| IVR | 50 mg/kg | 50 mg/kg | Oxidative stress in ovaries | ||
| IVR | 50 mg/kg | 50 mg/kg | Affects ovarian follicles population | ||
| IVR | 50 mg/kg | 50 mg/kg | Decreased Alanine aminotransferase (ALT) levels | ||
| IVR | 50 mg/kg | 50 mg/kg | Induce apoptosis of ovarian follicles | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Increased liver weights | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Increased spleen weights | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Decreased progesterone levels | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Decreased estradiol levels | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Affects steroid metabolism | ||
| IVR | 0.1 mg/kg | 0.1 mg/kg | Induce apoptosis of ovarian follicles |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.