2-Amino-1,3,4-triazole

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:18779953	IVR	300 mg/kg	-	No significant effects observed	-
	IVR	40 mg/kg	-	No significant effects observed	-
	IVR	25 mg/kg	25 mg/kg	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg	-	No significant effects observed	-
	IVR	25 mg/kg	25 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg	-	No significant effects observed	-
	IVR	25 mg/kg	25 mg/kg	Hypertrophy in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	-	No significant effects observed	-
	IVR	200 mg/kg	-	No significant effects observed	-
	IVR	125 mg/kg	125 mg/kg	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Increased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Decreased spleen weights	Immunological endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Hypertrophy in thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Increased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	125 mg/kg	125 mg/kg	Affects liver function	Hepatic endocrine-mediated perturbations
PMID:4177895	IVR	0.5 mg/L	0.5 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/L	0.5 mg/L	Affects iodine uptake into thyroid	Metabolic endocrine-mediated perturbations
	IVR	0.25 mg/L	-	No significant effects observed	-
	IVR	10 mg/L	10 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	50 mg/L	50 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects iodine uptake into thyroid	Metabolic endocrine-mediated perturbations
	IVR	2 mg/L	2 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
PMID:6868082	IVR	100 mg/L	100 mg/L	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	100 mg/L	100 mg/L	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	100 mg/L	100 mg/L	Changes in morphology of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	100 mg/L	100 mg/L	Thyroid gland carcinoma	Endocrine-mediated cancer;Metabolic endocrine-mediated perturbations
	IVR	100 mg/L	100 mg/L	Pituitary gland carcinoma	Endocrine-mediated cancer;Neurological endocrine-mediated perturbations
	IVR	10 mg/L	-	No significant effects observed	-
	IVR	1 mg/L	-	No significant effects observed	-

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