| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:2344992 | IVR | 0.5 mg/kg | - | No significant effects observed | - |
| IVR | 5 mg/kg | - | No significant effects observed | - | |
| IVR | 50 mg/kg | 50 mg/kg | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in immune responses | Immunological endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| PMID:2916230 | IVR | 2 - 16 mg/kg/day | 10 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations |
| IVR | 2 - 16 mg/kg/day | 10 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 16 mg/kg/day | 16 mg/kg/day | Causes vaginal bleeding | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 16 mg/kg/day | 16 mg/kg/day | Decreased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 2 - 16 mg/kg/day | 12 mg/kg/day | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 2 - 16 mg/kg/day | 12 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 2 - 16 mg/kg/day | 12 mg/kg/day | Causes vaginal bleeding | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.