4-Nitro-3-cresol

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:14736814	IVR	100 mg/kg	100 mg/kg	Affects uterine contraction	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	-	No significant effects observed	-
	IVR	10 mg/kg	-	No significant effects observed	-
PMID:16822498	IVR	0.1 mg/kg	0.1 mg/kg	Decreased weights of penis	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Decreased weights of penis	Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg	0.01 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:18057729	IVR	100 mg/kg/day	100 mg/kg/day	Increased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in corticosterone levels	Neurological endocrine-mediated perturbations
PMID:19734673	IVR	100 mg/kg	100 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.