| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10097800 | IVR | 100 mg/kg | 100 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| PMID:10746942 | IVR | 100 mg/kg | 100 mg/kg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | - | No significant effects observed | - | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:10974597 | IVR | 500 mg/L | - | No significant effects observed | - |
| IVR | 25 mg/L | - | No significant effects observed | - | |
| IVR | 2000 mg/L | 2000 mg/L | Affects social behavior | Neurological endocrine-mediated perturbations | |
| PMID:11137316 | IVR | 100 mg/kg | 100 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | - | No significant effects observed | - | |
| IVR | 100 mg/kg | 100 mg/kg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:11936222 | IVTH | 0.00000001 - 0.001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| PMID:12547330 | IVR | 100 mg/kg | 100 mg/kg | Affects uterine function | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg | - | No significant effects observed | - | |
| IVR | 500 mg/kg | 500 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Affects uterine function | Reproductive endocrine-mediated perturbations | |
| PMID:12709020 | IVR | 5 mg/kg | 5 mg/kg | Changes in T-cell populations | Immunological endocrine-mediated perturbations |
| PMID:14654251 | IVR | 200 mg/kg/day | - | No significant effects observed | - |
| IVR | 400 mg/kg/day | - | No significant effects observed | - | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| PMID:14692339 | IVR | 0.00001 M | 0.00001 M | Changes in thymus gland morphology | Immunological endocrine-mediated perturbations |
| IVR | 0.00001 M | 0.00001 M | Alterations in splenocytes population | Immunological endocrine-mediated perturbations | |
| PMID:14709801 | IVTH | 0.00000001 - 0.0001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:14763995 | IVR | 40 mg/kg | 40 mg/kg | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations |
| PMID:15132767 | IVR | 10 mg/L | 10 mg/L | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/L | 25 mg/L | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 25 mg/L | 25 mg/L | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/L | 250 mg/L | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/L | 250 mg/L | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:15219628 | IVR | 600 mg/kg/day | 600 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 400 mg/kg/day | 400 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:15456915 | IVR | 750 mg/L | 750 mg/L | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/L | 25 mg/L | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/L | 200 mg/L | Exhibit sexual dimorphism | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:15458794 | IVR | 20 mg/kg | - | No significant effects observed | - |
| IVR | 80 mg/kg | 80 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg | 80 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:15509668 | IVR | 100 mg/kg | - | No significant effects observed | - |
| IVR | 500 mg/kg | 500 mg/kg | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects uterine contraction | Reproductive endocrine-mediated perturbations | |
| PMID:15518916 | IVR | 0.087 M | 0.087 M | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 0.087 M | 0.087 M | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects insulin signaling | Metabolic endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects dopaminergic pathways | Neurological endocrine-mediated perturbations | |
| PMID:15620428 | IVR | 0.087 M | 0.087 M | Affects social behavior | Neurological endocrine-mediated perturbations |
| IVR | 0.087 M | 0.087 M | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.087 M | 0.087 M | Affects dopaminergic pathways | Neurological endocrine-mediated perturbations | |
| PMID:16847671 | IVR | 10 mg/kg | 10 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased weights of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Hyperplasia in mammary glands | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Thymus atrophy | Immunological endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Alteration in vaginal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| PMID:16984955 | IVTH | 0.0000125 - 0.0002 M | 0.0001 - 0.0002 M | Affects embryonic development | Developmental endocrine-mediated perturbations |
| PMID:17010207 | IVR | 600 mg/kg | 600 mg/kg | Affects neuronal differentiation | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| PMID:17033158 | IVR | 10 mg | 10 mg | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 10 mg | 10 mg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:17038804 | IVR | 1.23 mg/kg | 1.23 mg/kg | Decreased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 1.23 mg/kg | 1.23 mg/kg | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1.23 mg/kg | 1.23 mg/kg | Decreased liver weights in offspring | Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations | |
| IVR | 1.23 mg/kg | 1.23 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Decreased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 123 mg/kg | 123 mg/kg | Decreased liver weights in offspring | Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations | |
| IVR | 12.3 mg/kg | 12.3 mg/kg | Decreased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 12.3 mg/kg | 12.3 mg/kg | Increased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 12.3 mg/kg | 12.3 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 12.3 mg/kg | 12.3 mg/kg | Decreased liver weights in offspring | Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations | |
| PMID:17229994 | IVR | 10 mg/kg | 10 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | - | No significant effects observed | - | |
| IVR | 50 mg/kg | 50 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:17365578 | IVR | 600 mg/kg | 600 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 600 mg/kg | 600 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 400 mg/kg | 400 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:17558187 | IVR | 100 mg/kg | 100 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:17679765 | IVR | 100 mg/kg | 100 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg | 250 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| PMID:17683461 | IVR | 0.0025 mg/kg | 0.0025 mg/kg | Decreased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0025 mg/kg | 0.0025 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:18174953 | IVTH | 0.00000001 - 0.0001 M | 0.000000001 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| PMID:18174954 | IVR | 80 mg/kg | 80 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 80 mg/kg | 80 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:18621119 | IVR | 0.1 mg/kg | 0.1 mg/kg | Affects skeletal development in fetus | Developmental endocrine-mediated perturbations |
| PMID:18839522 | IVR | 100 mg/kg | 100 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 100 mg/kg | 100 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 200 mg/kg | 200 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:18854640 | IVTH | 0.000000001 - 0.00001 M | 0.00000001 - 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:19145065 | IVR | 10 mg/kg | - | No significant effects observed | - |
| IVR | 100 mg/kg | - | No significant effects observed | - | |
| IVR | 600 mg/kg | 600 mg/kg | Increase in Growth Hormone (GH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 600 mg/kg | 600 mg/kg | Increased prolactin levels | Reproductive endocrine-mediated perturbations | |
| PMID:1935846 | IVTH | 0.000001 M | 0.000001 M | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000001 M | 0.000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| IVTH | 0.00001 M | 0.00001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| IVTH | 0.00001 M | 0.00001 M | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 50 mg | 50 mg | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.0000001 M | 0.0000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| IVTH | 0.0000001 M | 0.0000001 M | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| PMID:20172022 | IVTH | 0.000001 - 0.000005 M | 0.000001 - 0.000005 M | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations |
| PMID:20194071 | IVTH | 0.00000000001 M | 0.00000000001 M | Affects cytokine signaling | Immunological endocrine-mediated perturbations |
| IVTH | 0.000000001 M | 0.000000001 M | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| IVTH | 0.0000000000001 M | - | No significant effects observed | - | |
| PMID:20197112 | IVTH | 0.00000000001 - 0.0000001 M | 0.0000000001 - 0.00000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| PMID:20922811 | IVR | 50 mg/kg/day | - | No significant effects observed | - |
| IVR | 100 mg/kg/day | - | No significant effects observed | - | |
| IVR | 40 mg/kg/day | - | No significant effects observed | - | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decreased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects spatial memory | Neurological endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased spleen weights | Immunological endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:22414680 | IVTH | 0.00000000000001 - 0.00000001 M | 0.0000001 M | Affects estrogen metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:22531466 | IVTH | 0.0000001 - 0.00001 M | 0.0000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:22765982 | IVR | 2 mg/L | 2 mg/L | Increase in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVR | 2 mg/L | 2 mg/L | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Increased aldosterone levels | Metabolic endocrine-mediated perturbations | |
| PMID:23672405 | IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000000001 - 0.000001 M | 0.0000001 - 0.000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.000000001 - 0.000001 M | 0.00000001 - 0.000001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000001 - 0.000001 M | 0.00000001 - 0.000001 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:23830829 | IVR | 40 mg/kg/day | 40 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 80 mg/kg/day | 80 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:23862621 | IVTH | 0.0000001 M | 0.0000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:24278580 | IVTH | 0.000000001 - 0.00001 M | 0.000000001 - 0.00001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| PMID:24308608 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000001 M | 0.000001 M | Affects cytokine signaling | Immunological endocrine-mediated perturbations | |
| PMID:25058900 | IVR | 50 mg/kg/day | 50 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Alteration in gonadal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| PMID:25474107 | IVR | 50 mg/kg | 50 mg/kg | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| IVR | 50 mg/kg | 50 mg/kg | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| PMID:25690688 | IVTH | 0.000001 M | 0.000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer |
| PMID:25849766 | IVTH | 0.000000001 - 0.000001 M | 0.0000001 - 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000000001 - 0.000001 M | 0.0000001 - 0.000001 M | Induce cancer metastasis | Endocrine-mediated cancer | |
| PMID:26027920 | IVTH | 0.000000000000001 - 0.0000001 M | 0.00000000001 - 0.000000001 M | Affects placental development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| PMID:26804032 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.000001 M | 0.000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| PMID:26905877 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:27036933 | IVTH | 0.000000001 M | 0.000000001 M | Affects xenobiotic transport | Metabolic endocrine-mediated perturbations |
| IVTH | 0.0000001 M | - | No significant effects observed | - | |
| PMID:27087316 | IVR | 25 mg/kg | - | No significant effects observed | - |
| IVR | 100 mg/kg | 100 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| PMID:27832966 | IVR | 100 mg/kg/day | 100 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| PMID:27835057 | IVTH | 0.04 - 5 mg/L | 1 - 5 mg/L | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.04 - 5 mg/L | 1 - 5 mg/L | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.04 - 5 mg/L | 1 - 5 mg/L | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:28041982 | IVR | 10 mg/kg/day | - | No significant effects observed | - |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Induce apoptosis of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Induce apoptosis of sertoli cells | Reproductive endocrine-mediated perturbations | |
| PMID:28160177 | IVR | 30 mg/kg | 30 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations |
| IVR | 270 mg/kg | 270 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| PMID:28686624 | IVR | 180 mg/kg/day | 180 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations |
| IVR | 180 mg/kg/day | 180 mg/kg/day | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 180 mg/kg/day | 180 mg/kg/day | Increased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 180 mg/kg/day | 180 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 180 mg/kg/day | 180 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 180 mg/kg/day | 180 mg/kg/day | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| PMID:28785733 | IVR | 0.05 mg/L | 0.05 mg/L | Decreased ovarian weights | Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/L | 0.5 mg/L | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:28891310 | IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in morphology of pancreas | Metabolic endocrine-mediated perturbations |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| PMID:28962484 | IVR | 10 mg/kg | 10 mg/kg | Increased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Increased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Increased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| PMID:29250801 | IVR | 250 mg/kg/day | 250 mg/kg/day | Hyperplasia in liver | Hepatic endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects estrogen metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects locomotor activity | Neurological endocrine-mediated perturbations | |
| PMID:29445187 | IVR | 0.005 mg/kg/day | 0.005 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations |
| IVR | 0.0005 mg/kg/day | - | No significant effects observed | - | |
| IVR | 0.05 mg/kg/day | - | No significant effects observed | - | |
| PMID:29522864 | IVR | 0.2 mg/kg | - | No significant effects observed | - |
| IVR | 2 mg/kg | 2 mg/kg | Cognitive impairment | Neurological endocrine-mediated perturbations | |
| PMID:29641977 | IVR | 500000 mg/kg/day | 500000 mg/kg/day | Affects amino acid metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 500000 mg/kg/day | 500000 mg/kg/day | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 500000 mg/kg/day | 500000 mg/kg/day | Causes insulin resistance | Metabolic endocrine-mediated perturbations | |
| IVR | 500000 mg/kg/day | 500000 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 500000 mg/kg/day | 500000 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| PMID:30021644 | IVTH | 0.00002 M | 0.00002 M | Affects fatty acid metabolism in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 2 mg/L | 2 mg/L | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Affects steroid metabolism in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Increase in corticosterone levels in offspring | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 2 mg/L | 2 mg/L | Increased aldosterone levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:30069898 | IVR | 250 mg/kg/day | 250 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Induce apoptosis in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| PMID:30090504 | IVR | 180 mg/kg | 180 mg/kg | Changes in morphology of pancreas | Metabolic endocrine-mediated perturbations |
| IVR | 180 mg/kg | 180 mg/kg | Oxidative stress in pancreas | Metabolic endocrine-mediated perturbations | |
| IVR | 180 mg/kg | 180 mg/kg | Reduced insulin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 20 mg/kg | 20 mg/kg | Oxidative stress in pancreas | Metabolic endocrine-mediated perturbations | |
| IVR | 60 mg/kg | 60 mg/kg | Changes in morphology of pancreas | Metabolic endocrine-mediated perturbations | |
| IVR | 60 mg/kg | 60 mg/kg | Oxidative stress in pancreas | Metabolic endocrine-mediated perturbations | |
| PMID:30228064 | IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 mg/kg/day | 0.15 mg/kg/day | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Affects testicular function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Increased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:30339805 | IVR | 30 mg/kg | 30 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations |
| IVR | 30 mg/kg | 30 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| PMID:30469005 | IVR | 100 mg/kg/day | 100 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| PMID:30629985 | IVR | 0.002 mg/kg/day | 0.002 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
| IVR | 0.00002 mg/kg/day | 0.00002 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 0.0002 mg/kg/day | 0.0002 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:31084616 | IVR | 15 mg/kg | 15 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 15 mg/kg | 15 mg/kg | Increase in uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg | 30 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg | 30 mg/kg | Increase in uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 120 mg/kg | 120 mg/kg | Increase in uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 120 mg/kg | 120 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 120 mg/kg | 120 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 240 mg/kg | 240 mg/kg | Increase in uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 60 mg/kg | 60 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 60 mg/kg | 60 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 60 mg/kg | 60 mg/kg | Increase in uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:31108418 | IVTH | 0.0000000001 M | 0.0000000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.0000000001 M | 0.0000000001 M | Prostate carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000001 M | 0.0000000001 M | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000000001 M | 0.0000000001 M | Induce tumor progression | Endocrine-mediated cancer | |
| IVTH | 0.00000001 M | - | No significant effects observed | - | |
| IVTH | 0.000000000001 M | - | No significant effects observed | - | |
| IVTH | 0.00000000001 M | - | No significant effects observed | - | |
| IVTH | 0.000000001 M | - | No significant effects observed | - | |
| IVTH | 0.000001 M | - | No significant effects observed | - | |
| IVTH | 0.0000001 M | - | No significant effects observed | - | |
| PMID:31144530 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVTH | 0.00001 M | 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.000000001 M | 0.000000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.0000000001 M | - | No significant effects observed | - | |
| IVTH | 0.00000000001 M | - | No significant effects observed | - | |
| IVTH | 0.0000001 M | 0.0000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.0000005 M | 0.0000005 M | Cancer phenotype | Endocrine-mediated cancer | |
| IVTH | 0.00000001 M | 0.00000001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:31201952 | IVTH | 0.000005 M | 0.000005 M | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations |
| PMID:31245175 | IVR | 25 mg/kg | 25 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| PMID:31279116 | IVR | 30 mg/kg/day | 30 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 270 mg/kg/day | 270 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg/day | 90 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated | |
| PMID:31280147 | IVR | 4 mg/kg | 4 mg/kg | Abnormal neuronal distribution | Neurological endocrine-mediated perturbations |
| IVR | 4 mg/kg | 4 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:31321349 | IVR | 0.05 mg/L | 0.05 mg/L | Changes in morphology of seminiferous tubules in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased prostate weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased weights of epididymis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Decreased weights of seminal vesicles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Increased testis weights in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:31660452 | IVR | 0.05 mg/L | 0.05 mg/L | Increased weights of epididymis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/L | 0.05 mg/L | Changes in morphology of seminiferous tubules in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.05 mg/L | 0.05 mg/L | Affects survival of germ cells in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:31660453 | IVR | 0.05 mg/L | 0.05 mg/L | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 0.05 mg/L | 0.05 mg/L | Alterations in endometrial morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/L | 0.5 mg/L | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:31911191 | IVR | 30 mg/kg | 30 mg/kg | Affects tryptophan metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 30 mg/kg | 30 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 30 mg/kg | 30 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 30 mg/kg | 30 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Affects tryptophan metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 270 mg/kg | 270 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Affects tryptophan metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Increased serotonin (5-HT) levels | Neurological endocrine-mediated perturbations | |
| IVR | 90 mg/kg | 90 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.