4-hydroxy-2,3,3,4,5-pentachlorobiphenyl

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15310862	IVR	0.5 mg/kg	0.5 mg/kg	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:18025052	IVTH	0.00002 M	0.00002 M	Affects uterine morphology	Reproductive endocrine-mediated perturbations
PMID:29788408	IVR	0.0000011 mmol	0.0000011 mmol	Necrosis of liver	Hepatic endocrine-mediated perturbations
	IVR	0.0000011 mmol	0.0000011 mmol	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.0000011 mmol	0.0000011 mmol	Affects fatty acid metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.0000011 mmol	0.0000011 mmol	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	0.000011 mmol	0.000011 mmol	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	0.000011 mmol	0.000011 mmol	Affects fatty acid metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.000011 mmol	0.000011 mmol	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.000011 mmol	0.000011 mmol	Necrosis of liver	Hepatic endocrine-mediated perturbations
	IVR	0.00000011 mmol	-	No significant effects observed	-

---

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.